Clinical trials: Replacement, Total Knee
Total Hip Replacement, Total Knee Replacement
An Open Label Data Collection Study of My Connect Post-Op, a Post-Operative Communication Tool
This open label, multi-center study will collect data from the participant's use of My Connect Post-Op Software as a post-operative communication solution in supporting patient recovery through Technology-Assisted Conversation…
- Trial name
- NCT07120191
- Testing
- post op communication software
- Where
- 3 sites in United States
- Volunteers
- 652 people
- Sponsor
- Concentra AI, inc
Arthroplasty Replacement, Knee, Arthroplasty Total Hip Replacement
A Prospective, Single-arm, Trial to Determine Contamination Rates When Using an Antibacterial Incise Drape During Orthopedic Surgery
The goal of this clinical study is to generate data on the intended use of a chlorhexidine gluconate (CHG)-impregnated antimicrobial incise drape.
- Trial name
- NCT07356323
- Testing
- 3M™ Ioban™ CHG Chlorhexidine Gluconate Incise Drape (2% w/w CHG)
- Where
- 2 sites in United States
- Volunteers
- 179 people
- Sponsor
- Solventum US LLC
Osteo Arthritis Knee, Knee Arthritis
Persona IQ Cohort Study
A prospective multicenter longitudinal cohort study of Zimmer Biomet (ZB) Persona IQ The Smart Knee which consists of the Persona Personalized Knee (PPK) System with mymobility® platform that is attempting to develop correlative…
- Conditions
- Osteo Arthritis Knee, Knee Arthritis, Monitoring Orthopedic Devices, Total Knee Arthroplasty
- Trial name
- NCT06089291
- Testing
- Persona IQ
- Where
- 4 sites in United States
- Volunteers
- 200 people
- Sponsor
- Zimmer Biomet
Postoperative Pain, Total Knee Replacement
Treatment of Post-Operative Pain Following Orthopedic Surgery With SPRINT® Peripheral Nerve Stimulation (PNS) System
The purpose of this study is to gather information about how knee pain changes when small amounts of electricity are delivered to the nerves in the leg.
- Conditions
- Postoperative Pain, Total Knee Replacement, Total Knee Arthroplasty, Partial Knee Replacement
- Trial name
- NCT04341948
- Testing
- SPRINT Peripheral Nerve Stimulation (PNS) System
- Where
- 10 sites in United States
- Volunteers
- 56 people
- Sponsor
- SPR Therapeutics, Inc.
Knee Arthroplasty, Total, Partial Knee Replacement
Exactech Knee Systems Post Market Clinical Follow-up
This is a multi-center, open-label, prospective and retrospective clinical outcomes study. Patient outcomes data is important for assessing the post-market safety and effectiveness of orthopedic medical devices.
- Trial name
- NCT07107581
- Testing
- Prospective / Subjects Knee Arthroplasty, Retrospective to Prospective, Retrospective Only Subjects
- Where
- United States
- Volunteers
- 1,879 people
- Sponsor
- Exactech
Primary Total Knee Replacement
Clinical Study Evaluating the Outcomes of a New Knee System with a Physiological Rollback Mechanism
The aim of this study is to assess the clinical, radiographic and patient-reported outcome measures (PROMs) after total knee replacement with Physica KR, define the survivorship of the implants and identify possible risk factors…
- Trial name
- K-06 (NCT02118272)
- Testing
- Physica KR
- Where
- 3 sites in Italy, United Kingdom
- Volunteers
- 156 people
- Sponsor
- Limacorporate S.p.a
Total Knee Replacement
Physica System KR Vs Physica System CR (K-20)
Post-market, monocentric, randomised, open-label, parallel group, prospective study conducted in patients who have to perform a total knee replacement (TKR) with Physica KR or Physica CR system.
- Trial name
- NCT04594447
- Testing
- Physica Kinematic Retaining knee replacement, Physica Cruciate Retaining knee replacement
- Where
- United Kingdom
- Volunteers
- 3 people
- Sponsor
- Limacorporate S.p.a
Total Knee Arthroplasty, Knee Disease
Observational Study to Evaluate Clinical Performance and Safety in Total Knee Arthroplasty
The aim of this study is to assess the long-term performance and safety of HLS KneeTec cementless and hybrid fixation knee prosthesis when used in standard medical practice.
- Conditions
- Total Knee Arthroplasty, Knee Disease, Total Knee Replacement, Osteo Arthritis Knee
- Trial name
- NCT04872855
- Testing
- patient with knee arthroplasty
- Where
- 3 sites in France
- Volunteers
- 163 people
- Sponsor
- Corin
Osteo Arthritis Knee, Total Knee Replacement
LEGION™ Primary Safety and Efficacy
This study will look at the health results of using the LEGION™ Primary Knee System over a period of ten (10) years. This type of surgery uses an artificial knee made of plastic and metal.
- Trial name
- NCT04040985
- Testing
- Total Knee Arthroplasty using LEGION™ Total Knee System
- Where
- 5 sites in United States
- Volunteers
- 128 people
- Sponsor
- Smith & Nephew, Inc.
Total Knee Replacement
A Post-market Observational ORIGIN® CR Clinical Study
The study objective is to evaluate safety and performance of the ORIGIN® CR (cruciate retaining) devices and associated instruments, more precisely to evaluate safety by the proportion of patients requiring a revision (i.e.
