Clinical trials: Renal Replacement Therapy
Prevention of Thromboembolic Events
Study to Assess the Safety, Tolerability, Effects on the Body, Absorption, Distribution and Elimination of 25 mg BAY2433334 in Renal Impairment Including Renal Replacement Therapy ("Dialysis")
BAY2433334 is under clinical development for prevention of complications in diseases such as heart attack, irregular heart beat or stroke which can arise by formation of blood clots elsewhere in the body and travels through the…
- Trial name
- NCT04510987
- Testing
- BAY2433334 single dose in treatment groups 1-4 and 6 as well as on the dialysis free day of treatment 5, BAY2433334 on dialysis treatment day
- Where
- Germany
- Volunteers
- 48 people
- Sponsor
- Bayer
End-stage Renal Disease
Effect of Different Dialysis Dosage on Prognosis in Maintenance Peritoneal Dialysis Patients
Peritoneal dialysis (PD) is an important model of renal replacement therapy for end-stage renal disease (ESRD) patients. Thus far, evidence for the initiation dosage of PD treatment is lacking, most patients begin their PD with…
- Trial name
- NCT00912821
- Testing
- 6 L dialysate, 8 L dialysate
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Renal Replacement Therapy for Acute Kidney Injury in ICU
Timing of Renal Replacement Therapy Initiation in Tumor Lysis Syndrome
The TENDERS study aims to evaluate the impact of the timing of renal replacement therapy (RRT) initiation on outcomes in patients with tumor lysis syndrome (TLS) and associated acute kidney injury (AKI).
- Trial name
- TENDERS (NCT06889974)
- Where
- 10 sites in France
- Volunteers
- 800 people
- Sponsor
- University Hospital, Bordeaux
Shock
High Volume Veno-venous Hemofiltration Versus Standard Care for Post-cardiac Surgery Shock
This study seeks to determine if early continuous High Volume Veno-venous Hemofiltration (HVHF) reduces 30-day all cause mortality in post-cardiac surgery patients developing shock requiring high doses catecholamines.
- Trial name
- HEROICS (NCT01077349)
- Testing
- high volume hemofiltration, standard care
- Where
- France
- Volunteers
- 226 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Peritoneal Dialysis (PD), Hemodialysis
A Survey for Patients and Caregivers Aiming to Understand and Improve the Care of Patients at High Risk of Transfer From Peritoneal Dialysis to Hemodialysis:
Home dialysis is encouraged in Canada and peritoneal dialysis is the most common home dialysis method. However, many patients discontinue peritoneal dialysis, often transferring to hemodialysis.
- Conditions
- Peritoneal Dialysis (PD), Hemodialysis, Kidney Replacement Therapy, Transition
- Trial name
- ULIFT-PD (NCT07437677)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Septic Shock
Changes in Microvascular Perfusion During Blood Purification With Cytosorb® in Septic Shock
Sepsis is defined as a life-threatening event due to a dysregulated immune response to an host. Blood purification techniques may be considered as a therapeutic weapon to front sepsis and septic shock.
- Trial name
- NCT03456180
- Testing
- Haemoadsorption with Cytosorb cartridge
- Volunteers
- 10 people
- Sponsor
- Università Politecnica delle Marche
CKD, ACS (Acute Coronary Syndrome)
Early Coronary Angiography in Advanced Chronic Kidney Disease With Acute Coronary Syndrome
This is the retrospective study regarding the association of invasive coronary angiography and time to renal replacement therapy initiation and mortality in patients with chronic kidney disease stage 4-5 who develop acute…
- Conditions
- CKD, ACS (Acute Coronary Syndrome), Coronary Angiography (CAG)
- Trial name
- CAG in CKD-ACS (NCT07474441)
- Testing
- coronary angiography
- Volunteers
- 139 people
- Sponsor
- Chulalongkorn University
Hypomagnesemia
Magnesium Replacement Therapy to Prevent Acute Renal Failure in Critically Ill Patients
Acute renal failure (ARF) is a serious and common complication in hospitalized patients, occurring in more than 25% of intensive care unit (ICU) patients.
- Trial name
- NCT01700998
- Testing
- Magnesium
- Where
- Brazil
- Volunteers
- 140 people
- Sponsor
- Universidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude
Continuous Renal Replacement Therapy, Intensive Care Unit
Diagnosis Accuracy of Hemoconcentration to Detect Hypovolemia During CRRT
The aim of the study is to analyze if blood protein concentration variation during continuous renal replacement therapy (CRRT) with fluid removal can predict a decrease of 15 % of cardiac index in intensive care unit (ICU)…
- Conditions
- Continuous Renal Replacement Therapy, Intensive Care Unit, Hypovolemia, Fluid Overload
- Trial name
- NCT03144349
- Where
- 2 sites in France
- Volunteers
- 52 people
- Sponsor
- Hopital Louis Pradel
Acute Kidney Injury
IHD Versus CRRT for Severe Acute Kidney Injury in Critically Ill Patients
Intermittent hemodialysis (IHD) and continuous RRT (CRRT) provided as continuous hemofiltration or hemodiafiltration are the main RRT modalities in ICU.
