Clinical trials: Resolution of Pathologic Process
Pulmonary Arterial Hypertension, Ayerza Syndrome
Trial of Iloprost Inhaled Solution as Add-On Therapy With Bosentan in Subjects With Pulmonary Arterial Hypertension (PAH)
The purpose of this study is to determine the safety and efficacy of Iloprost in subjects that have Pulmonary Arterial Hypertension who are concurrently taking bosentan (Tracleer TM).
- Conditions
- Pulmonary Arterial Hypertension, Ayerza Syndrome, Pulmonary Hypertension
- Trial name
- NCT00086463
- Where
- 17 sites in United States
- Volunteers
- 60 people
- Sponsor
- Actelion
Tendinopathy
Tracking of Red Blood Cells Using Super Resolution Ultrasound in Persons With Healthy or Overuse Injured Tendons
The goal of this observational study is to test whether a new ultrasound method, called SUper Resolution ultrasound imaging of Erythrocytes (SURE), can image the small blood vessels found in tendons of persons with a tendon…
- Trial name
- SURE-TEND (NCT06142747)
- Testing
- Super-Resolution Ultrasound Imaging of Erythrocytes (SURE)
- Where
- Denmark
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Periapical Diseases, Postoperative Dental Pain
Postoperative Pain in Photodynamic Therapy Using Curcumin As a Photosensitizer
In endodontics, various irrigation solutions are used to achieve antibacterial efficacy within the root canal. The antibacterial effect of curcumin-containing root canal solutions, when combined with photodynamic therapy, has…
- Conditions
- Periapical Diseases, Postoperative Dental Pain, Irrigation Solution, Photodynamic Therapy (PDT)
- Trial name
- NCT06752655
- Testing
- Curcumin with photodynamic thearpy, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Caregivers
Cereset Research for Caregivers
Caregivers experience high levels of prolonged stress that can lead to chronic problems with health, including increased risk of cardiovascular disease that is linked to autonomic dysregulation.
- Trial name
- NCT05209438
- Testing
- Cereset Research
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Immune Thrombocytopenic Purpura (ITP)
Efficacy and Safety Study of a 10% Triple Virally Reduced Intravenous Immune Globulin Solution in Adult Subjects With Chronic Idiopathic Thrombocytopenic Purpura
The purpose of this study is to evaluate whether Immune Globulin Intravenous (Human), 10% TVR (Triple Virally Reduced) Solution is an effective and safe treatment in patients with chronic idiopathic thrombocytopenic purpura.
- Trial name
- NCT00162006
- Testing
- Immune Globulin Intravenous (Human), 10% Triple Virally Reduced Solution
- Where
- 11 sites in Czechia, Germany and 2 more
- Volunteers
- 28 people
- Sponsor
- Baxalta now part of Shire
Gastro-esophageal Reflux
Post Prandial High Resolution Impedance- Manometry
Nine to 30% of the population suffers from gastro-esophageal reflux disease (GERD) - suggestive symptoms (heartburn, regurgitation, chest pain, chronic couch, sore throat).
- Trial name
- NCT03306485
- Testing
- Correlating the number of reflux episodes detected on 1-h post prandial esophageal high resolution manometry combined and those detected on ambulatory 24-h pH-impedance monitoring performed on PPI
- Where
- France
- Volunteers
- 9 people
- Sponsor
- Hospices Civils de Lyon
Postmenopause
Bone Microstructure in Nasal Salmon Calcitonin Treated Postmenopausal Women
Calcitonin has been used for many years for treating osteoporosis in postmenopausal women. Recent data from the 2 years placebo-controlled QUEST study have shown a preservation of microarchitecture as measured by high resolution…
- Trial name
- NCT00372099
- Testing
- Salmon calcitonin
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Rene Rizzoli
the Correlation Between the Barium Examination and High Resolution Impedance Manometry
The Correlation Between the Barium Examination and High Resolution Impedance Manometry
In many cases, the manometric examination is not feasible because of the pharyngeal sinusitis or pharyngeal torsion. In addition, although previous conventional manometry was used to estimate pharyngeal swallowing, the bolus flow…
- Trial name
- NCT04878588
- Testing
- patients received high resolution impedance manometry
- Volunteers
- 20 people
- Sponsor
- National Taiwan University Hospital
Infertility, Female
Cabergoline Before or After Oocyte Collection for Follicular Resolution
Randomized trial comparing the efficacy of two different times of administration of cabergoline in patients undergoing controlled ovarian stimulation and oocyte collection.
- Trial name
- NCT04096027
- Testing
- Cabergoline Pill
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Fertility Center of Las Vegas
Colonic Adenoma
High Definition Endoscopy and Virtual Chromoendoscopy Versus Standard Resolution Endoscopy in Detection of Colon Polyps
Over the last years a number of new endoscopic imaging modalities have been introduced (high-definition and virtual chromoendoscopy).
- Trial name
- NCT03243669
- Testing
- High-definition, Virtual chromoendoscopy, Standard
- Where
- Belgium
- Volunteers
- 2,146 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Bleeding Hemorrhage
Efficacy of Prophylactic Epinephrine Solution Injection in Prevention of Delayed Post-sphincterotomy
Bleeding is the most frequently reported serious complication of endoscopic sphincterotomy, and severe bleeding has occurred in about 1% to 2% of patients.
