Clinical trials: Resection Margins
Breast Cancer
ICG-fluorescence Imaging for Intraoperative Breast Cancer Margins Evaluation: a Dose-timing Study
Designed in five-arm, single-center, prospective randomized, observational- interventional, open-label study which will evaluate patients with histological proven early-stage BC that will undergo planned BCS for their local…
- Trial name
- BREASTIFLU-1 (NCT06227338)
- Testing
- Indocyanine green
- Where
- Belgium
- Volunteers
- 250 people
- Sponsor
- Jules Bordet Institute
Liver Neoplasms
Assessment of Indocyanine Green as a Near-Infrared Fluorescent Contrast Agent for Image-guided Liver Surgery
This is a prospective, monocentric, non-randomized, phase I-II study. The goal is to assess the faisability and the capabilities of fluorescence imaging in hepatic surgery, and specially to help the surgeon while performing liver…
- Trial name
- HEPATOFLUO (NCT01738217)
- Testing
- Fluobeam
- Where
- France
- Volunteers
- 48 people
- Sponsor
- Centre Leon Berard
Class V Dental Caries
Clinical Performance Of Conserved Chalky White Demineralized Enamel Cavity Margins Versus Totally Removed Carious Margins In Class V Cavities Restored With Composite Resin
This study aims to compare the clinical performance of conserved chalky white demineralized enamel margins with total removal of demineralized enamel margins in class v cavities restored with composite in patients with acute…
- Trial name
- NCT05614076
- Testing
- conserved chalky white enamel margins of class V cavities, Total removal of demineralized enamel margins of class V cavities
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Cairo University
High-grade Squamous Intraepithelial Lesions (HSIL), Cervical Conization
Predicting Treatment Failure in HSIL Patients with Positive Margins After Conization Via Detection of PAX1 Methylation
The goal of this multicenter, observational study is to evaluate whether methylation testing of paired box gene 1 (PAX1) can better predict and diagnose recurrence or persistent disease in patients with positive margins after…
- Trial name
- NCT06713655
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Brain Metastases, Adult, Brain Tumor - Metastatic
Stereotactic Radiation for Growing/Changing Brain Metastases With Same-Day Radiation Planning and Treatment With Margin Reduction
The goal of this study is to evaluate the feasibility and effectiveness of same-day radiation planning and treatment. The study will shorten the time interval between radiation planning (radiation mapping) and radiation…
- Conditions
- Brain Metastases, Adult, Brain Tumor - Metastatic, Brain Metastases From Non-small Cell Lung Cancer (NSCLC), Brain Metastases From Extra-cranial Solid Tumors
- Trial name
- NCT07132190
- Testing
- Linear accelerator-based stereotactic radiation for brain metastases using 0mm or 1mm PTV
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Ayal A. Aizer, MD
Breast Cancer
Cavity Shaving in Breast Conserving Surgery for Breast Cancer Patients
This randomized controlled trial is to evaluate the impact of additional cavity shaving (CS) on pathological cavity margin (CM) status in breast cancer patients.
- Trial name
- NCT02648802
- Testing
- Cavity shaving, Standardized BCS+CM assessment.
- Where
- China
- Volunteers
- 181 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Cancer Colon
The Efficacy Of Complete Mesocolic Excision With Central Vessel Ligation Technique On Lymph Nodes And Safety Margins Compared With Conventional Surgery For Colon Cancer Treatment
Cancer Colon is one of the major public health problems worldwide. Complete eradication of the tumor with no recurrence or residual masses is a challenge which faces all the surgeons and medical staff all over the world.
- Trial name
- NCT04079946
- Testing
- Total Mesocolic Excision with Central Vessel Ligation, conventional surgery of cancer colon
- Volunteers
- 40 people
- Sponsor
- Assiut University
Adenocarcinoma of Pancreas
FOLFIRINOX in Patients With Inoperable Pancreatic Cancer
The prognosis of patients with locally advanced unresectable pancreatic cancer is poor, and the median survival is less than 1 year.
- Trial name
- NCT01359007
- Testing
- Irinotecan, Oxaliplatin, Leucovorin, 5-FU
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Oklahoma
Soft Tissue Sarcoma of the Trunk and Extremities, Sarcoma
Fluorescence-Guided Optimization of Sarcoma Margins
This is a Danish national multicenter prospective cohort study to evaluate if fluorescence-guided surgery (FGS) using indocyanine green (ICG) can reduce the rate of positive margins following sarcoma resection.
- Trial name
- FOCUS (NCT07134192)
- Testing
- Fluorescent-guided Surgery
- Where
- 2 sites in Denmark
- Volunteers
- 90 people
- Sponsor
- University of Aarhus
Retroperitoneal Sarcoma, Margin, Tumor-Free
Retroperıtoneal Soft-Tıssue Sarcomas
: Soft Tissue Sarcomas are rare mesenchymal tumors with many subtypes. Clean margin-wide resection is recommended for treatment. The guidelines recommend that sarcoma treatments be carried out in sarcoma centers.
- Trial name
- NCT05044624
- Testing
- retroperitoneal mass excision
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Breast Cancer Female, Breast Neoplasms
Intra-operative PET-CT: a Novel Approach to Determine Excision Margins in Lumpectomy Breast Cancer.
