Clinical trials: Replacement, Knee
Osteoarthritis, Pain Assessment
A Study to Evaluate the Effectiveness and Safety of Multiple Doses of Tapentadol(CG5503) in Patients Awaiting Joint Replacement Surgery
The purpose of this study is to evaluate in patients who are eligible for elective primary total or partial joint replacement of the hip or knee due to chronic osteoarthritis the efficacy (level of pain control) of CG5503 over 5…
- Conditions
- Osteoarthritis, Pain Assessment, Arthralgia
- Trial name
- NCT00361582
- Testing
- CG5503 IR; tapentadol
- Volunteers
- 669 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Knee Arthroplasty, Total, Knee Osteoarthritis
Cementless Triathlon 5YR Follow-Up
All artificial joint implants need to be solidly held (fixed) within the bone. Cementless fixation has become a popular method to achieve fixation for total knee replacements where the bone grows directly onto the implanted…
- Conditions
- Knee Arthroplasty, Total, Knee Osteoarthritis, Radiostereometric Analysis
- Trial name
- NCT05877261
- Testing
- Cementless Total Knee Replacement
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Osteo Arthritis Knee
The Need for Compression Bandage Following Total Knee Arthroplasty A Prospective Randomized Controlled Trial Conducted in Simultaneous Bilateral Total Knee Replacements
The purpose of this study is to evaluate if applying a compression bandage on the leg alters early outcome following TKA. The primary objective of this study is to evaluate leg swelling by measuring leg circumference following…
- Trial name
- NCT03521869
- Testing
- Compression bandage, Gauze dressing
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Rothman Institute Orthopaedics
Arthroplasty, Replacement, Knee, Osteoarthritis, Knee
Nurse-Led Telehealth vs In-Person Follow-Up After Total Knee Replacement
Brief Summary The goal of this clinical trial is to learn if nurse-led telehealth consultations can help detect complications and support recovery after total knee replacement surgery.
- Trial name
- NCT07058623
- Testing
- Nurse-Led Telehealth Consultation, Traditional In-Person Nursing Consultation
- Where
- Hong Kong
- Volunteers
- 98 people
- Sponsor
- Hospital Authority, Hong Kong
Total Knee Arthroplasty
Fall Prevention in Total Knee Replacement Patients
Falls, one of the patient safety goals, lead to injury and death if not prevented. This study was conducted to determine the effect of algorithm-guided care on falling, fear of movement, fear of falling and postoperative recovery…
- Trial name
- NCT06977529
- Testing
- Algorithm; Algorithm-based maintenance created by researchers:such as falls training, early mobilization
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- University of Gaziantep
Knee Osteoarthritis, Arthritis Knee
How Does the Addition of Adductor Canal Block to Local Infiltration Affect Recovery in Patients Undergoing Total Knee Arthroplasty? A Feasibility Study.
The use of periarticular injection and adductor canal block are well-established techniques used both in combination or in isolation in the management of postoperative pain for patients undergoing total knee arthroplasty.
- Conditions
- Knee Osteoarthritis, Arthritis Knee, Knee Disease, Opioid Use
- Trial name
- TRUE KnORTH (NCT04648072)
- Testing
- Adductor Canal Block, Periarticular Injection
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Health Sciences North Research Institute
Postsurgical Pain
Study to Evaluate Safety/Efficacy of a Single Pre-Op Dose of AYX1 Injection to Treat Pain After Knee Replacement Surgery
The objectives of this study are to evaluate the safety and analgesic efficacy of a single preoperative intrathecal administration of AYX1 Injection at two dose/volume levels.
- Trial name
- NCT02081703
- Testing
- AYX1 Injection 660 mg / 6 mL, AYX1 Injection 1100 mg / 10 mL
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Adynxx, Inc.
Arthroplasty, Replacement, Knee
Multigen Plus H Study and AMF TT Cones
The aim of this study is to assess the clinical, patient-reported, and radiographic outcomes of a revision Total Knee Arthroplasty with Multigen Plus H and AMF TT Cones.
- Trial name
- NCT04884542
- Testing
- Revision Total Knee Arthroplasty
- Where
- 2 sites in Belgium, Slovakia
- Volunteers
- 43 people
- Sponsor
- Limacorporate S.p.a
Osteoarthritis
A Single Time-Point Study to Evaluate the ConforMIS iTotal® (CR) Knee Versus Off-the-Shelf
It has been noted that patients "dramatically overestimate their functional ability early after surgery." Despite use of assistive devices increasing and functional testing scores decreasing post-surgery, the patient reported…
- Trial name
- STEPS (NCT02251522)
- Testing
- ConforMIS Total Knee Replacement System, Off-the-Shelf Knee Replacement System
- Where
- 16 sites in United States, Germany
- Volunteers
- 873 people
- Sponsor
- Restor3D
Osteo Arthritis Knee
Radiographic Migration Analysis of the ATTUNE Cementless CR Fixed-Bearing Total Knee Replacement
This is a multi-centre, single cohort trial of patients undergoing cruciate-retaining total knee arthroplasty with the Attune Cementless, Fixed Bearing, Cruciate Retaining TKA System.
- Trial name
- NCT06189872
- Testing
- Attune Cementless
- Where
- 3 sites in Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Canadian Radiostereometric Analysis Network
ARTHROPLASTY, REPLACEMENT
Patient-Centered Weight Loss Program for Knee Replacement Patients
PACE is a patient-centered weight loss program that was developed specifically for knee replacements based on input from stakeholders, including knee replacement patients, physical therapists, and orthopedic surgeons.
- Trial name
- PACE (NCT02728661)
- Testing
- PACE, Delayed PACE
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Northwestern University
Total Knee Replacement
A Post-market Observational ORIGIN® CR Clinical Study
The study objective is to evaluate safety and performance of the ORIGIN® CR (cruciate retaining) devices and associated instruments, more precisely to evaluate safety by the proportion of patients requiring a revision (i.e.
- Trial name
- NCT05607966
- Testing
- ORIGIN® CR devices
- Where
- 2 sites in Belgium
- Volunteers
- 199 people
- Sponsor
- Symbios Orthopedie SA
Arthroplasty, Replacement, Knee
Silkeborg Knee Replacement Cohort Study
In this cohort study, we will investigate short and long term outcomes after knee replacement surgery and identify preoperative and early postoperative factors associated with long term outcome.
- Trial name
- NCT03411083
- Testing
- Total or unicompartmental knee replacement
- Where
- Denmark
- Volunteers
- 1,225 people
- Sponsor
- Central Jutland Regional Hospital
Knee Osteoarthritis
A Quantitative Assessment of Early Mobility in Total Knee Replacement Patients Using Smart Activity Tracker
This study aims to evaluate the patients' mobility and quality of life prior to their total knee replacement surgery and their progress pre-operatively and 6 months post-operatively using the smart activity tracker.
- Trial name
- Geospatial (NCT05076539)
- Testing
- Garmin GPS activity tracker
- Where
- Singapore
- Volunteers
- 50 people
- Sponsor
- Singapore General Hospital
Total Knee Replacement, Venous Thromboembolism
Total Knee Arthroplasty And Thromboembolism: A Comparison Between Two Surgical Techniques
In patients undergoing total knee arthroplasty, thromboembolism is a common occurrence, especially following tourniquet deflation.
- Trial name
- NCT00755300
- Testing
- Measurement of total thrombolic load
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of California, Davis
Knee Osteoarthritis
Bespoke vs Standard Instrumentation in TKR
Total knee replacement (TKR) is an established treatment for knee osteoarthritis and leads to a satisfactory outcome in over 75% of patients.
- Trial name
- NCT02845206
- Testing
- Patient specific cutting blocks, Conventional cutting blocks
- Where
- United Kingdom
- Volunteers
- 172 people
- Sponsor
- NHS Lothian
Thromboembolism
Factor Xa Inhibitor, PRT054021, Against Enoxaparin for the Prevention of Venous Thromboembolic Events (EXPERT)
Randomized study of PRT054021 40 mg and 15 mg bid vs. enoxaparin 30 mg q12h for the prophylaxis of venous thromboembolic events after unilateral knee replacement surgery.
- Trial name
- NCT00375609
- Testing
- Betrixaban, Enoxaparin
- Where
- Canada
- Volunteers
- 215 people
- Sponsor
- Portola Pharmaceuticals
Knee Replacement Surgery
The Effect of Nasal Continuous Positive Airway Pressure (N-CPAP) on Arterial pCO2 During Spinal Anesthesia
The proposed study intends to investigate several aspects of the respiratory effects of intravenous sedation of patients undergoing spinal anesthesia for knee replacement surgery.
- Trial name
- NCT01622647
- Testing
- Nasal Continuous Positive Airway Pressure (NCPAP)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Pediatrix
Number of Deep Venous Thrombosis (DVT)
Doppler Ultrasound Following Unicondylar Knee Replacement to Determine the Incidence of Postoperative DVT
Purpose of this study is to determine the incidence of deep venous thrombosis after partial knee replacement.
- Trial name
- NCT02148757
- Testing
- Doppler Ultrasound
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Hospital for Special Surgery, New York
Arthroplasty, Replacement, Knee, Pain, Postoperative
Pharmacogenomics Information in Enhancing Post-operative Total Joint Replacement Pain Management: a Pilot Study
The objective of this study is to see how pain management and its outcomes are effected when pharmacogenomic testing is used to determine patient specific pain medication and dosing.
- Trial name
- NCT02711592
- Testing
- Genetic Panel for Analgesics
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- TriHealth Inc.