Clinical trials: Renal Stone Disease
Renal Calculi
SMP vs RIRS for Symptomatic Lower Pole Renal Calculi of 10-20 mm Size: a Randomized Controlled Trial
Shock wave lithotripsy (SWL) is recommended for kidney stones < 20 mm. However, the stone clearance of lower pole calculi after SWL is limited, thus leading to an extended indication for mini-percutaneous nephrolithotripsy (PCNL)…
- Trial name
- NCT02519634
- Testing
- Super-Mini Percutaneous Nephrolithotomy, Retrograde Intrarenal Surgery
- Where
- China
- Volunteers
- 160 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Fasting, Chronic Disease
A Retrospective and Prospective Cohort Study of the 21-day Fasting-like Diet in Patients With Metabolic and Autoimmune Diseases
Effectiveness of fasting or fasting-mimicking diet has been proved an effective approach to treat metabolic and autoimmune diseases in mice.
- Conditions
- Fasting, Chronic Disease, Autoimmune Diseases, Metabolic Disease
- Trial name
- NCT03193177
- Testing
- the 21-day fasting-like diet
- Where
- China
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Tsinghua University
Kidney Stones
Narrow Versus Wide Focal Zones for Shock Wave Lithotripsy of Renal Calculi
Shockwave lithotripsy (SWL) is a safe, non-invasive treatment for renal calculi. During SWL energy is focused on in order to break kidney stones and this energy can be varied in size from a narrow (or small) focal zone to a wide…
- Trial name
- NCT01226875
- Testing
- SWL: Shock Wave Lithotripsy Intervention
- Where
- 3 sites in Canada
- Volunteers
- 275 people
- Sponsor
- Unity Health Toronto
Urolithiasis, Nephrolithiasis
Access Sheaths With Aspiration for Renal RetrOgrade Surgery, Randomized CompArative Outcomes
The goal of this clinical trial is to learn whether the ClearPetra ureteral access sheath (Coloplast) is more effective than the Navigator ureteral access sheath (Boston Scientific) in treating intrarenal kidney stones of 1-3 cm…
- Conditions
- Urolithiasis, Nephrolithiasis, Kidney Calculi, Ureteroscopy
- Trial name
- ARROCA01 (NCT07678255)
- Testing
- ClearPetra ureteral access sheath, Navigator ureteral access sheath
- Where
- Spain
- Volunteers
- 156 people
- Sponsor
- Hospitales Universitarios Virgen del Rocío
Kidney Stone, Ureteroscopy
Retrograde Intrarenal Stone Surgery - A Method of Treating the ESWL Resistant Kidney Stone
Is it possible to decrease the intrarenal pressure in the kidney during endoscopic management of kidney stone by topical administration of drugs? In order to secure fewer complications in ureteroscopic operations the…
- Trial name
- NCT00323843
- Testing
- Isoproterenol
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Fredericia Hosptial
Kidney Stones, Kidney Calculi
Endogenous Oxalate Synthesis in Idiopathic Calcium Oxalate Kidney Stone Disease
The goal of this clinical trial study is to test if patients with idiopathic calcium oxalate kidney stones have an increased production of oxalate by the body, which would lead to increased urinary excretion of oxalate.
- Conditions
- Kidney Stones, Kidney Calculi, Urolithiasis, Urolithiasis, Calcium Oxalate
- Trial name
- NCT06989320
- Testing
- Low-oxalate diet and glycolate dosing, Oral glycolate dosing, Oral 13C- ascorbic acid dosing
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Nephrolithiasis, Flexible Ureteroscopy
Bendable Suction Ureteral Access Sheath Versus Conventional Ureteral Access Sheath in Management of Renal Stones Using Flexible Ureteroscopy
Urinary calculus is a globally recognized urological condition, with prevalence rates ranging from 1% to 13% across different geographical regions (1) Therapeutic approaches for renal calculi encompass extracorporeal shock wave…
- Trial name
- NCT06862141
- Testing
- bendable suction ureteral access sheath, conventional suction ureteral access sheath
- Where
- Egypt
- Volunteers
- 172 people
- Sponsor
- Menoufia University
Kidney Stones
Durability of Flexible Ureteroscopes and Causes of Infection During Flexible Ureterorenoscopy
This is an observational study in which data on consecutive patients who undergo ureterorenoscopy with the use of a flexible ureterorenoscope are collected.
- Trial name
- NCT03087812
- Where
- Netherlands
- Volunteers
- 400 people
- Sponsor
- Clinical Research Office of the Endourological Society
Renal Calculi, Renal Insufficiency
The Effect of Three Endourological Procedures for the Management of Renal Calculi Regarding Acute Kidney Injury
The main aim of the study is to investigate and compare the possible acute effect of standard PCNL, mini-PCNL and RIRS on renal function.
