Clinical trials: Resolution of Pathologic Process
Constipation - Functional, Irritable Bowel Syndrome Characterized by Constipation
Reclassifying Constipation Using Imaging and Manometry
Constipation is a common condition in which an individual suffers with hard stools which are infrequent and difficult to pass. It is poorly understood and treatment is often unsatisfactory.
- Trial name
- RECLAIM (NCT03226145)
- Testing
- MRI Motility, High Resolution Manometry, Bisacodyl
- Where
- 3 sites in United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Healthy Volunteer
A Single-volunteer Study of Immune Response Following OTS-412 Vaccinia Virus Systemic Injection(Self-experiment)
Following oncolytic virus (OV) administration, the host immune response is initiated immediately and evolves dynamically. However, in clinical OV therapy, it is virtually impossible to capture these immune events in real time.
- Trial name
- NCT07302945
- Testing
- OTS-412
- Where
- South Korea
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Bionoxx Inc.
COPD
Single and Multiple Ascending Dose Study of AER-01
This is a first-in-human, randomized, double-blind, placebo-controlled, Phase 1 study of AER-01 (solution for inhalation, delivered via nebulizer) to assess the safety, tolerability and PK of AER-01.
- Trial name
- NCT05862623
- Testing
- AER-01
- Where
- 2 sites in Australia
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Aer Therapeutics
Dehydration
Oral Rehydration Solution and Dehydration Recovery
This is a prospective, randomized, controlled, blinded, crossover, study to evaluate the effects of an oral hydration solution.
- Trial name
- NCT06368765
- Testing
- Oral Rehydration Solution (ORS), Water
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Abbott Nutrition
Tuberculosis
The Role of High Resolution-Computed Tomography (CT) in Tuberculosis (TB) Outbreak Investigation
The aim of this study is to evaluate the role of high-resolution computed tomography of the chest (HRCT) in the investigation of an outbreak of TB that developed in the South Korean army.
- Trial name
- NCT00889759
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Armed Forces Capital Hospital, Republic of Korea
Acetaminophen-protein Adduct Formation
Acetaminophen-Protein Adduct Resolution
The purpose of this study is to better understand the pharmacokinetics of acetaminophen and further clinical interpretations of laboratory results that confirm the presence of acetaminophen-cys adducts.
- Trial name
- AR (NCT01021410)
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Denver Health and Hospital Authority
Inflammation, Obesity
Inflammatory Resolution in Cardiometabolic Health and Disease
The specific aim of this study is to determine molecular pathways that differentiate metabolically healthy vs unhealthy human phenotypes, and to investigate the therapeutic potential of pro-resolving lipids.
- Conditions
- Inflammation, Obesity, Cardiovascular Diseases
- Trial name
- RESOLVE AU (NCT06390189)
- Where
- Denmark
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Constipation
Usefulness of High Resolution Manometry in Constipation
Constipation is a frequent symptom that is reported by more than 10% of the general population. In a few case, constipation is resistant to medical standard care, including osmotic and stimulant laxatives.
- Trial name
- MANOCOHR (NCT04623359)
- Testing
- High resolution manometry
- Where
- 3 sites in France
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Alcoholism, Alcohol Dependence
Study of the Neural Substrates of Alcohol Craving by High-resolution Electroencephalography
Alcohol is the most consumed psychoactive substance in France and is responsible for 49,000 deaths per year in the country. Addictions, characterized by "the repeated impossibility of controlling a behavior and the continuation…
- Trial name
- CRAVING-NET (NCT05275166)
- Testing
- Induction of alcohol craving, Questionnaires
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Mental Health, Conflict
The Happy Families Project: Testing the Effectiveness of a Conflict Resolution Program for Families
This study is designed to test the effectiveness of a psychoeducation-based program to address communication and conflict resolution in families, thereby supporting mental health in children and their caregivers.
- Trial name
- NCT04980794
- Testing
- Parent-child intervention, Self-study Intervention
- Where
- 3 sites in United States
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- University of Notre Dame
Breathing, Lung Function Decreased
Phase Resolved Functional Lung MRI and Oscillometry for the Observation of Healthy Lung Function
This study will examine the relationship of airways resistance measured by oscillometry with ventilation defects measured by Phase Resolved Functional Lung (PREFUL) MRI in healthy human subjects.