- Trial name
- NCT04964869
- Testing
- epinephrine solution injection
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- Wen-Hsin Huang
Chronic Obstructive Pulmonary Disease
Assessment of the Safety and Ability of a Once-a-day Dose of an Orally Inhaled Medicine [i.e., Glycopyrrolate Inhalation Solution = GIS] to Improve Airflow in the Lungs When Delivered Using an eFlow Nebulizer in Patients With Chronic Obstructive Pulmonary Disease (COPD)
The study assessed the safety and ability of an orally inhaled medicine [i.e., Glycopyrrolate Inhalation Solution = GIS] to improve airflow in the lungs when delivered using an eFlow nebulizer in 42 patients with Chronic…
- Trial name
- NCT02948582
- Testing
- Glycopyrrolate Inhalation Solution12.5μg, Glycopyrrolate Inhalation Solution 50μg, Glycopyrrolate Inhalation Solution 100μg
- Volunteers
- 42 people
- Sponsor
- Sunovion Respiratory Development Inc.
Breast Cancer
Using Magnetic Resonance Spectroscopy With MRI to Non-invasively Determine Breast Cancer Extent of Disease
The purpose of this study is to evaluate whether high-resolution magnetic resonance imaging of the axilla with spectroscopy can identify nodal features suggestive of metastatic involvement in patients diagnosed with invasive…
- Trial name
- NCT00312637
- Testing
- Magnetic Resonance Spectroscopy
- Where
- United States
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Sezary Syndrome
Extracorporeal Photopheresis in Sezary Syndrome
The primary endpoint is to determine if ECP induces a decrease in % of tumor cells after treatment. 20 patients with Sezary Syndrome will receive ECP weekly x4, then bi-weekly for 5 months.
- Trial name
- ECP (NCT05157581)
- Testing
- Extracorporeal photopheresis (ECP), Methoxsalen Injection
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Oleg E. Akilov, MD, PhD
Thyroid Nodular Disease
Microvascular Profiling of Nodules in the Thyroid Gland
The purpose of this study is to examine tiny blood vessels in different thyroid nodules using advanced ultrasound. In the long term, we hope this can help doctors better tell the difference between types of nodules and more…
- Trial name
- NCT07041307
- Where
- 2 sites in Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Papilloma Viral Infection, CIN1
Evaluation Of The Efficacy Of The Combination Of GLIZIGEN® Oral Solution 1/Day And Vaginal Gel 1/Night For 2 Months In Patients With Cervical Intraepithelial Neoplasia Grade 1 (LSIL/CIN-1) Caused By High-Risk Human Papillomavirus (HPV-AR)
HPV infection can lead to cancer, especially when precancerous lesions have developed and high-risk HPV is present. Glizigen is an oral and intravaginal treatment based on activated glycyrrhizinic acid that has shown potential…
- Conditions
- Papilloma Viral Infection, CIN1, LSIL, Low Grade Squamous Intraepithelial Lesion
- Trial name
- NCT05916911
- Testing
- Glizigen
- Where
- 4 sites in Spain
- Volunteers
- 120 people
- Sponsor
- Catalysis SL
Weight Loss
Plicated Laparoscopic Adjustable Gastric Banding (Lap Band)
This is a dual site, prospective study which will compare plicated-Laparoscopic Adjustable Gastric Banding (PLAGB) to standard LABG (SLAGB) to identify significant differences in bariatric surgical outcomes Weight Loss Co-morbid…
- Trial name
- NCT01497028
- Testing
- PLAGB will be studied and compared to the standard LAGB procedure through a dual center, prospective clinical trial.
- Where
- 2 sites in United States
- Sponsor
- Jacksonville Surgical Associates
Gastroesophageal Reflux
Thresholds of Straight Leg Raise Maneuver During High-Resolution-Manometry
High resolution manometry (HRM) is a key test in the preoperative assessment of patients with gastro-esophageal reflux disease (GERD) who are potential candidates for antireflux surgery.
- Trial name
- NCT04813029
- Testing
- Straight leg raise maneuver
- Where
- Italy
- Volunteers
- 336 people
- Sponsor
- University of Milan
Change in Serum Chloride Level
Change in Serum Chloride Level After Loading Dose of Sterofundin Solution Compared With Normal Saline Solution
Prospective, crossover, randomized trial to evaluate plasma compositions after loading dose of sterofundin solution given to healthy volunteer in the resuscitation manner compared with normal saline solution.
- Trial name
- NCT02950974
- Testing
- Sterofundin, NSS
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ramathibodi Hospital
Otorhinolaryngeal Neoplasms, Cancer of Head and Neck
Validation of High-resolution PET/CT for the Pretherapeutic Lymphnode Staging of Head/Neck Cancer
In head and neck squamous cell carcinoma (HNSCC), the presence of lymph node metastases in addition to free resection margins following surgical resection of the primary tumor is an important prognostic factor, and may impact…
- Trial name
- NCT02372890
- Where
- Switzerland
- Volunteers
- 153 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
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