- Trial name
- NCT03112499
- Testing
- PCNL, mini-PCNL, RIRS
- Where
- Greece
- Volunteers
- 75 people
- Sponsor
- Institute for the Study of Urological Diseases, Greece
Kidney Stones
Comparison of Multiple-, Single- and Zero-dose of Ciprofloxacin Prophylaxis in Retrograde Intrarenal Surgery
The purpose of this study is to compare the postoperative systemic inflammatory response syndrome (SIRS) rates undergoing retrograde intrarenal surgery (RIRS) after multiple-, single-, zero-dose of ceftriaxone prophylaxis in a…
- Trial name
- RIRS (NCT02304822)
- Testing
- Multiple-dose of Ciprofloxacin prophylaxis, Single-dose of Ciprofloxacin prophylaxis, Zero-dose of Ciprofloxacin prophylaxis
- Where
- China
- Volunteers
- 450 people
- Sponsor
- Guohua Zeng
Nephrolithiasis, Kidney Calculi
Comparison Between Supine Mini-PCNL and Flexible Ureteroscopy (FURS) for Dense Lower Calyceal Stones (1-2 cm) in School-Age Pediatric Patients
This randomized controlled clinical study compared supine mini percutaneous nephrolithotomy versus flexible ureteroscopy for the management of dense lower calyceal renal stones measuring 1-2 centimeters (≤20 millimeters) with…
- Conditions
- Nephrolithiasis, Kidney Calculi, Urolithiasis
- Trial name
- NCT07345234
- Testing
- Supine Mini Percutaneous Nephrolithotomy, Flexible Ureteroscopy
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Ain Shams University
Uric Acid Kidney Stone Disease
Pathophysiology of Uric Acid Nephrolithiasis
This study has two aims: Aim 1: To determine the presence of accumulation of fat within cells and the functional consequences of this in the kidney by correlating kidney fat content with urine test results.
- Trial name
- IUAN (NCT00904046)
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 172 people
- Sponsor
- University of Texas Southwestern Medical Center
Kidney Stones, Ureteral Stones
The Efficacy of Tamsulosin in the Treatment of Ureteral Stones in Emergency Department Patients
To determine if emergency department patients with acute ureteral colic pain due to a ureteral stone who are treated with tamsulosin, versus placebo, will experience a shorter time to passage of their stone or resolution of their…
- Trial name
- NCT00448123
- Testing
- Tamsulosin
- Where
- United States
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Robert Swor
Urolithiasis
Effect of Use of Ureteral Access Sheath on Levels of Netrin-1 in Patients Undergoing RIRS
In this study, it is aimed to evaluate whether use of a ureteral access sheath (UAS) during retrograde intrarenal surgery (RIRS) due to kidney stone has any effect on protecting the kidney functions by measuring blood and urine…
- Trial name
- NCT02533414
- Testing
- RIRS with UAS, RIRS without UAS
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Selcuk University
Nephrolithiasis, Calcium Oxalate, Nephrolithiasis, Calcium Phosphate
Use of Tolvaptan to Reduce Urinary Supersaturation: a Pilot Proof of Principle Study
In this study the investigators propose to use a daily dose of 45 mg (30 mg at 8 AM and 15 mg at 4 PM). This relatively small well-tolerated dose is likely to persistently increase urine volume and reduce urine supersaturation…
- Trial name
- NCT02096965
- Testing
- Tolvaptan
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Kidney Stone, Calculi, Renal
Our Stone Fixation Technique to Improve Efficiency and Results of Peumatic Lithotripsy in Suction Mini-PCNL.
Prospective study to assist safty and efficieny of our technique of using peumatic lithotripsy with suction mini-pcnl.
- Trial name
- NCT07328659
- Testing
- Peumatic lithotripsy in mini-pcnl
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Yasser Gamil Elnagar
Kidney Stones
Donors With Nephrolithiasis at the Time of Transplant Evaluation (DONATE). Long Term Follow-up.
We believe that kidney donors with kidney stones accepted for a donation do not have an increased risk of loss of kidney function and will not be at increased risk of symptomatic kidney stone events compared to donors without a…
- Trial name
- DONATE (NCT05519150)
- Testing
- low dose radiation abdomen/pelvis CT scan (stone protocol), Blood draw, 24 hour urine collection
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Indiana University
Renal Calculi, Ureteral Obstruction
Assessment of Drug-eluting Ureteral Stent on Bacterial Adherence and Biofilm Formation
The purpose of this study is to determine the clinical effects of a triclosan stent on adherent bacteria, stent biofilms, and patient urine cultures in patients with an indwelling triclosan ureteral stent.
- Trial name
- NCT00250406
- Testing
- Ureteral Stent
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Renal Lithiasis, Antiplatelet
Maintenance of an Antiaggregation by Acetylsalicylic Acid, While a Extracorporeal Lithotripsy Session on a Kidney Stone is Perfomed: Comparative Unicentric Prospective Study
Background/Rationale for the study: Lithiasis pathology is increasingly common because of the change in our lifestyle and our food.
- Conditions
- Renal Lithiasis, Antiplatelet, Hematoma
- Trial name
- KARLITHO (NCT03437057)
- Testing
- acetylsalicylic acid (below or equal to) 250 mg
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Clermont-Ferrand
Kidney Stones, Nephrolithiasis
Thulium Fiber Laser (TFL) vs Thulio Pulsed Thulium:YAG (p-Tm:YAG)
This research study is being conducted to assess the ability and efficiency of two laser systems to break up kidney stones during ureteroscopy with laser lithotripsy for kidney stone treatment.
- Trial name
- NCT06721975
- Testing
- Thulio pulsed Thulium:YAG (p-Tm:YAG), Thulium Laser Fiber (TFL)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Diego