Clinical trials: Resolution
Osteoarthritis
Wrist Cartilage - High Resolution in Vivo MR T2 Mapping- a Feasibility Study
Purpose:Evaluate the feasibility of T2 cartilage mapping on MRI of the wrist and correlate with T2 mapping of knee cartilage. Study protocol: Phase 1. 10 healthy volunteers, Phase 2.
- Trial name
- NCT00669201
- Where
- 2 sites in Israel
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Healthy
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Rising Oral Doses of BI 1356 BS Administered to Healthy Male Subjects
The objective of the current study was to investigate safety, tolerability, pharmacokinetics and pharmacodynamics of BI 1356 BS.
- Trial name
- NCT02173665
- Testing
- BI 1356 BS - Powder in bottle (PIB), BI 1356 BS - Tablet
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Breast Cancer Female
Evaluation of the Potential Impact of an Artificial Intelligence Solution in Second Reading of Organized Screening.
Based on data from a series of patients who underwent screening mammography with a "normal" or "benign" first-reading result. The main objective of the study is to evaluate the possibilities of subtracting from the second reading…
- Trial name
- ELIAS (NCT06479772)
- Where
- France
- Volunteers
- 55,589 people, healthy volunteers welcome
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Healthy
Solution-Focused Mindfulness: Impact on Students' Self-Esteem, Mindfulness, and Anxiety
Students have some problems related to stress and anxiety during their university years when they go through important transitions and change processes in their lives.
- Trial name
- NCT06810037
- Testing
- Mindfulness Practice Based on the Solution-Focused Approach
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Healthy Females, Vagus Nerve Stimulation
Effects of tVNS on Visceral Pain
Transcutaneous auricular vagal nerve stimulation (taVNS) has shown promise in reducing chronic abdominal pain, such as in irritable bowel syndrome (IBS).
- Conditions
- Healthy Females, Vagus Nerve Stimulation, Abdominal Pain
- Trial name
- NCT06659172
- Testing
- taVNS
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Blood Glucose, Appetite
The Effect of Lactisole on the Responses to Glucose Solution
The purpose of the study is to determine whether the sweet taste receptors in the gut are involved in sensing sweet substances and controlling appetite and the amount we eat.
- Conditions
- Blood Glucose, Appetite, Therapeutic Uses, Hormones
- Trial name
- NCT01121783
- Testing
- Lactisole
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Northern Care Alliance NHS Foundation Trust
Melasma
Effectiveness and Safety of Pigment Solution Program (PSP) as Adjuvant Therapy in Melasma
This research is a clinical study with a single-blind randomized clinical trial design (randomized controlled trial) in multicenters at two Dermatology and Venereology Education centers in Indonesia.
- Trial name
- NCT06174545
- Testing
- Pigment Solution Program
- Where
- Indonesia
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Dr.dr.Irma Bernadette, SpKK (K)
Chronic Obstructive Pulmonary Disease
Single Ascending Dose Study of TRN-157 in Healthy Subjects
This single ascending dose study is to determine and evaluate the safety and tolerability of TRN-157 in approximately 40 healthy subjects.
- Trial name
- NCT02133339
- Testing
- TRN-157
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Theron Pharmaceuticals, Inc.
Bronchitis
Crossover, Single Dose, Two-stage Bioequivalence Study of SCMC-Lys Salt 1.35 g Powder vs SCMC-Lys Salt 90 mg/mL Syrup
Objectives: The objectives of the study was to investigate the bioequivalence between two formulations containing S-carboxymethyl-L-cysteine L-lysine monohydrate salt (SCMC-lys) when administered as single oral dose in two…
- Trial name
- NCT02858193
- Testing
- SCMC-lys powder 1.35 g, Fluifort® syrup
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dompé Farmaceutici S.p.A
Healthy
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Rising Doses of BI 1356 BS in Healthy Male Volunteers
Study to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of BI 1356 as formulation for intravenous administration
- Trial name
- NCT02183298
- Testing
- BI 1356 BS - intravenous, BI 1356 BS - Tablet
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Pain
Bioequivalency Study of Morphine Sulfate Injection, Solution and Tablet Under Fasted Conditions
Determine the pharmacokinetics and optimize study design for subsequent studies with morphine sulfate tablets and solution.
- Trial name
- NCT00994942
- Testing
- morphine sulfate
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Roxane Laboratories
Non-healing Wounds
Effect of Natrox Oxygen Wound Therapy on Non-healing Wounds and Implication of Remote Monitoring and Telehealth for Management in the Home.
Single center pilot study examining the effect of Natrox topical oxygen therapy on chronic wounds along with the introduction of remote monitoring and telehealth for home care management.
- Trial name
- NCT04746573
- Testing
- Natrox Topical Oxygen Therapy
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Inotec AMD Limited
Healthy
A Study of Different Injectable Formulations of LY3375880 in Healthy Participants
The main purposes of this study are: 1. To learn more about the safety and side effects of different formulations of LY3375880 and 2.
- Trial name
- NCT03913260
- Testing
- LY3375880, Buffer Matrix (No LY3375880), Autoinjector (AI)
- Where
- 2 sites in United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Tourette Syndrome
MRI Study of Tic Remission in Tourette Syndrome
Doctors provide a ray of hope to children and their parents with the knowledge that, for most patients, symptoms of Tourette syndrome improve by the time they are young adults.
- Trial name
- NCT01405859
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Utah
Spinal Surgery
The Aim of This Investigation is to Compare the Influence of 0.9% Saline and Plasmalyte Solution on Acid-base Balance and Electrolytes in Healthy Patients Undergoing Major Spine Surgeries.
Chloride-rich isotonic crystalloid solutions have been shown to exert electrolyte imbalance and metabolic acidosis in critically ill patients.
- Trial name
- NCT01855542
- Testing
- 0.9% normal saline, plasmalyte
- Where
- South Korea
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Dental Caries
Fluoride Application on Preventing and Arresting Root Caries in Fluoridated and Non-fluoridated Areas
This study was a randomized clinical trial lasting for 24 months in two study sites, Hong Kong (water fluoridated) and Guangzhou (non-fluoridated area).
- Trial name
- NCT02742142
- Testing
- silver diammine fluoride
- Where
- 2 sites in China
- Volunteers
- 534 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Anesthesia, Local
A Study of the Safety and Anesthetic Effect of AG-920 Topical Ophthalmic Solution
This is a Phase 3, randomized, placebo-controlled, double masked, parallel design study in healthy subjects performed in the US.
- Trial name
- NCT04829344
- Testing
- AG-920
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- American Genomics, LLC
HIV, AIDS
TMC114-TiDP3-C181: Study to Assess the Pharmacokinetics of Darunavir (DRV) With Different Doses of Ritonavir in Healthy Volunteers.
The objectives are to determine the effect of different ritonavir doses on darunavir (DRV) oral exposure following once-daily oral dosing of DRV/rtv for 7 days, in order to establish an optimal ritonavir boosting dose for DRV and…
- Trial name
- NCT00744887
- Testing
- Darunavir
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Tibotec Pharmaceuticals, Ireland
Myopia
Safety and Tolerability Evaluation of PRO-230 Ophthalmic Solution
Phase I Study to evaluate safety and tolerability of PRO-230 (atropine sulphate 0.05%) ophthalmic solution through evaluation of incidence of non-expected adverse events (AE), photophobia, pupillary diameter, incidence of…
- Trial name
- PRO-230 (NCT05481489)
- Testing
- Atropine Sulfate
- Volunteers
- healthy volunteers welcome
- Sponsor
- Laboratorios Sophia S.A de C.V.
Healthy
Safety, Tolerance, and Pharmacokinetics of BILN 2061 ZW in Healthy Male Subjects, Combined With Preliminary Evaluation of Food Effect
To assess the safety, tolerance and pharmacokinetics of 5 mg to 2400 mg BILN 2061 ZW 1. In rising single doses 2. With and without a 64 g fat breakfast at one selected dose
- Trial name
- NCT02268760
- Testing
- BILN 2061 ZW single rising doses, BILN 2061 ZW fixed dose, Standardized breakfast
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
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