Clinical trials: Renal Insufficiency,Chronic
Chronic Kidney Disease, Hypertension
Diuretics and Volume Overload in Early CKD
Almost 15% of Americans have chronic kidney disease (CKD), with an even higher rate in Veterans due to common risk factors such as high blood pressure and diabetes.
- Trial name
- DOCK (NCT05171686)
- Testing
- Diuretic augmentation (hydrochlorothiazide, chlorthalidone, furosemide, torsemide, or bumetanide)
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- VA Office of Research and Development
Renal Failure, End Stage Renal Disease
Safety and Clinical Performance of a Dialyzer With a Modified Polysulfone Membrane
The clinical investigation will be performed to generate clinical data on clearances and removal rates (for ß2-microglobulin, myoglobin, phosphate, creatinine, and urea) as well as biocompatibility of the modified polysulfone…
- Trial name
- eMPORA (NCT03315624)
- Testing
- Dialyzer
- Where
- Germany
- Volunteers
- 49 people
- Sponsor
- Fresenius Medical Care Deutschland GmbH
Chronic Kidney Disease Due to Hypertension, Chronic Kidney Disease Due to Type 2 Diabetes Mellitus
Fecal Microbiota Transplantation as a Therapeutic Strategy in the Progression of Chronic Kidney Disease
What the investigators want to achieve with the protocol is to identify the impact of intestinal microbiota transplantation on the progression of chronic kidney disease.
- Trial name
- NCT04361097
- Testing
- Faecal microbiota transplant
- Where
- Mexico
- Volunteers
- 28 people
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Acute Kidney Injury
Transition of Acute Kidney Injury to Chronic Kidney Disease
Acute kidney injury is a complex clinical syndrome,associated with high short and long- term morbidity and mortality in critical ill patients.Acute kidney injury outcomes may vary from a complete resolution to a partial or…
- Trial name
- NCT04101110
- Testing
- Renal biopsy
- Where
- Egypt
- Volunteers
- 252 people
- Sponsor
- Assiut University
Atherosclerotic Cardiovascular Disease (ASCVD), Chronic Kidney Disease (CKD)
A Multinational Survey-based Study to Understand the Real-world Awareness and Perceptions of Systemic inFLAMmation and rolE of hsCRP as a Biomarker in Patients With AtheroSclerotic CardioVascular Disease and Chronic Kidney Disease Among Cardiologists
The purpose of this survey is to collect information for scientific research and to better understand the role of systemic inflammation in identification, treatment and management of patients with ASCVD and CKD.
- Trial name
- FLAME-ASCVD (NCT05755373)
- Testing
- No treatment given
- Where
- India
- Volunteers
- 602 people
- Sponsor
- Novo Nordisk A/S
End-stage Renal Disease, Left Ventricular Hypertrophy
In-Centre Nocturnal Hemodialysis (INHD): A Long-Term Follow-Up Study
Background: In 2010, approximately 39000 Canadians had end-stage renal disease (ESRD), and the prevalence rate of dialysis has increased by 189% over the past 2 decades.
- Trial name
- INHD (NCT02684773)
- Testing
- Conventional Hemodialysis, In-centre Nocturnal Hemodialysis
- Where
- 2 sites in Canada
- Volunteers
- 67 people
- Sponsor
- Unity Health Toronto
Cardiovascular Diseases, Coronary Artery Disease
ISCHEMIA-Chronic Kidney Disease Trial
The purpose of the ISCHEMIA-CKD trial is to determine the best management strategy for patients with stable ischemic heart disease (SIHD), at least moderate inducible ischemia and advanced chronic kidney disease (CKD; estimated…
- Conditions
- Cardiovascular Diseases, Coronary Artery Disease, Heart Diseases, Myocardial Ischemia
- Trial name
- ISCHEMIA-CKD (NCT01985360)
- Testing
- Cardiac Catheterization, Coronary Artery Bypass Graft Surgery, Percutaneous Coronary Intervention
- Where
- United States
- Volunteers
- 777 people
- Sponsor
- NYU Langone Health
Acidosis, Renal Insufficiency
Preserve-Transplant Study
The aim of this study is to test if alkali treatment will preserve kidney graft function and diminish the progression of chronic kidney disease in renal transplant patients.
- Conditions
- Acidosis, Renal Insufficiency, Kidney Transplantation
- Trial name
- NCT03102996
- Testing
- Nephrotrans
- Where
- 3 sites in Switzerland
- Volunteers
- 240 people
- Sponsor
- University of Zurich
Renal Insufficiency
Study of 2 Modalities of Dialysis and Nutrition on the Nutritional Status of Malnourished Chronic Renal Disease Patients
Describe the impact of dialysis by high permeability and adsorbent membrane (PEPA®) associated with oral nutritional supplementation on the nutritional status of malnourished chronic end-stage renal disease patients dependent on…
- Trial name
- NCT04445558
- Testing
- oral nutritional supplementation, intradialytic parenteral nutrition
- Where
- France
- Volunteers
- 11 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Chronic Kidney Diseases
The Chronic Kidney Disease Adaptive Platform Trial Investigating Various Agents for Therapeutic Effect
CAPTIVATE is an international, multi-centre, Phase III, adaptive, platform, randomised controlled trial in people with chronic kidney disease (CKD).
- Trial name
- CAPTIVATE (NCT06058585)
- Testing
- Finerenone, Semaglutide
- Where
- 51 sites in Australia, India and 3 more
- Volunteers
- 2,000 people
- Sponsor
- The George Institute
Chronic Kidney Diseases
Low Protein Diet, Gut Microbiome and Chronic Kidney Disease
Chronic kidney disease (CKD) is a worldwide public health dilemma because of close association with multiple comorbidities, demanding high cardiovascular events, mortality and expensive medical cost.
- Trial name
- NCT05019599
- Testing
- low protein diet
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
End Stage Renal Disease, Chronic Kidney Disease
Different Doses of Oral Melatonin Supplements in Chronic Kidney Disease (CKD)-Associated Sleep Disorders
The study will evaluate the safety and efficacy of melatonin supplementation in CKD and ESRD patients with sleep disorders to reduce sleep latency times, the number of apnea/hypopneic episodes, and prolong duration in rapid eye…
- Conditions
- End Stage Renal Disease, Chronic Kidney Disease, Sleep Disorder
- Trial name
- NCT01922999
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Southeast Renal Research Institute
Chronic Kidney Disease (Stage 3-4)
Impact of Mindfulness on Pain In SA
Background: Patients with end-stage renal disease (ESRD) undergoing hemodialysis often experience chronic pain, maladaptive pain cognitions, and diminished quality of life, yet evidence on mindfulness-based interventions (MBIs)…
- Trial name
- MPSA (NCT07837206)
- Testing
- Mindfulness-Based Intervention
- Where
- Saudi Arabia
- Volunteers
- 38 people
- Sponsor
- Jordan University of Science and Technology
Type 2 Diabetes Mellitus, Chronic Kidney Disease Stage 3
Safety and Efficacy Study of Sotagliflozin on Glucose Control in Participants With Type 2 Diabetes, Moderate Impairment of Kidney Function, and Inadequate Blood Sugar Control
Primary Objective: To demonstrate the superiority of Sotagliflozin 200 milligrams (mg) and Sotagliflozin 400 mg versus placebo on HbA1c reduction at 26 Weeks in participants with Type 2 diabetes who have inadequate glycemic…
- Trial name
- SOTA-CKD3 (NCT03242252)
- Testing
- Sotagliflozin
- Where
- 170 sites in United States, Argentina and 14 more
- Volunteers
- 787 people
- Sponsor
- Lexicon Pharmaceuticals
Kidney Failure, Chronic, Exercise
The Effect of Intradialytic Combined Exercise on Physical Outcomes in End-Stage Renal Disease Patients
Hemodialysis (HD) is an important and commonly used renal replacement therapy (RRT) for End-Stage Renal Disease (ESRD) patients worldwide.
- Conditions
- Kidney Failure, Chronic, Exercise, Physical Fitness
- Trial name
- NCT04124549
- Testing
- Intradialytic Combined Exercise
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Xi'an Jiaotong University
End Stage Renal Disease (ESRD)
The Effect of Gum Arabic (GA) on Residual Renal Function in Adult Dialysis Patients in Abu Dhabi
Gum Arabic (GA), derived from Acacia trees, has shown potential benefits in metabolic, renal, and inflammatory conditions. This study explores the impact of GA on residual renal function in end-stage renal disease (ESRD) patients…
- Trial name
- GAESRD (NCT06836206)
- Testing
- Gum Arabic, Water
- Where
- United Arab Emirates
- Volunteers
- 40 people
- Sponsor
- Abu Dhabi Health Services Company
End Stage Kidney Disease
The Reducing Adverse Outcomes in Dialysis by Adjusting the pRescription for Dialysate Potassium Trial
This will be a randomized controlled pilot trial comparing usual care to a precision approach to dialysis potassium prescribing.
- Trial name
- RADAR-K (NCT07051447)
- Testing
- PKRxHD, Dialysis
- Volunteers
- 120 people
- Sponsor
- NYU Langone Health
Chronic Kidney Diseases, Diabetes Mellitus
Prevalence of Chronic Kidney Disease (CKD) and Risk Factors in Sub-Saharan Africa
Prospective cross-sectional study at the outpatient clinic (OPC) of the Bagamoyo District Hospital (BDH) in Tanzania. Assessment of basic epidemiological data (Point prevalence and risk factors) on CKD with simple clinical…
- Conditions
- Chronic Kidney Diseases, Diabetes Mellitus, Hypertension, Tuberculosis
- Trial name
- RenalOne (NCT03458338)
- Testing
- estimated glomerular filtration rate and albuminuria
- Where
- Switzerland
- Volunteers
- 1,006 people
- Sponsor
- University Hospital, Basel, Switzerland
Chronic Kidney Disease
Preventing Early Dialysis Starts
Chronic kidney disease (CKD) and its end stage of kidney failure requiring dialysis are important contributors to morbidity, mortality and health care costs.
- Trial name
- NCT02183987
- Testing
- Active Knowledge Translation Intervention
- Where
- 2 sites in Canada
- Volunteers
- 55 people
- Sponsor
- University of Manitoba
Diabetes, Hypoglycemia
Insulin Dosing in Diabetic Patients With End Stage Renal Disease (ESRD) or Hemodialysis
The purpose of this study is to assess whether the current recommendation for a 50% dose reduction in insulin for diabetic patients with a creatinine clearance (CrCl) ≤15 mL/min or on hemodialysis results in an increased number…
- Conditions
- Diabetes, Hypoglycemia, Renal Dysfunction, Insulin Dosing
- Trial name
- DOSE-HD (NCT02083133)
- Where
- United States
- Volunteers
- 496 people
- Sponsor
- Cook County Health
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