Clinical trials: Resistance
Cardiovascular Disease
Clinical Study to Assess High-DHA Fish Oil on Biomarkers of Cardiovascular Disease Risk in Adults on Statin Therapy
The objective of this study is to determine the acute and chronic [4-week] effects of a high-DHA fish oil supplement on fasting and post-prandial (post-meal) biomarkers of cardiovascular disease risk, in adults on Statin therapy.
- Trial name
- NCT01690312
- Testing
- Fish Oil
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- Nutrasource Pharmaceutical and Nutraceutical Services, Inc.
Obesity
Metformin vs Conjugated Linoleic Acid and an Intervention Program With Healthy Habits in Obese Children
The purpose of this clinical trial is to examine the effects of conjugated linoleic acid (CLA) vs metformin along with an intervention program with healthy habits on body composition, weight, M value in CLAMP and clinical…
- Trial name
- NCT02063802
- Testing
- metformin, Conjugated Linoleic Acid, Healthy habits program
- Where
- Mexico
- Volunteers
- 120 people
- Sponsor
- Laboratorios Silanes S.A. de C.V.
Prostate Cancer
Study of Capivasertib + Docetaxel vs Placebo + Docetaxel as Treatment for Metastatic Castration Resistant Prostate Cancer (mCRPC)
This study will assess the efficacy and safety of capivasertib plus docetaxel versus placebo plus docetaxel in participants with metastatic castration resistant prostate cancer (mCRPC), all participants will receive the docetaxel…
- Trial name
- CAPItello280 (NCT05348577)
- Testing
- capivasertib, docetaxel
- Where
- 217 sites in United States, Australia and 20 more
- Volunteers
- 1,035 people
- Sponsor
- AstraZeneca
Peripheral Arterial Disease
Blood Flow Restricted Resistance Training in Peripheral Arterial Disease
A randomised controlled trial evaluating the feasibility and acceptability of a 12 week lower body blood flow restricted resistance exercise programme for people with peripheral arterial disease.
- Trial name
- NCT04890275
- Testing
- Blood flow restricted resistance exercise (BFR), Resistance exercise without blood flow restricted (NON-BFR)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Sheffield Hallam University
Ovarian, Primary Peritoneal
Study of IBI354 Versus Investigator's Choice of Chemotherapy in Patients With Platinum-resistant Ovarian, Primary Peritoneal, or Fallopian Tube Cancer
This is a multiregional, multicenter, randomized, open-label, phase III study to compare the efficacy, safety, and tolerability of IBI354 monotherapy with investigator's choice of chemotherapy (paclitaxel, gemcitabine, liposomal…
- Conditions
- Ovarian, Primary Peritoneal, Fallopian Tube Cancer
- Trial name
- NCT06834672
- Testing
- IBI354, paclitaxel/Gemcitabine/Liposomal doxorubicin
- Where
- China
- Volunteers
- 450 people
- Sponsor
- Innovent Biologics (Suzhou) Co. Ltd.
Non Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma
Study of NEO-201 in Solid Tumors Expansion Cohorts
The open label, first-in-human, phase 1, dose escalation component in refractory solid tumors has been completed. The Maximum Tolerated Dose and Recommended Phase 2 Dose (RP2D) was determined to be 1.5mg/kg.
- Conditions
- Non Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma, Cervical Cancer, Uterine Cancer
- Trial name
- NCT03476681
- Testing
- NEO-201 in combination with pembrolizumab
- Where
- 2 sites in United States
- Volunteers
- 121 people
- Sponsor
- Precision Biologics, Inc
Insulin Sensitivity
"Effect of Central Insulin Administration on Whole-body Insulin Sensitivity in Women"
The human brain is an insulin sensitive organ. Brain insulin action modulates peripheral insulin sensitivity in young lean men. As a underlying mechanism, the investigators previously detected suppression of endogenous glucose…
- Trial name
- NCT03929419
- Testing
- intranasal insulin
- Where
- Germany
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Weight Loss, Obesity
Weight Loss Using a Feedback Device in Obese People With the Metabolic Syndrome
The purpose of this study is to determine if a weight loss app (VA MOVE!® Coach App) along with regularly scheduled telephone counseling, will motivate obese people with metabolic syndrome to lose weight and improve the symptoms…
- Conditions
- Weight Loss, Obesity, Pre-Diabetes, Metabolic Syndrome
- Trial name
- NCT03491930
- Testing
- VA MOVE! Coach app, Telephone Coaching, Standard of Care for weight loss.
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rockefeller University
HIV-1-infection
The Effect of Biktarvy (B/F/TAF) on Whole-body Insulin Sensitivity, Lipid and Endocrine Profile in Healthy Volunteers
This study will investigate changes in insulin sensitivity, lipid metabolism and endocrine profile in HIV-negative subjects exposed to Biktarvy (B/F/TAF) compared to subject not exposed to B/F/TAF for 28 days.
- Trial name
- NCT04950530
- Testing
- BIKTARVY 50Mg-200Mg-25Mg Tablet
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Prostatic Neoplasms
A Multi-centre 3-arm Randomised Phase II Trial of BIBF 1120 Versus BIBW 2992 Versus Sequential Administration of BIBF 1120 and BIBW 2992 in Patients With Hormone-resistant Prostate Cancer
The primary objective of this trial is to estimate and compare the 12-week progression-free rate of BIBF 1120, BIBW 2992 or sequential administration of BIBF 1120 and BIBW 2992 in patients with HRPC as determined by radiographic…
- Trial name
- NCT00706628
- Testing
- BIBF 1120, BIBW 2992, Sequential BIBF 1120 + BIBW 2992
- Where
- 9 sites in United Kingdom
- Volunteers
- 87 people
- Sponsor
- Boehringer Ingelheim
Liver Diseases, Alcoholic, Fatty Liver
Personalized Transcranial Magnetic Stimulation (TMS) for Metabolic Dysfunction and Alcohol-Related Liver Disease
The goal of this clinical trial is to learn if repetitive Transcranial Magnetic Stimulation (rTMS), a non-invasive brain stimulation technique, works to treat Metabolic dysfunction-associated and alcohol-associated liver disease…
- Conditions
- Liver Diseases, Alcoholic, Fatty Liver, Metabolic Syndrome
- Trial name
- P-TMS MetALD (NCT07399600)
- Testing
- Individually Targeted rTMS, Conventional rTMS
- Where
- China
- Volunteers
- 105 people
- Sponsor
- The Affiliated Hospital of Hangzhou Normal University
Diabete Type 2, Diabetes Complications
Extreme Phenotypes to Identify Susceptibility of Patients Living With Type 2 to Diabetes Related Complications
The goal of this observational study is to learn more about the diverse susceptibility to micro and macrovascular complications in individuals living with Type 2 Diabetes (T2D).
- Trial name
- EXTREME-T2D (NCT07250607)
- Where
- 3 sites in Italy
- Volunteers
- 1,000 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Schizophrenia, Schizo Affective Disorder
Acetazolamide for Treatment Resistant Schizophrenia
This is a double blind adjunctive randomized controlled trial for schizophrenia using acetazolamide.
- Trial name
- APTS (NCT04887792)
- Testing
- Acetazolamide
- Where
- 2 sites in United States, India
- Volunteers
- 60 people
- Sponsor
- Vishwajit Nimgaonkar, MD PhD
Glycemic Control
Aggressive Versus Moderate Glycemic Control in Diabetic Coronary Bypass Patients
entGlycemic control has been found to improve clinical outcomes following Coronary Bypass Surgery. This study tests the hypothesis that obtaining tighter glycemic control(80-120mg/dl) as opposed to more moderate control…
- Trial name
- NCT00576394
- Testing
- IV Insulin drip, Insulin
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- American Heart Association
Depression
Study Comparing Outcomes for Patients With Treatment Resistant Depression Who Receive VNS Therapy at Different Doses
This is a postmarket medical device study. The objective of this study is to compare the safety and effectiveness of Vagus Nerve Stimulation (VNS) Therapy administered at different amounts of electrical charge for the treatment…
- Trial name
- NCT00305565
- Testing
- VNS Therapy
- Where
- 26 sites in United States
- Volunteers
- 331 people
- Sponsor
- Cyberonics, Inc.
Kidney Cancer
Aminocamptothecin in Treating Patients With Advanced or Recurrent Kidney Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of aminocamptothecin in treating patients with stage III…
- Trial name
- NCT00003551
- Testing
- aminocamptothecin colloidal dispersion
- Where
- 2 sites in United States
- Sponsor
- Emory University
Muscular Atrophy, Insulin Resistance
Human Skeletal Muscle Response to 5 Days of Bedrest in Young Adults
The goal of this intervention trial is to characterize skeletal muscle atrophy in healthy, young adults during short term bedrest.
- Conditions
- Muscular Atrophy, Insulin Resistance, Muscle Protein Synthesis
- Trial name
- FABRIC (NCT07178353)
- Testing
- Bedrest
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Queen's University
Basketball
Comparative Effects of High Intensity and Eccentric Resistance Among School Going Basketball Players
This will be experimental randomized clinical trial conducted in Pakistan sports board, Sacred Heart cathedral high school . Female school going basketball players will be screened for eligibility according to inclusion and…
- Trial name
- NCT07329439
- Testing
- High intensity resistance training, Eccentric resistance training
- Where
- Pakistan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Nutritional and Metabolic Diseases, Metabolic Syndrome
Effect of Moringa Oleifera Dehydrated Leaf Powder on the Components of Metabolic Syndrome in Mexican Adults.
Background: The increase in chronic degenerative diseases caused by Metabolic Syndrome (MS) has prompted the search for natural alternatives to develop new medications and to know the mechanism and dosages for their proper use.
- Trial name
- MOMS (NCT07194577)
- Testing
- Moringa oleifera
- Where
- Mexico
- Volunteers
- 36 people
- Sponsor
- Universidad de Colima
Hyperglycemia, Insulin Sensitivity
Glycemic and Hormone Responses After the Intake of Four Types of Bread.
The purposes of the present study are to determine the glycemic and insulinemic responses, the satiety rate and the postprandial plasma concentrations of free fatty acids, triglycerides and satiety hormones after the ingestion of…
- Trial name
- NCT02653677
- Testing
- intake of the specific kind of bread
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy