Clinical trials: Resistant to Conventional Therapy
Hodgkin Lymphoma
Addition of Chidamide to the Combination Treatment of Decitabine Plus Camrelizumab in Combination Treatment Resistant/Relapsed Patients With Classical Hodgkin Lymphoma
This is a Phase II clinical trial for Decitabine plus Camrelizumab resistant/relapsed patients with Hodgkin Lymphoma. The purpose is to evaluate the efficacy and safety of the combination therapy of Chidamide plus Decitabine Plus…
- Trial name
- NCT04233294
- Testing
- Chidamide, Camrelizumab, Decitabine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chinese PLA General Hospital
Lupus Nephritis
Comparison of the Efficacy of Two Rituximab Treatment Regimens in Patients With Lupus Nephropathy
Comparison of the Efficacy of Two Rituximab Treatment Regimens in Patients With Lupus Nephropathy Resistant to Conventional Treatments
- Trial name
- RITULUP (NCT01765842)
- Testing
- Rituximab
- Where
- 3 sites in Spain
- Volunteers
- 9 people
- Sponsor
- Fundación Pública Andaluza Progreso y Salud
Hypertension, Resistant to Conventional Therapy
MANP in African Americans With Hypertension
Evaluate the cardiovascular properties of MANP in AA with Hypertension
- Trial name
- MANP-2 (NCT04542681)
- Testing
- MANP - 1st Cycle, MANP - 2nd Cycle
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mayo Clinic
Hypertension, Resistant to Conventional Therapy
Baroloop Multicenter Trial (Baroloop MCT)
The goal of this clinical trial is to learn weather the baroloop system is safe and works to treat hypertension in adults that do not respond sufficiently to medication.
- Trial name
- NCT06518915
- Testing
- baroloop system
- Where
- 4 sites in Germany, Netherlands
- Volunteers
- 3 people
- Sponsor
- neuroloop GmbH
Metastatic Cancer, Newcastle Disease Virus (NDV)
Newcastle Disease Virus (NDV) for Cancer Patients Resistant to Conventional Anti-cancer Modalities
NDV is a virus tht is harmful in chicken, but harmless in man. There are 2 major sub-strains of NDV, one oncolytic and one non-oncolytic.
- Trial name
- NCT00348842
- Testing
- Newcastle Virus
- Where
- Israel
- Sponsor
- Hadassah Medical Organization
Hypertension, Resistant to Conventional Therapy
Addition of Homeopathy in Patients With Resistant Arterial Hypertension
Resistant hypertension (RHTN) is a common clinical problem faced by both primary care clinicians and specialists worldwide. Patients with RHTN have higher rates of cardiovascular events and mortality compared with patients with…
- Trial name
- NCT02124473
- Testing
- Homeopathy
- Where
- 2 sites in India
- Volunteers
- 79 people
- Sponsor
- Macmillan Research Group UK
Depressive Disorder, Treatment-Resistant
Effects of a Classic High-frequency rTMS Treatment Versus a Deep rTMS Treatment
The main objective is to demonstrate that dTMS is more efficient than high frequency rTMS with a conventional coil. The patient will receive treatment arm A or B : Arm A : classic rTMS treatment (use of the 8-shaped coil) and…
- Trial name
- HAUVERDEEP (NCT04956016)
- Testing
- classic rTMS using the 8-shaped coil, deep rTMS using the H1-shaped coil
- Where
- France
- Volunteers
- 152 people
- Sponsor
- Centre Hospitalier Henri Laborit
Diabetes Mellitus, Type 1
Safety and Efficacy of Artificial Pancreas With and Without a Meal Detection Module on Glycemic Control in Adolescents With Type 1 Diabetes After a Missed Bolus
Despite current treatments for type 1 diabetes, maintaining blood glucose levels within a good range is a difficult task. A primary source for poor glucose control in adolescents is skipping insulin boluses at mealtimes.
- Trial name
- NCT02909829
- Testing
- Closed Loop Delivery, Closed Loop Delivery with Meal Detection Module, Conventional Pump Therapy
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- McGill University
Hypertension, Resistant to Conventional Therapy
Continued Safety and Performance of the TIVUS System
The TIVUS II is a prospective, multicenter, non-randomized, open-label clinical study of the safety and performance of the TIVUS™ System consisting of three (3) concurrent cohorts: TIVUS™ Severe Resistant HTN Cohort TIVUS™…
- Trial name
- NCT01835535
- Testing
- TIVUS
- Where
- Australia
- Volunteers
- 80 people
- Sponsor
- Cardiosonic
Hypertension, Resistant to Conventional Therapy, Obstructive Sleep Apnea
CPAP Effect on Blood Pressure and Arterial Stiffness in Obstructive Sleep Apnea Patients With Resistant Hypertension
Resistant hypertension is defined as uncontrolled blood pressure (BP ≥ 140/90mmHg) despite the current use of three or more antihypertensive drugs at full doses, including a diuretic.