- Trial name
- NCT05607966
- Testing
- ORIGIN® CR devices
- Where
- 2 sites in Belgium
- Volunteers
- 199 people
- Sponsor
- Symbios Orthopedie SA
Total Knee Replacement
ORIGIN® PS Modular & Associated Instruments
The study objective is to evaluate safety and performance of the ORIGIN® PS (postero-stabilized) Modular devices and associated instruments, more precisely to evaluate safety by the proportion of patients requiring a revision…
- Trial name
- NCT06628050
- Testing
- ORIGIN® PS Modular devices
- Where
- 2 sites in France
- Volunteers
- 200 people
- Sponsor
- Symbios Orthopedie SA
Total Knee Arthroplasty, Knee Disease
Open Label Study to Collect Clinical Data to Document Clinical Performance and Safety in Total Knee Arthroplasty
The purpose of this study is to evaluate clinical performance and safety in total knee arthroplasty using HLS implants.
- Conditions
- Total Knee Arthroplasty, Knee Disease, Total Knee Replacement, Osteo Arthritis Knee
- Trial name
- NCT04727060
- Testing
- patient with knee arthroplasty
- Where
- France
- Volunteers
- 2,146 people
- Sponsor
- Corin
Total Knee Arthroplasty, Knee Disease
Study to Evaluate Long Term Performance and Safety of the Knee Prosthesis (HLS KneeTec Deep Dish)
The aim of this study is to assess the long-term performance and safety of HLS KneeTec Deep Dish knee prosthesis when used in standard medical practice
- Conditions
- Total Knee Arthroplasty, Knee Disease, Total Knee Replacement, Osteo Arthritis Knee
- Trial name
- NCT05211141
- Testing
- HLS KneeTec Deep Dish
- Where
- France
- Volunteers
- 119 people
- Sponsor
- Corin
Total Knee Replacement
Clinical and Functional Outcome of the Gemini SL Fixed Bearing at Midterm Follow-up
This is a retrospective, multicenter case series with a prospective follow-up to confirm the safety and performance of the Gemini SL Fixed Bearing knee prosthesis in midterm follow-up under routine conditions.
- Trial name
- NCT03575546
- Where
- 3 sites in Germany, Spain
- Volunteers
- 254 people
- Sponsor
- Waldemar Link GmbH & Co. KG
Total Knee Replacement
Qualitative Interviews With Healthcare Professionals
PLANNING PHASE- Qualitative interviews with Healthcare Professionals to assist in the development of a new Patient Reported Outcome Measure (PROM) to assess patient's emotional wellbeing, and perceptions of Total Knee Replacement…
- Trial name
- NCT05597046
- Testing
- Interview
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Invibio Ltd
Total Knee Replacement, Total Knee Arthroplasty
Electrical Stimulation for the Treatment of Pain Following Total Knee Arthroplasty Using the SPRINT Beta System
The purpose of this study is to determine if electrical stimulation (small levels of electricity) in addition to the standard of care can safely and effectively reduce pain following total knee replacement more than the standard…
- Conditions
- Total Knee Replacement, Total Knee Arthroplasty, Pain, Postoperative Pain
- Trial name
- NCT03286543
- Testing
- SPRINT Beta System
- Where
- 5 sites in United States
- Volunteers
- 47 people
- Sponsor
- SPR Therapeutics, Inc.
Primary Osteoarthritis Patients Scheduled for Total Knee Replacement Surgery
First-in-human Single Ascending Dose Study of LNA043 in Patients Scheduled for Total Knee Replacement
This study is designed to evaluate the safety and tolerability of ascending single doses of LNA043 given intra-articularly into the human knee joint prior to its removal at total knee replacement surgery.
- Trial name
- NCT02491281
- Testing
- LNA043
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Novartis Pharmaceuticals
Total Knee Replacement
Physica KR Fluoroscopy Study
The aim of this study is to assess the in vivo kinematics and range of motion of a single-surgeon clinical series of TKA performed with a fixed-bearing cruciate retaining total knee arthroplasty that has a roll-back mechanism and…
- Trial name
- NCT02655809
- Testing
- Fluoroscopic examination
- Where
- United Kingdom
- Volunteers
- 23 people
- Sponsor
- Limacorporate S.p.a
Total Knee Replacement, Postoperative Pain
Safety and Activity of F14 for Management of Pain Following Total Knee Replacement
The safety and activity of a single, 3.5 mL dose of F14 (celecoxib) concurrent with standard of care analgesia administered following total knee replacement will be compared to standard of care analgesia alone.
- Trial name
- NCT03541655
- Testing
- Bupivacaine HCl, F14 (celecoxib)
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Arthritis Innovation Corporation
VTE Prophylaxis With Anticoagulation After Total Knee Replacement Surgery
A Study to Evaluate the Safety and Efficacy of Intravenous JNJ-64179375 Versus Oral Apixaban in Participants Undergoing Elective Total Knee Replacement Surgery
The primary purpose of Part 1 in this study is to assess the safety and tolerability of JNJ-64179375 for each dose level for dose escalation and any bleeding events (the composite of major, clinically relevant non-major, and…
- Trial name
- TEXT-TKR (NCT03251482)
- Testing
- JNJ-64179375 0.3 mg/kg, JNJ-64179375 0.6 mg/kg, JNJ-64179375 1.2 mg/kg
- Where
- 103 sites in United States, Argentina and 14 more
- Volunteers
- 308 people
- Sponsor
- Janssen Research & Development, LLC