Clinical trials: Renal Insufficiency, Chronic
End Stage Renal Disease
Comparison of the Impact of Dialysis Treatment Type on Patient Survival
As the influence of type of dialysis on survival of end stage renal disease (ESRD) patients remains unanswered, the present study is designed (randomized, prospective, multicenter, interventional) to assess clinical outcomes, and…
- Trial name
- NCT00510549
- Testing
- Modality: Peritoneal Dialysis
- Where
- 2 sites in China
- Volunteers
- 50 people
- Sponsor
- Baxter Healthcare Corporation
Cognitive Function, Preclinical, Chronic Kidney Diseases
Exercise Training and Cognitive Function in Kidney Disease
Chronic kidney disease (CKD), affects over 45% of all individuals over 70 years of age. Patients with moderate CKD have more than a two-fold increased risk of cognitive impairment than those without CKD; furthermore, as many as…
- Conditions
- Cognitive Function, Preclinical, Chronic Kidney Diseases, Older Adults
- Trial name
- NCT03197038
- Testing
- Partially supervised home-based walking exercise, Control
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
End Stage Renal Disease
A Pilot Study To Evaluate The CreatiVasc Hemoaccess Valve System In Patients Requiring Arteriovenous Graft Placement
The ability to selectively control blood flow through an arteriovenous (AV) graft only when it is needed for dialysis may reduce the current repetitive complications such as thrombosis, venous hypertension post-dialysis bleeding…
- Trial name
- NCT01644526
- Testing
- Hemoaccess Valve System
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Diaxamed LLC
Cardiomyopathy, Renal Impairment
Study to Determine How Cialis Effects the Renal Function in Response to Volume Expansion in Preclinical Diastolic Cardiomyopathy (Aim3)
To determine the effect of 12 weeks of chronic PDEV inhibition with Tadalafil versus placebo on basal cardiorenal and humoral function and on the integrated cardiorenal and humoral response to acute sodium loading in subjects…
- Trial name
- Aim 3 (NCT02058095)
- Testing
- Tadalafil
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Mayo Clinic
Secondary Hyperparathyroidism, Chronic Kidney Disease
E.V.O.L.V.E. Trial™: EValuation Of Cinacalcet Hydrochloride (HCl) Therapy to Lower CardioVascular Events
The purpose of this study is to evaluate the effects of cinacalcet (cinacalcet HCl or Sensipar®/Mimpara®) on cardiovascular events and death in chronic kidney disease (CKD) patients with secondary hyperparathyroidism (HPT) who…
- Trial name
- EVOLVE (NCT00345839)
- Testing
- Cinacalcet
- Volunteers
- 3,883 people
- Sponsor
- Amgen
Acute Kidney Injury
Double-Blind Placebo-Controlled CIN Trial
This double-blinded placebo-controlled study will examine the incidence and significance of contrast-induced acute kidney injury following IV iodine-based contrast material administration in subjects with stage IIIB or stage IV…
- Trial name
- NCT02467075
- Testing
- Iopamidol 300 (Contrast)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Michigan
Fabry Disease
A Study in Patients With Fabry Disease Who Are on Chronic Hemodialysis Therapy for Treatment of End-stage Renal Insufficiency.
People with Fabry disease have an alteration in their genetic material (DNA) which causes a deficiency of the a-galactosidase A enzyme.
- Trial name
- NCT00312767
- Testing
- Fabrazyme (agalsidase beta)
- Where
- United States
- Sponsor
- Genzyme, a Sanofi Company
Kidney; Disease (Functional), Chronic Kidney Disease
Early Screening and Diagnosis of CKD
Chronic kidney disease (CKD) is a global public health problem. The prevalence of CKD in adults in China was 10.8%. Albuminuria measurement and estimating glomerular filtration rate (GFR) are the primary means of screening for…
- Trial name
- NCT02841371
- Testing
- 99mTc-DTPA
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Chronic Kidney Diseases
Sex Differences in Chronic Kidney Disease
This study aims to describe sex specific differences of the hemodialysis population in Austria, to quantify sex specific differences in treatment and outcomes in hospitalized patients with chronic kidney disease and to examine…
- Trial name
- NCT03771703
- Where
- Austria
- Volunteers
- 1,100 people
- Sponsor
- Assoc. Prof. Dr. Manfred Hecking, MD PhD
Hemodialysis, Kidney Disease, Chronic
Intradialysis Exercise Functional Capacity, Body Composition and Survival in Hemodialysis Patients
Chronic kidney disease and renal replacement treatments (hemodialysis, peritoneal dialysis, kidney transplant) produce various alterations at the level of muscle, bones, fat content and the heart; can alter physical capabilities…
- Conditions
- Hemodialysis, Kidney Disease, Chronic, Physical Activity, Physical Deconditioning
- Trial name
- NCT06788054
- Testing
- intradialysis exercise
- Where
- Mexico
- Volunteers
- 50 people
- Sponsor
- Universidad de Guanajuato
Critical Ill Patients, Patients Needing Continuous Renal Replacement Therapy
Efficacy and Safety of Heparin-coated Surface-treated Polyacrylonitrile Membrane Hemofilter in Critical Ill CRRT Patients
CRRT patients are generally critical ill patients with unstable conditions, such as low blood pressure,severe SIRS,et al. Acute kidney injury(AKI)is especially prevalent,with even two or more organ failure.
