Clinical trials: Reproducibility
Cardiovascular Diseases
Vascular Reactivity Assessment by the AngioDefender Device -- A Precision Study
The objective of this study is to define the repeatability and reproducibility of quantifying flow-mediated dilation (FMD) of the brachial artery (BA) using the AngioDefender (AD) methodology.
- Trial name
- NCT02641197
- Testing
- AngioDefender
- Where
- 2 sites in Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Everist Genomics, Inc
Achilles Tendon, Plantar Fascia
Evaluation of Shear Wave Elastography Reproducibility in Achilles Tendons and Plantar Fascia
Achilles tendon plays a significant role in walking and sporting activities, particularly through ankle joint and lower limbs stability.
- Trial name
- ME1 (NCT03014739)
- Testing
- Supersonic ShearWave Elastography
- Where
- 2 sites in China
- Volunteers
- 1,165 people, healthy volunteers welcome
- Sponsor
- SuperSonic Imagine
Liver Fibrosis, Liver Cirrhosis
Acoustic Radiation Force Impulse Imaging (ARFI) : a New Technique to Assess Liver Elasticity
Liver stiffness measurement (LSM) by non invasive methods is increasingly used to estimate liver fibrosis in patients with chronic liver diseases.
- Conditions
- Liver Fibrosis, Liver Cirrhosis, Viral Hepatitis, Liver Tumour
- Trial name
- NARFI (NCT01082419)
- Testing
- ARFI measurement
- Where
- France
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
White Coat Hypertension
Short Term Reproducibility of Office White-coat Effect
While a theoretical increase in systolic blood pressure (BP) of 10 mmHg can triple the relative risk of cardiovascular disease (CVD), the potential presence of a white coat effect (WCE) can interfere with the assessment of blood…
- Trial name
- REBBRE (NCT06523062)
- Testing
- blood pressure measurement
- Volunteers
- 922 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Dry Eyes
Reproducibility of Anterior Segment Optical Coherence Tomography (AS-OCT) for Imaging Conjunctivochalasis
Conjunctivochalasis refers to loose redundant, non-edematous inferior conjunctiva that is situated between the globe and lower eyelid, and usually it occurs bilaterally.
- Trial name
- NCT01933178
- Testing
- Cirrus AS-OCT
- Where
- Singapore
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Singapore National Eye Centre
Respiratory Muscle
Sensitivity and Reproducibility of 18F-fluorodeoxyglucose Positron Emission Tomography for Assessment of Respiratory Muscle Activity
The assessment of respiratory muscle function is critical within both clinical and research settings. Tools for the assessment of respiratory muscle function are especially useful in diagnosing, phenotyping, understanding…
- Trial name
- ResPET (NCT05234099)
- Testing
- 18F-FDG Positron emission tomography - MRI, Multiparametric ultrasound imaging, Surface electromyography
- Where
- 2 sites in France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Institut de Myologie, France
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Reproducibility and Accuracy of a Portable System for Early Detection of Cardiac Dysfunction in Childhood Cancer Survivors
The clinical trial compares the reproducibility and accuracy of cardiac tonometry-based portable systems that may detect early cardiac dysfunction (SphygmoCor® Xcel and Oscar 2™ ambulatory blood pressure monitor) at home and in…
- Trial name
- NCT05138991
- Testing
- Echocardiogram Recording, Questionnaire Administration, Stress Cardiac Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Obesity and Obesity-related Medical Conditions, Diabetes
Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)
The purpose of this research study is to validate (check the accuracy of) laboratory assays, intravenous catheter insertion, and equipment or devices and their reproducibility, which is necessary to perform high quality research…
- Conditions
- Obesity and Obesity-related Medical Conditions, Diabetes, Atherosclerotic Disease, Heart Failure
- Trial name
- VALD (NCT07083557)
- Testing
- Endothelial cell collection
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Bettina Mittendorfer
Allergic Rhinitis, Rhinoconjunctivitis
Red Maple Trials Cat Allergen Natural Exposure Chamber Validation in Cat-allergic Subjects
To assess the reproducibility of the allergic response in the cat allergic subjects, measured as the change from baseline of the Total Nasal Symptom Score (TNSS) on the two challenge days.
- Conditions
- Allergic Rhinitis, Rhinoconjunctivitis, Exposure
- Trial name
- NEC (NCT03414801)
- Testing
- Allergen Exposure
- Where
- Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Red Maple Trials Inc.
Single Leg Squat Performance, Athletic Injuries
Single Leg Squat Performance in Physically and Non-physically Active Individuals
Single-leg squat (SLS) is a functional test visually rated by clinicians for assessing lower limb function as a preventive injury strategy.
