Clinical trials: Renal Transplant Patient
Acute Kidney Injury, Kidney Transplant
MEMRI and Kidney Disease
Acute kidney injury (AKI) is common and costly.1 Although patients who suffer an episode of AKI may recover, many will go on to develop cardiovascular disease and chronic kidney disease (CKD).
- Conditions
- Acute Kidney Injury, Kidney Transplant, Vasculitis, Chronic Kidney Disease(CKD)
- Trial name
- NCT06698614
- Testing
- MRI, Blood tests, Urine tests
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University of Edinburgh
Medication Adherence, Kidney Transplantation
Teen Adherence in KidnEy Transplant Improving Tracking To Optimize Outcomes - Stage 3
Medication non-adherence is a major problem in kidney transplant recipients; young people 12-24 years of age are at particularly high risk for non-adherence and graft failure compared to young children and adults.
- Trial name
- NCT04288271
- Testing
- Adherence Intervention, Healthy living education intervention
- Where
- 8 sites in United States, Canada
- Volunteers
- 96 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Anemia, Kidney Failure
Dynepo Infrequent Dosing Study
The purpose of this study is to demonstrate non-inferiority of efficacy between twice weekly and once weekly dose schedule of Dynepo in previously erythropoietin (EPO)-naive patients, as measured by haemoglobin at week 24 and…
- Trial name
- NCT00450333
- Testing
- Dynepo (Epoetin delta), Dynepo
- Where
- 53 sites in Austria, Belgium and 5 more
- Volunteers
- 407 people
- Sponsor
- Shire
Chronic Kidney Disease (CKD), Kidney Transplant
Remote vs In-Person Prehabilitation for Kidney Transplant Candidates
Patients with advanced chronic kidney disease awaiting deceased-donor kidney transplantation frequently experience progressive functional decline, frailty, reduced mobility, and poor quality of life while on the transplant…
- Conditions
- Chronic Kidney Disease (CKD), Kidney Transplant, Frailty, Prehabilitation
- Trial name
- KIDFIT (NCT07701382)
- Testing
- In-Person Multimodal Prehabilitation, Remote Multimodal Prehabilitation
- Where
- Spain
- Volunteers
- 84 people
- Sponsor
- Hospital Clinic of Barcelona
Immunosuppression
Influenza Vaccination in Immunocompromized Patients
Evaluation of the immunogenicity and reactogenicity of two different formulations of commercially avail-able influenza vaccines in 4 different groups of immunocompromized outpatients (HIV positive patients, patients suffering…
- Trial name
- NCT00783380
- Testing
- Virosomal influenza vaccine, Subunit influenza vaccine
- Where
- 3 sites in Switzerland
- Volunteers
- 304 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Acute Kidney Injury (AKI), Coronary Artery Bypass Graft (CABG)
Effect of Cardiovascular Autonomic Neuropathy on AKI and Outcomes in Isolated CABG Surgery
This study aims to investigate the effects of Cardiovascular Autonomic Neuropathy (CAN) on Acute Kidney Injury (AKI) and clinical outcomes in patients undergoing isolated Coronary Artery Bypass Graft (CABG) surgery requiring…
- Conditions
- Acute Kidney Injury (AKI), Coronary Artery Bypass Graft (CABG), Cardiovascular Autonomic Neuropathy (CAN), Postoperative Outcomes
- Trial name
- CAN-AKI-CABG (NCT07254468)
- Where
- Turkey (Türkiye)
- Volunteers
- 912 people
- Sponsor
- Akdeniz University
Renal Insufficiency, Chronic
Effect of Pre- and Probiotics on P-cresol Plasma Levels in Patients Bearing a Kidney Allograft
The purpose of this study is to establish whether a short treatment with the synbiotic combination Probinul neutro® may decrease the plasma concentration of the uremic toxin p-cresol in patients bearing a kidney allograft.
- Trial name
- NCT02179229
- Testing
- CONTROL, SYNBIOTIC
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Federico II University
Renal Transplantation, Chronic Kidney Insufficiency
Urinary Biomarkers in Paediatric Kidney Transplantation (pKTx)
This study aims to test and validate the panel of study urinary biomarker to assess whether (1) reference values differ between paediatric renal transplant patients, patients with chronic kidney disease stage IV and V (CKD IV-V)…
- Conditions
- Renal Transplantation, Chronic Kidney Insufficiency, Healthy Controls
- Trial name
- NCT05208788
- Testing
- Biomarker test
- Where
- Germany
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Herpes Zoster
ZOSTAVAX® in Renal Transplant Patients
The purpose of this study is to test the safety of a licensed zoster vaccine, ZOSTAVAX® (Zoster Vaccine Live) in 40 subjects, age 18 years or older, with chronic kidney disease (CKD) who are scheduled to receive a living donor…
- Trial name
- NCT01137669
- Testing
- Live attenuated herpes zoster vaccine
- Where
- 3 sites in United States
- Volunteers
- 34 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Liver Transplantation, Kidney Transplantation
Impact of P-gp, MRP2, ENT-1 and CNT3 on the Blood Concentration / Intra-PBMC Concentration of Tacrolimus
Prospective and monocentric pharmacokinetic study
- Trial name
- TRANS-TAC (NCT03910868)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Rennes University Hospital
Kidney Cancer
Pentostatin Followed by Peripheral Stem Cell Transplantation in Treating Patients With Advanced Kidney Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with donor peripheral stem cell transplantation may allow the doctor to give higher…
- Trial name
- NCT00006968
- Testing
- filgrastim, cyclosporine, pentostatin
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Medication Adherence, Compliance
Compliance/Adherence After Kidney Transplant, With or With Out Med-O-Wheel™.
