Clinical trials: Residual
Cataract
Evaluate Performance of Callisto Eye vs. Wavetec AnalyzOR
The goal of this clinical trial is to evaluate two separate operating room cataract measuring tools in predicting the residual astigmatism (prediction error) in patients with corneal astigmatism.
- Trial name
- CORTCO (NCT06216067)
- Testing
- CALLISTO eye, Wavetec AnalyzOR
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Chesapeake Eyecare and Laser Center, LLC
Acute Lymphoid Leukemia, Philadelphia Chromosome-Negative B-Cell Precursor
Sequential Chemotherapy and Blinatumomab to Improve MRD Response and Survival in Acute Lymphoblastic Leukemia
The present study aims at analyzing the response to treatment of adult patients homogeneously treated with supportive care, chemotherapy and blinatumomab.
- Trial name
- LAL2317 (NCT03367299)
- Testing
- Chemotherapy + Blinatumomab
- Where
- 62 sites in Italy
- Volunteers
- 149 people
- Sponsor
- Gruppo Italiano Malattie EMatologiche dell'Adulto
Voiding Disorders, Voiding Dysfunction
Patient Self Measurement of Post-Void Residual Bladder Volume (PVR) Using Ultrasound
This study would be the first to demonstrate feasibility, accuracy, reliability, clinical care impact, and patient satisfaction with remote monitoring of post-void residual bladder volume (PVR) using the Butterfly portable…
- Trial name
- NCT05295823
- Testing
- Butterfly portable ultrasound device with bladder ultrasound images, Butterfly portable ultrasound device with abstract bladder images
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Yale University
Osteoarthritis, Knee
Residual Pain After Successful Implant of Metaphyseal Sleeves in Total Knee Arthroplasty
: Total knee revision arthroplasty is increasing in daily practice and will become more relevant in the years to come. Bone loss is a significant challenge in total knee arthroplasty (TKA) especially in revision procedures.
- Trial name
- NCT04995679
- Testing
- Implant of metaphyseal sleeves in Total knee arthroplasty
- Where
- Italy
- Volunteers
- 85 people
- Sponsor
- University of Milan
Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Biphenotypic Leukemia
Umbilical Cord Blood Transplant With Added Sugar and Chemotherapy and Radiation Therapy in Treating Patients With Leukemia or Lymphoma
This phase II trial studies how well an umbilical cord blood transplant with added sugar works with chemotherapy and radiation therapy in treating patients with leukemia or lymphoma.
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Biphenotypic Leukemia, Acute Leukemia, Acute Lymphoblastic Leukemia
- Trial name
- NCT03096782
- Testing
- Anti-Thymocyte Globulin, Busulfan, Clofarabine
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer, Hormonreceptor Positive
A Study of Palbociclib in Addition to Standard Endocrine Treatment in Hormone Receptor Positive Her2 Normal Patients With Residual Disease After Neoadjuvant Chemotherapy and Surgery
The PENELOPEB study is designed to demonstrate that, in the background of standard anti-hormonal therapy, palbociclib provides superior invasive disease-free survival (iDFS) compared to placebo in pre- and postmenopausal women…
- Conditions
- Breast Cancer, Hormonreceptor Positive, Her2-normal, Postneoadjuvant Treatment With CDK 4/6 Inhibitor
- Trial name
- PENELOPE-B (NCT01864746)
- Testing
- Palbociclib PD-0332991
- Where
- 11 sites in United States, Australia and 9 more
- Volunteers
- 1,250 people
- Sponsor
- GBG Forschungs GmbH
Diffuse Large B-Cell Lymphoma
Chidamide Maintenance for MRD-Positive Double-Expressor DLBCL in First Complete Remission
This is a prospective, multicenter, single-arm, open-label phase 2 study designed to evaluate the efficacy and safety of chidamide maintenance in adults with newly diagnosed double-expressor diffuse large B-cell lymphoma (DLBCL)…
- Trial name
- DEL-MRD-CHID (NCT07507318)
- Testing
- Chidamide
- Where
- China
- Volunteers
- 69 people
- Sponsor
- Rong Tao
Olfaction Disorders, Sinusitis
Trial of Directed High-dose Nasal Steroids on Residual Smell Loss in Sinus Patients After Sinus Surgery
The purpose of this study is to determine if a trial of directed high-dose nasal steroids improves residual smell loss in patients with chronic rhinosinusitis following sinus surgery.
- Conditions
- Olfaction Disorders, Sinusitis, Paranasal Sinus Diseases
- Trial name
- NCT01814618
- Testing
- Budesonide Respules
- Where
- United States
- Sponsor
- University of North Carolina, Chapel Hill
TOF
Residual Neuromuscular Blockade and PACU Admission
Residual neuromuscular blockade (RNMB) remains an underrecognized postoperative safety concern associated with pulmonary complications, prolonged post-anesthesia care unit stay, and reduced patient satisfaction.
- Trial name
- NCT07758868
- Where
- Turkey (Türkiye)
- Volunteers
- 179 people
- Sponsor
- Ankara Etlik City Hospital
Club Foot
Midfoot Osteotomy Versus 8-Plate Epiphysiodesis for Residual Metatarsal Adductus
Epiphysiodesis
- Trial name
- NCT07466043
- Testing
- Midfoot Osteotomy, 8-Plate Epiphysiodesis
- Volunteers
- 40 people
- Sponsor
- Assiut University
Neoplastic Pathology, Minimal Residual Disease
Validation of a Method to Search Residual Disease in Auto-cryopreserved Ovarian Tissues
Cryopreservation of ovarian tissue is offered to young girls and women aged under 35 who have to undergo sterilizing gonadotoxic treatment, with the aim of preserving their fertility.