- Trial name
- NCT03203083
- Testing
- performance of the single leg squat task
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Suspect NPC Patients, NPC Multiplex Families
Reproducibility and Reliability of Epstein-Barr Virus (EBV) DNA/RNA Measures in Nasopharyngeal Swabs
Nasopharyngeal carcinoma (NPC) is a virus-associated cancer that is rare among Caucasians but occurs at an elevated rate among Southern Asians.
- Trial name
- NCT01972815
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Healthy, Alzheimer Disease
A Non-therapeutic Feasibility Study of the Radioligand [11C]-UCB-J for Imaging Synaptic Density
Up to 20 subjects will receive an injection with [11C]-UCB-J followed by a PET scan on Days 1 and 28
- Trial name
- NCT03577262
- Testing
- [11C]-UCB-J
- Where
- 3 sites in Netherlands
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Alkermes, Inc.
Multiparametric MRI
Reproducibility of Multiparametric Renal Magnetic Resonance Imaging on 1.5T MRI Scanners
This is an interventional, multicenter, prospective study involving healthy volunteers, to primarily assess the reproducibility of multiparametric renal MRI on 1.5T scanners.
- Trial name
- NCT06884410
- Testing
- MRI
- Where
- 4 sites in Denmark, Germany and 2 more
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Mario Negri Institute for Pharmacological Research
Keratitis
Reliability of Pachymetry Measurement With FD-oCT, ORA, Confoscan 4 and Ultrasound
The purpose of this study is to assess the repeatability, reproducibility, and agreement of central corneal thickness measured by Fourier Domain Optical Coherence tomography (FD-OCT, OptoVue, USA) with anterior corneal module…
- Trial name
- NCT00838422
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Far Eastern Memorial Hospital
Normal, Glaucoma & Retinal Pathology
Evaluation of the Repeatability and Reproducibility of AngioVue
The purpose of this study is to assess the repeatability and reproducibility of measurements of the vascular structures and the anatomical structures of the posterior pole of the eye based on AngioVue volume scans in normal…
- Trial name
- NCT02911883
- Testing
- Optical Coherence Tomography Angiography
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Optovue
Sarcopenia
Evaluation of the Reproducibility of Jumping Mechanography
Sarcopenia, the age-related decline in muscle mass and function (widely recognized as "frailty"), is increasingly being appreciated, primarily in the research environment.
- Trial name
- Jump (NCT01164670)
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
No Disease
A Study to Test the Repeatability and Reproducibility in Rod Intercept Time Within the AdaptDx Pro in Healthy Subjects With Normal Vision (FlashForward)
The purpose of this study is to test the repeatability and reproducibility in Rod Intercept (RI) time with two AdaptDx Pro devices in healthy subjects with normal vision.
- Trial name
- FlashForward (NCT07860905)
- Testing
- AdaptDx Pro
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- AdaptDx, Inc.
Macular Degeneration
MP3 (Microperimeter 3) Reproducibility in Healthy Subjects and Macular Patients
The aim of the present study is to investigate the reproducibility of the MP3 and to compare the results with conventional perimetry using the Octopus 101 in healthy subjects and patients with macular disease.
- Trial name
- NCT02941406
- Where
- Austria
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Vienna Institute for Research in Ocular Surgery
Chronic Kidney Diseases, Healthy
Multiparametric MRI in Healthy Volunteers and CKD Patients
Chronic kidney disease (CKD) is a global health concern because more than 10% of the world's population have it, its prevalence is increasing, and CKD is an important contributor to morbidity and mortality for this population.
- Trial name
- RESPECT (NCT05229263)
- Testing
- Non- contrast Enhanced Multiparametric Renal Magnetic Resonance
- Where
- 4 sites in Denmark, Germany and 2 more
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Mario Negri Institute for Pharmacological Research
Open Angle Glaucoma, Normal Tension Glaucoma
Reproducibility of Blood Flowmetry in Human Retina Using the Nidek Laser Speckle Flowgraphy LSFG-NAVI System
In addition to intraocular pressure blood perfusion pressure in the optic nerve is an important factor determing the cause of glaucoma. Increasing evidence suggests that in glaucoma patients retinal blood may be decreased.
- Conditions
- Open Angle Glaucoma, Normal Tension Glaucoma, Healthy
- Trial name
- LSFG Repro (NCT04014933)
- Testing
- LASER SPECKLE FLOWGRAPHY
- Where
- Switzerland
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Zurich