Clinical trials: Resistant Hypertension
Hypertension, Resistant to Conventional Therapy, Renal Denervation
Renal Denervation in Hypertension
The DENER-HTN study is a, multicenter, prospective, open, randomized, controlled study of the effectiveness and costs of renal denervation in addition to standardized medical treatment compared to medical treatment alone in…
- Trial name
- DENER-HTN (NCT01570777)
- Testing
- renal denervation and optimized medication regimen, optimized medication regimen
- Where
- France
- Volunteers
- 121 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypertension, Metabolic Syndrome X
Clinical EvaluatioN of TElmisartan-based Antihypertensive Regimen
To determine the efficacy and safety of telmisartan-based treatment among patients with metabolic syndrome in actual setting in Philippines.
- Trial name
- NCT00613314
- Where
- 122 sites in Philippines
- Volunteers
- 15,268 people
- Sponsor
- Boehringer Ingelheim
Hypertension, Concurrent Obesity
Evaluation of the Metabolic Effects of LCZ696 and Amlodipine in Obese Hypertensive Subjects
This study investigated the effects of LCZ696 on insulin sensitivity, lipolysis, and oxidative metabolism in obese hypertensive subjects.
- Trial name
- NCT01631864
- Testing
- LCZ696, amlodipine
- Where
- 3 sites in Germany, Netherlands
- Volunteers
- 98 people
- Sponsor
- Novartis Pharmaceuticals
Metabolic Syndrome
Healthy Oils for Women (HOW Study)
The purpose of this study is to understand the role of a dietary oil to alter chronic disease risk factors in women who are at risk for heart disease and/or diabetes.
- Trial name
- HOW (NCT02063165)
- Testing
- High Linoleic Safflower Oil
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Ohio State University
Treatment Resistant Hypertension
Protocol for a Multicentre Survey of Patients With Treatment Resistant Hypertension
Project aims to determine the number of individuals with treatment resistant hypertension and to define the characteristics of these patients and estimate disease frequency.
- Trial name
- SPIRIT (NCT03078244)
- Testing
- N/A, observational study
- Volunteers
- 1,500 people
- Sponsor
- Emerald Clinical Inc.
Cardiovascular Diseases, Heart Diseases
Lipoprotein Metabolism in Hypertensive African-Americans
To study relationships among lipoprotein metabolism, hypertension, and hyperinsulinemia-insulin resistance in African American males and females.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hyperinsulinism, Hypertension
- Trial name
- NCT00005709
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Insulin Resistance, Obesity
Developing an Adaptive Lifestyle Intervention Program in Family Medicine Clinics
The purpose of this study is to investigate the feasibility of conducting a multicomponent lifestyle intervention research study within the UAB Family Medicine Clinic at Highlands and to obtain preliminary data on the…
- Conditions
- Insulin Resistance, Obesity, Diabetes, Hypertension
- Trial name
- NCT04392284
- Testing
- Diet Counseling, Exercise Counseling
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Alabama at Birmingham
Diabetes Mellitus, Type 2, Hypertension
The Effect of Progressive Resistance Exercise Training (PRET) on CVRF in Adults With ID.
Thanks to improved healthcare, the life expectancy of people with ID is increasing and is approaching that of the general population.
- Conditions
- Diabetes Mellitus, Type 2, Hypertension, Hypercholesterolemia, Obesity
- Trial name
- PRET (NCT06579898)
- Testing
- Progressive resistance exercise training
- Where
- 3 sites in Netherlands
- Volunteers
- 36 people
- Sponsor
- Erasmus Medical Center
Resistant Hypertension
JX09 SAD/MAD in Healthy Participants
This is a phase 1, randomized, double-blind, placebo-controlled, multi-part, single and multiple ascending dose study in healthy adult to test the safety, tolerability, pharmacokinetics, pharmacodynamics, and food effect of JX09…
- Trial name
- NCT06183671
- Testing
- JX09
- Where
- Australia
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Ji Xing Pharmaceuticals Australia Pty Ltd
Resistant Hypertension, Obstructive Sleep Apnea
Effect of Continuous Positive Airway Pressure (CPAP) Versus Auto-titrating Continuous Positive Airway Pressure (APAP) on Resistant Hypertension (HTN) and Arterial Stiffness
The primary objective is to evaluate the relative effectiveness of fixed CPAP in comparison to APAP in reducing arterial blood pressure in patients with resistant hypertension and obstructive sleep apnea (OSA).
- Trial name
- NCT01044355
- Testing
- CPAP, APAP
- Where
- 2 sites in Canada
- Volunteers
- 34 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Group 2 Pulmonary Hypertension, CpcPH
Phosphodiesterase Type 5 Inhibitors in Patients With Group 2 Pulmonary Hypertension
The goal of this clinical trial is to test the efficacy of tadalafil in patients with group II pulmonary hypertension with CpcPH with elevated pulmonary vascular resistance (PVR equals or more than 4 WU).
- Trial name
- NCT06350773
- Testing
- tadalafil 20 mg then 40 mg if tolerated
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Beni-Suef University
Resistant Hypertension
The Effect of BATon BP and Sympathetic Function in Resistant Hypertension (The Nordic BAT Study)
Resistant hypertension (RH) affects some 10% to 15% of all patients with hypertension. These patients are at a clearly increased risk for end organ damage and mortality.
- Trial name
- BAT (NCT02572024)
- Testing
- BAT
- Where
- 5 sites in Denmark, Finland and 2 more
- Volunteers
- 100 people
- Sponsor
- Helsinki University Central Hospital
Hypertension
Sham Controlled Clinical Trial of Renal Denervation in Patients With Resistant Hypertension
The purpose of this study is to assess the efficacy of catheter-based renal denervation in reducing blood pressure in patients with resistant hypertension compared to a sham procedure.
- Trial name
- NCT02444442
- Testing
- Renal Denervation
- Where
- Australia
- Volunteers
- 105 people
- Sponsor
- Baker Heart and Diabetes Institute
Uncontrolled or Resistant Hypertension
A Trial of HRS-1780 in Participants With Uncontrolled Hypertension or Resistant Hypertension.
The study is being conducted to evaluate the efficacy and safety of HRS-1780 in participants with uncontrolled hypertension or resistant hypertension.
- Trial name
- NCT07708441
- Testing
- HRS-1780 tablet
- Where
- 2 sites in China
- Volunteers
- 914 people
- Sponsor
- Shandong Suncadia Medicine Co., Ltd.
Hypertension, Resistant to Conventional Therapy
Antihypertensive Mechanisms of Minocycline in Resistant Hypertension
The goal of this clinical trial is to learn about the mechanisms by which minocycline effect blood pressure in individuals with treatment-resistant hypertension.
- Trial name
- NCT06246396
- Testing
- Minocycline Hydrochloride
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Florida
Metabolic Syndrome, Insulin Resistance
Continuous Tart Cherry Juice Supplementation With Metabolic Syndrome Participants
The present study examined the effect of Montmorency tart cherry juice on functional and blood-based cardio-metabolic markers in humans with Metabolic Syndrome.
- Conditions
- Metabolic Syndrome, Insulin Resistance, Hypertension
- Trial name
- NCT03619941
- Testing
- Montmorency Tart Cherry Juice
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Hertfordshire
Hypertension, Metabolic Syndrome
Effect of Valsartan on Lipid Subfractions in Hypertensive Patients With Metabolic Syndrome
The purpose of this study is to evaluate potential effects of valsartan on lipid subfractions and other parameters in lipid metabolism in patients with essential hypertension and metabolic syndrome.
- Trial name
- NCT00394745
- Testing
- Valsartan
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 45 people
- Sponsor
- Novartis
Uncontrolled Hypertension
EuroNetrod HTN OFF-Med Study of Renal Denervation With NetrodTM Six-electrode Radiofrequency RDN System
This randomized controlled investigation aims to evaluate the efficacy and safety of the Netrod™ RDN system in patients with uncontrolled primary hypertension in the absence of antihypertensive medication, comparing the outcomes…
- Trial name
- EuroNetrod (NCT06722651)
- Testing
- Netrod™ six-electrode radiofrequency renal denervation system
- Where
- Switzerland
- Sponsor
- Shanghai Golden Leaf MedTec Co. Ltd
Hypertension
The Effect of Nebivolol on Insulin Sensitivity
The purpose of this study is to conduct a randomised trial to compare the insulin sensitivity, 24 hour blood pressure profile, and tolerability of nebivolol plus a thiazide-like diuretic versus atenolol plus a thiazide-like…
- Trial name
- NCT00125853
- Testing
- Nebivolol, Atenolol
- Where
- United Kingdom
- Volunteers
- 54 people
- Sponsor
- Imperial College London
Primary Hypertension, Secondary Hypertension
HaemoDYNAMICs in Primary and Secondary Hypertension
The primary aim of the present study was to examine the haemodynamic changes in primary hypertension and secondary hypertension (renal diseases, endocrine diseases, obesity-associated hypertension) with a non-invasive…
- Conditions
- Primary Hypertension, Secondary Hypertension, Aortic Stenosis, Renal Insufficiency
- Trial name
- DYNAMIC (NCT01742702)
- Testing
- Nitroglycerin 0.25 mg (single dose, no longer given since January 2017), Salbutamol 400 µg (single dose, no longer given since January 2017), L-arginine (10 min infusion, no longer given since January 2017)
- Where
- 2 sites in Finland
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Tampere University