- Trial name
- NCT02355873
- Testing
- AN69ST hemofilter, AN69 hemofilter
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University First Hospital
Chronic Kidney Disease
Niacin and Endothelial Function in Early CKD
The purpose of this study is to obtain information on whether raising levels of HDL-cholesterol (the "good" cholesterol) can improve how blood vessels work in kidney disease.
- Trial name
- NCT00852969
- Testing
- Niacin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Tufts Medical Center
Chronic Kidney Diseases, Obesity
Intermittent Low Energy Diet in CKD: MIX UP Feasibility Study
This study proposes to investigate the acceptability and efficacy of intermittent VLED (5:2 diet) plus exercise, compared with the investigator's established Weight Management Programme (WMP), in obese patients with CKD, using…
- Trial name
- MIX-UP (NCT03736551)
- Testing
- 5:2 diet, Renal Weight Management Programme
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- King's College Hospital NHS Trust
Chronic Kidney Disease, Secondary Hyperparathyroidism
Evaluation of Treatment With Zemplar Capsules in the Therapy of Secondary Hyperparathyroidism (SHPT)
The aims of this post-marketing observational study (PMOS) are to evaluate the time period needed to achieve > 30% decrease of intact parathyroid hormone (iPTH) compared to the initial values and to provide data on the…
- Trial name
- NCT01224782
- Where
- 69 sites in Bulgaria, Czechia and 1 more
- Volunteers
- 994 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Heart Failure, Chronic Kidney Disease
Staged Kidney Transplantation During Combined Heart/Kidney Transplantation
The primary purpose of this study is to evaluate the safety and efficacy of ex vivo machine perfusion with staged implantation of kidney allografts during combined heart/kidney transplantation.
- Conditions
- Heart Failure, Chronic Kidney Disease, End-stage Kidney Disease
- Trial name
- NCT06877169
- Testing
- Planned delayed implantation of kidney allograft with ex vivo machine perfusion kidney preservation.
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cedars-Sinai Medical Center
Chronic Kidney Disease
Barriers to Peritoneal Dialysis Selection
The purpose of this study is to understand what prevents chronic kidney disease patients from making a timely decision about dialysis modality options.
- Trial name
- NCT01517841
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- MetroHealth Medical Center
Kidney Failure, Chronic
Efficacy and Safety of Lanthanum in Controlling Serum Phosphate Levels in Subjects With End Stage Renal Disease Who Require Treatment for High Levels of Phosphate in Their Blood
The purpose of this study is to test how well higher doses of lanthanum carbonate reduce the pre-dialysis level of serum phosphorus in subjects undergoing dialysis due to end stage renal disease.
- Trial name
- NCT00150566
- Testing
- Lanthanum carbonate
- Volunteers
- 460 people
- Sponsor
- Shire
End Stage Renal Disease, Chronic Kidney Diseases
Berinert (C1INH) vs Placebo for DGF/IRI
This is a Phase I/II double-blind, randomized, placebo-controlled study assessing safety and limited efficacy of intraoperative C1INH (500U/kidney) vs.
- Trial name
- NCT04696146
- Testing
- Berinert
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Cedars-Sinai Medical Center
Chronic Kidney Disease Stage 3B, Chronic Kidney Disease stage4
Effect of Broccoli Sprout Extract in Patients With Chronic Kidney Disease With Diabetes Type 2
This research project aims to test if sulforaphane, administered as broccoli sprout extract (BSE) can ameliorate glucose control in adult patients with chronic kidney disease (CKD) and DM 2 with GFR > 15 < 45 ml/min/1.73 m2.
- Conditions
- Chronic Kidney Disease Stage 3B, Chronic Kidney Disease stage4, Diabetes Mellitus, Type 2
- Trial name
- INITIATE (NCT04858854)
- Testing
- Sulforaphane, administered as Broccoli sprout extract
- Where
- 12 sites in Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska Institutet
Chronic Kidney Disease Requiring Chronic Dialysis
Integrating BIA and eGFR for Nutritional Status in Hemodialysis Patients
This study looks at how measurements of body composition from Bioelectrical Impedance Analysis (BIA) and estimates of kidney function (eGFR) can be applied together to better assess the health of people on hemodialysis.
- Trial name
- NCT06873880
- Where
- Estonia
- Volunteers
- 30 people
- Sponsor
- University of Tartu
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