Clinical trials: Resolution
Pulmonary Hypertension, Pulmonary Arterial Hypertension
Safety, Tolerability, and PK Parameters of Sodium Nitrite Inhalation Solution in Healthy Subjects
This is a four-part study of the safety, tolerability, and PK profile of sodium nitrite inhalation solution (AIR001) of ascending multiple doses (Part A) and of escalating doses with steady-state sildenafil (Part B) to healthy…
- Trial name
- NCT01409122
- Testing
- 15 mg sodium nitrite inhalation solution, 90 mg sodium nitrite inhalation solution, 45 mg sodium nitrite inhalation solution
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Aires Pharmaceuticals, Inc.
Smoking Cessation
Safety and Efficacy Study of the NRT CQSS2 System for Smoking Cessation in Treatment-Seeking Subjects
Transdermal nicotine delivery systems are a cigarette smoking cessation aid designed to deliver nicotine into the systemic circulation via the skin.
- Trial name
- NCT03178422
- Testing
- CQSS2, NicoDerm CQ Patch
- Where
- 5 sites in United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Chrono Therapeutics, Inc.
Analgesia
Effectiveness of Pre-administered Natural Sweet-tasting Solution (Honey) for Decreasing Pain of Needle Insertion
This study aims to assess Effectiveness of Pre-administered Natural Sweet-tasting Solution (honey) for Decreasing Pain Associated with Dental Injections (infiltration) prior to dental extraction in 6-8 years old healthy Children…
- Trial name
- NCT06393777
- Testing
- honey
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Cairo University
Healthy
A Bioequivalence Study of Mirikizumab (LY3074828) in Healthy Participants
The main purpose of this study is to evaluate amount of mirikizumab (test) that gets into the blood stream and how long it takes the body to get rid of it, when given via autoinjector compared to mirikizumab (reference) solution…
- Trial name
- NCT05515601
- Testing
- Mirikizumab
- Where
- 6 sites in United States
- Volunteers
- 396 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Healthy
Safety, Pharmacodynamics, and Pharmacokinetics of BIBT 1011 BS in Healthy Subjects
A study to assess safety, pharmacokinetics and the effect of BIBT 986 BS, given as BIBT 1011 BS, on coagulation parameters.
- Trial name
- NCT02182037
- Testing
- Single rising doses of BIBT 1011 BS
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Moyamoya Disease
Family-Based Moyamoya Susceptibility and Early Detection
This single-center, prospective, family-based observational cohort study aims to investigate susceptibility to moyamoya disease (MMD) and to develop strategies for early screening in individuals at increased familial risk.
- Trial name
- FAMES (NCT07517354)
- Testing
- 5T High-Resolution MRI
- Where
- China
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Hemodynamic Instability
The Cold Fluids Study
In this single center crossover study the aim is to investigate the effect of Ringer's lactate solution at high and low temperatures on physiological response in healthy adults.18 healthy volunteers will be included.
- Trial name
- NCT05610254
- Testing
- Ringer's Lactate
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Pain Disorders
Crossover, Single Dose Randomized, Bioequivalence of Ketoprofen Lysine Salt Immediate Release vs Oral Solution
Objectives: The objective of the study was to investigate the bioequivalence between two formulations containing ketoprofen lysine salt (KLS) when administered as single oral doses in two consecutive study periods to healthy male…
- Trial name
- NCT02350296
- Testing
- KSL 40 mg, OKi® 80 mg
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dompé Farmaceutici S.p.A
Skin Diseases
Deep Learning on 3D Cellular-resolution Tomogram
Skin biopsy is the main method to diagnose skin tumors, skin inflammation, and pigmented diseases. However, biopsy is an invasive method that can cause wounds and scars.
- Trial name
- NCT04679961
- Testing
- ApolloVue® S100 Image System (Apollo Medical Optics)
- Where
- Taiwan
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Mackay Memorial Hospital
Androgenetic Alopecia
Assessment of Dutasteride Topical Solution in Male Androgenetic Alopecia
This is a randomized, open-label phase 1/2a study designed to evaluate the pharmacokinetics, pharmacodynamics, and safety of AD-303A (topical formulation) and AD-3031 in male patients with androgenetic alopecia.
- Trial name
- NCT07490327
- Testing
- AD-303A, AD-3031
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Moogene Medi Co., Ltd
Neurological Disorders, Neuroscience
Advanced Space-time Resolved Techniques for Functional Neuroimaging at 7 Tesla MRI
In recent years, the in vivo study of the central nervous system has undergone significant advancement through the implementation of magnetic resonance imaging (MRI)-based neuroimaging techniques.
