Clinical trials: Renal Replacement Therapies
AKI - Acute Kidney Injury, Pneumonia
To Compare the Efficacy and Safety of Using oXiris and M100 During CRRT
The purpose of this study aimed to compare the efficacy of Oxiris (Baxter) and M100 filters on IL-6 as primary outcomes and other blood cell counts, blood biochemistry (serum urea, creatinine, potassium, sodium), inflammation…
- Trial name
- NCT06440759
- Testing
- oXiris filter, M100 filter
- Where
- Malaysia
- Volunteers
- 60 people
- Sponsor
- Mohd Zulfakar Mazlan, MBBS
Sepsis, Acute Kidney Injury
Nafamostat Mesylate Versus Regional Citrate Anticoagulation for Continuous Renal Replacement Therapy in Sepsis-Associated Acute Kidney Injury
This multicenter, randomized, open-label, active-controlled, parallel-group trial will evaluate the efficacy and safety of nafamostat mesylate anticoagulation compared with regional citrate anticoagulation in adult patients with…
- Conditions
- Sepsis, Acute Kidney Injury, Continuous Renal Replacement Therapy (CRRT)
- Trial name
- NICE-AKI (NCT07518303)
- Testing
- Citrate anticoagulation, Nafamostat Mesylate
- Volunteers
- 1,162 people
- Sponsor
- Jianfeng Xie
End Stage Kidney Disease, Chronic Kidney Diseases
The WavelinQ™ Arterio-Venous Endovascular Fistula: A Global, Post-Market Investigation
This is a global, multi-center, prospective, post-market, confirmatory, interventional, non-randomized, single-arm clinical investigation evaluating arteriovenous fistula (AVF) creation by means of the WavelinQ™ EndoAVF System in…
- Conditions
- End Stage Kidney Disease, Chronic Kidney Diseases, Kidney Failure, Kidney Insufficiency
- Trial name
- WAVE-Global (NCT04626427)
- Testing
- WavelinQ™ EndoAVF System
- Where
- 3 sites in Belgium, Greece and 1 more
- Volunteers
- 21 people
- Sponsor
- C. R. Bard
Liver Cirrhosis, Kidney Failure, Acute
Intermittent ADVOS vs. Hemodialysis in Non-intensive Care Patients With Liver Dysfunction
In the planned randomized controlled prospective pilot study, we aim to evaluate ADVOS compared with conventional hemodialysis regarding the elimination of protein-bound toxins in patients with therapy-refractory hepatorenal…
- Conditions
- Liver Cirrhosis, Kidney Failure, Acute, Kidney Replacement, Multi Organ Failure
- Trial name
- ADVOMITTENT (NCT06129617)
- Testing
- Hemodialysis, ADVOS
- Where
- Germany
- Volunteers
- 14 people
- Sponsor
- University Medical Center Mainz
Critical Illness, Multi Organ Failure
Parathyroid Hormone Kinetics During CRRT
The objective of this study is to assess the parathyroid hormone serum concentrations and kinetics in critically ill patients admitted to the intensive care unit due to multi-organ failure and undergoing citrate anticoagulation…
- Conditions
- Critical Illness, Multi Organ Failure, Renal Failure, Circulatory Failure
- Trial name
- NCT03873675
- Testing
- parathyroid hormone
- Where
- 3 sites in Poland
- Volunteers
- 30 people
- Sponsor
- Uniwersytecki Szpital Kliniczny w Opolu
Acute Kidney Injury
Pharmacokinetics of Vancomycin in the ICU in Renal Replacement Therapy
This study is an observational analysis that monitors the effect of different dialysis methods on vancomycin levels when patients are critically ill.
- Trial name
- NCT00848809
- Testing
- Blood sample
- Where
- United States
- Sponsor
- Avera McKennan Hospital & University Health Center
Acute Kidney Injury, Chronic Kidney Infection
Safety and Efficacy of Intermittent Renal Replacement Therapy Using CITRASATE in Critically-ill Patients
Renal Replacement Therapy (RRT) needs an extracorporeal circulation to conduct blood to the dialysis membrane and driving back to the patient.
- Trial name
- CITRA-SAFE (NCT05313230)
- Testing
- CITRASATE SLED
- Where
- France
- Volunteers
- 61 people
- Sponsor
- University Hospital, Montpellier
COVID-19, Renal Replacement Therapy
Urinary Biomarkers for AKI Diagnosis in Patients With SARS-CoV-2 (COVID-19)
Among patients with SARS-CoV-2 pneumonia, approximately 20% have an acute kidney injury (AKI) and 5% require renal replacement therapy.
- Conditions
- COVID-19, Renal Replacement Therapy, Acute Kidney Injury
- Trial name
- COVID-AKI (NCT04393428)
- Testing
- [TIMP-2]*[IGFBP-7]
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Critical Illness, Sepsis
Elimination of Antibiotics During Renal Replacement Therapy and Cytosorb Adsorptive Therapy
Cytokine adsorption using the cytosorb adsorber is currently investigated to reduce the levels of proinflammatory cytokines in patients with severe sepsis and septic shock.
- Conditions
- Critical Illness, Sepsis, Acute Kidney Injury
- Trial name
- NCT02611271
- Testing
- Monitoring of antibiotic drug removal
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Acute Kidney Injury
Immunomodulation Effect of Regional Citrate Anticoagulation in Acute Kidney Injury Requiring Continuous Renal Replacement Therapy
The purpose of this study is to study the effect of anticoagulation in immune response with Acute Kidney Injury (AKI) undergoing Continuous Renal Replacement Therapy (CRRT).
- Trial name
- NCT02423642
- Testing
- Continuous renal replacement therapy with regional citrate anticoagulation, Continuous renal replacement therapy with no anticoagulation or heparin
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Chulalongkorn University
Critical Illness, Acute Kidney Injury
Standard Dose Continuous Renal Replacement Therapy (CRRT) Versus Low-Dose CRRT ( KETZEREI )
Acute kidney injury (AKI) is a well-recognized complication in critically ill patients, which often leads to the necessity of mechanical kidney support (CRRT).
- Trial name
- KETZEREI (NCT06021288)
- Testing
- Effluent dose of CRRT
- Where
- 2 sites in Germany
- Volunteers
- 165 people
- Sponsor
- Universität Münster
Renal Failure, Hemodynamics
Hemodynamic Assessment APCO Monitor vs Crit Line for Renal Replacement Rx
Fluid and volume management are a challenging part of critical care and the difficulties increase in the face of renal failure. Utilizing the Crit-Line to monitor blood volume changes in conjunction with arterial pressure cardiac…
- Trial name
- APCOvC-Line (NCT00666003)
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Baystate Medical Center
Septic Shock
Changes in Microvascular Perfusion During Blood Purification With Cytosorb® in Septic Shock
Sepsis is defined as a life-threatening event due to a dysregulated immune response to an host. Blood purification techniques may be considered as a therapeutic weapon to front sepsis and septic shock.
- Trial name
- NCT03456180
- Testing
- Haemoadsorption with Cytosorb cartridge
- Volunteers
- 10 people
- Sponsor
- Università Politecnica delle Marche
CKD, ACS (Acute Coronary Syndrome)
Early Coronary Angiography in Advanced Chronic Kidney Disease With Acute Coronary Syndrome
This is the retrospective study regarding the association of invasive coronary angiography and time to renal replacement therapy initiation and mortality in patients with chronic kidney disease stage 4-5 who develop acute…
- Conditions
- CKD, ACS (Acute Coronary Syndrome), Coronary Angiography (CAG)
- Trial name
- CAG in CKD-ACS (NCT07474441)
- Testing
- coronary angiography
- Volunteers
- 139 people
- Sponsor
- Chulalongkorn University
Fabry Disease
Fabry: Renal Function During Long-term ERT by 51Cr-EDTA Clearance
The aim of this study was to investigate renal function decline by measured glomerular filtration rate (mGFR) in patients with FD during enzyme replacement therapy, and to explore the influence of age on renal function in FD.
- Trial name
- NCT02969200
- Testing
- Enzyme replacement therapy
- Where
- Denmark
- Volunteers
- 52 people
- Sponsor
- Ulla Feldt-Rasmussen
Myocardial Fibrosis, End Stage Renal Failure on Dialysis
MRI Assessment of Myocardial Fibrosis Associated With Monocyte Phenotype in End Stage Renal Failure
Firstly, this study aims to understand how cardiac fibrosis mediated by inflammatory microvascular disease evolves during advanced chronic kidney disease and end stage renal failure and importantly how this changes with…
- Conditions
- Myocardial Fibrosis, End Stage Renal Failure on Dialysis, Chronic Kidney Disease, Stage IV (Severe), Chronic Kidney Disease Stage V
- Trial name
- CM3 (NCT03857633)
- Testing
- Cardiac MRI 1 - With Gadolinium Contrast, Cardiac MRI 2 - With Gadolinium Contrast, Cardiac MRI 3 - Without Gadolinium Contrast
- Where
- United Kingdom
- Sponsor
- Imperial College London
Liver Failure, Acute Kidney Injury
Continuous Renal Replacement Therapy (CRRT) in Surgery Room During Orthotopic Liver Transplantation (OLT)
The study is interventional, non-pharmacological, single-center. The aim of this study is to test the possible added value of CRRT in the surgery room during liver transplantation, compared to the investigators center current…
- Conditions
- Liver Failure, Acute Kidney Injury, Kidney Disease, Chronic
- Trial name
- CRRT-OLT (NCT06844435)
- Testing
- continuous renal replacement therapy
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
End Stage Renal Disease (ESRD), Chronic Kidney Disease (CKD)
Advancing Renal TRANSplant eFficacy and Safety Outcomes With an eveRolimus-based regiMen (TRANSFORM)
This is a 2-year, randomized, multicenter, open-label, 2-arm study evaluating the graft function of everolimus and reduced CNI versus MPA and standard CNI in adult de novo renal transplant recipients.
- Conditions
- End Stage Renal Disease (ESRD), Chronic Kidney Disease (CKD), Hemodialysis, Renal Replacement Therapy
- Trial name
- TRANSFORM (NCT01950819)
- Testing
- Induction therapy, Corticosteroids, EVR+rCNI
- Where
- 184 sites in United States, Argentina and 40 more
- Volunteers
- 2,037 people
- Sponsor
- Novartis Pharmaceuticals
Chronic Kidney Diseases, Subclinical Hypothyroidism
Supplementation of Thyroid Hormone for TSH Control in Patients With Chronic Kidney Disease Without TRR.
Study design: Phase II study, randomized, double-blind, unicentric, two-arm, placebo-controlled clinical trial. Methods and participants: Patients with Chronic Kidney Disease G2-G5 with proteinuria without renal replacement…
- Trial name
- TSHrenal (NCT03898622)
- Testing
- Levothyroxine
- Where
- Mexico
- Volunteers
- 32 people
- Sponsor
- Hospital Civil de Guadalajara
Hyperphosphatemia Patients With Chronic Kidney Disease on 3x/Week Replacement Therapy
Efficacy of SBR759 in Lowering Serum Phosphate Levels in Chronic Kidney Disease Patients on Hemodialysis
This study will evaluate the efficacy of SBR759 compared to sevelamer HCl in lowering serum phosphate levels in Chronic Kidney Disease patients on hemodialysis
- Trial name
- SBR759 (NCT00704483)
- Testing
- SBR759, Sevelamer HCl
- Where
- 66 sites in United States, Australia and 11 more
- Volunteers
- 321 people
- Sponsor
- Novartis Pharmaceuticals