- Conditions
- Breathing, Lung Function Decreased, MRI Imaging, Healthy
- Trial name
- PROOF (NCT07614685)
- Testing
- Airway Oscillometer, Phase Resolved Functional Lung MRI
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Retinitis Pigmentosa, Maculopathy, Age Related
High Resolution, High-speed Multimodal Ophthalmic Imaging
Knowledge of the pathogenesis of ocular conditions, a leading cause of blindness, has benefited greatly from recent advances in ophthalmic imaging.
- Conditions
- Retinitis Pigmentosa, Maculopathy, Age Related, Macular Dystrophy, Macular Edema
- Trial name
- IMA-MODE (NCT04129021)
- Testing
- High-resolution retinal imaging through adaptive optics, High-resolution retinal imaging through holographic systems
- Where
- France
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Meconium Obstruction of Prematurity
Saline Enema Administration in Meconium Obstruction of Prematurity and Impact on the Resolution, Feeds, Microbiome, and Gut-brain Axis.
The goal of this clinical trial is to study the effect of twice-daily saline enema (SE) in the treatment obstruction of prematurity (MOP) in infants with the birth weight ≤1.25kg.
- Trial name
- NCT06048614
- Testing
- Saline Enema (SE), Glycerin Suppository
- Where
- 2 sites in Singapore
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Hypovolemia, Fluid Loss
Acetated Ringer´s Solution in Experimental Hypovolemia
Intravenous fluids are often given to increase stroke volume and thereby improve global oxygen delivery. The effect is however often transient, but the effect of a fluid bolus on stroke volume and other hemodynamic variables over…
- Conditions
- Hypovolemia, Fluid Loss, Hemodynamic Instability
- Trial name
- Volu-Flow (NCT05705115)
- Testing
- Ringer acetate, Lower body negative pressure
- Where
- Norway
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Implant Complication, Implant Infection
Local Antibiotics for Breast Implants
The BREAST-AB Trial is a multi-center, randomized, double blind, placebo-controlled trial investigating the efficacy of local application of gentamicin, vancomycin and cefazolin in decreasing all-cause implant explantation after…
- Conditions
- Implant Complication, Implant Infection, Implant Site Infection, Implant Capsular Contracture
- Trial name
- BREAST-AB (NCT04731025)
- Testing
- Gentamicin, Cefazolin and Vancomycin
- Where
- 8 sites in Denmark
- Volunteers
- 1,003 people, healthy volunteers welcome
- Sponsor
- Mikkel Herly
Metabolic Syndrome, Physical Activity
The Effect of Feedback on Physical Activity Surveillance Using Wearable Device-Smartphone Application for Resolution of Metabolic Syndrome in Aged 60 or Older
The Effect of Feedback on Physical Activity Surveillance using Wearable Device-Smartphone Application for Resolution of Metabolic Syndrome in Aged 60 or older; a 12-Week Randomized Control Study
- Conditions
- Metabolic Syndrome, Physical Activity, Wearable Device
- Trial name
- NCT05830552
- Testing
- Receving feedback, No regular feedback
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Pusan National University Hospital
Moyamoya Disease
Family-Based Moyamoya Susceptibility and Early Detection
This single-center, prospective, family-based observational cohort study aims to investigate susceptibility to moyamoya disease (MMD) and to develop strategies for early screening in individuals at increased familial risk.
- Trial name
- FAMES (NCT07517354)
- Testing
- 5T High-Resolution MRI
- Where
- China
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Auditory Perception, Psychoacoustics
The Gaps-in-Noise Test: Gap Detection Thresholds in Normal-Hearing Young Adults
The aim of this study was to establish parameters for the Gaps-in-Noise test in normal-hearing young adults. One hundred subjects (50 males and 50 females) received an audiological evaluation to rule out hearing loss and auditory…
- Trial name
- NCT00593788
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Double Incontinence, Faecal Incontinence
Prospective Database of Factors Associated With Faecal vs. Double Incontinence in Patients Referred for High Resolution Anorectal Manometry.
This study aims to verify the results from our previous retrospective cohort analysis by establishing a database of well-characterised patients prospectively.
- Conditions
- Double Incontinence, Faecal Incontinence, Urinary Incontinence
- Trial name
- NCT05550675
- Testing
- Questionnaires
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Injury of Diaphragm, Mechanical Ventilation Complication
Using Ultrasound to Study Respiratory Muscle Function in Critically Ill Patients
Mechanical ventilation can be life saving strategy for patients with respiratory failure due to a variety of reasons. Once the underlying illness has resolved, intensive care doctors have to take a decision on when the patient is…
- Conditions
- Injury of Diaphragm, Mechanical Ventilation Complication, Critical Illness
- Trial name
- NCT03139695
- Testing
- Ultrasound
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences