Clinical trials: Resistant to Conventional Therapy
Hypertension Resistant to Conventional Therapy
Sequential Nephron Blockade vs. Dual Blockade Renin-angiotensin System + Bisoprolol in Resistant Arterial Hypertension
A randomized clinical trial comparing sequential nephron blockage (SNB) with dual blockade of the renin-angiotensin system (RAAS) plus bisoprolol (DBB) in the treatment of resistant arterial hypertension (RH) was designed to…
- Trial name
- ResHypOT (NCT02832973)
- Testing
- Spironolactone, Furosemide,, Amiloride
- Where
- Brazil
- Volunteers
- 72 people
- Sponsor
- Sao Jose do Rio Preto Medical School
Primary Hypertension, Hypertension, Resistant to Conventional Therapy
Causal Inference Research of Resistant Hypertension Treatment With Chinese Approach in a Cohort Study
The research of clinical effectiveness assessment is to explore the causal relationship between treatment and outcome.Accordingly, based on the effectiveness of tan-yu treatment, the research takes the Resistant Hypertension (RH)…
- Trial name
- NCT01904695
- Testing
- Herbs, Antihypertensive drugs
- Where
- China
- Volunteers
- 192 people
- Sponsor
- China Academy of Chinese Medical Sciences
Hypertension, Resistant to Conventional Therapy
Safety and Efficacy Study of Extracorporeal Shockwave Therapy in the Treatment of Patients With Resistant Hypertension
Low intensity shockwaves have been proven in animal and human studies to increase tissue perfusion, promote angiogenesis and tissue regeneration and improve neural function.
- Trial name
- RHT (NCT02042066)
- Testing
- Omnispec model Vascuspec
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Medispec
Hypertension, Resistant to Conventional Therapy
Antihypertensive Mechanisms of Minocycline in Resistant Hypertension
The goal of this clinical trial is to learn about the mechanisms by which minocycline effect blood pressure in individuals with treatment-resistant hypertension.
- Trial name
- NCT06246396
- Testing
- Minocycline Hydrochloride
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Florida
Musculoskeletal Injury, Muscle Weakness
The ADAPTation to Therapeutic Resistance Training (ADAPT) Study
In 2018, the Academic Department of Military Rehabilitation (ADMR) published a pilot randomised controlled trial (RCT), demonstrating the feasibility and acceptability of integrating twice-daily blood flow restriction (BFR)…
- Trial name
- NCT05719922
- Testing
- Resistance Training
- Where
- 6 sites in United Kingdom
- Volunteers
- 150 people
- Sponsor
- Defence Medical Rehabilitation Centre, UK
Hypertensive Disease, Hypertension, Resistant to Conventional Therapy
Medication Adherence and "True" Resistance in Patients With Resistant Hypertension
The purpose of this study is to estimate the proportion of patients with "true" resistance among patients referred to the Medical Outpatient Department of the Charité - Universitätsmedizin Berlin with the diagnosis "resistant…
- Trial name
- NCT02128386
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Charite University, Berlin, Germany
Hypertension, Resistant to Conventional Therapy
Resistant Hypertension and Physical Activity Performed in a Heated Pool
patients with resistant hypertension will be submitted to an exercise protocol in a heated pool for three months
- Trial name
- HAR (NCT01863082)
- Testing
- exercise
- Where
- Brazil
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Hypertension Resistant to Conventional Therapy, Kidney Failure, Chronic
Chemical Renal Ethanol Sympatholysis Under CT Guidance Use for the Control of Therapy-Resistant Hypertension
In this study the investigators are going to assess the feasibility of this innovate technique of renal sympathetic denervation by translumbar access under ct-guidance.
- Trial name
- SCRATCH (NCT02653222)
- Testing
- Renal sympathicolysis, Ambulatory Blood Pressure Monitoring, Magnetic Resonance Angiography
- Where
- 2 sites in France
- Volunteers
- 2 people
- Sponsor
- University Hospital, Grenoble
Arterial Hypertension, Hypertension, Resistant to Conventional Therapy
The Effect of Spironolactone on Blood Pressure in Type-2 Diabetics With Resistant Hypertension
The purpose of this study is to estimate the effect of spironolactone on blood pressure resistant to therapy in type-2 diabetics.
- Conditions
- Arterial Hypertension, Hypertension, Resistant to Conventional Therapy, Diabetes Mellitus
- Trial name
- SDHDS (NCT01062763)
- Testing
- spironolactone
- Volunteers
- 119 people
- Sponsor
- Ib Abildgaard Jacobsen
Type 1 Diabetes
Closed-loop Control of Glucose Levels After Meal Intake in Adults With Type 1 Diabetes
Closed-loop strategy is composed of three components: glucose sensor to read glucose levels, insulin pump to infuse insulin and a dosing mathematical algorithm to decide on the required insulin dosage based on the sensor's…
- Trial name
- NCT01930097
- Testing
- 14 hours intervention
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Type 1 Diabetes
Closed-loop Control of Overnight Glucose Levels in Adults and Adolescents With Type 1 Diabetes
Closed-loop strategy is composed of three components: glucose sensor to read glucose levels, insulin pump to infuse insulin and a dosing mathematical algorithm to decide on the required insulin dosages based on the sensor's…
- Trial name
- NCT01905020
- Testing
- Carbohydrate-rich meal, Exercise
- Where
- 3 sites in Canada
- Volunteers
- 28 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Hypertension Resistant to Conventional Therapy, Bradycardia
Moderato System: A Double-Blind Randomized Trial Ver 1.1
The purpose of this double blind randomized study is the evaluation of the safety and efficacy of the Moderato System. The Moderato implantable pulse generator is indicated for patients who have hypertension and also require a…
- Conditions
- Hypertension Resistant to Conventional Therapy, Bradycardia, Atrioventricular Block
- Trial name
- NCT02837445
- Testing
- PHC ON, PHC OFF
- Where
- 12 sites in Austria, Belgium and 5 more
- Volunteers
- 70 people
- Sponsor
- BackBeat Medical Inc
Vascular Disease, Cardiovascular
A Preventive, Multidisciplinary Primary Care Intervention Organized Around a Therapeutic Garden: Acceptability to Patients Suffering from Cardio-neurovascular Pathology and to Those Involved in the Action.
