Clinical trials: Resolution of Pathologic Process
Bradycardia, Left Bundle Branch Area Pacing
Left Bundle Branch Area Pacing (LBBAP) Monitoring Assistant: Evaluation of Portable ECG Solution
To evaluate the capability to monitor LBB success criteria with the use of a Smart ECG system (ECG monitor, 12 leads ECG cable, ECG viewer software ) during a cardiac device implantation involving the placement of a pacing lead…
- Conditions
- Bradycardia, Left Bundle Branch Area Pacing, Cardiac Resynchronisation Therapy (CRT), ECG
- Trial name
- LBBOT (NCT07254013)
- Testing
- LBBAP implant
- Where
- 4 sites in France
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- MicroPort CRM
Pain, Postoperative, Analgesic Adverse Reaction
Neodolpasse® Infusion Solution Versus Diclofenac 75 mg Infusion in the Treatment of Postoperative Pain After Elective Knee Surgery
The clinical study is planned as a double-blind, randomised, placebo-controlled, parallel-group, single-centre exploratory clinical study with the aim to investigate the analgesic efficacy of the Neodolpasse® Infusion Solution in…
- Conditions
- Pain, Postoperative, Analgesic Adverse Reaction, Cruciate Ligament Rupture
- Trial name
- NCT03493490
- Testing
- Neodolpasse, Diclofenac
- Where
- Austria
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Dysphagia, Swallowing Disorders
Novel Pharyngeal Metrics to Predict Dysphagia Outcomes
This multi-site trial will follow a cohort of Veterans with dysphagia for 8 weeks as they undergo clinically guided oropharyngeal exercises with oropharyngeal strengthening as the primary goal.
- Trial name
- NCT04569097
- Testing
- standard of care lingual strengthening
- Where
- 3 sites in United States
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Apical Periodontitis, Periapical Radiolucency
Comparative Evaluation of Clinical and Radiographic Treatment Outcomes of Garlic Gel and Calcium Hydroxide as an Intracanal Medicament in Nonsurgical Root Canal Treatment of Permanent Teeth.
Researchers want to check how well garlic works inside permanent teeth as a medicament during root canal treatments. Garlic has shown to possess many helpful properties, like reducing inflammation, helping wounds heal, and…
- Trial name
- NCT07289971
- Testing
- Allium Sativum as an intracanal medicament
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Health Sciences Lahore
Keratoconus
Distinguishing Healthy and Keratoconic Eyes Using Ultrahigh-Resolution OCT
The OCT used in this trial offers the advantage of both a non-contact method and a very high axial resolution. Determined parameters with the highest potential of diagnostic discrimination between eyes with Keratoconus and…
- Trial name
- NCT03184610
- Testing
- OCT-scanning
- Where
- Austria
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Anatomical Pathological Condition, Educational Problems
3D Printed Enlarged Carpal Models for Anatomy Training
3D modeling enables medical professionals or students to better understand complex structures. In many studies, 3D printed models have been used in the training, treatment and surgery of medical disciplines such as neuroscience…
- Trial name
- NCT06639633
- Testing
- Anatomy Training with Enlarged %100 3D Printed Carpal Model Group, Anatomy Training with Enlarged %50 3D Printed Carpal Model Group, Anatomy Training with Conventional Carpal Models
- Where
- Turkey (Türkiye)
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Tendinopathy
Tracking of Red Blood Cells Using Super Resolution Ultrasound in Persons With Healthy or Overuse Injured Tendons
The goal of this observational study is to test whether a new ultrasound method, called SUper Resolution ultrasound imaging of Erythrocytes (SURE), can image the small blood vessels found in tendons of persons with a tendon…
- Trial name
- SURE-TEND (NCT06142747)
- Testing
- Super-Resolution Ultrasound Imaging of Erythrocytes (SURE)
- Where
- Denmark
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Head and Neck Cancer, Lymphoma
SUper-Resolution Ultrasound Imaging of Erythrocytes (SURE) in Normal and Malignant Lymph Nodes
The goal of this observational study is to visualize the small vessels in normal and cancerous lymph nodes on the neck with a new ultrasound technique.
- Conditions
- Head and Neck Cancer, Lymphoma, Lymph Node Metastasis
- Trial name
- NCT05754814
- Testing
- Malignant lymph nodes
- Where
- 2 sites in Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Functional Disorder of Stomach, Healthy
Elucidating Mechanisms That Underlie the Symptomatology of Functional Dyspepsia Using Novel Techniques and Its Therapeutic Validation Using Neuromodulators
The goal of this study is to investigate the mechanisms of impaired gastric accommodation and emptying, dysfunctional duodenum, and micro-inflammation using novel imaging techniques of SPECT/CT, gastric emptying scintigraphy…
- Trial name
- NCT06213948
- Testing
- Mirtazapine 15 MG
- Where
- Malaysia
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Normal CT Scan, Dysplasic Disease
Dose-Quality Study in the Temporal Bone Computed Tomography in Routine Care
Because of the complexity of the structures studied, imaging the temporal bone requires compliance with a number of image quality criteria, in order to achieve optimum spatial resolution of the most clinically relevant anatomical…
- Conditions
- Normal CT Scan, Dysplasic Disease, Tumoral Disease, Infectious Disease
- Trial name
- NCT06827106
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aix Marseille Université
Necrotic Pulp
Effect of Commiphora Myrrh Solution as a Root Canal Irrigant on Post Operative Pain and Bacterial Load Reduction in Necrotic Tooth
Clinically compare the post-operative pain , incidences post-operative swelling , post-operative number of analgesic tablets taken by patient and amount of bacterial load reduction after using 50% Commiphora Myrrh Chemomechanical…
- Trial name
- NCT06310044
- Testing
- Root canal irrigant Commiphora Myrrh 50%
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Cairo University
Substance Misuse, Interpersonal Conflict
Oxytocin for Couples Conflict Resolution
Oxytocin is a promising new medication found to have positive effects on prosocial behavior, reduce negative affect such as fear and anxiety, and reduce stress-induced addictive behaviors.
- Conditions
- Substance Misuse, Interpersonal Conflict, Neuroendocrine Reactivity
- Trial name
- NCT02941692
- Testing
- Oxytocin
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Corneal Neovascularisation, Keratoconus
Investigation of Different Scanning Protocols for 3 Dimensional High-resolution Imaging of the Human Cornea With Optical Coherence Tomography (OCT) - A Pilot Study
The aim of the present study is to develop a protocol for optimal corneal 3-dimensional imaging based on measurements in healthy volunteers. For this purpose, a customized ultra-high resolution Spectral Domain OCT will be used.
- Trial name
- NCT01843101
- Testing
- Optical Coherence Tomography
- Where
- Austria
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Inflammation
Investigation of the Distinct Mechanisms Involved in Inflammatory Resolution Between Healthy Men and Women
Important differences exist between sexes in incidence, disease patterns and outcomes in coronary artery disease that is not well understood.
- Trial name
- RESOLVE-SEX (NCT05597098)
- Testing
- Cantharidin
- Where
- United Kingdom
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Nearsightedness, Astigmatism
High Resolution Wavefront-guided vs. Wavefront Optimized LASIK
The investigators are comparing outcomes of LASIK surgery using a high definition wavefront-guided laser to a wavefront-optimized laser in patients with nearsightedness with and without astigmatism.
- Trial name
- NCT02565537
- Testing
- LASIK
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Stanford University
Achalasia Cardia, Gastroesophageal Reflux
To Investigate the Incidence of Reflux in Patients After Per-oral Endoscopic Myotomy in Achalasia Cardia Patients
Achalasia is a rare motility disorder of the oesophagus that is characterized by aperistalsis of the oesophagal body and dysrelaxation of the lower oesophagal sphincter (LES).
- Trial name
- NCT04951739
- Testing
- Peroral endoscopic myotomy
- Where
- India
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
Inflammatory Response, Muscular Injury
Mangoes and Exercise Inflammation
Vigorous exercise bouts result in significant inflammation and muscle soreness. Our research group has published several papers showing that ingestion of various types of fruits enhances inflammation resolution after exercise.
- Trial name
- NCT05409105
- Testing
- Mangoes, Water
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Dementia, Movement Disorders
Comparison of NeuroEXPLORER PET/CT Versus Standard-of-care PET/CT of the Head and Neck Region.
The goal of this clinical study is to compare the current standard-of-care PET/CT scanner with the new NeuroEXPLORER PET/CT, with the aim of demonstrating the added diagnostic value of the new scanner.
- Conditions
- Dementia, Movement Disorders, ALS - Amyotrophic Lateral Sclerosis, Epilepsy
- Trial name
- NCT07595666
- Testing
- Standard-of-care PET/CT, NeuroEXPLORER
- Where
- Belgium
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- prof. dr. Koen Van Laere
Resolution of Pathologic Process
Reconstructive Management of Peri-implantitis
With the growing burden of peri-implantitis around the globe, interest has flourished on the management of this pathology. Nevertheless, lack of consensus exists in the pursuit of a predictable therapy.
- Trial name
- NCT05282667
- Testing
- Reconstructive therapy of peri-implantitis by means of bone graft (and barrier membrane in the test group)
- Where
- Spain
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Center of Implantology, Oral and Maxillofacial Surgery, Badajoz, Spain
Gingivitis
Atlas of Experimental Gingivitis in Humans
Pilot case series with a split-mouth design to track subjects with known exposure (dental biofilm accumulation) over 21 days. Descriptive design, using single cell RNA sequencing as a "digital biopsy" to catalog and contrast…
- Trial name
- ATL (NCT04105569)
- Testing
- Stent-Induced Biofilm Overgrowth
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill