Clinical trials: Residual Disease
Deep Vein Thrombosis of Lower Limb, Lower Extremity Deep Venous Thrombosis Recurrent
Optimal Duration of Anticoagulation in Deep Venous Thrombosis
Prospective cohort study aimed at optimizing the duration of anticoagulant treatment in patients at their first episode of proximal deep venous thrombosis (DVT) of the lower extremities, whose pathogenesis is either unknown…
- Trial name
- MORGAGNI (NCT01285661)
- Testing
- Sodium warfarin
- Where
- Italy
- Volunteers
- 584 people
- Sponsor
- University of Padova
Breast Cancer, Non Small Cell Lung Cancer
Minimal Residual Disease in Solid Malignancies
The IMRD study is a single-centre, prospective observational study which will investigate the rate of ctDNA (circulating tumor DNA) detection from the start of adjuvant therapy following curative-intent surgery.
- Conditions
- Breast Cancer, Non Small Cell Lung Cancer, Prostate Cancer, High Grade Serous Ovarian Cancer
- Trial name
- IMRD (NCT07268469)
- Testing
- ctDNA detection
- Volunteers
- 840 people
- Sponsor
- European Institute of Oncology
Multiple Myeloma
Multiple Myeloma Minimal Residual Disease
Three methods including flow cytometry, next generation sequencing and determination of circulating tumor cells will be performed at different time points in patients with previously undiagnosed multiple myeloma in order to…
- Trial name
- MMRD (NCT02627261)
- Testing
- blood samples and bone marrow aspirates will be collected
- Where
- 3 sites in France
- Volunteers
- 48 people
- Sponsor
- Hospices Civils de Lyon
Periodontal Pocket
Effects of Polynucleotides and Hyaluronic Acid Based Subgingival Periodontal Pockets Re-instrumentation
The purpose of this randomized controlled clinical trial (RCT) was to investigate the clinical and biochemical efficacy of a gel containing PDRN and HA used in association with subgingival re-instrumentation in the treatment of…
- Trial name
- NCT05210686
- Testing
- subgingival re-instrumentation
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Residual Gastric Contents, Pulmonary Aspiration of Gastric Contents
Effect of Fasting Recommendations Among Patients Using GLP-1 Receptor Agonists
The aim of this randomised controlled trial is to determine the effect of a 24-hour clear liquid diet compared to standard fasting guidelines on the proportion of participants who present with increased residual gastric contents…
- Trial name
- NCT06839248
- Testing
- 24-hour clear liquid diet, Standard fasting guidelines
- Where
- 2 sites in Australia
- Volunteers
- 154 people
- Sponsor
- St Vincent's Hospital Melbourne
Acute Lymphoblastic Leukemia ALL
Study of Cell-free DNA in Children and Adolescents With Acute Lymphoblastic Leukemia
Minimal residual disease (MRD) monitoring is a key prognostic factor in pediatric acute lymphoblastic leukemia (ALL). Currently, MRD assessment relies mainly on cellular DNA obtained from bone marrow aspirates.
- Trial name
- CIRCALL (NCT07483476)
- Testing
- Biological sample collection
- Where
- 2 sites in France
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ovarian Cancer
Phase II Investigation of Pembrolizumab in Combination With Bevacizumab and Oral Cyclophosphamide in Patients With High Grade Ovarian Cancer and Surgically Documented Minimal Residual Disease After Frontline Therapy
To find out if combining pembrolizumab, bevacizumab (or an equivalent biosimilar drug), and low-dose cyclophosphamide can help control high-grade ovarian cancer that has MRD after treatment.
- Trial name
- NCT06083844
- Testing
- Pembrolizumab, Bevacizumab, Cyclophosphamide
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- M.D. Anderson Cancer Center
Non Small Cell Lung Cancer
Local Radiotherapy for Residual Tumor Lesions During the First-line Treatment
This study aimed to confirmed that local radiotherapy for residual lesions can significantly prolong the efficacy of chemotherapy combined with immunotherapy in the initial treatment of advanced non-small cell lung cancer.
- Trial name
- NCT05205226
- Where
- China
- Volunteers
- 636 people
- Sponsor
- Hunan Province Tumor Hospital
Colorectal Cancer, Colon Cancer
DAILY: Vitamin D, Aspirin, ExercIse, Low Saturated Fat Foods StudY in Colorectal Cancer Patients With Minimal Residual Disease
To learn if lifestyle changes (such as diet and exercise) combined with daily aspirin and vitamin D can affect the likelihood of advanced colorectal cancer coming back (recurring)
- Trial name
- NCT05036109
- Testing
- Aspirin, Vitamin D, Diet
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer
A PoC Study to Evaluate Treatments' Efficacy by Monitoring MRD Using ctDNA in HR-positive/HER2-negative EBC Population
This trial is a multicenter, open-label, non-comparative, phase II, biomarker-driven adjuvant treatment study involving the periodic collection and analysis of blood samples from patients with HR-positive/HER2-negative…
- Trial name
- MiRaDoR (NCT05708235)
- Testing
- Giredestrant, Abemaciclib, Inavolisib
- Where
- 41 sites in Spain, United Kingdom
- Volunteers
- 976 people
- Sponsor
- MedSIR
Major Depressive Disorder
Music Therapy for Major Depressive Disorder Residual Symptoms
Residual Symptoms of Depression (SRD) are those symptoms that persist despite remission of MDD. They are characterized by a high incidence (approx.