- Trial name
- ICRAKI (NCT06032884)
- Testing
- continuous renal replacement therapy (CRRT), Intermittent hemodialysis (IHD)
- Where
- France
- Volunteers
- 554 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Kidney Injury, Renal Insufficiency
Pharmacokinetics of Antiepileptics in Patients on CRRT
The purpose of the study is to measure levels of any of the following AEDs (levetiracetam, phenobarbital, phenytoin, ketamine, valproic acid, lacosamide) in blood and effluent on critically ill patients receiving CRRT in order to…
- Conditions
- Acute Kidney Injury, Renal Insufficiency, Renal Failure, Pharmacokinetics
- Trial name
- PADRE (NCT03632915)
- Testing
- Levetiracetam, Lacosamide, Phenytoin
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Maryland, Baltimore
Liver Cirrhosis, Kidney Failure, Acute
Intermittent ADVOS vs. Hemodialysis in Non-intensive Care Patients With Liver Dysfunction
In the planned randomized controlled prospective pilot study, we aim to evaluate ADVOS compared with conventional hemodialysis regarding the elimination of protein-bound toxins in patients with therapy-refractory hepatorenal…
- Conditions
- Liver Cirrhosis, Kidney Failure, Acute, Kidney Replacement, Multi Organ Failure
- Trial name
- ADVOMITTENT (NCT06129617)
- Testing
- Hemodialysis, ADVOS
- Where
- Germany
- Volunteers
- 14 people
- Sponsor
- University Medical Center Mainz
Bacterial Infection, Critically Ill
Study of Tigecycline Pharmacokinetics in Patients Undergoing Continuous Renal Replacement Therapy(CRRT)
The aim of this study is to determine the Pharmacokinetics/Pharmacodynamics(PK/PD) of tigecycline in critical ill patients undergoing continuous renal replacement therapy（CRRT）and examine whether the dosage needs adjustment.
- Trial name
- NCT02931526
- Testing
- Tigecycline
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Zhujiang Hospital
Sepsis, Septic Shock
OxiCLEAR (Oxiris Cytokines and Endotoxin Adsorption Rate) Study
This study examines how well the Oxiris® hemofilter works over time in adults with septic shock who require continuous kidney support in the intensive care unit (ICU).
- Conditions
- Sepsis, Septic Shock, Blood Purification, Hemoadsorption
- Trial name
- OxiCLEAR (NCT07419802)
- Testing
- AN69-polyethylenimine hemofilter (Oxiris®) used for continuous veno-venous hemofiltration (CVVH)
- Where
- Latvia
- Volunteers
- 29 people
- Sponsor
- Pauls Stradins Clinical University Hospital
Renal Replacement Therapy
Citrate Anticoagulation in Renal Replacement Therapy: Impact of a High Post-filter Calcium Target on Efficacy
Regional citrate anticoagulation (RCA) is the recommended method for anticoagulation in continuous renal replacement therapy (CRRT). However, the optimal post-filter ionized calcium (iCa) target level remains unclear.
- Trial name
- Ca-CIBLE (NCT05814341)
- Testing
- Citrate
- Where
- France
- Volunteers
- 108 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Regional Citrate Anticoagulation, Ionized Calcium
No Monitoring of Post-filter Ionized Calcium in Regional Citrate Anticoagulation
Do no monitor of post-circuit ionized calcium affact the filter life time of continueous renal replacement therapy with regional citrate anticoagulation circuit? A randomized control trial
- Conditions
- Regional Citrate Anticoagulation, Ionized Calcium, Continuous Renal Replacement Therapy
- Trial name
- NCT04792424
- Testing
- Regional citrate anticoagulation, Vasopressor, Antibiotic
- Where
- Thailand
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Renal Failure, Renal Insufficiency, Acute
The Effect of Vitamin E-coated Polysulfone Membrane on Oxidative Stress, Inflammation and Monocytes in Critically Ill Patients in CRRT
The study evaluate the effect of a membrane in polysulfone covered with vitamin E (ViE15-A, ASAHI Kasey, Tokyo, Japan) versus non-vitamin E polysulfone membrane (REXEED-15A, ASAHI Kasey, Tokyo, Japan) in critically ill patients…
- Trial name
- Vitabrane E (NCT03489759)
- Testing
- ViE15-A, REXEED-15A
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- St. Bortolo Hospital
Renal Replacement Therapy
A Clinical Study to Evaluate the Efficacy, Safety and PK/PD Profiles of Anticoagulation of HSK36273 for Injection in Continuous Renal Replacement Therapy Subjects
This study is divided into Stage I and Stage II. It is planned to include 156 subjects who need CRRT treatment for more than 48 hours.
- Trial name
- NCT05602129
- Testing
- HSK36273, Heparin sodium
- Where
- China
- Volunteers
- 156 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Acute Renal Failure (ARF), Acute Kidney Injury (AKI)
Retrospective Analysis of Prismaflex HF20 Set Versus ppCRRT Registry
A retrospective multicenter, observational design intended to capture data on pediatrics (weighing between 8 - 20 kg) who underwent continuous renal replacement therapy (CRRT) using the HF20 set.
- Conditions
- Acute Renal Failure (ARF), Acute Kidney Injury (AKI), Fluid Overload in Dialysis Patients
- Trial name
- NCT06633029
- Testing
- Prismaflex HF20
- Where
- 5 sites in United States
- Volunteers
- 59 people
- Sponsor
- Vantive Health LLC
Acute Kidney Injury, Fluid Overload
Use of Biomarkers to Optimize Fluid Dosing,CRRT Initiation and Discontinuation in Pediatric ICU Patients With AKI
Acute Kidney Injury (AKI) is a common clinical problem defined by an abrupt (< 48 hour) increase in serum creatinine (SCr) resulting from an injury or insult that causes a functional or structural change in the kidney.
- Trial name
- NCT01416298
- Testing
- Continuous Renal Replacement Therapy
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati