Clinical trials: Repetitive Negative Thinking
Major Depressive Disorder
Low Intensity Ultrasound Neuromodulation of Repetitive Negative Thinking In Depression
The investigators propose to use low-intensity transcranial focused ultrasound (LIFU), a novel neuromodulation method, to probe the causal involvement of individually defined components of an anteromedial brain circuit in the…
- Trial name
- NCT05697172
- Testing
- Low-intensity focused ultrasound
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Laureate Institute for Brain Research, Inc.
Repetitive Negative Thinking
Feasibility and Preliminary Efficacy of a Web-Based Self-Help Program for College Students
The goal of this pilot study is to test the feasibility and preliminary efficacy of the repetitive negative thinking (RNT) focused web-based self-help program in college students.
- Trial name
- NCT06192056
- Testing
- RNT Focused Web- Based Self-Help Program
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Halic University
Repetitive Negative Thinking, Serious Mental Illness Symptoms
Mindfulness-based Neurofeedback to Reduce Negative Thinking in CHARMS Adolescents
The study will test the hypothesis that mindfulness-based neurofeedback (mbNF) will improve repetitive negative thinking and social and role functioning over sham neurofeedback in adolescents at risk for serious mental illness.
- Trial name
- CHARMS (NCT06901232)
- Testing
- Mindfulness Training, Active mindfulness-based neurofeedback (Active mbNF)
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Massachusetts General Hospital
Anxiety Disorders, Obsessive-Compulsive Disorder
Relationship Between Repetitive Negative Thinking and CBT Outcomes
The goal of this observational study is to learn about the role of repetitive negative thinking (measured by the RTQ) in adult populations from an anxiety disorders and trauma clinic.
- Conditions
- Anxiety Disorders, Obsessive-Compulsive Disorder, Post-traumatic Stress Disorder, Social Anxiety Disorder
- Trial name
- NCT06370559
- Where
- United Kingdom
- Volunteers
- 320 people
- Sponsor
- South London and Maudsley NHS Foundation Trust
Repetitive Negative Thinking, Neurofeedback
Effect of Mindfulness-based Neurofeedback for Adolescents With Elevated Repetitive Negative Thinking
This study will test the hypotheses that adolescent with repetitive negative thinking who at at-risk for serious mental illness will show greater default mode network (DMN) connectivity than healthy controls, at-risk adolescents…
- Trial name
- CHARMS (NCT07055217)
- Testing
- Mindfulness Training, Mindfulness-based Neurofeedback (Real mbNF)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Attention Impaired, Mental Health Issue
Brief Mental Training and Internal Attentional Control
Previous research documented that real-time feedback on attention as well as related forms of mental training (e.g. mindfulness meditation) may be used to train and impact external attentional control.
- Conditions
- Attention Impaired, Mental Health Issue, Rumination
- Trial name
- NCT05353231
- Testing
- Attention Feedback Awareness and Control Training (A-FACT), Mindful Disengagement from Thoughts Training (MDTT)
- Where
- Israel
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Haifa
Obsessive-Compulsive Disorder, Generalized Anxiety Disorder
Improving Attentional and Cognitive Control in the Psychological Treatment of Intrusive Thoughts
The investigators are conducting this study to learn more about the cognitive and attentional processes among individuals with three types of repetitive negative thinking (RNT): mental rituals (as seen in obsessive compulsive…
- Conditions
- Obsessive-Compulsive Disorder, Generalized Anxiety Disorder, Major Depressive Disorder
- Trial name
- NCT04225624
- Testing
- Emotion Regulation Therapy - Attention Regulation (AR-ERT), Supportive Psychotherapy (SPT)
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Massachusetts General Hospital
Chronic Pain
Repetitive Thinking in FibroMyalgia and Attentional Bias
Theoretical models of chronic pain hypothesize a privileged treatment of pain-related information that would be the basis of avoidance behaviors in chronic pain.
- Trial name
- PRFM-BA (NCT03466892)
- Testing
- Questionnaires and computer paradigm
- Where
- France
- Volunteers
- 43 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Anxiety, Anxiety Depression
Calming Minds Study
The goal of this study is to understand why certain treatments help people reduce repetitive negative thinking (RNT), which is common in many mental health problems. We want to: 1.
- Conditions
- Anxiety, Anxiety Depression, Worry, Depression
- Trial name
- NCT07577401
- Testing
- Be Specific, Be Kind, Be Present
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of California, Los Angeles
Depression, Anxiety
Group-Based Acceptance and Commitment Therapy Versus Active Control in University Students With Emotional Symptoms
This study evaluates the efficacy of a group-based Acceptance and Commitment Therapy (ACT) protocol compared to a non-directive group therapy used as an active control condition in university students presenting moderate to…
- Trial name
- ACT-EMA-RCT (NCT07506148)
- Testing
- Acceptance and Commitment Therapy (ACT), Non-Directive Group Therapy (NDT)
- Where
- Uruguay
- Volunteers
- 48 people
- Sponsor
- Mónica Larrosa Signorelli
Rumination, Fibromyalgia
Repetitive Thinking in Fibromyalgia
Some fibromyalgia patients may use inappropriate emotional regulation strategies to respond to pain. Rumination could be one of this inefficient regulation strategies.
- Conditions
- Rumination, Fibromyalgia, Chronic Pain, Repetitive Negative Thinking
- Trial name
- PRFM-3 (NCT03964285)
- Testing
- rumination induction, distraction induction
- Where
- France
- Volunteers
- 47 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Repetitive Negative Thinking, Healthy Controls Group - Age and Sex-matched
Emotion Regulation in RNT
The goal of this study is to understand why some people become stuck in repetitive negative thinking, which is common among individuals with depression and anxiety.
- Trial name
- NCT07513766
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Repetitive Negative Thinking, General Anxiety Disorder
Training Protocol 'Drop it'. The Impact of a Training Protocol Focused on Coping With Negative Repetitive Thinking on Cognitive and Behavioural Functioning of People Suffering From GAD or Minor or Moderate Depressive Disorder or Depressive Disorder in Remission
Repetitive negative thinking (RNT) plays an important role in different psychiatric disorders, such as depressive and anxiety disorders, complicated grief, posttraumatic stress disorders, anorexia nervosa.
- Conditions
- Repetitive Negative Thinking, General Anxiety Disorder, Depressive Disorder, Depression
- Trial name
- Drop It (NCT01983033)
- Testing
- Drop It training session, treatment as usual
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- University Hospital, Ghent
Depressive Disorder, Major
Modulating Repetitive Negative Thinking Related Brain Networks in Young Adults With Depression
In this project, the investigators use real-time fMRI neurofeedback (rtfMRI-nf) to causally relate dysfunction of right anterior insula (rAI) and right superior temporal sulcus (rSTS) connectivity with the intensity of repetitive…
- Trial name
- CNF-RNT (NCT06219681)
- Testing
- Active neurofeedback
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Laureate Institute for Brain Research, Inc.
Stress, Anxiety
A Brief Online Mindfulness Intervention: An RCT Protocol
University students often experience emotional distress that originates from inside or outside academia, and for which treatment would be welcome.
- Conditions
- Stress, Anxiety, Depression
- Trial name
- NCT05882565
- Testing
- A brief (14-day) online mindfulness intervention, Psychoeducation online
- Where
- Indonesia
- Volunteers
- 426 people, healthy volunteers welcome
- Sponsor
- Ka Yan
Rumination, Worry
Evaluating the Effects of a Self-help Mobile Phone Application on Worry and Overthinking in Young Adults Aged Between 16 and 24.
This project seeks to understand if a new self-help mobile phone application (called MyMoodCoach) is effective at reducing worry and overthinking, prominent risk factors that predict reduced well-being and poor mental health.
- Conditions
- Rumination, Worry, Repetitive Negative Thinking
- Trial name
- NCT04950257
- Testing
- digital CBT self-help including specific intervention elements to target worry and rumination.
- Where
- United Kingdom
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- University of Exeter