Clinical trials: Renal Replacement Therapies
Renal Replacement Therapy, Pharmacokinetics
Safety and Therapeutic Drug Monitoring of Cefazolin in Continuous Renal Replacement Therapy
This investigation is intended to collect safety information for the technique of mixing cefazolin in the CRRT solution on the CRRT circuit, the patient, in addition to collecting information regarding the ability to obtain…
- Trial name
- NCT03672149
- Testing
- Cefazolin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Drexel University
Severe Sepsis, Carbapenem Resistant Bacterial Infection
Clinical Study on Monitoring the Plasma Concentration of Ceftazidime-Avibactam in Critically Ill Patients
This prospective observational study is conducted at the First Affiliated Hospital of Zhejiang University School of Medicine from June 1, 2021 to January 1, 2024.
- Trial name
- NCT05413343
- Testing
- Ceftazidime-avibactam
- Where
- China
- Volunteers
- 33 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Septic Shock
Changes in Microvascular Perfusion During Blood Purification With Cytosorb® in Septic Shock
Sepsis is defined as a life-threatening event due to a dysregulated immune response to an host. Blood purification techniques may be considered as a therapeutic weapon to front sepsis and septic shock.
- Trial name
- NCT03456180
- Testing
- Haemoadsorption with Cytosorb cartridge
- Volunteers
- 10 people
- Sponsor
- Università Politecnica delle Marche
Acute Kidney Injury
Dexmedetomidine Pharmacokinetics During Continuous Renal Replacement Therapy (CRRT)
The purpose of this study is to determine dexmedetomidine pharmacokinetics during continuous renal replacement therapy on critically ill patients.
- Trial name
- NCT01314209
- Testing
- Dexmedetomidine
- Where
- Finland
- Volunteers
- 10 people
- Sponsor
- Helsinki University Central Hospital
Selective Plasma Filtration
Selective Plasmofiltration for Abdominal Septic Shock: a Clinical Ctudy
Group 1: 34 patients received prolonged hemodiafiltration (CVVHDF) on an emergency basis. Group 2: 35 patients received early isolated CVVHDF.
- Trial name
- SPASS (NCT07121647)
- Testing
- renal replacement therapy., early isolated CVVHDF., combined extracorporeal blood purification therapy
- Where
- Russia
- Volunteers
- 101 people
- Sponsor
- Pirogov Russian National Research Medical University
Infection During Renal Replacement Therapy, Critically Ill
Ceftaroline Pharmacokinetics in Continuous Renal Replacement Therapy
Dosing of ceftaroline in patients with chronic kidney disease is defined, but there is no data on pharmacokinetics and pharmacodynamics of the drug in patients receiving continuous renal replacement therapy (CRRT).
- Trial name
- NCT04152694
- Testing
- Ceftaroline levels in CRRT
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Maryland, Baltimore
Acute Renal Failure
Furosemide in Early Acute Kidney Injury
Acute renal failure, now referred to as acute kidney injury, is common in intensive care unit patients, contributes to high morbidity and mortality, and has no proven interventions with benefit once established.
- Trial name
- SPARK (NCT00978354)
- Testing
- Furosemide, Normal Saline
- Where
- 4 sites in Australia, Canada
- Volunteers
- 72 people
- Sponsor
- University of Alberta
Renal Replacement Therapies
Evaluating the Usability of New Dialysis Bags
Objective: To compare the usability, efficiency, and ergonomics of new dialysis bags with current bags from the nursing perspective in ICU settings. Study Type: Prospective, single-center observational study.
- Trial name
- NCT07426575
- Where
- Netherlands
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Acute Kidney Injury, Citrate
Citrate Versus Heparin in Continuous Renal Replacement Therapy :
This study is a prospective, multicenter, open-label randomized trial comparing regional citrate anticoagulation (RCA) with heparin-free protocol.
- Conditions
- Acute Kidney Injury, Citrate, Cytokines, Hemodynamic Responses
- Trial name
- NCT04865510
- Testing
- Regional citrate anticoagulation
- Where
- Thailand
- Volunteers
- 41 people
- Sponsor
- Bangkok Metropolitan Administration Medical College and Vajira Hospital
Chronic Kidney Diseases
Peoples Perceptions of Forms of Renal Replacement Therapy
Chronic kidney disease (CKD) causes symptoms and potential loss of independence. These effects are increased as the disease progress to endstage renal disease (ESRD), particularly when external intervention (i.e.
- Trial name
- NCT04427800
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Portsmouth
Critical Care
Efficacy and Safety of a Citrate-based Anticoagulation With Calcium-free Phosphate-containing Fluid in Renal Replacement Therapy
In the present prospective multicenter RCT we will evaluate the effects on efficacy, acid-base status and serum phosphate levels of a new RCA protocol for Continuous Venovenous Hemodiafiltration (CVVHDF) using an 18 mmol/l…
- Trial name
- Phosphorus (NCT04215965)
- Testing
- Biphozyl (dialysate and replacement), Prismocal B22 (dialysate) + phoxilium (replacement)
- Volunteers
- 100 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Acute Kidney Injury, Shock
Methylene Blue for the Prevention of Hypotension During Hemodialysis
Hypotension is a common complication of intermittent renal replacement therapy. Methylene blue, an inhibitor of nitric oxide synthesis, has been suggested to improve hemodynamics during renal replacement therapy in ambulatory…
- Conditions
- Acute Kidney Injury, Shock, Intradialytic Hypotension, Intradialytic Hypertension in Hemodialysis Patients
- Trial name
- BLUE (NCT05092165)
- Testing
- Methylene Blue, Control
- Where
- Brazil
- Volunteers
- 261 people
- Sponsor
- Federal University of São Paulo
End Stage Renal Disease on Dialysis
The Immune System in End Stage CKD Patients - Comparison Among Different Modalities of RRT
The evaluation and assessment of the influence of the different modalities of renal replacement therapy (RRT), including peritoneal dialysis (PD), conventional hemodialysis with high flux dialyzers, hemodiafiltration (HDF) and…
- Trial name
- NCT04286477
- Where
- Greece
- Volunteers
- 45 people
- Sponsor
- University of Ioannina
Congestion, RRT
Optimization of Fluid Balance Guided by Bioelectrical Impedance Analysis in Patients Undergoing Continuous Renal Replacement Therapy in Critical Care
In critical care, hemodynamic instability often requires volume expansion to restore tissue perfusion, increasing fluid balance and TBW, factors associated with higher mortality.
- Conditions
- Congestion, RRT, UF, Bio-impendance Analysis
- Trial name
- OBHIMER (NCT06799910)
- Testing
- continuous renal replacement therapy (CRRT), Free UF Prescription
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens