Clinical trials: Resolution
Healthy
A Study of Mirikizumab Solution (LY3074828) in Healthy Participants
The main purpose of this study is to assess the safety and tolerability of mirikizumab (LY3074828) solution formulation administered as a single injection compared with two injections under the skin in healthy participants.
- Trial name
- NCT07446101
- Testing
- Mirikizumab
- Where
- 5 sites in United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Undergoing Esophagogastroduodenoscopy (EGD)
High Resolution Optical Imaging of the Esophagus Using the NvisionVLE™ Imaging System
This is a single center, single arm, open label observational trial of patients undergoing EGD. The primary objective of this clinical trial is to evaluate the ability of physicians to position the NvisionVLE Optical Probe to…
- Trial name
- NCT02031900
- Testing
- NvisionVLE Imaging System: NvisionVLE Imaging Console, NvisionVLE Optical Probe and Inflation Accessory Kit
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- NinePoint Medical
Healthy
Safety, Tolerance, and Pharmacokinetics of Single Rising Oral Doses of BILB 1941 ZW Solution in Healthy Male Subjects, Followed With Bioavailability Comparison of BILB 1941 ZW Tablet and Solution Formulation Administered With or Without Food
The objective of the current study was to investigate the safety, tolerability, and pharmacokinetics of BILB 1941 ZW following the administration of single rising doses from 5 mg to 300 mg.
- Trial name
- NCT02256787
- Testing
- BILB 1941 ZW - single rising dose part, BILB 1941 ZW - solution, BILB 1941 ZW - tablet
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Obesity, Diabetes
Early Diabetes Resolution After Weight Loss Surgery
The primary objective is to compare inflammatory, hormonal, and metabolic changes in the very short term after various bariatric surgical procedures (Roux-en Y Gastric Bypass, Vertical Sleeve Gastrectomy, and Adjustable Gastric…
- Trial name
- NCT00790309
- Testing
- Weight loss surgery, Laparoscopic abdominal surgeries
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Contact Lens, Tear Film Thickness
High-resolution Imaging of Tear Film Thickness in Contact Lenses Wearers With Optical Coherence Tomography (OCT). A Pilot Study
A refractive error is the most common reason for reduced visual acuity. Myopia, hyperopia, astigmatism and presbyopia belong to the four basic refractive errors and, unfortunately, cannot be prevented.
- Trial name
- NCT02713399
- Testing
- Optical Coherence Tomography
- Where
- Austria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Keratoconjunctivitis Sicca
A Dose-Escalation Study to Assess the Safety and Tolerability of LX214 Ophthalmic Solution in Healthy Volunteers, Followed by an Open-Label Evaluation of LX214 in Patients With Keratoconjunctivitis Sicca (KCS)
This is a first-in-man study for the purpose of determining the safety and tolerability of LX214 ophthalmic solution in healthy volunteers and in patients with dry eye syndrome.
- Trial name
- NCT00851734
- Testing
- voclosporin ophthalmic solution
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Lux Biosciences, Inc.
Otitis Media
Long-term Antibiotics for Treatment and Prevention of Otitis Media in Aborignal Children
This clinical trial was conducted in a population where tympanic membrane perforation occurs in 60% infants in the first year of life.
- Trial name
- COMIT1 (NCT00539149)
- Testing
- Amoxycillin
- Where
- Australia
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Menzies School of Health Research
No Disease or Condition is Being Studied, The Aim: to Determine the Impact of a 25-minute Nap on Cognitive Function
The Effect of a Nap Protocol on the Cognitive Abilities of Experienced Teachers
This protocol aims to investigate the effects of a 25-minute nap on various cognitive variables, such as, simple and selective reaction time, stress and the detection and management of disruptive behaviors during instructional…
- Trial name
- NCT07655167
- Testing
- the nap routine
- Where
- Tunisia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Higher Institute of Sport and Physical Education, Ksar-Said
Healthy Subjects
A Controlled Study of the Aqueous Humor Dynamics of AR-13324 Ophthalmic Solution in Healthy Adult Volunteers
To evaluate the effect of netarsudil (AR-13324) ophthalmic solution on aqueous humor dynamics relative to its placebo.
- Trial name
- NCT02406287
- Testing
- Netarsudil (AR-13324) Ophthalmic Solution
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Aerie Pharmaceuticals
Covid19
Phase 1 Study to Assess Safety, Tolerability, PD, PK, Immunogenicity of IV NTR-441 Solution in Healthy Volunteers and COVID-19 Patients
This first-in-human clinical study is a Phase 1a/ 1b, randomized, double-blind, placebo-controlled study to assess the safety, tolerability, and PK/PD of NTR-441 in healthy subjects and patients with COVID-19 after single…
- Trial name
- NCT04941183
- Testing
- NTR-441
- Where
- 4 sites in Austria, Ukraine
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Neutrolis
Spinal Cord Injury, Cervical Spondylosis With Myelopathy
High-Resolution Diffusion Tensor Imaging (DTI) of the Cervical Spinal Cord in the Setting of Spinal Cord Injury (SCI)
The investigators propose a prospective study, designed to analyze the efficacy of High-Resolution Diffusion Tensor Imaging for accurately sensing white matter tracts in subjects with spinal cord injury.
- Conditions
- Spinal Cord Injury, Cervical Spondylosis With Myelopathy, Degenerative Disorder
- Trial name
- NCT01407705
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Utah
Carpal Tunnel Syndrome
Ultrasonographic Measurements of the Median Nerve Before and After Splinting for Carpal Tunnel Syndrome
A prospective cohort follow-up study design is undertaken. Both males and females with mild to moderate carpal tunnel syndrome will receive standard-of-care wrist splint for 6 weeks and undergo follow up studies for data…
- Trial name
- NCT02038205
- Where
- United States
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Ketosis
A Trial of Intravenous Fluids During Labor
The purpose of this study is to determine if intrapartum use of a glucose-containing solution will improve the outcomes in pregnant women and their babies.
- Trial name
- RARHY (NCT01110005)
- Testing
- D5 Lactated Ringer's Solution (D5LR), Lactated Ringer's Solution (LR)
- Where
- 4 sites in United States
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Fibrosis, Cirrhosis
Radiological Spectrum Of Fatty Liver Correlate With High Resolution Ultrasonography Of Fibrosis And Cirrhosis
Fatty liver is a condition in which fat builds up in liver. it is very common health issue.it is major public health problems in the world. there is particular concern because fatty liver causes mortality among patients.
- Trial name
- NCT06749522
- Testing
- high resolution ultrasonography
- Where
- Pakistan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Superior University
Safety, Tolerability
Clinical Study for the Evaluation of Safety and Tolerability of PRO-172 Ophthalmic Solution+
Clinical phase I, controlled, non comparative, open, single center study evaluating the safety and tolerability of ophthalmic solution PRO-172 when applied on the ocular surface of healthy volunteers.
- Conditions
- Safety, Tolerability, Ocular Surface, Ocular Comfort
- Trial name
- PRO-172 (NCT04693429)
- Testing
- Bepotastine Besilate
- Where
- Mexico
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Laboratorios Sophia S.A de C.V.
Asthma
Assessing the Efficacy of CREWS01 to Decrease Usage of Rescue Inhalers in Moderate to Severe Asthmatic Adults
This is a double-blind, randomized, placebo-controlled, proof of concept, study in adults with poorly controlled moderate to severe asthma.
- Trial name
- CREWS01 (NCT02153541)
- Testing
- Antipyrine-benzocaine otic solution, Glycerin with Oxyquinoline Sulfate
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Global United Pharmaceutical Corporation
Glaucoma, Ocular Hypertension
Pharmacokinetic Study of OPC-1085EL Ophthalmic Solution in Healthy Male Adult Volunteers
OPC-1085EL ophthalmic solution, carteolol long-acting ophthalmic solution or latanoprost ophthalmic solution are administered once daily for 7 days and the effect on the blood concentration of carteolol and latanoprost in…
- Trial name
- NCT02108288
- Testing
- OPC-1085EL ophthalmic solution, Carteolol long-acting ophthalmic solution, Latanoprost ophthalmic solution
- Where
- Japan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Necrotic Pulp
Effect of Etidronate in Sodium Hypochlorite Versus Sodium Hypochlorite on the Intensity of Postoperative Pain
To compare the effect of using Etidronate in sodium hypochlorite versus sodium hypochlorite irrigating solution on: Postoperative pain in patients with necrotic pulp.
- Trial name
- NCT04035330
- Testing
- etidronate in sodium hypochlorite, sodium hypochlorite
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Cairo University
Wet Age Related Macular Degeneration
Clinical Study for the Evaluation of Safety and Tolerability of SCAI-005 Eye Drops
To assess the single-dose and multiple-dose pharmacokinetics (PK), safety and tolerability of SCAI-005 eyedrops(axitinib) in healthy volunteers
- Trial name
- NCT06969001
- Where
- South Korea
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- SCAI Therapeutics
Colonoscopy
Amitiza® Plus GoLYTELY® (PEG) Versus Placebo Plus GoLYTELY® for Outpatient Colonoscopy Preparation
The primary objective is to compare the effectiveness and tolerance of the medication named lubiprostone plus a large volume liquid laxative versus placebo which is a look alike medication that has no effect such as a sugar pill…
- Trial name
- PEG (NCT00645801)
- Testing
- lubiprostone (Amitiza)
- Where
- 3 sites in United States
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
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