Clinical trials: Renal Insufficiency, Acute
Septic Shock, Acute Renal Failure (as Defined by the "Failure" Stage of the RIFLE Classification)
I.D.E.A.L.-I.C.U. (Initiation of Dialysis EArly Versus deLayed in Intensive Care Unit)
The purpose of this multicentric, randomized controlled trial is to assess whether the timing of renal replacement therapy initiation (early vs delayed) has an impact on mortality at 90 days in patients with severe acute kidney…
- Trial name
- IDEAL-ICU (NCT01682590)
- Testing
- Renal Remplacement Therapy
- Where
- 27 sites in France
- Volunteers
- 500 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Hepato-Renal Syndrome
Nor-epinephrine Versus Midodrine/Octreotide in Patients With Hepatorenal Syndrome
Hepatorenal syndrome is a functional renal impairment occurring in cirrhotic patients . It develops secondary to splanchnic arterial vasodilatation which decreases the effective blood volume, activate the…
- Trial name
- NCT04522297
- Testing
- Midodrine/Octreotide, Nor-epinephrine
- Where
- Egypt
- Volunteers
- 91 people
- Sponsor
- National Hepatology & Tropical Medicine Research Institute
Diabetes Mellitus, Type 2
Risk of Acute Kidney Injury Among Patients With Type 2 Diabetes Exposed to Oral Antidiabetic Treatments
The purpose of this study is to compare the incidence of hospitalization for acute kidney injury among patients with type 2 diabetes who are new initiators of Saxagliptin and those who are new initiators of other oral…
- Trial name
- NCT01377935
- Volunteers
- 113,505 people
- Sponsor
- AstraZeneca
Acute Kidney Injury
Role of Neuronal Guidance Proteins as Diagnostic Markers for Acute Kidney Injury (AKI)
Acute kidney failure remains one of the most challenging entities to diagnose in clinical medicine, especially in the field of intensive care.
- Trial name
- NEUKID (NCT05924269)
- Volunteers
- 600 people
- Sponsor
- University Hospital Tuebingen
Acute Coronary Syndrome, Chronic Kidney Diseases
The Predictive and Diagnostic Value of Cystatin C and High Sensitive Troponin
Our study is planning to evaluate patients with chronic kidney disease who come to the emergency department with chest pain. Estimated GFR (cisGFR) with cystatin and estimated GFR (creaGFR) with creatinine will be calculated.
- Trial name
- NCT05303441
- Testing
- percutaneous coronary intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 172 people
- Sponsor
- Ankara Diskapi Training and Research Hospital
Heart Failure, Renal Dysfunction
Low Dose Intravenous (IV) Infusion of BNP in the Presence and Absence of Acute Type V Phosphodiesterase (PDE V) in Improving Renal Function in Hospitalized Chronic Heart Failure (CHF) Patients With Renal Dysfunction
The purpose of the study is to determine if low doses of BNP can improve renal function in people with chronic heart failure with renal dysfunction, also to determine whether Sildenafil assists with improvement.
- Trial name
- Aim 3 BNP/PDEV (NCT00972569)
- Testing
- BNP and PDE-V, BNP
- Volunteers
- 60 people
- Sponsor
- Mayo Clinic
Acute Kidney Injury (Nontraumatic), Coronary Artery Disease
Contrast RISK (Reducing Injury Sustained by Kidneys)
Diagnostic and therapeutic cardiac catheterization procedures are important interventions to reduce the risk of death, avoid future cardiovascular events, and improve quality of life of people with heart disease.
- Trial name
- Contrast RISK (NCT03453996)
- Testing
- Intervention, Control
- Where
- 3 sites in Canada
- Volunteers
- 7,280 people
- Sponsor
- University of Calgary
COVID-19
TXA127 for the Treatment of Severe COVID-19
The purpose of this study is to determine if administration of angiotensin-(1-7) (TXA127) prevents acute kidney injury and deterioration into multi-organ failure in patients with severe COVID-19.
- Trial name
- NCT04401423
- Testing
- TXA127
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Columbia University
Covid19, AKI
Global Assessment of Acute and Chronic Kidney Disease Incidence and Outcomes in Patients With COVID-19 Infection
The coronavirus (COVID-19) pandemic has created a significant strain on health care resources across the world for managing critically ill patients.
- Conditions
- Covid19, AKI, CKD, ESRD
- Trial name
- NCT04491227
- Where
- 12 sites in United States, Bolivia and 4 more
- Volunteers
- 2,000 people
- Sponsor
- University of California, San Diego
Covid19, Acute Kidney Injury
Urine Alkalinisation in COVID-19
Since the outbreak of coronavirus disease 2019 (COVID-19), more than 100,000 patients have died in the United Kingdom. Acute kidney injury is common in critically ill patients with COVID-19.