- Trial name
- POP-ART (NCT02385864)
- Where
- 4 sites in France
- Volunteers
- 166 people
- Sponsor
- University Hospital, Grenoble
Insulin Resistance, Prediabetic State
Impact of Digital Therapeutic on Metabolic Parameters
The purpose of this prospective randomized controlled study is to evaluate the impact of a six-month digitally administered behavioral change program on body weight, glycemic control and other metabolic parameters in obese adults…
- Conditions
- Insulin Resistance, Prediabetic State, Diabetes Mellitus, Type 2, Obesity
- Trial name
- NCT04573296
- Testing
- Vitadio, Conventional high-intensity lifestyle intervention program
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- Vitadio s.r.o.
Systemic Arterial Hypertension, Hypertension Resistant to Conventional Therapy
Renin-angiotensin-aldosterone System Polymorphisms in Resistant Hypertension and Adverse Cardiovascular Events
Renin-angiotensin-aldosterone system (RAAS) polymorphisms influence 24h arterial pressure fluctuation. Resistant systemic arterial hypertension (RSAH) has an increased risk of end organ damage and unfavourable prognosis, whereas…
- Conditions
- Systemic Arterial Hypertension, Hypertension Resistant to Conventional Therapy, Myocardial Infarction, Stroke
- Trial name
- GENHART (NCT01173029)
- Testing
- Anti-hypertensive drug treatment
- Where
- Brazil
- Volunteers
- 92 people
- Sponsor
- Universidade Gama Filho
Hypertension, Resistant to Conventional Therapy, Sleep Apnea
Physical Activity Program for Reducing Blood Pressure in Sleep Apnea Patients With Resistant Hypertension
Investigators hypothesize that CPAP treatment for suppressing OSAS in combination with a physical activity program will optimize 24-hour blood pressure control in patients with OSA-related resistant hypertension.
- Trial name
- RAP (NCT02057783)
- Testing
- Physical activity
- Where
- 5 sites in Canada, France and 1 more
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- AGIR à Dom
Hypertension, Resistant to Conventional Therapy
Renal Sympathetic Denervation and Potential Effects on Glucose Metabolism and Cardiovascular Risk-Factors
The Re-Shape CV-Risk Study is a clinical study where renal adrenergic denervation (RDN) is done in high risk patients with treatment-resistant hypertension.
- Trial name
- Re-Shape (NCT01630928)
- Testing
- Renal sympathetic denervation
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- University Hospital of North Norway
Hypertension, Resistant to Conventional Therapy, Diabetes Mellitus
Efficacy of Spironolactone in Cameroonian Diabetic Patients With Resistant Hypertension
This is a four-week randomized controlled single blinded trial of subjects presenting with resistant hypertension in a specialized diabetes care unit of Cameroon.
- Trial name
- SPIRY (NCT02426099)
- Testing
- Low dose spironolactone, Routine intensification of antihypertensive treatment
- Where
- Cameroon
- Volunteers
- 17 people
- Sponsor
- Sobngwi Eugene
Hypertension, Resistant to Conventional Therapy
Renal Denervation in Refractory Hypertension
Open, multicenter, randomized study is enrolling patients in 3 sites in Czech Republic. Patients with refractory hypertension will be randomized in 1:1 manner either to renal denervation plus optimal medical antihypertensive…
- Trial name
- PRAGUE-15 (NCT01560312)
- Testing
- Renal denervation (Symplicity® Catheter System™)
- Where
- 3 sites in Czechia
- Volunteers
- 106 people
- Sponsor
- Charles University, Czech Republic
Hypertension, Resistant to Conventional Therapy
Autonomic Dysfunction in Resistant Hypertension
The contribution of this study is the unedited evaluation of the circadian autonomic profiles of resistant hypertension with and without white-coat response.
- Trial name
- RH (NCT01833429)
- Where
- Brazil
- Volunteers
- 44 people
- Sponsor
- University of Campinas, Brazil
Hypertension, Resistant to Conventional Therapy, Renal Denervation
Renal Denervation in Hypertension
The DENER-HTN study is a, multicenter, prospective, open, randomized, controlled study of the effectiveness and costs of renal denervation in addition to standardized medical treatment compared to medical treatment alone in…
- Trial name
- DENER-HTN (NCT01570777)
- Testing
- renal denervation and optimized medication regimen, optimized medication regimen
- Where
- France
- Volunteers
- 121 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Multivessel Coronary Artery Disease, Hypertension Resistant to Conventional Therapy
Expand Management of Blood Pressure With Renal Denervation in Patients Undergoing Staged PCI for Advanced Coronary Artery diseasE
EMBRACE is a randomized, controlled, multicenter clinical study evaluating the effect of renal denervation on clinical adverse events in hypertensive patients undergoing staged percutaneous coronary intervention (PCI) for…
- Trial name
- EMBRACE (NCT07602790)
- Testing
- Renal denervation
- Volunteers
- 1,000 people
- Sponsor
- Ceric Sàrl
Baroreflex Failure Syndrome, Hypertension, Resistant to Conventional Therapy
UK Registry for Baroreflex Activation Therapy
This study is a post-marketing open label single arm, single centre clinical trial of electrical carotid sinus stimulation with the Barostim Neo device to target sub-optimally controlled arterial hypertension or highly variable…
- Trial name
- UK-BAT (NCT03730519)
- Testing
- Baroreflex Activation Therapy with Barostim Neo
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- Queen Mary University of London