Clinical trials: Residual
Neuromuscular Block, Residual
Diaphragm Function After Reversal of Rocuronium-induced Neuromuscular Blockade With Sugammadex or Neostigmine in Children
This study is to evaluate the recovery of diaphragm function and atelectasis after reversal of neuromuscular blockade with Neostigmine and Sugammadex using lung ultrasound and diaphragm ultrasound for children aged 2 to 7 who are…
- Trial name
- NCT05724550
- Testing
- Sugammadex, Neostigmine
- Where
- South Korea
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
Circulating Tumor DNA Based Minimal Residual Disease Detection for Patients With Early-Stage Breast Cancer
This clinical trial studies how well circulating tumor deoxyribonucleic acid (ctDNA) based minimal residual disease (MRD) detection works for patients with early-stage breast cancer.
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, Estrogen Receptor-Positive Breast Carcinoma
- Trial name
- NCT07136493
- Testing
- Biospecimen Collection, Electronic Health Record Review, Survey Administration
- Where
- 5 sites in United States
- Sponsor
- City of Hope Medical Center
Mechanical Ventilation, Acute Respiratory Distress Syndrome
The Effect of Positive End-Expiratory Pressure on Functional Residual Capacity During Mechanical Ventilation
Although positive end-expiratory pressure (PEEP) has been widely used in mechanical ventilated patients with acute respiratory distress syndrome (ARDS), how to select the "optimal" PEEP is far from consensus.
- Conditions
- Mechanical Ventilation, Acute Respiratory Distress Syndrome, Functional Residual Capacity
- Trial name
- NCT03511651
- Testing
- PEEP
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Capital Medical University
Breast Cancer, Non Small Cell Lung Cancer
Minimal Residual Disease in Solid Malignancies
The IMRD study is a single-centre, prospective observational study which will investigate the rate of ctDNA (circulating tumor DNA) detection from the start of adjuvant therapy following curative-intent surgery.
- Conditions
- Breast Cancer, Non Small Cell Lung Cancer, Prostate Cancer, High Grade Serous Ovarian Cancer
- Trial name
- IMRD (NCT07268469)
- Testing
- ctDNA detection
- Volunteers
- 840 people
- Sponsor
- European Institute of Oncology
Acromegaly Due to Pituitary Adenoma
Multicenter Evaluation of the Effect of Upfront Radiosurgery on Residual Growth Hormone-secreting Pituitary Adenoma
In this study, the investigators hypothesize that upfront gamma knife radiosurgery with drug therapy is superior in the treatment of growth hormone-secreting pituitary tumors after primary surgical treatment compared with the…
- Trial name
- MERGE (NCT03439709)
- Testing
- Gamma knife radiosurgery, Lanreotide 60Mg Solution for Injection
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Samsung Medical Center
Physical Activity, Healthy
The Effects of Dietary Intake of Cod Residual Material Meal on Lipid Regulation, Glucose Regulation and Body Composition in Physically Active Adults
A high intake of fish is associated with positive health effects, including prevention and treatment of chronic non-communicable diseases, such as cardiovascular diseases (CVDs) and type 2 diabetes.
- Trial name
- COD2016 (NCT03538834)
- Testing
- Cod meal from residual material, Control
- Where
- Norway
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Neuromuscular Blockade
Use of Neuromuscular Blocking Agents and Neuromuscular Monitoring in 7 Danish Teaching Hospitals
Aim: To explore the frequency of use of objective neuromuscular monitoring for assessment of depth of neuromuscular blockade in general anaesthesia the incidence of residual neuromuscular blockade, and the timing of reversal of…
- Trial name
- NCT02914119
- Testing
- Rocuronium, Succinylcholine, Cisatracurium
- Where
- Denmark
- Volunteers
- 30,430 people
- Sponsor
- Jakob Louis Thomsen
Acute Lymphoblastic Leukemia, B-precursor
Blinatumomab Intensification for MRD-Negative Acute B-Cell Lymphoblastic Leukemia Before Allogeneic Hematopoietic Stem Cell Transplantation
This is a prospective, multicenter, randomized controlled trial designed to evaluate whether short-term blinatumomab intensification before allogeneic hematopoietic stem cell transplantation (allo-HSCT) can improve survival…
- Trial name
- NCT07003737
- Testing
- Blinatumomab, Consolidation Chemotherapy or Direct Allogeneic HSCT
- Where
- China
- Volunteers
- 114 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Neuroma Amputation
Evaluation of Ultrasonic Neuroma Size With Residual Limb Pain in Above-Knee Amputees
Background: The formation of neuromas, a fusiform swelling of a nerve or nerve ending, is a well documented response to limb amputation.
- Trial name
- NCT00686764
- Testing
- Observational
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Residual Neuromuscular Block
Impact of Sugammadex Versus Neostigmine on Early Postoperative Pulmonary Function
Residual neuromuscular blockade (NMB) after general anesthesia increases the risk of postoperative respiratory complications (atelectasis, pneumonia, re-intubation) and delays pulmonary function recovery.
