Clinical trials: Renal Transplanted Recipients
Cardiac Transplantation, Chronic Renal Insufficiency
Efficacy Study of Everolimus on Renal Function in Heart Transplant Recipients With Established Chronic Renal Failure
After transplantation, renal impairment, incidence and progression of atherosclerosis lead to modification of immunosuppressive regimens, as switch, reduction or discontinuation of CNI and/or introduction of everolimus.
- Trial name
- COREV (NCT00716573)
- Testing
- everolimus
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Hospices Civils de Lyon
Renal Transplantation
Efficacy and Safety of Early Versus Delayed Administration of Everolimus in de Novo Renal Transplant Patients
The purpose of this study is to evaluate if the delayed administration of everolimus could reduce the everolimus associated "anti-proliferative complications" (e.g.
- Trial name
- NCT00154297
- Testing
- Everolimus (RAD001)
- Where
- Switzerland
- Volunteers
- 139 people
- Sponsor
- Novartis Pharmaceuticals
Diabetes Mellitus
Modification of the "Edmonton Protocol" to Allow for Successful Islet Transplantation From a Single Pancreas and Extension of the "Edmonton Protocol" to Kidney Transplant Recipients
The experience of the Edmonton Group with islet transplantation and use of the "Edmonton Protocol" provides much promise for T1DM patients.
- Trial name
- NCT00021580
- Testing
- human cadaveric islet cell transplantation
- Where
- United States
- Sponsor
- National Center for Research Resources (NCRR)
Liver Transplantation
Liver Spare the Nephron (STN) Study - A Study of CellCept (Mycophenolate Mofetil) and Sirolimus in Recipients of a Liver Transplant
This two-arm study will assess the efficacy and safety of a long-term calcineurin inhibitor-free maintenance regimen with CellCept and sirolimus in recipients of an orthotropic liver transplant.
- Trial name
- NCT00118742
- Testing
- mycophenolate mofetil [CellCept], Tacrolimus, Cyclosporine
- Where
- 46 sites in United States, Canada
- Volunteers
- 293 people
- Sponsor
- Hoffmann-La Roche
Actinic Keratosis
Safety and Efficacy of Ingenol Mebutate Gel 0.015% for Treatment of AK on the Face in Solid Organ Transplant Recipients
This is a single arm, open-label interventional study of ingenol mebutate 0.015% in solid organ transplant recipients. The investigators plan to treat 20 subjects, 10 kidney transplant recipients and 10 lung transplant…
- Trial name
- NCT02866695
- Testing
- ingenol mebutate gel 0.015%
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
Immunosuppression
Tacrolimus C:D Ratio Measured in Renal Transplant Recipients Treated With Once-daily Prolonged-release Drugs
The goal of this clinical trial is to compare the bioavailability and practicability of two different formulations of tacrolimus in kidney transplant recipients.
- Trial name
- TaC:Drop (NCT06268769)
- Testing
- Tacrolimus Pill, Tacrolimus capsule
- Where
- 9 sites in Germany
- Volunteers
- 300 people
- Sponsor
- Edward Geissler
Renal Transplantation, Kidney-pancreas Transplantation
Interstitial Lung Abnormalities in Renal Transplant Recipients
Immunosuppressive drugs such as tacrolimus, cyclosporine, mycophenolate mofetil, sirolimus and everolimus may have toxic pulmonary effects, particularly interstitial alterations.
- Trial name
- LCRT (NCT01017757)
- Testing
- High-resolution CT scanning
- Where
- Italy
- Volunteers
- 63 people
- Sponsor
- University of Parma
Kidney Transplantation
Study of a JAK3 Inhibitor for the Prevention of Acute Rejection in Kidney Transplant Patients
A new immunosuppressive drug, based on the inhibition of an important enzyme in the immune system called JAK3, is being developed by Pfizer to prevent transplant rejection.
- Trial name
- NCT00483756
- Testing
- Cyclosporine, CP-690,550
- Where
- 69 sites in United States, Australia and 13 more
- Volunteers
- 338 people
- Sponsor
- Pfizer
Renal Transplant Rejection, Transplants and Implants
Prospective Pilot Study of Pre-Transplant Thymoglobulin Administration in Living Donor Renal Transplant Recipients
To determine how safe and effective giving Thymoglobulin before transplantation to patients who are going to be receiving kidney transplants.
- Trial name
- NCT00771745
- Testing
- Thymoglobulin
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Cincinnati
Kidney Transplant Recipients
A Study to Evaluate the Efficacy and Safety in Kidney Transplant Recipients When Changed From Cyclosporine to Tacrolimus Prolonged-release Capsule or Tacrolimus Capsule
KTx recipients receiving cyclosporine-based immunosuppressive therapy, and in the opinion of the investigator would benefit from switch to a tacrolimus-based immunosuppression, will switch the immunosuppressive therapy to a…
- Trial name
- NCT02268201
- Testing
- Advagraf, Prograf
- Where
- 7 sites in China
- Volunteers
- 17 people
- Sponsor
- Astellas Pharma China, Inc.
Kidney Transplantation, Renal Transplantation
Envarsus XR® in Adolescent Renal Transplant Recipients
Adolescents commonly experience barriers to adherence that entail forgetfulness, distraction, poor planning, and scheduling problems.
- Conditions
- Kidney Transplantation, Renal Transplantation, Grafting, Kidney
- Trial name
- EnvarsusXR (NCT03266393)
- Testing
- Envarsus XR, Tacrolimus
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of California, Los Angeles
COVID-19, Kidney Transplant
COVID Protection After Transplant - Sanofi GSK (CPAT-SG) Study
An open label, non-randomized pilot study in kidney transplant recipients who received a completed primary series and bivalent booster of mRNA based COVID-19 vaccine and have ≤2500 U/mL SARS-CoV-2 S antibody concentration using…
- Trial name
- CPAT-SG (NCT05518487)
- Testing
- Sanofi-GSK monovalent (B.1.351) CoV2 preS dTM-AS03 COVID-19 vaccine
- Where
- 6 sites in United States
- Volunteers
- 15 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Kidney Transplantation
Testing the Effect of KnowMAP (Knowledge Management for Renal Transplant Recipients). A Randomized Controlled Study
A randomized controlled study (RCT) aiming to test the effect of a new health literacy intervention for renal transplant recipients, KnowMAP (knowledge management for renal transplant recipients).
- Trial name
- KnowMAP (NCT04296955)
- Testing
- Motivational interview as a new health communication intervention
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- Oslo University Hospital
Kidney Transplant Donor, Diet Habit
MedDiet in Kidney Transplant Recipients
In recent years, increasing attention has been directed toward the role of diet and lifestyle factors in influencing graft function and patient survival after kidney transplantation (KT).
- Trial name
- MedDiet_KT (NCT07740928)
- Testing
- MedDiet
- Where
- Slovenia
- Volunteers
- 23 people
- Sponsor
- University Medical Centre Ljubljana
Kidney Transplantation
Mycophenolic Acid Monotherapy in Recipients of HLA-identical Living-Related Transplantation
This randomized trial will enroll adult recipients of HLA-identical living kidney transplants who are at least 1 year post-transplant.
- Trial name
- NCT01053221
- Testing
- Mycophenolic Acid, Standard of Care: CNI and MPA
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Wisconsin, Madison
Organ Transplantation, Renal Transplantation
Everolimus in a Cyclosporine Microemulsion-free Regimen Compared to a Low-dose Cyclosporine Microemulsion Regimen, in de Novo Kidney Transplant Patients
The purpose of this study is to evaluate the safety and efficacy of everolimus in combination with basiliximab, and steroids with and without cyclosporine microemulsion in de novo kidney transplant recipients.
- Trial name
- CERTES02 (NCT00154284)
- Testing
- Everolimus (Certican), Cyclosporine (Neoral), Steroid
- Volunteers
- 114 people
- Sponsor
- Novartis
Kidney Transplant Recipients
Measuring and Improving Medication Adherence in Kidney Transplant Patients
Nonadherence to medication is a major obstacle to successful treatment of renal transplant patients. This study has two primary aims.
- Trial name
- NCT02639949
- Testing
- Cognitive-behavioral adherence promotion program, Standard Care
- Volunteers
- 45 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Kidney Transplant Infection, BK Virus Infection
Prediction of BK Virus Reactivation in Kidney Transplant Recipient
There has been no effective predicting tool to accurately predict BKV reactivation after kidney transplantation. The aim is to elucidate the use of flow cytometric analysis for both intracellular cytokines and surface activation…
- Conditions
- Kidney Transplant Infection, BK Virus Infection, BK Virus Nephropathy
- Trial name
- NCT06219616
- Testing
- BKV immune monitoring
- Where
- Thailand
- Volunteers
- 80 people
- Sponsor
- King Chulalongkorn Memorial Hospital
Renal Failure Chronic, Hepatitis C
Multi-center Study to Transplant Hepatitis-C Infected Kidneys
Open label multi center study for the donation of HCV positive kidneys to HCV negative recipients with interventional treatment to prevent HCV transmission upon transplantation.
- Trial name
- MYTHIC (NCT03781726)
- Testing
- glecaprevir/pibrentasvir treatment
- Where
- 7 sites in United States
- Volunteers
- 30 people
- Sponsor
- Raymond Chung
Renal Transplant Recipients
Research Study of ATG and Rituximab in Renal Transplantation
The purpose of this study is see if a combination of two drugs, (ATG and rituximab), given at the time of the transplant surgery, will help reduce or eliminate the need for long term immunosuppressive medication.
- Trial name
- RESTARRT (NCT01318915)
- Testing
- ATG, Rituximab, Tacrolimus
- Where
- 6 sites in United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)