A preventive, multidisciplinary primary care intervention organized around a therapeutic garden: Acceptability to patients suffering from cardio-neurovascular pathology and to those involved in the action.
- Conditions
- Vascular Disease, Cardiovascular, Atrial Fibrillation (AF), Heart Failure NYHA Class II
- Trial name
- ArTERRE (NCT06646601)
- Testing
- Intervention of prevention
- Where
- France
- Volunteers
- 157 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Hypertension, Resistant to Conventional Therapy
The Use of Ambulatory Blood Pressure Monitors to Assess Angiotensin Converting Enzyme Inhibitors
The purpose of this study is to use ambulatory blood pressure monitors to investigate whether enalapril is superior to lisinopril in managing nocturnal hypertension in patients with resistant hypertension currently treated with…
- Trial name
- NCT02623036
- Testing
- Equivalent dose enalapril, Equivalent dose lisinopril
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Memorial Health University Medical Center
Hypertension, Resistant to Conventional Therapy, Atrial Fibrillation
Combined Treatment of Resistant Hypertension and Atrial Fibrillation
The purpose of this study is the comparative evaluation of systolic blood pressure (SBP) lowering, atrial fibrillation (AF) recurrence and clinical data in patients with paroxysmal/persistent AF and resistant hypertension…
- Trial name
- NCT01117025
- Testing
- Circumferential PV isolation, Circumferential PVI+renal denervation
- Where
- 2 sites in United States, Russia
- Volunteers
- 26 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Hypertension, Resistant to Conventional Therapy, Essential Hypertension
Monotherapy Versus Dual Therapy for Initial Treatment for Hypertension
To test whether the current custom of initiating treatment for hypertension with a single drug is less effective in the short-term than initial combination therapy, and results in the eventual need for comparatively more…
- Trial name
- Pathway 1 (NCT00994617)
- Testing
- Losartan and hydrochlorothiazide, Hydrochlorothiazide switched over with Losartan at 8 weeks
- Where
- 13 sites in United Kingdom
- Volunteers
- 600 people
- Sponsor
- University of Cambridge
Rheumatoid Arthritis, Psoriatic Arthritis
Prospective Analysis of Blood Flow Restriction Training in Patients With Rheumatoid Arthritis and Psoriatic Arthritis Compared to Conventional Strength Training
This single-centre, randomized prospective interventional study assesses the effect of blood flow restriction training in patients with rheumatoid arthritis compared with conventional resistance training.
- Trial name
- BFR-RA/PSA (NCT07772687)
- Testing
- Blood Flow Restriction Training (BFRT), Conventional Strength Training
- Where
- Germany
- Volunteers
- 102 people
- Sponsor
- University of Bonn
Advanced Solid Tumor, Metastatic Solid Tumor
A Study to Evaluate the Safety and Therapeutic Activity of GI-102 As a Single Agent and in Combination with Conventional Anti-cancer Drugs, Pembrolizumab or Trastuzumab Deruxtecan(T-DXd) in Patients with Advanced Solid Tumors (KEYNOTE-G08)
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, and therapeutic activity of GI-102 as a single agent and in combination with conventional anti-cancer drugs, pembrolizumab or trastuzumab…
- Conditions
- Advanced Solid Tumor, Metastatic Solid Tumor, Soft Tissue Sarcoma (STS), Platinum-resistant Ovarian Cancer (PROC)
- Trial name
- NCT05824975
- Testing
- GI-102 subcutaneous (SC), GI-102, doxorubicin
- Where
- 11 sites in United States, South Korea
- Volunteers
- 358 people
- Sponsor
- GI Innovation, Inc.
Diabetic Macular Edema
Utility of Intravitreal Methotrexate in Diabetic Macular Edema Resistant to Conventional Therapies
It is well known that blindness is one of the most feared disabilities expressed by patients in the United States. Estimates of the economic impact of visual disability in the current population exceed 30 million US dollars in…
- Trial name
- NCT00779142
- Testing
- Methotrexate intravenous 25mg/ml
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Wake Forest University
Hypertension Resistant To Conventional Therapy, Baroreflex
Effect Baroreflex Activation Therapy on the Carotid Body
Carotid baroreflex activation therapy (BAT) by the Rheos® system produces a sustained fall in blood pressure in patients with resistant hypertension.
- Conditions
- Hypertension Resistant To Conventional Therapy, Baroreflex, Carotid Body
- Trial name
- NCT02210923
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Maastricht University Medical Center