Clinical trials: Renal Transplant Patient
Renal Failure, End Stage Renal Disease
Comparison of the Human Acellular Vessel (HAV) With ePTFE Grafts as Conduits for Hemodialysis
The main purpose of this study is to compare the Human Acellular Vessel (HAV) with ePTFE grafts when used for hemodialysis access.
- Conditions
- Renal Failure, End Stage Renal Disease, Hemodialysis, Vascular Access
- Trial name
- NCT02644941
- Testing
- Human Acellular Vessel (HAV), ePTFE graft
- Where
- 38 sites in United States, Germany and 4 more
- Volunteers
- 355 people
- Sponsor
- Humacyte, Inc.
Type 1 Diabetes Mellitus
Islet After Kidney Transplant for Type 1 Diabetes
The purpose of this study is to determine if prolonged administration of the anti TNF (tumor necrosis factor)-Alpha agent etanercept is associated with enhanced graft survival in patients undergoing islet after kidney…
- Trial name
- NCT00784966
- Testing
- etanercept
- Where
- United States
- Sponsor
- Virginia Commonwealth University
Kidney Transplantation
Safety and Tolerability Study of Inhaled Carbon Monoxide in Kidney Transplant Patients
The purpose of this study is to evaluate the safety and tolerability of two carbon monoxide doses when administered as an inhaled gas for 1 hour in patients receiving kidney transplants.
- Trial name
- NCT00531856
- Testing
- Inhaled carbon monoxide
- Where
- 3 sites in United States
- Sponsor
- Mallinckrodt
Delayed Graft Function
TxAccess and Dd-cfDNA for Improved Care of Patients With Delayed Graft Function
This is a prospective multicenter nonrandomized pragmatic hybrid effectiveness-implementation study to test the effectiveness of TxAccess in improving time to renal recovery and immunologic outcomes in patients with delayed graft…
- Trial name
- NCT07825688
- Testing
- TxAccess, Donor-Derived Cell-Free DNA (dd-cfDNA)
- Volunteers
- 450 people
- Sponsor
- Duke University
Depression, ESRD
Morbidity and Mortality Among Dialysis Patients After Treatment for Depression
Morbidity and Mortality among Dialysis Patients after Treating Depression Objectives Our investigation has two objectives: 1. To assess whether treatment and recovery from depression decreases adverse clinical events in chronic…
- Trial name
- NCT00442429
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Portland VA Medical Center
Kidney Transplant Rejection, Kidney Transplantation
Precision Risk Stratification in Kidney Transplant Patients - EU-TRAIN
Main objective: To design a precision risk stratification system that predicts individual risk of rejection
- Conditions
- Kidney Transplant Rejection, Kidney Transplantation, Risk Stratification, Prognosis
- Trial name
- EU-TRAIN (NCT03652402)
- Testing
- kidney transplantation
- Where
- 9 sites in France, Germany and 2 more
- Volunteers
- 558 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Kidney Failure, Chronic
A Study in Participants With End-Stage Renal Disease
The purpose of this trial is to explore the effect of LY2127399 on those antibodies that are a barrier to kidney transplant. Transplantation is currently the definitive treatment for End-Stage Renal Disease (ESRD), providing…
- Trial name
- NCT01200290
- Testing
- LY2127399
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Eli Lilly and Company
Immune System Disorder
Safety, Pharmacokinetics, and Preliminary Efficacy of Isatuximab in Patients Awaiting Kidney Transplantation
Primary Objectives: Phase 1: To characterize the safety and tolerability of isatuximab in kidney transplant candidates. Phase 2: To evaluate the efficacy of isatuximab in desensitization of participants awaiting kidney…
- Trial name
- NCT04294459
- Testing
- Isatuximab SAR650984, Acetaminophen (paracetamol) or equivalent, Ranitidine or equivalent
- Where
- 6 sites in United States, Spain
- Volunteers
- 23 people
- Sponsor
- Sanofi
Kidney Transplant Rejection
Tacrolimus Exposure in Kidney Transplantation
Using CDW data from 5 tertiary hospitals in Korea, this study identify the optimal range of trough level that can prevent adverse outcome in the early periods after transplantation.
- Trial name
- NCT06348446
- Where
- 4 sites in South Korea
- Volunteers
- 12,000 people
- Sponsor
- Seoul National University Hospital
Narcotic Use, Renal Transplant Donor of Left Kidney
Postoperative Pain Protocol Limiting Narcotics for Laparoscopic Hand-assisted Donor Nephrectomy
Kidney donors represent healthy patients and their anticipated postoperative course should be uncomplicated and brief. This study looks to optimize the perioperative pain regimen of laparoscopic donor nephrectomy patients by…
- Trial name
- NCT06458842
- Testing
- Ketamine
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Renal Insufficiency, Acute
New Urine and Blood Markers for Acute Kidney Injury in Liver Transplant Patients
The purpose of this study is to find new blood and urine tests that detect acute kidney injury earlier than our current blood tests in patients receiving a liver transplant.
