Clinical trials: Renal Insufficiency, Chronic
Cardiovascular Diseases, Heart Diseases
Role of Chronic Kidney Disease in Cardiovascular Disease
The purpose of this study is to determine how the progressive loss of kidney function influences cardiovascular disease.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Kidney Failure, Chronic
- Trial name
- NCT00069810
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Washington
Hyperuricemia, Renal Insufficiency, Chronic
Comparison of the Effect of Allopurinol Versus Febuxostat on Serum Uric Acid in Patients With Chronic Kidney Disease Associated With Hyperuricemia
This randomized study was designed to compare how well allopurinol and febuxostat lowered blood uric acid in adults with chronic kidney disease and high uric acid levels.
- Trial name
- NCT07850713
- Testing
- Febuxostat, allopurinol
- Where
- Pakistan
- Volunteers
- 66 people
- Sponsor
- Nishtar Medical University
Heart Failure, Kidney Dysfunction
The Effects of Decreasing the Lasix Dose on the Cardiorenal System
The investigators' objective is to define the effects of decreasing the furosemide dose on heart, kidney and humoral function in people with compensated heart failure and kidney dysfunction and also in people with compensated…
- Trial name
- Aim1 (NCT00982423)
- Testing
- Furosemide
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Mayo Clinic
Stenosis of Vascular Prosthetic Devices, Implants and Grafts
Post-Approval Study for the FLAIR Endovascular Stent Graft
The purpose of this study is to confirm the long-term safety and effectiveness of the FLAIR Endovascular Stent Graft for treatment of stenoses at the venous anastomosis of ePTFE or other synthetic arteriovenous (AV) access grafts.
- Trial name
- RENOVA (NCT00677235)
- Testing
- FLAIR Endovascular Stent Graft, PTA
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- C. R. Bard
IgA Nephropathy, ESRD
TESTING -ON Post-Trial ObservatioNal Cohort Study
The primary aim of this study is to extend follow up of TESTING study participants and to assess the long-term effects of a 6-9-month course of oral methylprednisolone on End Stage Kidney Disease (ESKD), according to dose…
- Conditions
- IgA Nephropathy, ESRD, Glomerulonephritis, Kidney Diseases
- Trial name
- TESTING-ON (NCT05434325)
- Where
- 59 sites in Australia, Canada and 4 more
- Volunteers
- 211 people
- Sponsor
- The George Institute
Renal Failure Chronic, Hepatitis C
Direct-acting Antiviral Therapy to Prevent HCV Infection for HCV Positive Donor to HCV Negative Recipient Kidney Transplant
Open label single center study for the donation of HCV positive kidneys to HCV negative recipients with interventional treatment to prevent HCV transmission upon transplantation.
- Trial name
- NCT03093740
- Testing
- Zepatier, Zepatier plus Sofosbuvir
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Chronic Kidney Disease, Kidney Disease
Adia Med of Winter Park LLC Chronic Kidney Disease Research Study
The goal of this clinical trial is to learn whether a new regenerative treatment called AdiaVita, made from umbilical cord blood-derived stem cells and exosomes combined with glutathione, is safe and can help improve kidney…
- Conditions
- Chronic Kidney Disease, Kidney Disease, Kidney Disease, Chronic, Chronic Kidney Disease (CKD)
- Trial name
- NCT07572890
- Testing
- Umbilical Cord Blood-Derived Stem Cells and Exosomes, Glutathione IV, Glutathione Spray
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Adia Med of Winter Park LLC
Chronic Kidney Disease, Dialysis
Study of MCI-196 in Chronic Kidney Disease Stage V Subjects on Dialysis With Hyperphosphatemia
The primary objective of this study is to demonstrate the long-term safety and tolerability of MCI-196 in the subjects with stage V chronic kidney disease on dialysis with hyperphosphatemia.
- Conditions
- Chronic Kidney Disease, Dialysis, Hyperphosphatemia
- Trial name
- NCT00772382
- Testing
- MCI-196
- Where
- 21 sites in United States, Canada
- Volunteers
- 116 people
- Sponsor
- Tanabe Pharma Corporation
Hyperphosphataemia, Chronic Kidney Disease
Post Authorisation Safety Study of Renvela® in Chronic Kidney Disease Patients Not on Dialysis With Hyperphosphataemia
The primary objective of this study is to assess in a post-approval clinical setting the safety profile of sevelamer carbonate (Renvela®) tablets and powder in adult hyperphosphataemic chronic kidney disease (CKD) patients not on…
- Trial name
- NCT01857024
- Testing
- sevelamer carbonate (Renvela®)
- Where
- 26 sites in Austria, Denmark and 5 more
- Volunteers
- 210 people
- Sponsor
- Genzyme, a Sanofi Company
Chronic Kidney Diseases
Respiratory Training in Hemodialysis Patients
Patients with chronic kidney disease in hemodialysis have complex syndrome with diverse effects on cardiovascular, nervous, respiratory, musculoskeletal, immune and endocrine-metabolic systems.
