Clinical trials: Replacement, Total Knee
Venous Thrombosis
The Use of NMES as a Home-based Therapy Following Total Knee Arthroplasty
The use of neuromuscular electrical stimulation (NMES) as a home-based therapy following total knee arthroplasty. Measures of interest: lower limb venous hemodynamics, joint range of motion, lower limb swelling, walking speed…
- Trial name
- NCT02343198
- Testing
- Custom-built research muscle stimulator
- Where
- Ireland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National University of Ireland, Galway, Ireland
Osteoarthritis
Comparison of Stability and Outcomes in Single-radius Femoral Component for Total Knee Arthroplasty
This is a comparison of the functional results and Varus-Valgus Stability in Single-radius versus Multi-radius Femoral Component for Total Knee Arthroplasty.
- Trial name
- NCT01379755
- Where
- South Korea
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- Chonnam National University Hospital
Manipulation Under Anesthesia
Effect of Colchicine on Range of Motion After Manipulation Under Anesthesia for the Stiff Total Knee Replacement
The specific aim of this study is to evaluate the effect of oral colchicine in primary TKA patients at 3 months following a manipulation under anesthesia.
- Trial name
- Colchine MUA (NCT02926248)
- Testing
- Colchicine
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
POSTOPERATIVE ANALGESIA FOR TKA PARECOXIB/CFB
Combination of Continuous Femoral Block and Intravenous Parecoxib For Postoperative Analgesia After Total Knee Arthroplasty
Combination of continuous femoral block with parEcoxib vs placebo. Investigation of morphine consumption, opioid sparing effects, VAS pain scores, haemodynamics, Anxierty scores, transfusion requirements , Range of motion and…
- Trial name
- NCT02185924
- Testing
- Parecoxib, CONTINUOUS FEMORAL BLOCK WITH ROPIVACAINE 0,2%, N/S 0.9%
- Where
- Greece
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Asklepieion Voulas General Hospital
OsteoArthritis Knee
A Comparison of 2-octyl Cyanoacrylate Skin Adhesive and Polyester Mesh for Wound Closure in Total Knee Arthroplasty, A Randomized Controlled Study
The goal of this randomized controlled study is to investigate the Efficacy of Using skin adhesive (Dermabond) and skin adhesive with polyester mesh (Dermabond Prineo )for Wound Closure in Total Knee Arthroplasty, The main…
- Trial name
- NCT06232018
- Testing
- Skin adhesive (Dermabond), skin adhesive + polyester mesh (Dermabond prineo)
- Where
- Thailand
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Pooriwat Lertsurawat
Knee Osteoarthritis
Porous Baseplate in Total Knee Replacement
This is a multi-centre single cohort trial of patients undergoing cruciate-retaining total knee arthroplasty with the Advance Porous fixed bearing tibial baseplate and compatible femoral, patellar, and bearing components.
- Trial name
- NCT05226689
- Testing
- POROUS TIBIA BASEPLATE W/ JRNY LOCK
- Where
- 2 sites in Canada
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Canadian Radiostereometric Analysis Network
Total Knee Replacement
Effects of Combined Topical and Systemic Steroid Administrations on Better Early Postoperative Pain Management in Total Knee Arthroplasty
With the aging of population, osteoarthritis of knees and hips has become major orthopaedic problems in Hong Kong. Osteoarthritis of knees and hips is associated with significant pain problems and functional disability.
- Trial name
- NCT03901768
- Testing
- Dexamethasone, Triamcinolone
- Where
- Hong Kong
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Total Knee Arthroplasty
Treatment With Iovera° for Total Knee Arthroplasty (TKA) Post-Operative Pain
This study is designed to investigate whether iovera° treatment prior to TKA decreases cumulative participant opioid use over the course of 6 weeks following TKA while maintaining similar levels of pain relief.
- Trial name
- NCT03327220
- Testing
- iovera°
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Pacira Pharmaceuticals, Inc
Intraoperative Bleeding, Post-operative Bleeding
Study to Compare the Addition of Floseal to Our Standard of Care to Control Post Operative Bleeding in TKR
The purpose of this study is to compare Floseal to our standard of care (SOC) to decrease intraoperative and immediate post-operative bleeding.
