Clinical trials: Renal Replacement Therapy
Critically Ill, Acute Kidney Injury
Comparison of Biphozyl® and Phoxilium® as a Replacement Fluid During CVVH for AKI in Adults and Their Effects on pH-, Bicarbonate-levels and Respiratory Situation
The primary objectives of the BiPhox-Trial are to demonstrate, that the use of Biphozyl® as a replacement fluid in adult critically ill acute kidney injury (AKI) patients, results in a lower rate of pH excursions and of…
- Conditions
- Critically Ill, Acute Kidney Injury, Renal Replacement Therapy, Continuous Renal Replacement Therapy
- Trial name
- NCT04071171
- Testing
- CVVH with Phoxilium® in the first 48h after randomization, CVVH with Biphozyl® in the first 48h after randomization, CVVH with Phoxilium® in the second 48h after randomization (after previous 48h with Biphozyl®)
- Where
- Austria
- Volunteers
- 88 people
- Sponsor
- Medical University Innsbruck
End Stage Renal Disease, Left Ventricular Hypertrophy
Does ALlopurinol Regress lefT Ventricular Hypertrophy in End Stage REnal Disease: The ALTERED Study
Kidney patients on dialysis commonly die because of heart disease. One of the biggest problems in their hearts is that the muscle wall of the heart thickens. This makes it less efficient.
- Trial name
- Altered (NCT01951404)
- Testing
- Allopurinol
- Where
- 3 sites in United Kingdom
- Volunteers
- 80 people
- Sponsor
- University of Dundee
Acute Kidney Injury, Uremia
Timing of Renal Replacement Therapy in the Critically Ill Patients
Background: Severe acute kidney injury (AKI) among critically ill patients is sometimes treated with renal replacement therapy (RRT), and in Sweden continuous RRT (CRRT) is the dominant modality used in this population.
- Conditions
- Acute Kidney Injury, Uremia, Fluid Overload, Dialysis; Complications
- Trial name
- TORRT (NCT03629977)
- Testing
- CRRT
- Where
- Sweden
- Volunteers
- 50,000 people
- Sponsor
- Karolinska University Hospital
Renal Replacement Therapy, Mortality
Referral Patterns for Hospital Acquired Acute Kidney Injury and Relevance to Renal Outcomes
Few studies analyzed the referral time to nephrologists and its impact on the patient outcome in a large cohort. The investigators described the incidence and determined the outcome with respect to renal function recovery, renal…
- Trial name
- HA-AKI (NCT01151514)
- Testing
- Nephrologist referral
- Where
- Switzerland
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Critically Ill, Renal Replacement Therapy
Analgesia Nociception Index to Explore Autonomic Nervous System in Patients With Continuous Renal Replacement Therapy
The Analgesia Nociception Index (ANI) reflects the balance between sympathetic and parasympathetic tone. It is based on a specific interpretation of the R-R interval variation.
- Trial name
- UFANI (NCT06285162)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Acute Kidney Injury Due to Sepsis
Hemodynamic Stability in Septic Shock Patients Undergoing Continuous Renal Replacement Therapy With oXiris Membrane
The new adsorbing membrane for continuous renal replacement therapy (CRRT), oXiris, can reduce plasma cytokines and endotoxins in septic shock patients with severe acute kidney injury, compared with standard membranes.
- Trial name
- HISTORIX (NCT05575024)
- Testing
- oXiris membrane, Polysulfone membrane
- Where
- South Korea
- Volunteers
- 98 people
- Sponsor
- Seoul National University Hospital
Critical Illness, Acute Kidney Injury
Standard Dose Continuous Renal Replacement Therapy (CRRT) Versus Low-Dose CRRT ( KETZEREI )
Acute kidney injury (AKI) is a well-recognized complication in critically ill patients, which often leads to the necessity of mechanical kidney support (CRRT).
- Trial name
- KETZEREI (NCT06021288)
- Testing
- Effluent dose of CRRT
- Where
- 2 sites in Germany
- Volunteers
- 165 people
- Sponsor
- Universität Münster
Acute Kidney Injury
Metabolic Complications Using a Low- Versus High Concentration Citrate Solution for Regional Anticoagulation in Continuous Kidney Replacement Therapy: A Pragmatic Randomized Trial.
This study is a pragmatic, randomized trial comparing two commercially available citrate solutions to determine their impact on metabolic complications in critically ill patients with acute kidney injury receiving continuous…
- Trial name
- LEON1 (NCT07751861)
- Testing
- low concentrated citrate solution (18 mmol/L), high concentrated citrate solution (136 mmol/L)
- Where
- Belgium
- Volunteers
- 176 people
- Sponsor
- University Hospital, Antwerp
Chronic Kidney Disease
Impact of Specialised Renal Care in Patients With Chronic Kidney Disease
This is a prospective randomised trial studying patients with stage 3 to 5 chronic kidney disease (CKD) in order to determine the impact of specialised care by nephrologists compared to guidelines-directed management by primary…
- Trial name
- IMPLICATE (NCT00929760)
- Testing
- specialised renal care
- Where
- Switzerland
- Volunteers
- 242 people
- Sponsor
- Patrick Saudan
Chronic Pain, Neuralgia
Acupuncture Versus Conventional Treatment for Chronic Pain in Patients With Chronic Kidney Disease
This study evaluated acupuncture plus optimized conventional pharmacological treatment compared with optimized conventional pharmacological treatment alone for chronic pain in adults with chronic kidney disease receiving…
- Conditions
- Chronic Pain, Neuralgia, Renal Insufficiency,Chronic
- Trial name
- NCT07891819
- Testing
- Acupuncture, Optimized conventional pharmacological treatment
- Where
- Brazil
- Volunteers
- 110 people
- Sponsor
- Federal University of São Paulo
Continuous Renal Replacement Therapy
Continuous Versus Conventional Volume Management During CRRT (Continuous Renal Replacement Therapy)
Use of on-line blood volume monitoring during continuous renal replacement therapy can improve volume management in acute kidney injury patients requiring renal replacement
- Trial name
- NCT01405092
- Testing
- use of continuous renal replacement machine for renal replacement, use of blood volume monitoring device in conjunction with machine used for continuous renal replacement to assess and determine volume removal
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Dallas VA Medical Center
Renal Replacement Therapy, Acute Kidney Injury
Saline Versus Albumin Fluid for Extracorporeal Removal With Slow Low Efficiency Dialysis Feasibility Study
Objective: The primary aim of this 60 patient feasibility trial is to determine if, for critically ill patients treated with SLED for AKI, randomization to receive albumin (25%) boluses versus normal saline placebo boluses is…
- Conditions
- Renal Replacement Therapy, Acute Kidney Injury, Hypotension
- Trial name
- SAFER-SLED (NCT03665311)
- Testing
- 25% Albumin fluid, Normal Saline
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Ottawa Hospital Research Institute
AKI, Continuous Renal Replacement Therapy
Renal Physiology During Continuous Renal Replacement Therapy
Approximately 50% of patients in the intensive care unit (ICU) develop acute kidney injury (AKI) and more than 10% need dialysis. There is no treatment for AKI.
- Conditions
- AKI, Continuous Renal Replacement Therapy, Dialysis, Intensive Care
- Trial name
- NCT04114747
- Testing
- Starting at high or low blood pressure
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Sahlgrenska University Hospital
Chronic Renal Failure
Efficacy of an Intradialysis Combined Training Program on Disability Level and Physical Performance.
The patient subjected to hemodialysis has a low physical capacity due to being advanced in years and the complexity of the process, which is encouraged by family members and caregivers who lead them to a total dependence.
- Trial name
- PTH-CKD0113 (NCT02883309)
- Testing
- intradialytic physical training program
- Sponsor
- Universidad Austral de Chile
Aluminium Phosphide Poisoning
CRRT Versus Plasmapheresis in Aluminum Phosphide Poisoning
Aluminum phosphide (AlP) is a solid fumigant pesticide sold as tablets in use since the 1940s. It is considered to be an ideal pesticide because of its cheapness, efficiency, and easy availability in the market and is widely used…
- Trial name
- AlP (NCT05334667)
- Testing
- Routine management, CRRT, PPH
- Volunteers
- 75 people
- Sponsor
- Assiut University
Wound Surgical, Diabetes
Negative Pressure Wound Therapy Devices in Total Knee Arthroplasty
This study is a single-center, prospective, randomized, open-label clinical trial evaluating three commercially available closed-incision negative pressure wound therapy (ciNPWT) devices: NPseal, PICO, and Prevena, in adult…
- Conditions
- Wound Surgical, Diabetes, Obesity, Chronic Kidney Diseases
- Trial name
- NCT07770633
- Testing
- NP Seal, PICO, Prevena
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Acute Kidney Injury
Systemic Metabolic Contribution From Continuous Renal Replacement Therapy (CRRT)
The purpose of this observational study is to measure the number of calories delivered from fluids used in continuous renal replacement therapy (CRRT).
- Trial name
- NCT02998346
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
Critically Ill Renal Failure Requiring CVVHD and Oseltamivir, Critically Ill Requiring ECMO and Oseltamivir
Pharmacokinetics of Tamiflu® (Oseltamivir) in Patients Receiving Extracorporeal Membrane Oxygenation (ECMO)and or Continuous Venovenous Hemodialysis (CVVHD)
Critically ill patients with flu may receive a drug called oseltamivir. They may also receive medical therapies to support their lung function (extracorporeal membrane oxygenation; ECMO) and kidney function (continuous venovenous…
- Trial name
- NCT01048879
- Testing
- pharmacokinetic blood sampling, pharmacokinetic blood and dialysate sampling
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Michigan
Acute Renal Failure
Clinical Trial Comparing Continuous Versus Intermittent Hemodialysis in ICU Patients
The mortality of acute renal failure (ARF) remains to be high (around 60-70%) despite manifold improvements in ICU care. At present, it is not clear if the method chosen for renal replacement therapy, i.e.
- Trial name
- CONVINT (NCT01228123)
- Testing
- RRT for acute kidney failure using the CVVH method, RRT for acute kidney failure using the IHD (intermittent HD)
- Where
- Germany
- Volunteers
- 252 people
- Sponsor
- Charite University, Berlin, Germany
Acute Kidney Injury, Renal Replacement Therapy
Efficacy, Safety and Pharmacokinetics of Tinzaparin During Slow Low Efficient Daily Dialysis in Intensive Care Patients
This study evaluates the pharmacokinetics of tinzaparin during renal replacement therapy (RRT). 60 patients with clinical indication for pharmacological thromboprophylaxis and slow low efficient daily dialysis (SLEDD) will be…
- Conditions
- Acute Kidney Injury, Renal Replacement Therapy, Anticoagulants
- Trial name
- Tinza-SLEDD (NCT03614741)
- Testing
- Tinzaparin continuous infusion, Tinzaparin bolus
- Where
- Finland
- Volunteers
- 60 people
- Sponsor
- Tampere University Hospital