Background: Adherence to the immunosuppressive drug regimen is critical to the outcome after an organ transplant. Patients need to take their prescribed medications and attend their appointments with the doctor.
- Conditions
- Medication Adherence, Compliance, Medication Nonadherence, Communication
- Trial name
- C/A (NCT01709097)
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Karolinska University Hospital
Kidney Transplantation
ATG Versus Basiliximab in Kidney Transplant Displaying Low Immunological Risk But High Susceptibility to DGF
The primary objective of the following randomized open label trial is to demonstrate how low immunological risk patients (no anti HLA immunization and first kidney transplantation) but diagnosed at high-risk of delayed graft…
- Trial name
- PREDICT-DGF (NCT02056938)
- Testing
- Anti-Thymocyte Globulins treatment, Basiliximab treatment
- Where
- 4 sites in France
- Volunteers
- 19 people
- Sponsor
- Nantes University Hospital
Kidney Transplant; Complications
Modification of Diet in Renal Transplantation (MDRT)
Abnormalities in lipid metabolism are present in 50-80% of patients with a kidney transplant and together with concurrent comorbidities and other associated cardiovascular risk factors put kidney transplant recipients at a…
- Trial name
- MDRT (NCT03612778)
- Testing
- Plant-based diet, Mediterranean diet
- Where
- Slovenia
- Volunteers
- 86 people
- Sponsor
- University Medical Centre Ljubljana
Kidney Transplant Rejection
Expressive Writing in Kidney Transplant Patients
Kidney transplantation is a replacement treatment for chronic renal failure that improves quality of life. However, it can be experienced as traumatic in relation to the changes it entails in terms of lifestyle, redefinition of…
- Trial name
- EWKTP (NCT04143178)
- Testing
- Expressive Writing, Neutral Writing
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- University of Roma La Sapienza
End Stage Renal Disease, Antibody Mediated Rejection
Belatacept in Kidney Transplantation of Moderately Sensitized Patients
The purpose of this study is to evaluate the safety and effectiveness of an immunosuppressive medication, Belatacept, as a replacement for a calcineurin inhibitor, in combination with a standard of care regimen of…
- Trial name
- BelatPilot (NCT02130817)
- Testing
- Belatacept, Tacrolimus withdrawal, Plasmapheresis/Intravenous Immunoglobulin G
- Where
- United States
- Sponsor
- University of Wisconsin, Madison
End-stage Heart Failure
Acute Reno-Cardiac Action of Dapagliflozin In Advanced Heart Failure Patients on Heart Transplant Waiting List
In the DAPA-HF trial, the use of dapagliflozin, an inhibitor of sodium-glucose cotransporter 2 (SGLT2), reduced significantly the risk of worsening heart failure or death from cardiovascular causes compared to placebo among…
- Trial name
- ARCADIA-HF (NCT04782245)
- Testing
- Dapagliflozin 10mg
- Where
- France
- Sponsor
- Hospices Civils de Lyon
Cytomegalovirus (CMV), Kidney Disease
A Study of Maribavir in Adults With Kidney Failure Who Have a Cytomegalovirus (CMV) Infection After Transplantation
The main aim of this study is to assess the safety of maribavir in adults with severe CKD or comorbid ESRD including participants on artificial filtering of the kidney (dialysis) or the blood (hemodialysis).
- Conditions
- Cytomegalovirus (CMV), Kidney Disease, Kidney Failure
- Trial name
- NCT06243731
- Testing
- No Intervention
- Where
- 25 sites in Belgium, Estonia and 5 more
- Volunteers
- 10 people
- Sponsor
- Takeda
Kidney Transplant; Complications, Cardiovascular Diseases
Romanian Kidney Transplant Cardiovascular Risk Registry
Kidney transplantation (KT) represents the best treatment for patients with end-stage kidney disease, being associated with improved outcomes and reduced mortality.
- Trial name
- ROKET-CV (NCT04451356)
- Testing
- Bioimpedance Spectroscopy, Arterial Stiffness, Echocardiography
- Where
- Romania
- Volunteers
- 300 people
- Sponsor
- Grigore T. Popa University of Medicine and Pharmacy
Living Donor Kidney Transplants Patients
Comparison of Tacrolimus and Myfortic Versus Tacrolimus and Sirolimus
The investigators center has also analyzed data over the last 7 years from deceased donor (DD) and living donor (LD) kidney transplant recipients who were randomized into 3 immunosuppressive arms between 2000 and 2001.
- Trial name
- NCT01038505
- Testing
- Tacrolimus, Myfortic and Sirolimus
- Sponsor
- University of Miami