Clinical trials: Repetitive Head Impacts
Trauma, Head
Effects of Soccer Heading on Ocular-motor Function and Blood Biomarker
Repetitive head impacts in sports and military may cause deleterious effects in the nervous system. Investigators' previous works in football players have shown promising results in prediction of concussion and prevention of…
- Trial name
- NCT03488381
- Testing
- Soccer Heading
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Indiana University
Traumatic Brain Injury, Concussion, Brain
" Acute Brain Changes After Repetitive Headers in Soccer and the Effects of a Protective Device "
Soccer, the most popular sport in the world, exposes players to repeated head impacts and concussions, due to contact with another player or with the ground.
- Trial name
- Soccer-BRAIN (NCT04426188)
- Testing
- Heading series, Magnetic Resonance Imaging (MRI), Cognitive computerized assessment
- Where
- France
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Repeated Head Impacts
Physiological Effects of Soccer Heading
There is growing concern for the resulting neurological and physiological outcomes from repeated head impacts in sports that do not manifest into traditional concussion symptoms.
- Trial name
- NCT04810130
- Testing
- Soccer Kicking, Soccer Heading (Frontal), Soccer Heading (Oblique)
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Repetitive Head Impacts
Monitoring Patients With Repetitive Head Impact With Gamma-glutamylcysteine Supplementation
The goal of this clinical trial is to test whether the gamma - glutamylcystiene (GGC) oral supplement can reach the brain and subsequently increase antioxidant glutathione (GSH) level in people with repetitive head impact (RHI).
- Trial name
- RHIGSH (NCT07050173)
- Testing
- Gamma-glutamylcysteine (GGC)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Pravat Mandal
Concussion
EEG Diagnostic for Repetitive Sub-concussive Head Impacts
The purpose of this study is to develop a diagnostic algorithm to help with the detection, diagnosis, and monitoring of sub-concussive head impacts.
- Trial name
- NCT05562544
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Chronic Traumatic Encephalopathy (CTE), Alzheimer Disease
The DIAGNOSE CTE Research Project-II
Each year, millions of people are exposed to repetitive head impacts (RHI) through contact sports. RHI can result in concussions and asymptomatic non-concussions to confer risk for Alzheimer's disease (AD) and related dementias…
- Conditions
- Chronic Traumatic Encephalopathy (CTE), Alzheimer Disease, Alzheimer Disease and Related Dementias (ADRD), Brain Injuries, Traumatic
- Trial name
- NCT06860828
- Where
- 5 sites in United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Boston University
Head Injuries
Monitoring & Mitigation of Neurologic Injuries to Optimize Resilience After Repetitive Head Impacts
The purpose of this Phase 2, double-arm study is to identify repetitive, non-concussive head impacts that impair neurologic functioning, and to test treatments that can mitigate these effects and return functioning to normal as…
- Trial name
- MONITOR-RHI (NCT06810193)
- Testing
- Aerobic exercise
- Where
- 3 sites in United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Repetitive Head Impacts
RHI Interval Effects on Brain Health
Military service members frequently experience repetitive insults or impacts to the head (RHIs). The purpose of the proposed randomized controlled trial is to understand how time intervals affect neurological responses to…
- Trial name
- NCT07010887
- Testing
- Short Interval, Long Interval, BrainScope qEEG
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Indiana University