Clinical trials: Reproductive Effects
Male Infertility
Comparison of the Effect of Gonadotropin and Clomiphene Citrate Treatment on Sperm Parameters and the Outcome of Assisted Reproductive Procedures in Subfertile Men Based on the APHRODITE Groups
Men enrolled in the study are assigned to each APHRODITE group. Group 2,3,4 are treated with either gonadotropin preparations or clompihene-citrate (except group 4).
- Trial name
- GONACLO (NCT07523022)
- Testing
- recFSH, HCG injection, Clomiphene Citrate 50 mg
- Where
- Hungary
- Volunteers
- 500 people
- Sponsor
- Szeged University
Female Reproductive System Disorder
Effect of Modifications of Nutritional Intake Upon Reproductive Hormones in Normal Women
Undernutrition has a known and well recognized negative impact on reproductive hormones, and ultimately fertility. In contrast, much less is known regarding the potential effects of overnutrition on the same hormones.
- Trial name
- Polynut (NCT02233283)
- Testing
- Clamp, Hypercaloric diet, Basal
- Where
- Switzerland
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Primary Dysmenorrhea
Effects of Pau d' Arco in Primary Dysmenorrhea
A single arm, open-label trial evaluating safety and tolerability of encapsulated Tabebuia avellanedae in 12 generally healthy women aged 18-45 with primary dysmenorrhea (PDM).
- Trial name
- EPAPD (NCT04245540)
- Testing
- Pau d' Arco
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- National University of Natural Medicine
Opiate Addiction, Pregnancy
Immediate Postpartum Nexplanon Placement in Opioid Dependent Women
The investigators have designed a single site, Phase IV open label, prospective observational clinical trial to compare the effect of immediate postpartum Nexplanon placement (IPP) versus standard postpartum contraceptive care…
- Conditions
- Opiate Addiction, Pregnancy, Contraceptive Behavior, Sexual Behavior
- Trial name
- NCT02657148
- Testing
- Nexplanon (etonogestrel contraceptive implant), Standard postpartum contraceptive care
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Pittsburgh
Pregnancy Malaria, Bacterial Vaginoses
The ASPIRE Trial - Aiming for Safe Pregnancies by Reducing Malaria and Infections of the Reproductive Tract
Malaria in pregnancy has devastating consequences for mother and foetus. WHO recommends intermittent preventive treatment in pregnancy (IPTp) with sulphadoxine-pyrimethamine (SP) for asymptomatic women, but high-level parasite…
- Conditions
- Pregnancy Malaria, Bacterial Vaginoses, Trichomonas Vaginitis
- Trial name
- NCT04189744
- Testing
- IPTp-sulphadoxine-pyrimethamine plus metronidazole, IPTp-dihydroartemisinin-piperaquine plus metronidazole, IPTp-sulphadoxine-pyrimethamine
- Where
- Zambia
- Volunteers
- 5,436 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Infertility, Spermatozoa
Ejaculatory Abstinence in IUI Cycles
Intrauterine insemination (IUI) combined with ovarian stimulation, has been an extensively used procedure for the treatment of patients with unexplained infertility.
- Conditions
- Infertility, Spermatozoa, Reproductive Disorder
- Trial name
- NCT04361292
- Testing
- INTRAUTERINE INSEMINATION
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Pamukkale University
Infertility, Recurrent Implantation Failure
Effect of Reproductive Tract Microbiota on Pregnancy Outcome in IVF/ICSI
A single center，observational cohort study to explore the relationship between reproductive tract microbiota and pregnancy outcome in the patients accepted IVF/ICSI.
- Conditions
- Infertility, Recurrent Implantation Failure, Recurrent Miscarriage
- Trial name
- NCT04293068
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking University Third Hospital
Diminished Ovarian Reserve (DOR), Thin Endometrium
A Randomized Controlled Study on the Effect of MRJPs on Improving Ovarian Function and Endometrial Receptivity
This study will assess the effects of the rose tablet candies produced by MRJPs on the subjects, evaluate the role of MRJPs in the ovarian function and endometrial receptivity of women, reveal the potential application value of…
- Trial name
- NCT07246733
- Testing
- Oral MRJPs Candy
- Where
- China
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Sexual Desire
Effects of Glucagon-like-Peptide-1 Analogues on Sexuality
This study is to investigate the effects of GLP-1 analogues (combined with lifestyle interventions in comparison to lifestyle interventions only) on sexual desire, mood, quality of life, the reproductive axis, retinal vessel…
- Trial name
- Desire PLUS (NCT05598008)
- Where
- Switzerland
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Infertility, Intrauterine Insemination
Personalized Insemination Treatment Study
This study is intended for women undergoing their first cycle of 3 intrauterine inseminations. All 3 inseminations will be personalized by using algorithms to determine the dose of study medication.
- Conditions
- Infertility, Intrauterine Insemination, Reproduction
- Trial name
- PITS (NCT03830723)
- Testing
- Follitropin delta
- Where
- Canada
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Clinique Ovo
Breast Carcinoma, Cancer Survivor
Memory and Thinking Skills Workshop to Improve Cognition in Gynecologic and Breast Cancer Survivors With Cognitive Symptoms
The purpose of this study is to examine thinking abilities, mood, and quality of life in cancer survivors before and after an 8-week group-based memory and thinking skills workshop.
- Conditions
- Breast Carcinoma, Cancer Survivor, Cognitive Side Effects of Cancer Therapy, Malignant Female Reproductive System Neoplasm
- Trial name
- NCT01641068
- Testing
- Cognitive Intervention, Educational Intervention, Functional Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Washington
Prostate Cancer, Psychosocial Effects of Cancer and Its Treatment
Communication and Intimacy-Enhancing Therapy for Men With Early Stage Prostate Cancer and Their Partners
RATIONALE: Participating in a therapy program may enhance communication and intimacy between men with prostate cancer and their partners.
- Conditions
- Prostate Cancer, Psychosocial Effects of Cancer and Its Treatment, Sexual Dysfunction and Infertility, Sexuality and Reproductive Issues
- Trial name
- NCT00503646
- Testing
- communication intervention, counseling intervention, questionnaire administration
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Family Planning
Effects of Family Planning Education Given to Illiterate Women Via Visual Material Support
This study was conducted to determine the effects of family planning education given to married illiterate women of reproductive age via visual material support on their family planning attitudes and contraceptive preferences.in…
- Trial name
- NCT06755749
- Testing
- Family Planning Education
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Inonu University
Hormones
CaREFREE Study (Calorie Restriction, Environment and Fitness: Reproductive Effects Evaluation Study)
Background: Functional hypothalamic amenorrhea (functional HA) is a condition where a woman s period stops for a temporary time. This is due to improper function of the hypothalamus.
- Trial name
- NCT02858336
- Testing
- NEA, DEA
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Energy Deficiency Due to Short-term Fasting, Hormonal Contraception
Energy Deficiency on Hormones in Contraceptive Users
The purpose of the present study is to characterize the endocrine and metabolic responses to a modest, short-term energy deficiency (~250 kcal/day) across the menstrual cycle in recreationally active women using different…
- Trial name
- NCT07651800
- Testing
- Energy Deficiency of approximately ~250 kcal/day
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Southern California
Transgender, Healthy
Hormone Secretion in Transgender Males
Aim 1 utilizes prospective clinical studies in TGN to test the hypothesis that prolonged exogenous androgens alter menstrual cyclicity by inhibiting gonadotropin secretion, steroid hormone release, and ovulation.
- Trial name
- NCT04321551
- Testing
- Testosterone Cyp 200Mg/Ml Inj (in Oil), Letrozole
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Diego
Women of Reproductive Age
The Effect Of Self-Breast Examination Training On The Belief Of Breast Health
The aim of the present research was to detect the effect of self-breast examination provided to women between 18 and 49 years of age and practice on the belief of women on their breast health.
- Trial name
- NCT06410573
- Testing
- Breast Self-Examination and Practice
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- KTO Karatay University
Hyperandrogenism
Effects of Androgen Administration on Inflammation in Normal Women
The hypothesis of this study is that DHEA administration to increase male hormone in healthy normal-weight young women to levels present in women with Polycystic Ovary Syndrome will cause an inflammatory response in white blood…
- Trial name
- NCT01753037
- Testing
- Dehydroepiandrosterone (DHEA)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Dehydroepiandrosterone, DHEAS
Effects of Dehydroepiandrosterone Supplementation on Cumulus Cells Gene Expression Under Controlled Ovarian Hyper-stimulation in Patients With Diminished Ovarian Reserve
Diminished ovarian reserve (DOR) is one the challenge in the field of artificial reproductive technology (ART) while there is still no effective resolution of this disorder.
- Conditions
- Dehydroepiandrosterone, DHEAS, Gene Expression of Cumulus Cells., Ovarian Hyper-stimulation Protocol.
- Trial name
- NCT02150330
- Testing
- Dehydroepiandrosterone (DHEAS)
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Anxiety
Randomised Controlled Trial of the Effect of Music on Women Undergoing Assisted Reproductive Technology Treatments.
To investigate whether listening to music at the time of embryo transfer reduces anxiety levels in women undergoing assisted conception treatment.
- Trial name
- NCT02223845
- Testing
- Music
- Where
- United Kingdom
- Volunteers
- 42 people
- Sponsor
- University of Southampton