Clinical trials: Resolution
Necrotic Pulp
Effect of Etidronate in Sodium Hypochlorite Versus Sodium Hypochlorite on the Intensity of Postoperative Pain
To compare the effect of using Etidronate in sodium hypochlorite versus sodium hypochlorite irrigating solution on: Postoperative pain in patients with necrotic pulp.
- Trial name
- NCT04035330
- Testing
- etidronate in sodium hypochlorite, sodium hypochlorite
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Cairo University
Healthy
A Study in Healthy Men to Test How BI 730357 is Processed by the Body
The main objectives of the study are as follows: To assess the mass balance recovery of (C-14) BI 730357-radioactivity (also expressed as 14C-BI 730357-EQ) in urine and faeces after a single oral dose of 50 mg BI 730357 base (BS)…
- Trial name
- NCT03664011
- Testing
- BI 730357 mixed with [C-14]BI 730357 BS
- Where
- Netherlands
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Vision Disorders
Study of A New Contact Lens Cleaning and Disinfecting Solution
The objective of this study is to evaluate the safety and efficacy of a new investigational cleaning and disinfecting solution (Test) compared to Clear Care cleaning and disinfecting solution (Control) when used by contact lens…
- Trial name
- NCT01318577
- Testing
- Investigational Cleaning & Disinfecting Solution, Clear Care Solution
- Where
- United States
- Volunteers
- 444 people, healthy volunteers welcome
- Sponsor
- Bausch & Lomb Incorporated
Psychosis, Food-drug Interaction
KF2022#3-trial: Effect of Tea and Cola Beverage on Absorption of Risperidone Oral Solution
Risperidone is widely used in the treatment of schizophrenia, bipolar disorder, and aggression associated with moderate or severe Alzheimer's dementia.
- Trial name
- KF2022#3 (NCT06218979)
- Testing
- Risperidone oral solution
- Where
- Finland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Breast Cancer
High-Resolution Lower Dose Dedicated Breast Computed Tomography (CT)
This study is being performed to find out if a new kind of breast imaging (called dedicated breast CT or BCT) can help doctors to see the small structures in breast tissue more clearly.
- Trial name
- LowerDoseBCT (NCT03954431)
- Testing
- Dedicated breast CT(BCT)
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Arizona
NAFLD
Resolution of Liver Fat in Non-alcoholic Fatty Liver Disease
The major adverse health consequences of obesity occur only when non-alcoholic fatty liver disease (NAFLD) also develops. NAFLD is characterized by abnormal hepatic accumulation of triglycerides and other lipids.
- Trial name
- NCT02558530
- Testing
- Low carbohydrate diet
- Where
- 2 sites in Finland, Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Blood Glucose, Appetite
The Effect of Lactisole on the Responses to Glucose Solution
The purpose of the study is to determine whether the sweet taste receptors in the gut are involved in sensing sweet substances and controlling appetite and the amount we eat.
- Conditions
- Blood Glucose, Appetite, Therapeutic Uses, Hormones
- Trial name
- NCT01121783
- Testing
- Lactisole
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Northern Care Alliance NHS Foundation Trust
Opioid Induced Pharyngeal and Esophageal Dysfunction
Opioid Effects on Swallowing and Esophageal Sphincter Pressure
The purpose of this study is to determine whether a dopamine receptor antagonist metoclopramide can counteract opioid induced effects on esophageal motility and lower esophageal sphincter.
- Trial name
- NCT01191645
- Testing
- naloxone, remifentanil, Sodium Chloride
- Where
- Sweden
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Region Örebro County
Dry Eye Syndromes, Lubricant Allergy
Safety and Tolerability of PRO-087 Versus Xyel Ofteno® and Systane Ultra®, on the Ocular Surface of Healthy Subjects
Phase I clinical study, to evaluate the safety and tolerability of the preservative-free ophthalmic solution PRO-087 versus Xyel Ofteno® and Systane Ultra®, on the ocular surface of ophthalmological and clinically healthy…
- Conditions
- Dry Eye Syndromes, Lubricant Allergy, Tear Disorder
- Trial name
- PRO-087/I (NCT03524157)
- Testing
- PRO-087, Systane Ultra, Xyel Ofteno
- Where
- Mexico
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Laboratorios Sophia S.A de C.V.
Acanthamoeba Keratitis
Safety and Tolerability of Preservative-free Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Healthy Subjects
Randomized, double-masked, placebo-controlled, multiple center, parallel-group Phase 1 study to evaluate the safety and tolerability of 3 doses of preservative-free PHMB ophthalmic solution compared to placebo in healthy subjects
- Trial name
- NCT02506257
- Testing
- 0.04% PHMB, 0.06% PHMB, 0.08% PHMB
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- SIFI SpA
Oocytes Vitrified at Prophase-I Stage, Oocytes Matured in Vitro
Comparison of Vitrification Effect Before or After In Vitro Maturation
Human oocyte cryopreservation is routinely used for fertility preservation of women who will be exposed to gonadotoxic effect of cancer treatment. After ovarian stimulation, matured oocytes are vitrified.
- Trial name
- NCT03416400
- Testing
- Oocyte vitrification
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Healthy Volunteers
A Study to Assess the Relative Bioavailability and to Assess the Effect of Food on the Bioavailability of a TAK-648 Tablet in Healthy Participants
The purpose of this study is to assess the relative bioavailability of a TAK-648 tablet compared with a TAK-648 oral solution, and to assess the effect of food on the bioavailability of a TAK-648 tablet in healthy participants.
- Trial name
- NCT02480439
- Testing
- TAK-648 Tablet, TAK-648 Oral Solution
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Takeda
Tendinopathy
A Repeat Insult Patch Test (RIPT) Study Evaluating the Sensitization Potential of Topical SM04755 Solution in Healthy Volunteers
This is a single center, randomized, controlled, within subject comparison, single dose study to determine the sensitization potential of SM04755 solution on normal skin under semi-occlusive patch conditions.
- Trial name
- NCT03502434
- Testing
- SM04755, Vehicle, White Petrolatum
- Where
- United States
- Volunteers
- 223 people, healthy volunteers welcome
- Sponsor
- Biosplice Therapeutics, Inc.
Barrett Esophagus
a/LCI-OCT Pilot in Esophagus
This study will test a newly developed dual modality probe, including optical coherence tomography (OCT) and angle-resolved low-coherence interferometry (a/LCI), in the human esophagus to determine 1) whether adequate tissue…
- Trial name
- NCT04392167
- Testing
- a/LCI-OCT imaging probe, esophageal biopsy
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Duke University
Healthy Subjects
A Study to Assess Isavuconazole Following a Single Dose of Isavuconazonium Sulfate Intravenous Solution Via Nasogastric (NG) Tube Compared to a Single Dose of Oral Capsules Under Fasting Conditions in Healthy Participants
The purpose of this study is to evaluate the bioequivalence of isavuconazole following a single dose of isavuconazonium sulfate intravenous (IV) solution via nasogastric (NG) tube (test formulation) compared to a single dose of…
- Trial name
- NCT04096157
- Testing
- Isavuconazonium sulfate IV, Isavuconazonium sulfate capsules
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Global Development, Inc.
Dental Pain, Anesthesia, Local
A Split Mouth Trial to Compare Microneedles vs. Standard Needles in Dental Anaesthetic Delivery
The study will be completed as a two part, prospective, single-centre, randomised controlled trial. Five volunteers (dentists) will be recruited in the first part of the study to evaluate and examine the microneedle device and…
- Trial name
- NCT02966067
- Testing
- Microneedle Device (Experimental), 30-gauge Short Hypodermic Needle
- Where
- Ireland
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Dublin, Trinity College
Healthy Subjects
A Comparative Study of the Pharmacokinetic Profiles of Timolol Maleate Ophthalmic Gel With Timolol Maleate Gel
The goal of this clinical trial is: 1)To evaluate the pharmacokinetic profiles and safety of 0.5% Timolol Maleate Ophthalmic Gel Forming Solution in healthy adult subjects after multiple dosing; 2)To compare the systemic exposure…
- Trial name
- NCT06813807
- Testing
- 0.5% TM
- Where
- China
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Auson Pharmaceuticals Inc.
Nasal Obstruction, Nasal Disease
Impact of Nasal Isotonic Solution Irigation on Healthy Athletes' Nasal Flow and Nasal Obstruction Exercise Outcomes
Nasal patency is an important component of performing exercises because it helps in humidifying, heating and filtering the inhaled air.
- Trial name
- ISOtastic! (NCT05948800)
- Testing
- Nasal irrigation with seawater isotonic solution
- Where
- Croatia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital Sestre Milosrdnice
Dry Eye Disease
Study to Assess Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses of Palovarotene Ophthalmic Solution in Healthy Adult Subjects
Dry eye disease (DED) is a keratoconjunctive disorder that "is a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance, and tear film instability with potential damage…
- Trial name
- NCT04762355
- Testing
- Palovarotene, Vehicle
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Clementia Pharmaceuticals Inc.
Foot Dermatoses
Chlorhexidine Scrub, ZnO Nanoparticles Socks and the Combination for Prevention of Pitted Keratolysis
This study aimed to study the efficacy of chlorhexidine scrub, zinc oxide nanoparticles (ZnO-NPs) socks and the combination of chlorhexidine scrub and ZnO-NPs socks in prevention of pitted keratolysis.
- Trial name
- PKprevention (NCT04337749)
- Testing
- Chorhexidine scrub, ZnO-NPs socks, Combination of chorhexidine scrub and ZnO-NPs socks
- Where
- Thailand
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mahidol University
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