- Conditions
- Neoplastic Pathology, Minimal Residual Disease, Cryopreserved Ovarian Tissue
- Trial name
- VMRDO (NCT02900625)
- Where
- France
- Volunteers
- 240 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Gastric Emptying
Ultrasound Assessment of Gastric Residual Volume in Children Scheduled for Elective Surgery After Clear Fluids Fasting for One Versus Two Hours: a Comparative Study
Ultrasound guided comparison of gastric residual volume after clear fluid fasting for one versus two hours in pediatrics scheduled for elective surgery.
- Trial name
- NCT04228497
- Testing
- gastric ultrasound, the clear fluid intake
- Where
- Egypt
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Post-void Residual Volume, Recatheterization
Effect of Voiding Position (Standing in the Shower vs. Sitting) on Post-Void Residual Urine Volume (PVR) After Removal of Urinary Catheter in Women Following Benign Vaginal Gynecologic Surgery
The goal of this clinical trial is to learn if voiding in a standing position in the shower, rather than sitting on a toilet, may reduce pain associated with the act of voiding, thereby facilitating micturition and decreasing…
- Conditions
- Post-void Residual Volume, Recatheterization, Pain, UTI
- Trial name
- NCT07372547
- Testing
- Voiding position - Standing in the shower, Voiding position - Sitting on the toilet
- Where
- 2 sites in Israel
- Volunteers
- 100 people
- Sponsor
- Assuta Ashdod Hospital
Breast Carcinoma In Situ, Invasive Breast Carcinoma
Testing MK-3475 (Pembrolizumab) as Adjuvant Therapy for Triple Receptor-Negative Breast Cancer
This randomized phase III trial studies how well pembrolizumab works in treating patients with triple-negative breast cancer. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system…
- Conditions
- Breast Carcinoma In Situ, Invasive Breast Carcinoma, Stage I Breast Cancer AJCC v7, Stage II Breast Cancer AJCC v6 and v7
- Trial name
- NCT02954874
- Testing
- Biospecimen Collection, Laboratory Biomarker Analysis, Patient Observation
- Where
- 919 sites in United States, Canada and 1 more
- Volunteers
- 1,195 people
- Sponsor
- National Cancer Institute (NCI)
Muscle Invasive Bladder Cancer
Clinical Performance Evaluation of the C2i Test
The overall objective of this study is to demonstrate the safety and effectiveness by means of investigation of the ability of C2i-Test to predict 2-year recurrence-free survival post-RC in stage II-IIIA MIBC patients.
- Trial name
- NCT05860543
- Testing
- C2i-WGS-MRD Test
- Sponsor
- University of Texas Southwestern Medical Center
Breast Cancer Female, Breast Cancer, Male
Vaccine to Prevent Recurrence in Patients With HER-2 Positive Breast Cancer
The main purpose of this study is to evaluate the safety of each study vaccine and to evaluate the effect on the time to disease recurrence (assessed by disease free survival).
- Conditions
- Breast Cancer Female, Breast Cancer, Male, Breast Cancer Stage I, Breast Cancer Stage II
- Trial name
- NCT03384914
- Testing
- DC1 Vaccine, WOKVAC Vaccine
- Where
- 7 sites in United States
- Volunteers
- 119 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Cystic Fibrosis
A Study of VX-121 Combination Therapy in Participants With Cystic Fibrosis (CF) Who Are Homozygous for F508del, Heterozygous for F508del and a Gating (F/G) or Residual Function (F/RF) Mutation, or Have At Least 1 Other Triple Combination Responsive (TCR) CFTR Mutation and No F508del Mutation
The purpose of this study is to evaluate the efficacy and safety of VX-121/tezacaftor/deutivacaftor (VX-121/TEZ/D-IVA) in CF participants who are homozygous for F508del, heterozygous for F508del and a gating (F/G) or residual…
- Trial name
- NCT05076149
- Testing
- VX-121/TEZ/D-IVA, ELX/TEZ/IVA, IVA
- Where
- 170 sites in United States, Australia and 18 more
- Volunteers
- 597 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Coronary Arterial Disease (CAD), Erectile Dysfunction
Erectile Dysfunction Progression After Percutaneous Coronary Angiography: Is Residual SYNTAX Score a Predictive Marker
Participant Information Sheet Dear Participant, Investigators would like to invite participants to participate in a research study and explain what it involves.
- Trial name
- NCT07010913
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Kırıkkale University
Lymphoma Patients With Complete Response (CR) or Partial Response (PR) After Standard Treatment Had a Positive Minimal Residual Lesion (MRD)
RGL-305+ Lymphoma + Exploratory Clinical Study
This study is an open, prospective, dose-increasing exploratory clinical trial. To evaluate the safety, cytodynamics and initial efficacy of RGL-305 in patients with lymphoma.
- Trial name
- NCT07006012
- Testing
- RGL-305
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Fudan University
Hemophilia A
Phase 3 Study for Efficacy and Safety Outcomes Data in Japanese Patients With Severe Hemophilia A
This Phase III clinical study will evaluate the safety and effectiveness of valoctocogene roxaparvovec in Japanese patients with severe hemophilia A.
- Trial name
- GENEr8-JPN (NCT06224907)
- Testing
- Valoctocogene roxaparvovec
- Where
- 4 sites in Japan
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- BioMarin Pharmaceutical
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