- Trial name
- NCT04806061
- Testing
- Sodium bicarbonate, standard care
- Where
- 2 sites in United Kingdom
- Volunteers
- 80 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Renal Replacement Therapy
Citrate Anticoagulation in Renal Replacement Therapy: Impact of a High Post-filter Calcium Target on Efficacy
Regional citrate anticoagulation (RCA) is the recommended method for anticoagulation in continuous renal replacement therapy (CRRT). However, the optimal post-filter ionized calcium (iCa) target level remains unclear.
- Trial name
- Ca-CIBLE (NCT05814341)
- Testing
- Citrate
- Where
- France
- Volunteers
- 108 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Kidney Injury, Acute
A Machine Learning Prediction Model for Postoperative Acute Kidney Injury in Non-Cardiac Surgery Patients
Primary objectives of this study is to develop and validate a predictive model for acute kidney injury after non-cardiac surgery based on machine learning.
- Trial name
- NCT07030166
- Testing
- No intervention measures were used.
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Lanyue Zhu
Sever Acute Respiratory Syndrome and Acute Kidney Injury, Acute Kidney Injury
Acute Kidney Injury Risk in COVID-19
Background. Within a year, COVID-19 has advanced from being an outbreak to a pandemic, spreading rapidly and globally with devastating impact.
- Trial name
- NCT04874779
- Testing
- non
- Where
- Egypt
- Volunteers
- 83 people
- Sponsor
- Zagazig University
Intensive Care Unit, Acute Kidney Injury
The Diagnostic Value of Contrast-enhanced Ultrasound in Acute Kidney Injury in ICU
The goal of this observational study is to quantitatively assess the renal microcirculation changes by contrast-enhanced ultrasound (CEUS) and to obtain systemic hemodynamic information by ultrasound Doppler at the same time, to…
- Conditions
- Intensive Care Unit, Acute Kidney Injury, Ultrasound
- Trial name
- NCT06353659
- Testing
- Contrast-enhanced Ultrasound
- Volunteers
- 60 people
- Sponsor
- Peking University Third Hospital
Contrast-induced Acute Kidney Injury (CI-AKI)
Hemodynamic Effects Of Impella On Renal Circulation And Risk Of CA-AKI Among Patients Undergoing Protected PCI
Patients undergoing Percutaneous Coronary Intervention (PCI) are exposed to the risk of suffering from a damage to the kidneys which goes under the name of Contrast-Associated Acute Kidney Injury (CA-AKI), which is more common if…
- Trial name
- NCT04928118
- Testing
- Evaluate the blood flow and pressure into kidneys
- Sponsor
- Virginia Commonwealth University
Nephrectomy, Acute Kidney Injury
Novel Biomarkers and Postoperative Kidney Injury in Radical Nephrectomy
The incidence of acute kidney injury (AKI) after radical nephrectomy exceeds 40%. Currently, the KDIGO criteria are the recognized diagnostic standard for AKI.
- Conditions
- Nephrectomy, Acute Kidney Injury, Biomarker
- Trial name
- NCT07088874
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University First Hospital
Patent Ductus Arteriosus (PDA), Acute Kidney Injury (AKI)
Fenoldopam to Prevent Renal Dysfunction in Indomethacin Treated Preterm Infants
The investigators will conduct a prospective, blinded, randomized, placebo-controlled trial with a sample size of 20 patients in each of the two arms (fenoldopam vs placebo) based upon a difference in serum creatinine by one…
- Trial name
- Fenaki (NCT02620761)
- Testing
- Fenoldopam, 0.9%NS
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Medical College of Wisconsin
Acute Kidney Injury
Safety & Efficacy of BCT197 in Patients Undergoing Cardiac Surgery
This study will assess the safety and efficacy of BCT197 on acute kidney injury in patients undergoing cardiac surgery with cardiopulmonary bypass.
- Trial name
- NCT01336959
- Testing
- BCT197 Part A, BCT197 Part B
- Where
- 13 sites in United States, Israel and 1 more
- Volunteers
- 91 people
- Sponsor
- Mereo BioPharma
Acute Kidney Injury
Identification and Validation of Biomarkers of Acute Kidney Injury Recovery
This study is to collect blood and urine samples to help identify and validate protein biomarkers of recovery from moderate or severe acute kidney injury (AKI).
- Trial name
- NCT01868724
- Where
- 21 sites in United States, Austria and 4 more
- Volunteers
- 362 people
- Sponsor
- Astute Medical, Inc.
Acute Heart Failure, Chronic Kidney Diseases
Empagliflozin in Acute Heart Failure
The objective is to study in a prospective, interventional, single arm, cohort study the potential synergistic diuretic effect of empagliflozin, in addition to furosemide, in hypervolemic patients admitted with acutely…
- Trial name
- DRIP-AHF-1 (NCT05305495)
- Testing
- Empagliflozin 25 MG
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre