Clinical trials: Renal Masses
Renal Cell Carcinoma (RCC)
ClAmpless, Sutureless PartIAl Nephrectomy for Renal Masses
During partial nephrectomy surgery, efforts at minimizing ischemia while maximizing renal parenchymal volume are desirable to preserve renal function1,2.
- Trial name
- CASPIAN (NCT06722807)
- Testing
- sutureless, clampless partial nephrectomy
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- University of Florida
Cancer of Kidney, Kidney Cancer
Safety Study With the Antibody, cG250, and Isotope, 124-Iodine, to Diagnose Patients With Renal Masses.
The purpose of this study is to see if an antibody (cG250) attached to a radioactive substance (Iodine-124) safely detects clear cell renal cancer in patients with kidney tumors scheduled for surgery.
- Conditions
- Cancer of Kidney, Kidney Cancer, Renal Cancer, Neoplasms, Kidney
- Trial name
- NCT00199888
- Testing
- 124-Iodine-cG250 (124I-cG250)
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Ludwig Institute for Cancer Research
Renal Malignant Tumor
Correlation of Renal Mass Pathologic Grade and Contrast Enhanced Ultrasound (CEUS)
Patients with renal lesions suspicious for renal cell carcinoma (RCC) have a variety of different treatment pathways available to them.
- Trial name
- NCT03821376
- Testing
- Contrast enhanced ultrasound with Lumason
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Indiana University
Carcinoma, Renal Cell
Follow up After Cryoablation of Small Renal Masses.
Currently there is no consensus on post procedural follow up imaging following percutaneous cryoablation of renal tumors. Interpretation of conventional contrast enhanced imaging (CT and MRI) during follow up can be very…
- Trial name
- NCT02411968
- Testing
- 111In-Girentuximab DOTA SPECT
- Where
- Netherlands
- Volunteers
- 9 people
- Sponsor
- Radboud University Medical Center
Small Renal Mass
Zero Ischemia Laparoscopic Partial Nephrectomy
Laparoscopic partial nephrectomy (LPN) is often reserved for patients with a small peripheral tumour, in the hands of an experienced surgeon since it demands a high degree of endoscopic skill.
- Trial name
- ZILPAREMZ (NCT02634385)
- Testing
- Renal Artery Embolization, Partial Nephrectomy (Surgical Resection)
- Where
- Canada
- Sponsor
- St. Joseph's Healthcare Hamilton
Renal Cyst
Multiphase CT Deep Learning for Bosniak II-III Renal Cysts
This retrospective study combine radiomics and deep learning models to predict malignancy in Bosniak II-III cystic renal masses, aiming for improving preoperative risk assessment and reducing unnecessary surgery for benign…
- Trial name
- NCT07833124
- Where
- China
- Volunteers
- 223 people
- Sponsor
- Shanghai Zhongshan Hospital
Clear Cell Renal Cell Carcinoma
68Ga-NYM096 PET/ CT for the Detection of Clear Cell Renal Cell Carcinoma in Presurgical Patients With Renal Masses
This is a prospective, single-center, single-arm, diagnostic phase 2 study in patients who have renal masses scheduled for surgical resection.
- Trial name
- NCT07101900
- Testing
- 68Ga-NYM096 PET/CT
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking Union Medical College Hospital
Renal Cell Carcinoma
European Active Surveillance of Renal Cell Carcinoma Study (EASE RCC Study)
The goal of this observational, prospective, multi-national clinical study is to assess overall survival of patients who are diagnosed with incidental, histologically (biopsy) confirmed, <4 cm Renal Cell Carcinoma (RCC) and are…
- Trial name
- EASE (NCT06336187)
- Testing
- active surveillance, molecular investigation
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Small Renal Masses
A Trial Comparing - Robotic Assisted Versus Laparoscopic Partial Nephrectomy For Small Renal Masses
A prospective, randomized, controlled trial including patients who are diagnosed with a small renal mass (<4 cm) amenable to resection using either RALPN or LPN.
- Trial name
- RALPLPNNX (NCT02933398)
- Testing
- Robotic Assisted Nephrectomy, Laparoscopic Assisted Nephrectomy
- Where
- Canada
- Volunteers
- 104 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Renal Malignant Tumor, Renal Tumor
Normotonic Partial Nephrectomy as Novel Approach in Treating Small Renal Masses
This study evaluates novel surgical approach in treating small renal masses. Half of participants will undergo hypotonic zero-ischaemia partial nephrectomy (standard of care), while the other half will undergo normotonic…
- Trial name
- NORPN (NCT04096534)
- Testing
- Normotonic partial nephrectomy, Hypotonic partial nephrectomy
- Where
- Russia
- Volunteers
- 108 people
- Sponsor
- Saint Petersburg State University, Russia
Cystic Renal Disease, Kidney Cancer
Comparison of Surgery and Active Surveillance in the Treatment of Bosniak III Renal Cysts
The incidence of renal cysts is rising due to increased abdominal imaging. Renal complicated cysts have been traditionally classified according to the Bosniak classification, which distinguishes cystic masses by specific features…
- Conditions
- Cystic Renal Disease, Kidney Cancer, Surgery
- Trial name
- NCT04670887
- Testing
- Delayed surgery, Immediate surgery
- Volunteers
- 200 people
- Sponsor
- Helsinki University Central Hospital
Renal Masses
Comparison of OpeN VErsus RoboTic Partial Nephrectomy
A prospective randomized controlled feasibility trial for patients undergoing partial nephrectomy for T1 renal masses at Princess Margaret. Participants will be randomized receive either open or robotic partial nephrectomy.
- Trial name
- CONVERT (NCT04011891)
- Testing
- Robotic Partial Nephrectomy, Open Partial Nephrectomy
- Where
- Canada
- Sponsor
- University Health Network, Toronto
Kidney Cancer
Investigation of Differential Biology of Benign and Malignant Renal Masses Using Advanced Magnetic Resonance Imaging Techniques
The aim of this study is to develop techniques for non-invasive imaging of biology in participants with benign or malignant renal masses based on the novel scanning MRI techniques, including recently invented Hyperpolarised MRI…
- Trial name
- IBM-Renal (NCT06016075)
- Testing
- Hyperpolarised MRI, Sodium MRI, Deuterium metabolic imaging (DMI) MRI
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Cambridge
Renal Masses
Ultrasound Elastography Combined With Conventional Mri in Differentiating Solid Renal Parenchyma Masses
Investigate the diagnostic accuracy of Ultrasound Elastography combined with conventional MRI in evaluation of solid renal masses using histopathology as a gold standard.
- Trial name
- NCT06517368
- Testing
- MRI, Ultrasound
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Small Renal Mass, Kidney Tumor
GRADE-SRM: Genomic Risk Assessment and Decisional Evaluation for Small Renal Masses
Purpose: The purpose of this study is to evaluate the role of renal mass biopsy on decision-making for patients presenting with clinical T1 kidney tumors.
- Trial name
- GRADE-SRM (NCT03819569)
- Testing
- Small Renal Mass Biopsy, No Small Renal Mass Biopsy
- Where
- United States
- Volunteers
- 265 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Renal Cancer
A Feasibility Study for a Multicentre Randomised Controlled Trial to Compare Surgery With Needle Ablation Techniques in People With Small Renal Masses (4cm)
The number of people diagnosed with kidney cancer has doubled over the past 20 years, making it the eight most common cancer in the UK.
- Trial name
- CONSERVE (NCT01608165)
- Testing
- Surgical treatment for renal mass, Percutaneous Radiofrequency ablation, Laparascopic or percutaneous cryoablation
- Where
- 5 sites in United Kingdom
- Volunteers
- 17 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Renal Cell Carcinoma, Kidney Cancer
REDECT 2: REnal Masses: Pivotal Trial to DEteCT Clear Cell Renal Cell Carcinoma With PET/CT
Study WX-20-002 will confirm diagnostic efficacy and safety of a PET/CT scan using Iodine (124I) Girentuximab performed during the diagnostic work-up in patients with indeterminate cT1-renal masses.
- Trial name
- NCT01762592
- Testing
- Iodine (124I) Girentuximab
- Where
- 8 sites in United States
- Sponsor
- Heidelberg Pharma AG
Renal Cancers
Cryoablation Versus Radiofrequency Ablation for Small Renal Masses
The purpose of this study is to verify the oncological efficacy and safety of cryoablation and radiofrequency ablation for the treatment of small renal tumors.
- Trial name
- NCT00922948
- Testing
- Cryoablation, Radiofrequency ablation
- Where
- Canada
- Sponsor
- St. Joseph's Healthcare Hamilton
Carcinoma, Renal Cell
Evaluation of a Laparoscopic High Intensity Focused Ultrasound Probe for the Ablation of Small Renal Masses
The Sonatherm device provides both advanced imaging (ultrasound guidance) and high intensity focused ultrasound to target and ablate tumors.
- Trial name
- HIFU-KIDNEY (NCT02248389)
- Testing
- Sonatherm 600i ablation system
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Indiana University
Renal Cell Carcinoma (RCC)
Comparing Two Weight Loss Programs for the Prevention of Kidney Cancer Progression Among Patients With Small Renal Masses on Active Surveillance
This clinical trial compares two different weight-loss programs, daily continuous calorie energy reduction (CER) versus (vs.) 5:2 intermittent fasting (IF), in preventing progression of kidney (renal) cancer among patients with…
- Trial name
- NCT07714018
- Testing
- Intermittent Fasting, Continuous Energy Restriction (CER)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Roswell Park Cancer Institute