- Trial name
- NCT00855127
- Where
- 2 sites in United States
- Sponsor
- University of Colorado, Denver
Hemodialysis Access Failure
Prospective, Multicenter, Non-randomized, Single Arm Clinical Trial to Evaluate the Safety and Efficacy of e-PTFE Grafts Inner Surface-treated With Paclitaxel as an Access for Hemodialysis in Patients With End-stage Renal Disease.
This prospective, multicenter, non-randomized, single-arm Clinical trial aims to evaluate the safety and effectiveness of the use of paclitaxel-coated arteriovenous graft (AVG) on the inner wall of ePTFE graft, which is designed…
- Trial name
- NCT04285073
- Testing
- Paclitaxel-eluting graft
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Samsung Medical Center
Renal Transplant
Assessment of Effectiveness of Belatacept Patient Alert Card in Patients Following Renal Transplantation in a Sample of EU Countries
The purpose of the study is to determine a) if the implementation of belatacept patient alert card (PAC) resulted in effective understanding of key safety messages and b) if the degree of understanding of key safety messages is…
- Trial name
- NCT02581644
- Where
- 14 sites in Austria, France and 2 more
- Volunteers
- 63 people
- Sponsor
- Bristol-Myers Squibb
Chronic Kidney Diseases
Proteinuria in Renal Transplant Patients Treated With Dapagliflozin
The prevalence of chronic kidney disease is rising steadily and represents a major public health challenge. Hypertension and proteinuria are two factors strongly associated with the progression of chronic kidney disease (CKD) and…
- Trial name
- DAPAGREFFE (NCT06165601)
- Testing
- Follow-up at D14, Follow-up at M1
- Where
- France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Montpellier
Quadratus Lumborum Block, Surgical Wound Infiltration
Surgeon Infiltration QL Block Comparison
The purpose of this study is to learn if using a Quadratus Lumborum (QL) plane injection technique (also called a "nerve block") that numbs the nerves going to the abdominal area improve pain control after surgery compared to…
- Trial name
- NCT03496610
- Testing
- Liposomal Bupivicaine, QL Block
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Duke University
End-Stage Renal Disease, End-Stage Kidney Disease
Global Study of MK-2060 (Anti-Factor XI Monoclonal Antibody) in Participants With End Stage Renal Disease Receiving Hemodialysis (FXI Hemodialysis Study) (MK-2060-007)
The purpose of this study is to evaluate the efficacy and safety of two different doses of MK-2060 (a monoclonal antibody against Factor XI) in end stage renal disease (ESRD) participants receiving hemodialysis via an…
- Conditions
- End-Stage Renal Disease, End-Stage Kidney Disease, Kidney Failure, Chronic
- Trial name
- NCT05027074
- Testing
- MK-2060
- Where
- 120 sites in United States, Argentina and 13 more
- Volunteers
- 506 people
- Sponsor
- Merck Sharp & Dohme LLC
COVID, Kidney Transplant; Complications
Maintenance Versus Reduction of Immunosuppression for Renal Transplant Patients Hospitalized With COVID-19 Disease
This will be a randomized trial of maintenance versus reduction in immunosuppression in adult patients (age >18 years old) with functioning renal transplants admitted to hospital with confirmed COVID-19 disease.
- Conditions
- COVID, Kidney Transplant; Complications, Immunosuppression
- Trial name
- NCT04420364
- Testing
- Maintenance or reduction of immunosuppression
- Sponsor
- Brigham and Women's Hospital
Viruria
CMX001 in Post-transplant Patients With BK Virus Viruria
This was a randomized, double-blind, multiple-dose placebo-controlled study of oral brincidofovir (BCV) in hematopoietic stem cell transplant and renal transplant recipients with BK virus viruria.
- Trial name
- NCT00793598
- Testing
- Brincidofovir
- Where
- 15 sites in United States
- Volunteers
- 29 people
- Sponsor
- Jazz Pharmaceuticals
Kidney Transplantation
Whole-body Vibration Physiotherapy in Kidney Transplantation
Kidney recipients loose significant amounts of muscle mass and skeleton minerals in the early post-transplantation period and suffer from increasing abnormalities of neuromuscular functions.
- Trial name
- NCT02345577
- Testing
- Stochastic whole body vibration (WBV) therapy - Physiotherapeutical intervention
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Organ Transplantation
Pharmacokinetic Study to Rectal and Sublingual Administration of Tacrolimus in Future Kidney Transplant Patients
The purpose of this study is to investigate the pharmacokinetics of rectal and sublingual administration of tacrolimus and to compare with pharmacokinetics after oral administration of tacrolimus in renal transplant patients…
- Trial name
- NCT00987103
- Testing
- Tacrolimus
- Where
- Netherlands
- Volunteers
- 18 people
- Sponsor
- Maastricht University Medical Center