- Trial name
- NCT03153124
- Testing
- Respiratory muscle training
- Where
- Brazil
- Volunteers
- 46 people
- Sponsor
- Faculdade de Ciências Médicas da Santa Casa de São Paulo
Dyspnea; Uremic, End Stage Renal Disease
Dyspnea Assessment in Hemodialysis Patients
Shortness of breath is very common among patients on dialysis for kidney failure; however, its causes are often not understood. This study will explore the lungs and the heart of these patients to determine the causes of…
- Conditions
- Dyspnea; Uremic, End Stage Renal Disease, Chronic Lung Disease, Chronic Heart Disease
- Trial name
- NCT03773991
- Testing
- Lung MRI, Sodium MRI, Chest CT
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Chronic Renal Failure, Peritoneal Membrane Disorder
Administration of pH-Neutral Peritoneal Dialysis Solutions Containing Lactate or Bicarbonate in Children
Peritoneal Dialysis (PD) is the preferred treatment modality in children with end-stage renal disease. Unfortunately progressive alterations of the peritoneal membrane occur with time on PD, leading to a continuous loss of…
- Trial name
- BIOKID (NCT01632046)
- Testing
- lactate and bicarbonate buffered dialysis solutions
- Where
- 7 sites in Austria, Finland and 3 more
- Volunteers
- 42 people
- Sponsor
- Heidelberg University
Atherosclerosis of Artery, Inflammation
The Impact of Selected Factors on the Cardiovascular System in Chronic Kidney Disease
Chronic kidney disease (CKD), is characterized by accelerated development of atherosclerosis and advanced remodelling of vessels and the heart.
- Conditions
- Atherosclerosis of Artery, Inflammation, Chronic Kidney Diseases, Dialysis; Complications
- Trial name
- NCT05214872
- Testing
- laboratory parameters - complete blood count, body mass index (BMI) [kg/m^2] calculation, selected parameters of oxidative stress (1)
- Where
- Poland
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Poznan University of Medical Sciences
Chronic Kidney Diseases, Albuminuria
Screening for Albuminuria at the First Line for Early Identification of CKD
Early detection of kidney disease
- Trial name
- SALINE (NCT05321095)
- Testing
- Albuminuria test, HbA1c test, Creatinine test
- Where
- Netherlands
- Volunteers
- 141 people
- Sponsor
- General Practitioners Research Institute
Diabetes Mellitus, Type 2, Heart Failure
A Pragmatic Trial Comparing Empagliflozin and Dapagliflozin Through Cluster Randomization Embedded in the Electronic Health Record
The aim of this clinical trial is investigate the comparative effectiveness of empagliflozin and dapagliflozin for the treatment of diabetes, chronic kidney disease, and heart failure.
- Conditions
- Diabetes Mellitus, Type 2, Heart Failure, Chronic Kidney Diseases
- Trial name
- APPLE TREE (NCT06642272)
- Testing
- Empagliflozin 10 MG, Dapagliflozin 10 MG
- Where
- 12 sites in Denmark
- Volunteers
- 17,200 people
- Sponsor
- Herlev and Gentofte Hospital
Type 1 Diabetes Mellitus, Chronic Kidney Disease (CKD) With Diabetes Mellitus (DM)
Mitigating DKA in Type 1 Diabetes for Safe Use of SGLT Inhibitors Using Dual Continuous Ketone and Glucose Monitoring.
The goal of this clinical trial is to develop and evaluate a novel diabetes ketoacidosis risk mitigation strategy to support the safe use of sodium-glucose cotransporter-2 inhibitors (SGLT2i) therapy in participants with type 1…
- Conditions
- Type 1 Diabetes Mellitus, Chronic Kidney Disease (CKD) With Diabetes Mellitus (DM), Chronic Kidney Disease, Diabetic Ketoacidosis
- Trial name
- SCOUT-CKD (NCT07325201)
- Testing
- Sotagliflozin initiation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- HealthPartners Institute
End Stage Renal Disease
Initial Safety Study of the TRUE AVC in Hemodialysis Access (TRUE AVC I Study)
Prospective, nonrandomized, single-arm, single-center, open-label, initial safety study in subjects requiring hemodialysis. Subjects will be followed with physical evaluation and ultrasound vessel imaging at days 15, 29, 57 and…
- Trial name
- NCT05567757
- Testing
- Arteriovenous conduit implant
- Where
- Panama
- Volunteers
- 11 people
- Sponsor
- Vascudyne, Inc.
ESRD
Pharmacoepidemiological Study of Secondary Hyperparathyroidism in Lorraine
The pharmacoepidemiological EPHEYL (Étude PHarmacoÉpidémiologique de l'hYperparathyroïdie secondaire en Lorraine) study is a 2-year, open-cohort, prospective, observational study on incident SHPT, i.e.
- Trial name
- EPHEYL (NCT02888639)
- Volunteers
- 305 people
- Sponsor
- Central Hospital, Nancy, France
Inflammation, Chronic Kidney Disease
Pentraxin-3 in Chronic Renal Failure
The aim of the study is to measure Pentraxin-3 levels in patients on hemodialysis, peritoneal dialysis and those in the pre-dialysis period; and to compare these groups with the control group; so as to investigate the eligibility…
- Trial name
- NCT01397773
- Where
- Turkey (Türkiye)
- Volunteers
- 85 people
- Sponsor
- Haseki Training and Research Hospital
End-stage Renal Disease
Changes in Renal Perfusion During Hemodialysis in Patients with End-stage Renal Disease
Residual renal function (RRF) characteristically declines after patients with end-stage renal disease (ESRD) initiate dialysis. Although RRF preservation correlates with improved patient\'s quality of life and survival…
- Trial name
- HD-RPC (NCT06587997)
- Volunteers
- 20 people
- Sponsor
- Yuanjun Yang
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