- Conditions
- Neurological Disorders, Neuroscience, Epilepsy, Brain Injuries, Focal
- Trial name
- AURORA (NCT07865546)
- Testing
- Functional neuroimaging
- Where
- Italy
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Imago 7 Fondazione di Ricerca onlus
SARS CoV 2 Infection
Use of a Hypochlorous Acid Spray Solution in the Treatment of COVID-19 Patients : COVICONTROL Study .
The objective is To evaluate the efficacy and safety of nasal spray and mouth spray application with hypochlorous acid-containing solution versus placebo as a curative treatment for hospitalized SARS-CoV-2 positive patients And…
- Trial name
- COVICONTROL (NCT05862480)
- Testing
- Spray with Hypochlorous Acid Group
- Where
- Tunisia
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Monastir
Healthy
Pharmacokinetics and Relative Bioavailability of 11634 Immediate Release Tablet in Healthy Male Volunteers
Characterisation of the relative bioavailability of the IR-tablet vs. oral drinking solution (no primary endpoint in a statistical sense) Safety and tolerability of the IR-tablet formulation and solution PK profile of the single…
- Trial name
- NCT02214927
- Testing
- BI 11634 tablet, BI 11634 drinking solution
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Pain
Trial of an Oral Sucrose Solution Versus Placebo in Children 1 to 3 Months Old Needing Nasopharyngeal Aspiration
Background: Early recognition and treatment of pain among children is important for their cognitive development and their future response to pain throughout their life.
- Trial name
- NCT01544946
- Testing
- 88% sucrose po
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Attention Deficit Hyperactivity Disorder
dHealth Solution for Improving Parent Adherence to Behavioral Treatment for ADHD
This study aims to develop, refine and preliminarily test a novel and scalable digital health solution designed to address parent adherence barriers in daily life contexts and increase parent's sustained use of evidence-based…
- Trial name
- dHealth (NCT04025814)
- Testing
- CaregiverAssist, Behavioral Parent Training (CLS Parent Group)
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Healthy
Study to Investigate Safety, Tolerability and Pharmacokinetics of AZD2423 Multiple Doses in Healthy Volunteers
Three-part study investigating the safety and tolerability of AZD2423 multiple doses in 98 healthy volunteers: Part 1 80 young and elderly subjects in a parallel, double blind, randomised study.
- Trial name
- NCT00977626
- Testing
- Part 2 - AZD2423, Part 3 - AZD2423
- Where
- United Kingdom
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy
Safety, Tolerability, Pharmacokinetics and Immunogenicity Study of GB002 Recombinant Peptide Inhalation Solution in Healthy Subjects
This trial is conducted in China. The purpose of this clinical trial is to evaluate the safety and tolerability, pharmacokinetic (PK) characteristics, and immunogenicity of single/multiple inhalation of different doses of GB002…
- Trial name
- NCT06423261
- Testing
- GB002 Recombinant Peptide Inhalation Solution
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Zhejiang Echon Biopharm Limited
Healthy
Single Rising Dose Study of BI 201335 ZW in Healthy Male Subjects
The objective of the current study is to investigate safety, tolerability, and pharmacokinetics of BI 201335 ZW following administration of single rising doses from 5 mg to 1500 mg.
- Trial name
- NCT02182271
- Testing
- BI 201335 ZW - single rising dose
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Breast Cancer Detection
Clinical Feasibility Study of Upright, Low-dose, High-resolution, 3D Breast CT (UBCT).
The investigators are doing this study to find out if a new kind of breast imaging (called upright dedicated breast CT or UBCT) can help doctors to see the small structures in breast tissue more clearly in 3-D and without…
- Trial name
- UBCT (NCT07705100)
- Testing
- Low dose, upright, dedicated breast CT
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Alzheimer Disease, Mild Cognitive Impairment Due to Alzheimer's Disease
Alzheimer's Disease Multinuclear Imaging Neuro-Enhanced Resolution (AD-MINER)
This single-center prospective cohort study will enroll 750 participants (250 cognitively Normal (CN) individuals, 250 with mild cognitive impairment (MCI), and 250 with Alzheimer's disease (AD)).
- Trial name
- AD-MINER (NCT07089303)
- Where
- China
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
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