Clinical trials: Residual Disease
Morbid Obesity, Bariatric Surgery Candidate
EPO2-PV: Evaluation of Pre-Oxygenation Conditions in Morbidly Obese Volunteer: Effect of Position and Ventilation Mode
The risk of complications associated with airway management in obese patients is significant. The results of pre-oxygenation allow a prolonged non-hypoxic apnea time for the clinician.
- Trial name
- EPO2-PV (NCT02121808)
- Testing
- NIPPV, Tidal volume
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Laval University
Residual Gastric Contents, Delayed Gastric Emptying
GLP-1 RA Cessation and Gastric Ultrasound Findings
This prospective observational study will evaluate the association between the time interval since the last dose of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and residual gastric contents before elective surgery.
- Trial name
- NCT07623148
- Testing
- GLP-1 RA Cessation Interval
- Where
- South Korea
- Volunteers
- 186 people
- Sponsor
- Wonkwang University Hospital
ACS (Acute Coronary Syndrome), SGLT2 Inhibitors
CCTA Evaluation of SGLT2i-related Pericoronary Fat Changes Patients With Stage 4 CKM Syndrome
The aim of this clinical trial is to investigate whether dapagliflozin (a sodium-glucose cotransporter 2 inhibitor, SGLT2i) can reduce levels of coronary inflammation in patients with stage 4 CKM syndrome.
- Trial name
- DAPA-PCAT (NCT07351643)
- Testing
- Dapagliflozin
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Shenyang Northern Hospital
Chronic Kidney Disease, Diabetic Kidney Disease
"Residual Kidney Function and Oxidative Stress in Incremental vs Standard Peritoneal Dialysis (2 Mexican Centers)"
Title: Comparison of Oxidative Stress and Preservation of Residual Kidney Function Between Incremental and Standard Peritoneal Dialysis in Incident Patients at the Regional General Hospital No.
- Conditions
- Chronic Kidney Disease, Diabetic Kidney Disease, Peritoneal Dialysis (PD), Hypertension
- Trial name
- INSPiRE (NCT07338435)
- Testing
- Standard Peritoneal Dialysis, Incremental Peritonal Dialysis
- Where
- Mexico
- Volunteers
- 100 people
- Sponsor
- Instituto Mexicano del Seguro Social
Leukemia
Imatinib Mesylate With or Without Hydroxychloroquine in Treating Patients With Chronic Myeloid Leukemia
RATIONALE: Imatinib mesylate may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Biological therapies, such as hydroxychloroquine, may stimulate the immune system in different ways and stop…
- Trial name
- NCT01227135
- Testing
- hydroxychloroquine, imatinib mesylate, cytogenetic analysis
- Where
- 3 sites in United Kingdom
- Volunteers
- 66 people
- Sponsor
- Lynn McMahon
Leukemia, Acute Lymphoblastic, Acute Myeloid Leukemia
Bridging Study to Eliminate Presence of MRD for Acute Leukemia Before HCT
This is a Phase 2 study designed for the purpose of estimating various parameters surrounding the efficacy of Clofarabine, Cyclophosphamide and Etoposide in eliminating minimal residual disease (MRD) in acute leukemia patients…
- Trial name
- NCT02349178
- Testing
- Clofarabine, Cyclophosphamide, Etoposide
- Where
- 4 sites in United States
- Volunteers
- 6 people
- Sponsor
- Medical College of Wisconsin
HIV -1 Infection, Methamphetamine Use
Short-term Effects of Methamphetamine on Residual Latent HIV Disease Study
The most commonly used illicit stimulant in people with HIV (PWH) is methamphetamine (MA). Prior studies demonstrate strong evidence that MA promotes increased HIV transcription as well as immune dysregulation.
- Trial name
- EMRLHD (NCT07584369)
- Testing
- Oral Methamphetamine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
Pediatric Obstructive Sleep Apnea, Pediatric Obesity
Treating Children With Obstructive Sleep Apnea After Surgery Failure
The aim of this study is to evaluate the potential improvement of sleep quality in children who have residual obstructive sleep apnea, using either an orthodontic intervention or continuous positive airway pressure (CPAP), versus…
- Trial name
- NCT03821831
- Testing
- Continuous Positive Airway Pressure, Orthodontic intervention
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- University of Alberta
Multiple Myeloma, Newly Diagnosed, Multiple Myeloma (MM)
Frontline T-cell Engager vs Autologous Stem Cell Transplant (ASCT) and Measurable Residual Disease (MRD)-Guided Sequential Intensification thERapy in Multiple Myeloma
This is an open-label, multi-site, Phase II randomized trial with response-adaptive design for newly diagnosed multiple myeloma (NDMM) participants who have had prior induction therapy.
- Trial name
- FASTER (NCT06974786)
- Testing
- Elranatamab, Daratumumab, Lenalidomide
- Where
- 11 sites in United States
- Volunteers
- 100 people
- Sponsor
- SCRI Development Innovations, LLC
Residual Neurological, Cognitive, Emotional, Behavioral Effects From Traumatic Brain Injury
Hyperbaric Oxygen Therapy and SPECT Brain Imaging in Traumatic Brain Injury
Hypothesis: That SPECT brain imaging tracks and is consistent with clinical improvements in patients receiving hyperbaric oxygen therapy (HBOT) for chronic traumatic brain injury.