- Trial name
- MTMDDRS (NCT02925325)
- Testing
- Music therapy, Usual Treatment
- Where
- Mexico
- Volunteers
- 48 people
- Sponsor
- Instituto Nacional de Psiquiatría Dr. Ramón de la Fuente
Myelodysplastic Syndromes
Pre-emptive Therapy With DEC-C to Improve Outcomes in MDS Patients With Measurable Residual Disease Post Allogeneic Hematopoietic Cell Transplant
The investigators hypothesize that early measurable residual disease (MRD)-guided pre-emptive therapy with decitabine + cedazaridine (DEC-C) will decrease the risk of progression in post-transplant myelodysplastic syndromes (MDS)…
- Trial name
- NCT04742634
- Testing
- DEC-C, MyeloSeq-HD
- Where
- United States
- Volunteers
- 209 people
- Sponsor
- Washington University School of Medicine
Anticoagulants and Bleeding Disorders, Surgery
Residual Anti-Xa Activity After Last Treatment Dose of Enoxaparin
The main objective of this study is to determine the time interval following the last treatment dose of enoxaparin at which the amount of anti-Xa level activity is reliably less than 0.2 international unit per milliliter (IU/mL)…
- Conditions
- Anticoagulants and Bleeding Disorders, Surgery, Regional Anesthesia Morbidity
- Trial name
- NCT03296033
- Testing
- Enoxaparin
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- Wake Forest University Health Sciences
Paranoid Schizophrenia
MK0249 for the Treatment of Cognitive Impairment in Patients With Schizophrenia (0249-016)
The purpose of this study is to determine the safety and effectiveness of an investigational drug MK0249 for the treatment of the cognitive impairment in patients with schizophrenia.
- Trial name
- NCT00506077
- Testing
- MK0249
- Volunteers
- 55 people
- Sponsor
- Merck Sharp & Dohme LLC
Deep Vein Thrombosis
Absence of Residual Vein Thrombosis Permits to Withdrawn Oral Anticoagulants
Background. The optimal duration of oral anticoagulant treatment in patients with idiopathic Deep Vein Thrombosis (DVT)of the lower limbs is still uncertain.
- Trial name
- Exten-DACUS (NCT00623987)
- Testing
- warfarin accordingly INR value
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Azienda Ospedaliera Universitaria Policlinico
Limb Pain, Phantom, Residual Limbs Pain
Pain and Disability Outcomes in Post Amputation Patients
The objective of this study is to evaluate efficacy of varied medical and procedural therapies used to treat pain after surgical amputation of a limb.
- Conditions
- Limb Pain, Phantom, Residual Limbs Pain, Disability Physical
- Trial name
- NCT05716321
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Milton S. Hershey Medical Center
Triple Negative Breast Cancer (TNBC), Early Setting, Early Stage Triple-Negative Breast Carcinoma
Pembrolizumab Adjuvant in Patients With Early-stage Triple Negative Breast Cancer With Residual Disease After Neoadjuvant Pembrolizumab Plus Chemotherapy
The phase III, multicenter, pragmatic PLANET trial aims to evaluate the benefit and safety of pembrolizumab as an addition to standard of care adjuvant treatment (capecitabine or olaparib) in triple negative breast cancer (TNBC)…
- Conditions
- Triple Negative Breast Cancer (TNBC), Early Setting, Early Stage Triple-Negative Breast Carcinoma, Triple -Negative Breast Cancer, Breast Cancer Stage II
- Trial name
- PLANET (NCT07486687)
- Testing
- Standard of care plus pembrolizumab, Standard of care (capecitabine or olaparib)
- Volunteers
- 1,000 people
- Sponsor
- The Netherlands Cancer Institute
Paroxysmal Nocturnal Hemoglobinuria
Study of Safety and Efficacy of MY008211A in Patients With Residual Anemia Despite Anti-C5 Antibody Treatment
The main purpose of this study is to evaluate the efficacy of MY008211A in PNH patients with residual anemia despite treatment with anti-C5 antibody.
- Trial name
- NCT06932471
- Testing
- MY008211A tablets
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Wuhan Createrna Science and Technology Co., Ltd
Aggressive B-cell Lymphomas
Proof of Concept for Real-time Multicentric Monitoring of MRD by PET and ctDNA in Aggressive B-Cell Lymphomas
RT4 (REAL TIME TAILORED THERAPY) study was designed as a national, multicenter proof of concept aiming to demonstrate the technical and operational capacity of the French Connect network and the Positron Emission Tomography (PET)…
- Trial name
- RT4 (NCT07514715)
- Testing
- blood test
- Where
- 30 sites in France
- Volunteers
- 129 people
- Sponsor
- The Lymphoma Academic Research Organisation
Morbid Obesity, Bariatric Surgery Candidate
EPO2-PV: Evaluation of Pre-Oxygenation Conditions in Morbidly Obese Volunteer: Effect of Position and Ventilation Mode
The risk of complications associated with airway management in obese patients is significant. The results of pre-oxygenation allow a prolonged non-hypoxic apnea time for the clinician.
- Trial name
- EPO2-PV (NCT02121808)
- Testing
- NIPPV, Tidal volume
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Laval University
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