Examination of the feasibility of intra-operative pet CT to detect surgical margins in breast conservative surgery to prevent re-excision.
- Trial name
- NCT04343079
- Testing
- PET CT
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- University Hospital, Ghent
Adenoma Colon Polyp
Evaluating Adenoma Recurrence After Endoscopic Mucosal Resection With Margin Marking or Post Treatment With Snare Tip Soft Coagulation
Non-inferiority trial comparing the recurrence rate of adenomas in non-pedunculated colonic lesions following endoscopic mucosal resection with margin marking (EMR-MM) and endoscopic mucosal resection with thermal margin ablation…
- Trial name
- ERADICATE (NCT06476145)
- Where
- United States
- Volunteers
- 342 people
- Sponsor
- AdventHealth
Breast Cancer, Resection Margin
Evaluation of Safety and Performance of Intraoperative Detection of Light Signals During Electrosurgical Breast Cancer Resection
This monocentric early feasibility first in human study is intended to evaluate safety and performance of intraoperative detection of light signals during electrosurgical breast cancer resection.
- Trial name
- NCT06020573
- Testing
- Clip-on electrode with fiber optics
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Erbe Elektromedizin GmbH
Squamous Cell Carcinoma of Head and Neck, Basal Cell Carcinoma of Skin
Intraoperative Assessment of Surgical Margins Using Confocal Microscopy in Comparison With Reference Extemporaneous Examination
Study to evaluate the use of confocal microscopy for detecting resection margins in patients undergoing surgery for basal cell carcinoma of skin and squamous Cell Carcinoma of Head and Neck
- Trial name
- HISTOBLOC (NCT05935995)
- Testing
- microscopy confocal (Histolog Scanner)
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Institut de Cancérologie de Lorraine
Hepatocellular Carcinoma (HCC), Radiotherapy, Adjuvant
Adjuvant Radiotherapy of Sintilimab Versus TACE for HCC
This study is an open-label, randomized controlled, multicenter, phase III clinical trial
- Conditions
- Hepatocellular Carcinoma (HCC), Radiotherapy, Adjuvant, Immune Checkpoint Inhibitor, TACE
- Trial name
- NCT07186621
- Testing
- Sintilimab, radiotherapy, TACE
- Where
- China
- Volunteers
- 286 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Colorectal Polyp, Colon Adenoma
Cold Snare Endoscopic Mucosal Resection (EMR) vs Cold EMR With Margin Snare Tip Soft Coagulation (STSC)
Randomised controlled trial comparing cold snare endoscopic mucosal resection (EMR) with cold snare EMR and adjuvant margin STSC in the complete resection of 15-40mm lateral-spreading adenomas
- Conditions
- Colorectal Polyp, Colon Adenoma, Colon Cancer
- Trial name
- NCT05041478
- Testing
- Cold Snare Endoscopic mucosal resection with adjuvant snare tip soft coagulation, Cold Snare Endoscopic Mucosal Resection
- Where
- Australia
- Volunteers
- 300 people
- Sponsor
- Western Sydney Local Health District
Liver Metastasis Colon Cancer
Prospective Clinical Study of Intraoperative Assessment of Resection Margin of Colo-Rectal Cancer Liver Metastases
This prospective single arm double-blind study approved by the Ethics Committee of the institution, will be conducted on at the Oncology Institute of Vojvodina in Sremska Kamenica, Serbia.
- Trial name
- NCT04634526
- Where
- Serbia
- Volunteers
- 250 people
- Sponsor
- Oncology Institute of Vojvodina
Breast-Conserving Surgery, Negative Surgical Margins
Endoscopic Breast Conserving Surgery With Intra-operative Navigation System
A growing number of Chinese breast cancer patients are diagnosed at a young age. The quality of life of young breast cancer patients has been a critical issue.
- Conditions
- Breast-Conserving Surgery, Negative Surgical Margins, Endoscopy, Esthetics
- Trial name
- NCT05458414
- Testing
- Intra-operative Navigation System
- Where
- China
- Volunteers
- 41 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Breast Cancer, Breast Cancer Female
Partial Chest Wall Radiation Therapy After Surgery for Lymph Node Negative Breast Cancer
The standard treatment for breast cancer when cancer cells were found near or within the margins of the tissue that is removed during breast surgery, is radiation of the entire chest wall.
- Conditions
- Breast Cancer, Breast Cancer Female, DCIS, Stage II Breast Cancer
- Trial name
- NCT05436808
- Testing
- Partial Chest Wall Radiation Therapy
- Where
- United States
- Sponsor
- Stony Brook University
Prostate Cancer, Erectile Dysfunction
Pentafecta Outcomes After Robot-assisted Laparoscopic Radical Prostatectomy
Robot-assisted laparoscopic radical prostatectomy (RALRP) is a surgical technique for the treatment of prostate cancer. The aim of this study was to report our initial experience with RALRP, by applying the concept of pentafecta.
- Conditions
- Prostate Cancer, Erectile Dysfunction, Complication of Surgical Procedure, Urinary Incontinence
- Trial name
- NCT03706508
- Testing
- Robot-assisted laparoscopic radical prostatectomy
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Hospital de Clinicas de Porto Alegre