- Trial name
- NCT00594503
- Testing
- Hyperbaric oxygen therapy
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Paul G. Harch, M.D.
Amyloidosis, Primary Amyloidosis
Minimal Residual Disease as a Possible Predictive Factor for Relapse in Patients With AL Amyloidosis
This protocol will assess patients with AL amyloidosis who achieve a complete response (CR) or very good partial response (VGPR) to therapy for minimal residual disease (MRD).
- Trial name
- NCT02555969
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Tufts Medical Center
Diabetic Macular Edema
Ranibizumab as a Rescue Therapy for Diabetic Macular Edema
Treatment with Ranibizumab of the residual diabetic edema in patients with failed response to Bevacizumab.
- Trial name
- NCT01253694
- Testing
- injection of 0.5 mg of Intravitreal Ranibizumab
- Where
- United States
- Sponsor
- New England Retina Associates
Non Small Cell Lung Cancer, Residual; State
Prognostic Significance of the Uncertain Resection in NSCLC
The concept of residual tumor classification proposed by the Union for International Cancer Control (UICC) was used to assess the completeness of surgical resection, and non-small cell lung cancer (NSCLC) patients with incomplete…
- Trial name
- NCT06511661
- Testing
- Complete lymphadenectomy, Incomplete lymphadenectomy
- Where
- China
- Volunteers
- 3,783 people
- Sponsor
- Sun Yat-sen University
Non-Small Cell Lung Cancer
MRD-Guided Aumolertinib-Based Adjuvant Therapy for Resected EGFR-Mutant NSCLC
Despite complete (R0) resection, patients with EGFR-mutant stage IIA-IIIB non-small cell lung cancer (NSCLC) still face a substantial risk of postoperative recurrence.
- Trial name
- NCT07873086
- Testing
- Aumolertinib, Pemetrexed, Carboplatin
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking University People's Hospital
Acute Myeloid Leukemia
FLYSYN in MRD Positive AML
This is a first in human, prospective, multicentric, nonrandomized, open-label study to investigate the safety, tolerability, preliminary efficacy, pharmacokinetics, pharmacodynamics and immunogenicity of the Fc-optimized…
- Trial name
- FLYSYN-101 (NCT02789254)
- Testing
- FLYSYN
- Where
- 5 sites in Germany
- Volunteers
- 31 people
- Sponsor
- Synimmune GmbH
Hyperhidrosis
Hyperhidrosis in Patients With Amputations-Botox
The objective is to establish and evidence base for hyperhidrosis treatment algorithm in amputees.This project will address a problem that has troubled Service members, Veterans, and civilians with amputations for decades…
- Trial name
- NCT03236012
- Testing
- Botulinum Toxin Type A (Botox)
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- University of Utah
Paranoid Schizophrenia, Schizophrenia
MK0557 for the Treatment of Cognitive Impairment in Patients With Schizophrenia (0557-027)
The purpose of this study is to determine the safety and effectiveness of an investigational drug for the treatment of cognitive impairment in patients with schizophrenia.
- Trial name
- NCT00482430
- Testing
- MK0557
- Volunteers
- 50 people
- Sponsor
- Merck Sharp & Dohme LLC
Breast Cancer
A Phase III Trial of Carboplatin as Adjuvant Chemotherapy in Triple Negative Breast Cancer
This study is designed to investigate the efficacy of carboplatin, as a post-operative adjuvant chemotherapy for triple negative breast cancer patients who have pathologic residual cancer after the preoperative chemotherapy.
- Trial name
- NCT01752686
- Testing
- carboplatin
- Volunteers
- 587 people
- Sponsor
- Severance Hospital
Muscle-Invasive Bladder Carcinoma, Gastroesophageal Adenocarcinoma
Personalized Cancer Vaccine (PCV) Strategy in Patients With Solid Tumors and Molecular Residual Disease
This is a phase 1 clinical trial to evaluate the safety, feasibility and immunogenicity of a personalized cancer vaccine strategy in patients with solid tumors and molecular residual disease.
- Conditions
- Muscle-Invasive Bladder Carcinoma, Gastroesophageal Adenocarcinoma, Melanoma, Non-small Cell Lung Cancer
- Trial name
- NCT06529822
- Testing
- Synthetic long peptide personalized cancer vaccine, Poly ICLC, Signatera or Altera testing
- Where
- 3 sites in United States
- Volunteers
- 64 people
- Sponsor
- Washington University School of Medicine
B-cell Lymphoma
A Phase 2 Trial of Glofitamab for Minimal Residual Disease in Patients With Large B-cell Lymphoma
The goal of this clinical research study is to learn if glofitamab can help to prevent recurrence of LBCL in patients who have achieved CR after standard first-line therapy but have tested positive for MRD.
- Trial name
- NCT06670105
- Testing
- Glofitamab
- Where
- United States
- Sponsor
- M.D. Anderson Cancer Center
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