Clinical trials: Renal Perfusion
Coronary Artery Disease, Acute Kidney Injury
Endothelial Glycocalyx Damage in Acute Kidney Injury
Abstract Significance: Cardiac surgery-associated acute kidney injury (CSA-AKI) is common and has serious immediate and long-term sequelae.
- Trial name
- NCT05471583
- Testing
- Main group
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- King's College London
Heart Failure With Reduced Ejection Fraction (HFrEF), Renal Impairment
AZD3427 Effects on Renal Perfusion in Heart Failure Patients With Reduced Ejection Fraction and Renal Impairment
The present study is designed to test the effect of AZD3427 on renal perfusion in participants with heart failure and reduced eGFR (30 to 90 mL/min/1.73m2).
- Trial name
- Re-PERFUSE (NCT06611423)
- Testing
- AZD3427, Dopamine, Radiolabelled ligand
- Where
- Sweden
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Acute Kidney Injury, Septic Shock
Targeting Abdominal Perfusion Pressure in Septic Shock
A randomized control trial among patients with septic shock, studying the incidence, progression and recovery of AKI.
- Conditions
- Acute Kidney Injury, Septic Shock, Resuscitations
- Trial name
- MAP-APP (NCT03582046)
- Testing
- Abdominal Perfusion Pressure (APP), Mean Arterial Pressure (MAP)
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- Potrero Medical
Kidney Transplant; Complications
Renal Ex Vivo Warm Advanced Resuscitation Through Machine Perfusion
The REWARM study is a randomized controlled clinical efficacy study, with primary outcome renal function 12 months after transplantation of kidneys recovered from deceased donors aged 50 years or older.
- Trial name
- REWARM (NCT05782543)
- Testing
- Normothermic machine perfusion
- Where
- 3 sites in Netherlands
- Volunteers
- 240 people
- Sponsor
- University Medical Center Groningen
Kidney Neoplasm, Renal Mass up to 7cm
Hyperspectral Imaging in Robot-Assisted Partial Nephrectomy
The goal of this prospective observational study is to learn about the use of a novel imaging technique called hyperspectral imaging in adult participants who are having surgery for removing a tumor from their kidney.
- Trial name
- HSI-Renal (NCT07803315)
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University of Leipzig
Kidney Transplant, Kidney Failure
Hypothermic Machine Perfusion With Omnisol of Deceased Donor Kidneys Prior to Transplantation
Insufficient availability of organs from brain dead (DBD) and living donors has necessitated increased use of less than optimal organs from donation after cardiac death (DCD) or from extended criteria donors.
- Conditions
- Kidney Transplant, Kidney Failure, Renal and Urinary Tract Therapeutic Procedures, End Stage Renal Disease (ESRD)
- Trial name
- NEWHOPE (NCT07792317)
- Testing
- Omnisol organ preservation solution
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Vivalyx GmbH
End Stage Renal Disease
PROlonged Ex-vivo Normothermic Machine PERfusion for Kidney Regeneration
The investigators would like to introduce and clinically evaluate prolonged normothermic machine perfusion (PNMP) to preserve and assess high-risk donor kidneys prior to transplantation.
- Trial name
- PROPER (NCT04693325)
- Testing
- Prolonged normothermic machine perfusion
- Where
- 2 sites in Netherlands
- Volunteers
- 18 people
- Sponsor
- Leiden University Medical Center
Pleural Metastases, Breast Cancer
Heated Chemotherapy for Cancers That Have Spread to the Chest Cavity
Cancers that have spread to the inner lining of the chest are classified as Stage IV and bear a poor prognosis. Surgery is rarely an option, with palliative chemotherapy and/or radiation therapy the only treatment options.
- Conditions
- Pleural Metastases, Breast Cancer, Colon Cancer, Ovarian Cancer
- Trial name
- NCT01163552
- Testing
- Surgical debulking and Intrathoracic Hyperthermic Chemotherapy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Polycystic Kidney Disease, Adult, Polycystic Kidney, Autosomal Dominant
PErfusioN, OxyGen ConsUmptIon and ENergetics in ADPKD (PENGUIN)
Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic cause of end-stage kidney disease (ESKD). The disorder is characterized by development and continued growth of multiple cysts requiring renal…
- Trial name
- PENGUIN (NCT04407481)
- Testing
- Aminohippurate Sodium Inj 20%, Iohexol Inj 300 milligrams per milliliter (MG/ML), PET/CT Scan
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Colorado, Denver
Delayed Function of Renal Transplant
Clinical Impact of Hypothermic Machine Perfusion in Renal Transplant Recipients
This is a multi-centers prospective, randomized, controlled trial. This trial will investigate the clinical outcome of kidney transplant recipients whose kidneys are under two different forms of organ preservation--hypothermic…
- Trial name
- CIHMP (NCT02621281)
- Testing
- Kidney Transporter machines, cold storage
- Where
- China
- Volunteers
- 400 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Renal Function Disorder, Critical Illness
Transcutaneous Electrical Nerve Stimulation for Tissues Perfusion
The aim of this study is to determine the effect of transcutaneous electrical nerve stimulation in mechanically ventilated patients on the lower limb and renal tissue perfusion.
- Conditions
- Renal Function Disorder, Critical Illness, Critical Illness Myopathy
- Trial name
- NCT04069871
- Testing
- trans-cutaneous electrical nerve stimulation.
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Septic Shock and Use of Vasopressin
Effect of Adding Vasopressin on Cardiac Output, Blood Pressure, Diuresis, and Tissue Perfusion Indices in Patients With Septic Shock
In patients with septic shock, vasopressin is increasingly used in combination with norepinephrine, but its timing of initiation remains heterogeneous and its clinical hemodynamic effects are still insufficiently characterized.
- Trial name
- VASO-PHENO (NCT07697144)
- Where
- 8 sites in France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Renal Artery Stenosis, Renal Blood Perfusion
A Study of Using Parenchymal Blood Volume(PBV) for Endovascular Treatment of Renal Arterial Stenosis
This study will use PBV technique to quantitatively assess the improvement of renal perfusion before and after endovascular treatment (EVT) of renal artery stenosis.
- Trial name
- NCT03252639
- Testing
- EVT for RAS & PBV acquisition protocol for target kidneys
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College Hospital
Renal Colic
Short-term Perfusion Effects: Dexketoprofen/Tramadol
Background: Acute renal colic is a common reason for admission to the emergency department (ED) and is associated with severe pain, sympathetic activation and metabolic stress.
- Trial name
- DeXTra-RC (NCT07386288)
- Testing
- Tramadol, Dexketoprofen Trometamol, IV Tramadol + IV Dexketoprofen Trometamol
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Ataturk University
Organ Preservation Solutions
Peri-operative rATG-perfusion of Solid Transplants
The increasing demand for organ transplantation and the shortage of available organs limit the success of organ transplantation programs.
- Trial name
- ATG-perfusion (NCT03377283)
- Testing
- organ perfusion with rabbit anti-thymocyte globulin (rATG), organ perfusion with saline
- Volunteers
- 80 people
- Sponsor
- Medical University Innsbruck
Kidney Transplant Failure and Rejection
Using the Speckle Doppler to Quantify Blood Flow in Kidney and Pancreas Grafts
Kidney and Pancreas transplantation is considered the treatment of choice for many people with End Stage Renal Disease and Type 1 diabetes because quality of life and survival is often better after transplantation.
- Trial name
- NCT04202237
- Testing
- Speckle Doppler imaging, Blood sample
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- Manchester University NHS Foundation Trust
Trauma (Including Fractures), Trauma Patients
Renal and Hepatic Abnormal Doppler Patterns in Trauma
The goal of this observational study is to learn about renal and hepatic blood flow abnormalities detected by bedside ultrasound in adult patients admitted to the intensive care unit (ICU) following major trauma.
- Conditions
- Trauma (Including Fractures), Trauma Patients, Kidney Disease, Hypovolemia
- Trial name
- RECREANT (NCT07492511)
- Testing
- Point of care ultrasound
- Where
- Italy
- Volunteers
- 350 people
- Sponsor
- Azienda Usl di Bologna
Hypotension, Poor Peripheral Perfusion
Effect of Vasopressin on Tissue Oxygen Saturation in Cardiac Surgery Patients During Cardiopulmonary Bypass
The objective of this research is to compare the effect of a low dose Vasopressin infusion or placebo during cardiopulmonary bypass on vasopressor requirements, hemodynamics and tissue oxygen saturation and its recovery using…
- Trial name
- NCT01532505
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Mohamed Ismail
Septic Shock
Changes in Microvascular Perfusion During Blood Purification With Cytosorb® in Septic Shock
Sepsis is defined as a life-threatening event due to a dysregulated immune response to an host. Blood purification techniques may be considered as a therapeutic weapon to front sepsis and septic shock.
- Trial name
- NCT03456180
- Testing
- Haemoadsorption with Cytosorb cartridge
- Volunteers
- 10 people
- Sponsor
- Università Politecnica delle Marche
Heart Failure, Chronic Kidney Disease
Staged Kidney Transplantation During Combined Heart/Kidney Transplantation
The primary purpose of this study is to evaluate the safety and efficacy of ex vivo machine perfusion with staged implantation of kidney allografts during combined heart/kidney transplantation.
- Conditions
- Heart Failure, Chronic Kidney Disease, End-stage Kidney Disease
- Trial name
- NCT06877169
- Testing
- Planned delayed implantation of kidney allograft with ex vivo machine perfusion kidney preservation.
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cedars-Sinai Medical Center