- Trial name
- NCT07309393
- Testing
- Sugammadex, Neostigmine
- Where
- 3 sites in China
- Volunteers
- 240 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Breast Cancer
Mini-invasive Detection of Residual Disease in Breast Cancer Patients in Remission After Primary Chemotherapy
Breast surgery may be overtreatment when there is a complete response to systemic neoadjuvant treatment as determined clinically and by imaging.
- Trial name
- NCT05951699
- Testing
- minimally invasive preoperative image-guided vacuum-assisted biopsy
- Where
- Italy
- Volunteers
- 105 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Respiratory Compliance, Functional Residual Capacity
Rescue Antenatal Steroids and Pulmonary Function Tests in Preterm Infants
One course of steroids given to a mother before a premature delivery helps the lungs of the premature infant and decreases breathing problems.
- Conditions
- Respiratory Compliance, Functional Residual Capacity, Pulmonary Function Testing
- Trial name
- NCT00669383
- Testing
- betamethasone
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Hairy Cell Leukemia
Cladribine With Simultaneous or Delayed Rituximab to Treat Hairy Cell Leukemia
Background: Hairy cell leukemia (HCL) is highly responsive to but not curable by cladribine (CdA). HCL responds to rituximab, which is not yet standard therapy for HCL.
- Trial name
- NCT00923013
- Testing
- Cladribine, Rituximab, BMbx
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- National Cancer Institute (NCI)
Upper Endoscopy, GLP1-R-related Disease
Effect of Prolonged Fasting Time on Gastric Residual Volume in Patients Taking GLP1 Receptor Agonists
The aim of this study is to determine whether a modified fasting protocol can reduce the potential risk of aspiration for patients currently prescribed GLP1-RAs.
- Trial name
- NCT07006142
- Testing
- Modified Fasting Guidelines
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Mayo Clinic
Phantom Limb Pain, Phantom Pain
Perioperative Mirror Therapy and Phantom Limb Pain
Mirror therapy will consist of observing the unaffected limb reflected in a mirror positioned in the midline to block the view of the affected limb.
- Conditions
- Phantom Limb Pain, Phantom Pain, Phantom Sensation, Pseudomelia
- Trial name
- NCT02383979
- Testing
- Mirror
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Kidney Function, Hemodialysis
Effects of Low Protein Diet Supplemented With Ketoanalogues on Preservation of Kidney Function in Incremental Dialysis
The investigators hypothesized that combination of incremental hemodialysis and ketoanologues will better preserve residual kidney function and maintenance of nutritional status among the incident ESRD patients during the early…
- Trial name
- NCT05030168
- Testing
- Ketosteril
- Volunteers
- 50 people
- Sponsor
- Chulalongkorn University
B ALL, Allogenetic Hematopoietic Stem Cell Transplantation
CD19 CAR-T vs DLI for Post-HSCT MRD in Ph- ALL: A RCT
This prospective, open-label randomized controlled trial compares CD19 CAR-T therapy with chemotherapy plus donor lymphocyte infusion (DLI) in 70 patients with Ph-negative B-cell acute lymphoblastic leukemia (B-ALL) who exhibited…
- Conditions
- B ALL, Allogenetic Hematopoietic Stem Cell Transplantation, MRD-positive
- Trial name
- NCT07441291
- Testing
- CAR-T, DLI
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Peking University People's Hospital
Malignant Colorectal Polyp, Colorectal Cancer
Malignant Polyp Registry
The purpose of this study is to learn more about malignant colorectal polyps (early colorectal cancers removed during colonoscopy) and the risk that cancer remains, comes back, or spreads after the polyp is removed.
- Conditions
- Malignant Colorectal Polyp, Colorectal Cancer, T1 Colorectal Cancer
- Trial name
- NCT07619079
- Testing
- Questionnaires
- Where
- 7 sites in United States
- Volunteers
- 500 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Stage III Colon Cancer
Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease
This Phase II/III trial will evaluate the what kind of chemotherapy to recommend to patients based on the presence or absences of circulating tumor DNA (ctDNA) after surgery for colon cancer.
- Trial name
- CIRCULATE-US (NCT05174169)
- Testing
- Signatera test, mFOLFOX6 3-6 month, CAPOX 3 month
- Where
- 1,085 sites in United States, Canada and 1 more
- Volunteers
- 1,912 people
- Sponsor
- NRG Oncology
Salpingectomy
Residual Tubal Tissue on the Ovarian Surface Following Salpingectomy With Laparoscopy and Laparotomy
Patients who undergo salpingo-oophorectomy +/- hysterectomy (laparoscopic or laparotomy) for benign indications, early cervical cancer or low-risk endometrial cancer will be included.
- Trial name
- NCT03322605
- Volunteers
- 60 people
- Sponsor
- Istanbul Medeniyet University
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