Clinical trials: Renal Transplant Recipients
Kidney Transplant
Study to Evaluate the Efficacy and Safety of Tacrolimus in Kidney Transplant Recipients (BLOSSOM)
The purpose of this study is to evaluate the efficacy and Safety after conversion to TacroBell SR cap. or TacroBell cap. in patients who in renal transplant patients undergoing maintenance therapy with Reference Tacrolimus.
- Trial name
- NCT04224350
- Testing
- TacroBell SR cap., Tacrolimus cap.
- Where
- South Korea
- Volunteers
- 184 people
- Sponsor
- Chong Kun Dang Pharmaceutical
BK Viremia
BK Treatment Study
Our hypothesis is that 30 days of oral levofloxacin (FDA approved antibiotic) in patients with persistent viremia (BK virus found in blood) will impair progress to BK virus induced kidney damage by significantly decreasing or…
- Trial name
- NCT01034176
- Testing
- levofloxacin
- Where
- 8 sites in United States
- Volunteers
- 43 people
- Sponsor
- Brigham and Women's Hospital
Kidney Transplant
Cell-mediated Immune Response to Influenza Vaccine
Influenza virus is an important cause of morbidity in the transplant population and can lead to viral and bacterial pneumonia. Although the annual influenza vaccine is recommended for organ transplant patients, studies have shown…
- Trial name
- NCT00677547
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Alberta
CMV Specific Immune Response, Kidney Transplant
Risk Factors Associated With the Absence of CMV-specific Cellular Immune Response in the Early Post-transplant Period in Low-risk CMV-seropositive Kidney Transplant Recipients
The goal of this observational study is to identify risk factors associated with the absence of CMV-specific cellular immune response in low-risk CMV-seropositive kidney transplant recipients in the early post-transplant period.
- Conditions
- CMV Specific Immune Response, Kidney Transplant, Kidney Transplant Recipient, CMV Reactivation
- Trial name
- PREDICOR (NCT07621835)
- Where
- Spain
- Volunteers
- 236 people
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
Transplant;Failure,Kidney
Mitra v Fingerprick Tacrolimus Creatinine
Patients with kidney transplant have blood tests very often. This is normally done in hospital and using a needle inserted into the vein.
- Trial name
- NCT03601208
- Testing
- Mitra
- Volunteers
- 100 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Renal Replacement Therapies
Drug Interaction Between Colchicine and Calcineurin Inhibitors in Renal Graft Recipients
Ciclosporin inhibits P-glycoprotein should increase colchicine bioavailability whereas tacrolimus should not influence colchicine disposition.
- Trial name
- COLCHINCAL (NCT01160276)
- Testing
- cyclosporine+colchicine, tacrolimus
- Where
- France
- Volunteers
- 17 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Medication Adherence, Transplant; Kidney
A Pilot Study of mDOT for Immunosuppressant Adherence in Adult Kidney Transplant Recipients
The investigators are interested in whether or not the use of a mobile health (mHealth) application increases the rate of immunosuppression medication adherence among adult kidney transplant recipients.
- Trial name
- mDOT (NCT03427008)
- Testing
- mHealth Intervention
- Where
- United States
- Sponsor
- Johns Hopkins University
Kidney Disease
Effects of Dexmedetomidine on Microcirculation of Kidney Transplant Recipient
The microcirculation is altered in acute kidney injury and chronic kidney disease. The microcirculation is poor in end-stage renal disease patients receiving hemodialysis.
- Trial name
- NCT02707809
- Testing
- Dexmedetomidine
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Kidney Transplantation, Cytomegalovirus Infections, EBV Infection
Is Valacyclovir Non-inferior to Valganciclovir as CMV and EBV Prophylaxis in Kidney Transplant Recipients? A Single-Center Prospective Randomized Pilot Study
Opportunistic CMV viremia (primary infection or reactivation) is usually managed by taking prophylactic medication for both adult and pediatric kidney transplant patients.
- Conditions
- Kidney Transplantation, Cytomegalovirus Infections, EBV Infection, Antiviral Prophylaxis
- Trial name
- NCT07294547
- Testing
- Valacyclovir (Valtrex), Valganciclovir (Valcyte)
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Taiwan University Hospital
Heart Transplant Patients, Kidney Transplant Patients
Multidisciplinary Non-Pharmacological Intervention to Improve Quality of Life in Solid Organ Transplant Recipients
This is a single-center interventional study aimed at evaluating the feasibility of a multidisciplinary non-pharmacological approach based on acupuncture, telerehabilitation-based physical rehabilitation, and brain health…
- Conditions
- Heart Transplant Patients, Kidney Transplant Patients, Lung Transplant, Liver Transplanted Patients
- Trial name
- TAO (NCT07870811)
- Testing
- Acupuncture, Telerehabilitation-Based Physical Rehabilitation, Psychological Support Program
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- The Mediterranean Institute for Transplantation and Advanced Specialized Therapies
Disorder Related to Renal Transplantation
Curcumin in Kidney Transplant Recipients
The primary goal of this study is to investigate if curcumin is beneficial for kidney transplant recipients, a population with extensive baseline vascular dysfunction and cognitive impairment who have few treatment options.
- Trial name
- NCT03935958
- Testing
- Curcumin
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Illinois Chicago
Kidney Transplantation
Certican (Everolimus) for Recipients of Kidney From HLA-identical Living Donors
Recipients from living donors kidneys HLA-identical were lower risk for acute rejection, graft loss or death. There is no clear definition of what is ideal immunosuppressive regimen for this population.
- Trial name
- NCT01653041
- Testing
- Everolimus
- Where
- Brazil
- Volunteers
- 47 people
- Sponsor
- Hospital do Rim e Hipertensão
End-Stage Renal Disease, Hepatitis C
Exploring Renal Transplants Using Hepatitis C Infected Donors for HCV-negative Recipients
In this study, individuals without hepatitis C infection who are on the kidney transplant waitlist will receive a kidney from a deceased donor with hepatitis C infection and will be treated for hepatitis C at the same time.
- Trial name
- EXPANDER-1 (NCT02781649)
- Testing
- Zepatier, Ribavirin, Sofosbuvir
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Johns Hopkins University
Pediatric Kidney Disease, Transplant;Failure,Kidney
Non-Invasive Monitoring of Pediatric Kidney Transplant Recipients and Immunosuppression Personalization: an Open-labeled Multicenter Randomized Controlled Study
Currently, the monitoring of children receiving a kidney transplantation includes surveillance biopsies to detect subclinical rejection and signs of toxicity of immunosuppressive drugs (tacrolimus).
- Trial name
- MONITOR (NCT06761482)
- Testing
- monitoring by dd-cfDNA, monitoring by T-Vis, monitoring by dd-cfDNA+ T-Vis
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Evaluate the Effectiveness of CMV Prevention Strategies in Kidney Transplant Recipients
Use of Tacrolimus and MTOR Inhibitors With Anticipatory Therapy vs. Tacrolimus and Mycophenolic Acid With Universal Prophylaxis in Renal Recipients at High Risk of Posttransplant Cytomegalovirus.
The overall objective of this project is to optimise preventive treatment of CMV infection/disease in renal transplant recipients at increased risk of CMV post-transplantation.
- Trial name
- NCT07203664
- Testing
- steroids, tacrolimus and mTOR inhibitors, steroids, tacrolimus and mycophenolic acid.
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Hospital Universitario La Paz
Kidney Transplant
Study Evaluating Cyclosporine Dose Reduction and Cyclosporine Elimination in Chinese Kidney Transplants
Evaluate the incidence of acute rejection at 12 months after transplantation in subjects receiving induction therapy with cyclosporine microemulsion (CsA) and Rapamune followed by CsA dose reduction (Phase I) with subjects…
- Trial name
- NCT00257387
- Testing
- Cyclosporine
- Volunteers
- 120 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Kidney Transplant, Hepatitis C
Utilization of Hepatitis C Positive Kidneys in Negative Recipients
To evaluate the safety and feasibility of transplanting kidneys from Hepatitis C virus (HCV) infected donors into recipients without HCV infection
- Conditions
- Kidney Transplant, Hepatitis C, HCV
- Trial name
- NCT03801707
- Testing
- Sofosbuvir / Velpatasvir Oral Tablet [Epclusa], Glecaprevir/Pibrentasvir 100 MG-40 MG Oral Tablet [MAVYRET]
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Ohio State University
Chronic Hepatitis C Infection
A Study to Evaluate Chronic Hepatitis C Infection in Adult Transplant Recipients
The purpose of this study is to evaluate the safety and efficacy of ABT-450/r/ABT-267 with or without ABT-333 and with or without ribavirin (RBV) in adult liver or renal transplant recipients with hepatitis C virus (HCV) genotype…
- Trial name
- CORAL-I (NCT01782495)
- Testing
- ombitasvir/paritaprevir/ritonavir and dasabuvir, ombitasvir/paritaprevir/ritonavir, ribavirin
- Volunteers
- 129 people
- Sponsor
- AbbVie
Actinic Keratosis
Safety and Efficacy of Ingenol Mebutate Gel 0.015% for Treatment of AK on the Face in Solid Organ Transplant Recipients
This is a single arm, open-label interventional study of ingenol mebutate 0.015% in solid organ transplant recipients. The investigators plan to treat 20 subjects, 10 kidney transplant recipients and 10 lung transplant…
- Trial name
- NCT02866695
- Testing
- ingenol mebutate gel 0.015%
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
End-Stage Renal Disease
Belatacept in Renal Transplantation With Intermediate Risk Maryland Aggregate Pathology Index (MAPI) Scores
This will be a pilot study to investigate the use of belatacept (BMS) therapy in kidney transplant patients who have a MAPI score of greater than or equal to 8.
- Trial name
- NCT01496417
- Testing
- Belatacept
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Maryland
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