- Trial name
- NCT01891461
- Testing
- Floseal
- Where
- Canada
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Metal Staple Removal After Total Knee Replacement
Topical Anesthesia for Removal of Stitches After Total Knee Arthroplasty
Lidocaine patch is a safe and effective topical anesthetic agent for removal of metal staples after total knee replacement
- Trial name
- NCT02812602
- Testing
- Lidocaine patch
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Osteoarthritis, Knee
Prehabilitation Using Aquatic Exercise
With aging population, total knee arthroplasty is performed with increasing frequency. Although the surgery is successful in general, significant number of patients suffers persistent pain and disability.
- Trial name
- NCT02773745
- Testing
- Aquatic Prehab
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Knee Arthritis Osteoarthritis, Cruciate Ligament Rupture
A Retrospective and Prospective Study: Monocompartimental Knee Arthroplasty Combined With Anterior Cruciate Ligament Reconstruction Surgery - a Pilot Study
This study aims to collect datas about patient who underwent simultaneous monocompartimental knee replacement and anterior cruciate ligament recontruction
- Trial name
- MONO-LCA (NCT07377669)
- Testing
- UKA + ACLr
- Where
- Italy
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Istituto Ortopedico Rizzoli
Use of Tourniquet in Total Knee Arthroplasty
Effects of the Use of Tourniquet in Total Knee Arthroplasty on the Clinical and Functional Outcomes With 5 Years of Follow up
This study is randomized controlled trial with 5 years follow up and involved 101 patients divided in two groups; group A in which tourniquet was used in total knee arthroplasty while group B in which tourniquet was not used.
- Trial name
- NCT04469166
- Testing
- tourniquet, No tourniquet
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Hawler Medical University
Total Knee Replacement
Motor Performance Modulation After Total Knee Replacement
Functional recovery after total knee replacement (TKR) is characterized by an incomplete muscle strength due to arthrogenic muscle inhibition (AMI) and tendency to estimate the functional level.
- Trial name
- NCT03997565
- Testing
- TKR
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Knee Osteoarthritis, Knee Arthroplasty
Development of an Outcome Score for Patients With Knee Osteoarthritis and Knee Joint Endoprosthesis Using an App
Total knee arthroplasty (TKA) and total hip arthroplasty (THA) is one of the most frequent orthopedic procedures. Over 50% of patients report higher expectations than their surgeons, and 10-50% remain dissatisfied…
- Conditions
- Knee Osteoarthritis, Knee Arthroplasty, Hip Osteoarthritis, Hip Arthroplasty
- Trial name
- KneeApp (NCT07212699)
- Testing
- KneeApp
- Where
- Germany
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Knee Injuries
Femoral/Sciatic Block for Knee Surgery
Knee arthroplasty has a high potential for postoperative pain. This study compares analgesia and postoperative bleeding from intrathecal morphine with the continuous femoral and a single-shot sciatic nerve blockades.
- Trial name
- NCT02882152
- Testing
- femoral nerve blockade, morphine
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Periprosthetic Knee Infection
Outcome After Revisions of Infected Knee Arthroplasties
A prospective multicenter cohort study on all types of revision knee arthroplasty procedures performed due to infection.
- Trial name
- RIKA (NCT04427943)
- Testing
- revision surgery
- Where
- 8 sites in Denmark
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Quad Atrophy
Trial of Essential Amino Acid Supplementation in Protein Deficient Patients Following Total Knee Arthroplasty
The goal of this trial is to assess the efficacy of essential amino acids (EAA) on muscle atrophy and malnutrition compared to a placebo in patients following a total knee arthroplasty.
- Trial name
- Amino Acid (NCT02926235)
- Testing
- Amino Acid
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Osteoarthritis of the Knee
Total Knee Arthroplasty Functional Outcomes Study Research Design
The purpose of this study is to obtain patient oriented and clinically oriented physical function outcomes both pre-operatively and post-operatively in patients receiving a total knee arthroplasty.
- Trial name
- NCT02228538
- Testing
- Total knee arthroplasty patients
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Restor3D
Postoperative Urinary Retention
Routine Bladder Catheterisation Through Fast-track Hip and Knee Replacement - What Are the Consequences?
To describe the need for re-catheterization and incidence of urological complications of routine use of perioperative fixed urinary catheter (KAD) for up to 24 hours of fast-track THA and TKA
- Trial name
- NCT02133768
- Where
- Denmark
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Lundbeck Foundation