Clinical trials: Resolution of Pathologic Process
Congenital Diaphragmatic Hernia
Fetal Endotracheal Occlusion (FETO) in the Resolution of Pulmonary Hypertension in Fetuses With Severe CDH
Congenital diaphragmatic hernia (CDH) occurs when the diaphragm fails to fully fuse and leaves a portal through which abdominal structures can migrate into the thorax.
- Trial name
- NCT03980717
- Testing
- Goldbal Detachable Balloon and delivery microcatheter
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Michael A Belfort
Chronic Obstructive Pulmonary Disease - COPD
Formoterol Dose Ranging Study (ACHIEVE Duaklir USA Phase IIb)
To assess the bronchodilation of three doses of formoterol fumarate (6 μg, 12 μg and 24 μg) twice daily (BID) administered via Pressair® compared to placebo and to open-label nebulized formoterol fumarate (20 μg and 40 μg).
- Trial name
- NCT02796651
- Testing
- Formoterol fumarate (6 μg), Formoterol furmarate (20 μg), Formoterol fumarate (12 μg)
- Where
- 20 sites in United States
- Volunteers
- 132 people
- Sponsor
- AstraZeneca
Dehydration
Oral Rehydration Solution in Healthy Adults
This is a prospective, randomized, controlled, blinded, crossover study to evaluate the effects of an oral hydration solution.
- Trial name
- NCT06130475
- Testing
- Oral Rehydration Solution (ORS), Water
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Abbott Nutrition
Atrial Fibrillation
Ultra-High-Resolution Mapping Guided Partial Antral Ablation for AF
The electrical isolation of the pulmonary veins (PVI) is the cornerstone of current ablation techniques for the treatment of atrial fibrillation (AF) because the PV is the most common trigger of AF.
- Trial name
- TAILOR (NCT03759912)
- Where
- South Korea
- Volunteers
- 75 people
- Sponsor
- Keimyung University Dongsan Medical Center
Decreased and Nonspecific Blood Pressure Disorders and Shock
Comparison of HES 130 in Balanced and in Unbalanced Solution
The purpose of this study is to evaluate the efficacy of HES 130/0.42 in an electrolyte infusion in comparison to HES 130/0.4 in a sodium chloride infusion.
- Trial name
- NCT01301469
- Testing
- 6% HES 130/0.42 in plasma adapted Ringer's solution, 6% HES 130/0.4 in a saline solution
- Where
- 4 sites in China
- Volunteers
- 240 people
- Sponsor
- B. Braun Melsungen AG
Breast Cancer, Breast-conserving Surgery
Intra-SURGerY High-resolution Specimen PET/CT Imager for Margin Assessment in Early-stage Breast Cancer
This study is a diagnostic open-label, prospective, single-arm non-inferiority clinical trial. The primary endpoint is the accuracy to detect positive invasive margins in invasive ductal carcinoma (IDC) patients by…
- Trial name
- SURGYPET (NCT06474975)
- Testing
- AURA 10 PET/CT
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- European Institute of Oncology
Prosthetic Treatment, Craniofacial Abnormalities
Digital Design for Maxillofacial Prosthetics
This study will use a 3D scanner to print a 3D model or mold for each patient's prosthesis. The goal of this study to provide patients with a new, faster method of imaging and creating prostheses that preserves the quality of the…
- Conditions
- Prosthetic Treatment, Craniofacial Abnormalities, Maxillofacial Abnormalities
- Trial name
- NCT04035928
- Testing
- 3D digital scanning for maxillofacial prosthetics
- Where
- United States
- Sponsor
- University of Michigan
Pulmonary Disease, Chronic Obstructive
A Single Dose Study to Determine the Excretion, Balance and Metabolic Disposition of Radiolabelled GW642444.
The purpose of this study is to characterise the metabolic disposition of radiolabelled GW642444 when administered orally.
- Trial name
- NCT01286831
- Testing
- [14C]GW642444
- Where
- Netherlands
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Intracranial Stenosis, Venous Sinus Stenosis
This Prospective Observational Study Aims to Evaluate the Capability of Ultra-high-resolution Photon-counting CT Angiography (UHR PCD-CTA) for Noninvasive Evaluation of Intracranial Venous Sinus Stents. The Study Will Compare Image Quality, Stent Visualization, Metal-related Artifacts, and Diagnosti
This prospective observational study aims to evaluate the effectiveness of ultra-high-resolution photon-counting CT angiography (UHR PCD-CTA) for noninvasive assessment of intracranial venous sinus stents.
- Conditions
- Intracranial Stenosis, Venous Sinus Stenosis, Stent Implantation, Intracranial Venous Pressures
- Trial name
- NCT07762677
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xin Lou
COVID 19 Disease, Mild to Moderate COVID 19 Disease
A Clinical Evaluation of the Safety and Efficacy of Randomized Placebo Versus the 8-aminoquinoline Tafenoquine for Early Symptom Resolution in Patients With Mild to Moderate COVID 19 Disease and Low Risk of Disease Progression
A clinical study to assess the efficacy and safety of oral tafenoquine compared to placebo in patients with mild to moderate COVID 19 disease and low risk of disease progression (the "ACLR8-LR" study).
- Conditions
- COVID 19 Disease, Mild to Moderate COVID 19 Disease, SARS-CoV-2, Infectious Disease
- Trial name
- NCT05947812
- Testing
- Tafenoquine Oral Tablet
- Volunteers
- 148 people
- Sponsor
- 60P Australia Pty Ltd
Parkinson's Disease (PD), Dysphagia
Biomechanical Effects of EMST® on Swallowing Function in Parkinson's Disease
The aim of this non-randomized intervention study is to investigate the detailed effects of a structured four-week EMST® training program on the biomechanics of swallowing function in dysphagic Parkinson's patients.
- Trial name
- NCT07606547
- Testing
- exspiratory muscle strength training
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University Hospital Muenster
Chronic Hepatitis c
Efficacy and Safety Study of PEG-IFN-SA and Ribavirin to Treat Chronic Hepatitis C
This study is to confirm the potential effects and assess the safety of a new bio-product Pegylated Recombinant Consensus Interferon Variant Solution for Injection (PEG-IFN-SA) and Ribavirin（RBV） in the treatment of Chronic…
- Trial name
- NCT01903278
- Testing
- PEG-IFN-SA /RBV, Pegasys /RBV
- Where
- 41 sites in China
- Volunteers
- 719 people
- Sponsor
- Beijing Kawin Technology Share-Holding Co., Ltd.
Diabetes Mellitus
Colonic Motility in Patients With Diabetes
Background: Gastrointestinal (GI) symptoms are overrepresented in patients with diabetes mellitus (DM) and often have a major impact on quality of life.
- Trial name
- NCT04551625
- Testing
- High Resolution Colonic Manometry and 3D-Transit system.
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- University of Aarhus
Gastroesophageal Reflux Disease
Diagnostic of Transient Lower Esophageal Sphincter Relaxation With Combined Impedance and High Resolution Manometry in Patients With GERD
The aim of this study is to establish and validate High resolution manometry (HRM) criteria for the definition of transient lower esophageal sphincter relaxations (tLESRs) in gastroesophageal reflux disease (GERD) patients.
- Trial name
- HRM RTSIO (NCT01844440)
- Testing
- High resolution manometry
- Where
- 3 sites in France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Bordeaux
Grief, Depressive Symptoms
Accelerated Resolution Therapy for Complicated Grief
This study will examine whether accelerated resolution therapy (ART) is effective for the treatment of prolonged and complicated grief and associated psychological trauma among older adult hospice caregivers who have experienced…
- Conditions
- Grief, Depressive Symptoms, Trauma, Psychological
- Trial name
- NCT03484338
- Testing
- Accelerated Resolution Therapy
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of South Florida
Constipation
Usefulness of High Resolution Manometry in Constipation
Constipation is a frequent symptom that is reported by more than 10% of the general population. In a few case, constipation is resistant to medical standard care, including osmotic and stimulant laxatives.
- Trial name
- MANOCOHR (NCT04623359)
- Testing
- High resolution manometry
- Where
- 3 sites in France
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Adenocarcinoma of Lung
HRCT in Prediction of Tumor Invasion in GGO Lung Adenocarcinoma (ECTOP-1008)
This study is one of Eastern Cooperative Thoracic Oncology Projects (ECTOP-1008). It aims to evaluate the correlation between radiological diagnosis based on HRCT and pathological invasiveness.Investigators observe the…
- Trial name
- NCT04165759
- Where
- 2 sites in China
- Volunteers
- 620 people
- Sponsor
- Fudan University
Workflow, Costs
Microcomplications in Lap. Cholecystectomy: Reducing Intraoperative Interruptions by High Resolution Standardization
Objective: Investigators aimed to evaluate the impact of a high resolution standardized laparoscopic (HRSL) cholecystectomy protocol on operative time and intraoperative interruptions in a teaching hospital.
- Conditions
- Workflow, Costs, Laparoscopy, Cholecystectomy
- Trial name
- NCT03329859
- Testing
- High resolution standardized laparoscopic cholecystectomy
- Where
- Switzerland
- Volunteers
- 39 people
- Sponsor
- University Hospital, Basel, Switzerland
Severe Pre-eclampsia
Rosuvastatin in Order to Induce Preeclampsia Resolution in Severe PET up to 48 Hours Following Delivery
Prospective randomized single blind trial. Study population are women diagnosed with severe pre-eclampsia during singleton pregnancy, between 24+0 weeks and 41+6 weeks gestational age.
- Trial name
- NCT02314286
- Testing
- Rosuvastatin
- Volunteers
- 100 people
- Sponsor
- Soroka University Medical Center
Fungemia, Fungal Infections
A Study to Compare Efficacy and Safety of Mycamine® and Itraconazole for Preventing Fungal Infections
The objective of this study is to compare the efficacy and safety between Mycamine and Itraconazole oral solution in preventing invasive fungal infections on autologous(malignant blood diseases) or allogeneic hematopoietic stem…
- Trial name
- NCT00794703
- Testing
- micafungin (Mycamine), itraconazole
- Where
- 10 sites in China
- Volunteers
- 288 people
- Sponsor
- Astellas Pharma Inc
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