Clinical trials: Resistant Arterial Hypertension
Insulin Resistance, Obesity
Pilot Study of GLY-LOW Supplementation in Postmenopausal Women With Obesity
A combination of generally regarded as safe (GRAS) compounds named GLY-LOW, which included: alpha lipoic acid, pyridoxamine, nicotinamide, piperine and thiamine, were examined in pre-clinical experiments.
- Conditions
- Insulin Resistance, Obesity, Cardiovascular Diseases, Cognitive Impairment
- Trial name
- NCT06242535
- Testing
- GLY-LOW
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Hoskinson Health and Wellness Clinic
Treatment-Resistant Hypertension
Lifestyle Interventions in Treatment-Resistant Hypertension
This study will examine the effects of lifestyle intervention on fitness, dietary habits, and body weight in patients with resistant hypertension (RH).
- Trial name
- TRIUMPH (NCT02342808)
- Testing
- Structured center-based lifestyle intervention, Standard education and physician advice
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Duke University
Hypertension
Effects of Sildenafil in Resistant Hypertensives and Genetic Polymorphism
Sildenafil citrate slightly reduces blood pressure in treated hypertensives patients. However, it is unknown if the simultaneous use of sildenafil plus, at least, 3 classes of antihypertensive agents in patients with resistant…
- Trial name
- NCT01392638
- Testing
- sugar pill, sildenafil
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- University of Campinas, Brazil
Apparent Resistant Hypertension, Hypertension
Rapid Management of Resistant Hypertension in the Public Health System (Fast Control)
This is a single-center, open-label, randomized clinical trial conducted at the Instituto Dante Pazzanese de Cardiologia, São Paulo, Brazil.
- Conditions
- Apparent Resistant Hypertension, Hypertension, High Blood Pressure
- Trial name
- FastControl (NCT07259733)
- Testing
- Triple Fixed-Dose Combination (Perindoprile/Indapamide/Amlodipine), Usual Care Antihypertensive Regimen
- Where
- Brazil
- Volunteers
- 142 people
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
Hypertension
Aliskiren Plus HCTZ Compared to Aliskiren in Metabolic Syndrome Patients With Stage 2 Systolic Hypertension
The purpose of the study is to evaluate the blood pressure lowering effect and safety of aliskiren in combination with Hydrochlorothiazide (HCTZ) compared to aliskiren monotherapy when given to metabolic syndrome patients with…
- Trial name
- AIMS (NCT00797316)
- Testing
- Aliskiren, Hydrochlorothiazide
- Where
- United States
- Volunteers
- 532 people
- Sponsor
- Novartis
Hypertension, Hyperlipidemias
Clinical Trials of Two Helichrysum Infusions in Adults
The study evaluates the effects of Helichrysum italicum and Helichrysum Arenarium on different components of the metabolic syndrome.
- Conditions
- Hypertension, Hyperlipidemias, Inflammation, Hyperglycemia
- Trial name
- SMILJ (NCT04866628)
- Testing
- Helichrysum italicum infusion, Helichrysum arenarium
- Where
- Slovenia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Primorska
Obesity, Metabolic Syndrome X
Drug Therapy Induced Weight Loss to Improve Blood Vessel Function in Subjects With Obesity
Obesity is common (>30% of US adults), contributes to substantial morbidity and mortality, but is difficult to treat. Partly this is due to the transient, arduous and modest nature of lifestyle interventions.
- Trial name
- REVIVE (NCT01351753)
- Testing
- Metformin, Orlistat, Topiramate
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- University of Iowa
Resistant Hypertension
Symplicity China Study
The Symplicity China study will evaluate the real-world long-term safety, efficacy, and durability of the Symplicity Spyral system in a population of approximately 500 renal denervation treated subjects with up to 36 months of…
- Trial name
- NCT07081243
- Testing
- Symplicity Spyral Renal Denervation System
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Medtronic Vascular
Hypertension, Metabolic Syndrome
WB-EMS Effects on Cardiometabolic Risk Factors
From the age of 50 onwards, there is a disproportionate decline in muscle strength, mass and function, which can be prevented or at least delayed by physical training.
- Conditions
- Hypertension, Metabolic Syndrome, Hypercholesterolemia, Hypertriglyceridemia
- Trial name
- NCT07406191
- Testing
- WB-EMS, Control
- Where
- 2 sites in Germany
- Volunteers
- 28 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Metabolic Syndrome, Dyslipidemia
Impact of Consumption of Beta-glucans on the Intestinal Microbiota and Glucose and Lipid Metabolism
The purpose of this study is to investigate if daily consumption of barley beta-glucans effect lipid and glucose metabolism and alter intestinal microbiota composition in participants with metabolic syndrome or with high risk for…
- Conditions
- Metabolic Syndrome, Dyslipidemia, Obesity, Abdominal, Hyperglycemia
- Trial name
- NCT02041104
- Testing
- Bread with added beta-glucans
- Where
- 3 sites in Slovenia
- Volunteers
- 51 people
- Sponsor
- Mlinotest Zivilska Industrija d.d.
Hypertension, Metabolic Syndrome
Jiangzhuo Qinggan Prescription and Irbesartan in the Treatment of Essential Hypertension(Hepatogastric Damp-heat)Clinical Study
Jangzhuo Qinggan prescription and irbesartan in the treatment of essential hypertension(Hepatogastric Damp-heat), randomized, parallel-controlled, multi-center clinical study.
- Trial name
- JZQG (NCT01082835)
- Where
- 5 sites in China
- Volunteers
- 240 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Obstructive Sleep Apnea
Effect of CPAP on Biomarkers in Patients With OSA
CPAP, the standard treatment for Obstructive sleep apnea syndrome (OSAS) that reduces sleep fragmentations and neurocognitive deficit in OSAS may also have a key role in reduction of cardiovascular, mortality risks in the same…
- Trial name
- CPAP (NCT01138865)
- Testing
- AutoSet Spirit--Wash--Modified-AutoSet Spirit, Modified-AutoSet Spirit--Wash-AutoSet Spirit
- Where
- India
- Volunteers
- 100 people
- Sponsor
- All India Institute of Medical Sciences
Hypertension
Essential Oil of Eucalyptus Effect on Cardiovascular Responses
The essential eucalyptus oil has therapeutic potential in the cardiovascular system, with possibilities of acting on the autonomic tonus and reduction of cardiovascular overload.
- Trial name
- NCT02656004
- Testing
- Essential Eucalyptus Oil, Control Session
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do vale do São Francisco
Nutrition Disorders, Hypertension
Assessment of Progranulin and FAM19A5 Protein Blood Levels in Metabolic Syndrome
The main objective of the study is to assess the serum levels of progranulin and FAM19A5 protein in adults with metabolic syndrome.
- Conditions
- Nutrition Disorders, Hypertension, Dyslipidemias, Glucose Intolerance
- Trial name
- PROG-FAM (NCT04451616)
- Testing
- Blood sample collection, Hair sample collection, Urine sample collection
- Where
- Poland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Poznan University of Medical Sciences
Diabetes, Hypertension
Renal and Hormonal Effects of Pioglitazone
This study examines the effects of pioglitazone on renal sodium handling in subjects prone to insulin resistance, i.e. diabetic and/or hypertensive subjects.
- Trial name
- NCT01090752
- Testing
- Pioglitazone, Metformin
- Where
- Switzerland
- Volunteers
- 16 people
- Sponsor
- University Hospital, Geneva
Obesity, Hypertension
A Randomized Clinical Trial To Study Losartan On Endothelial Dysfunction and Insulin Resistance In Obese Patients
The main purposes of this study are to find out if the study drug losartan (Cozaar) or placebo ("sugar pill") has an effect on insulin sensitivity (how your body responds to insulin) and to measure the effect of the study drug…
- Conditions
- Obesity, Hypertension, Hyperglycemia
- Trial name
- NCT00675987
- Testing
- losartan
- Where
- 9 sites in United States
- Volunteers
- 53 people
- Sponsor
- Brigham and Women's Hospital
Coronary Microvascular Dysfunction, Resistant Hypertension
Impact of Renal Denervation in Patients With Coronary Microvascular Dysfunction: Study Design and Rationale
Long-standing hypertension may cause an impairment in microvascular coronary circulation which is involved in many different cardiac conditions.
- Conditions
- Coronary Microvascular Dysfunction, Resistant Hypertension, Hypertensive Heart Disease
- Trial name
- IMPRESSION (NCT05994729)
- Testing
- Invasive Physiological Assessment of Coronary Circulation
- Volunteers
- 87 people
- Sponsor
- Aurelia Hospital
Hypertension
Efficacy and Safety of Lorundrostat in Subjects With Uncontrolled and Resistant Hypertension
This is a Phase 3 trial to evaluate the BP-lowering effect of lorundrostat (an aldosterone synthase inhibitor) in subjects with uncontrolled and resistant hypertension taking between 2 and 5 anti-hypertensive (AHT) medications.
- Trial name
- NCT06153693
- Testing
- lorundrostat Dose 1, lorundrostat Dose 2
- Where
- 184 sites in United States, Australia and 11 more
- Volunteers
- 1,083 people
- Sponsor
- Mineralys Therapeutics Inc.
Hypertension, Hyperglycemia
Targeting Metabolic Syndrome From the Emergency Department Through Mixed-Methods: Pilot Trial
The objective of this study is to pilot a multifaceted, optimized intervention for metabolic syndrome (MetS) in emergency department patients to establish feasibility.
- Conditions
- Hypertension, Hyperglycemia, Dyslipidemia, Metabolic Syndrome
- Trial name
- METS (NCT07119658)
- Testing
- Composite intervention to address MetS
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Indiana University
Hypertension, Resistant to Conventional Therapy
The Diagnosis and Treatment of Resistant Hypertension, the Prevalence and the Prognosis
Hypertension is still one of the major preventable risk factor for cardiovascular as well as cerebrovascular diseases globally, including ischaemic heart disease, heart failure, and renal impairment.
- Trial name
- doublepres (NCT01703780)
- Where
- 18 sites in China
- Volunteers
- 9,638 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital