Clinical trials: Resolution of Pathologic Process
Healthy
DBM-1152A Inhalation Solution in Healthy Volunteers
This is a single-center, randomized, double-blind, placebo-controlled Phase 1b study to evaluate the safety, tolerability, and pharmacokinetics (PK) of multiple-dose DBM-1152A inhalation solution in healthy Chinese adults.
- Trial name
- NCT07439419
- Testing
- DBM-1152A
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Joincare Pharmaceutical Group Industry Co., Ltd
Volunteers
Cardiometabolic Health and Inflammatory Resolution
The aim of this study is to determine how inflammatory resolution impacts cardiometabolic health and disease in subjects that are either lean (18.5-24.9 kg/m2), overweight (25.0-29.9 kg/m2) or obese (>30.0 kg/m2).
- Trial name
- REX (NCT04256330)
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Göteborg University
COPD
Impact of Ibis on Patients With Advanced COPD
The purpose of this research is to determine if Ibis™, a digital therapeutics solution developed by Senscio Systems, reduces the emergency room visits and hospitalizations of patients with COPD.
- Trial name
- NCT03131622
- Testing
- Digital Therapeutics
- Volunteers
- 240 people
- Sponsor
- Senscio Systems
Acute Deep Vein Thrombosis
Role of a Novel Exercise Program to Prevent Post-thrombotic Syndrome
Despite standard care, 25%-50% of patients with clots in the deep veins of the arms and legs progress to chronic post-clot problems resulting in significant disability, loss of productivity, and healthcare costs.
- Trial name
- EFFORT2 (NCT02148029)
- Testing
- Exercise, Standard Care
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- VA Office of Research and Development
Blood Stream Infections, Short Bowel Syndrome
Evaluation of 70% Ethanol Lock Solution to Prevent Catheter Related Blood Stream Infections in Pediatric Patients
The purpose of this study is to evaluate the clinical practice of the prophylactic use of ethanol locks for the prevention of catheter related blood stream infections in pediatric intestinal rehabilitation program patients…
- Trial name
- NCT01409772
- Testing
- Ethanol Lock
- Sponsor
- University of Nebraska
Metabolic Syndrome, Physical Activity
The Effect of Health Provider's Feedback on Physical Activity Surveillance Using Wearable Device-Smartphone Application for Resolution of Metabolic Syndrome
The Effect of Health Provider's Feedback on Physical Activity Surveillance using Wearable Device-Smartphone Application for Resolution of Metabolic Syndrome; a 12-Week Randomized Control Study
- Trial name
- NCT05630456
- Testing
- Receving feedback, No regular feedback
- Where
- South Korea
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Pusan National University Hospital
Chronic Obstructive Pulmonary Disease, Bronchitis
Efficacy Safety Study of Arformoterol/Tiotropium Combination Versus Either Therapy Alone in Chronic Obstructive Pulmonary Disease (COPD)
The purpose of this study is to evaluate and compare the efficacy of arformoterol twice a day and tiotropium once a day (dosed sequentially) versus tiotropium once a day alone in subjects with Chronic Obstructive Pulmonary…
- Conditions
- Chronic Obstructive Pulmonary Disease, Bronchitis, Emphysema
- Trial name
- NCT00424528
- Testing
- Arformoterol Tartrate Inhalation Solution, Tiotropium, Arformoterol and Tiotropium
- Where
- 28 sites in United States
- Volunteers
- 235 people
- Sponsor
- Sumitomo Pharma America, Inc.
Cerebral Small Vessel Diseases
White Matter Hyperintensities Subtypes in Cerebral Small Vessel Disease : 7 Tesla Ultra-high Resolution Imaging MRI
Cerebral small vessel diseases (SVD) are a very frequent group of disorders all characterized by alterations of the structure and/or function of small arteries, veins and capillaries.
- Trial name
- SV7 (NCT04298866)
- Testing
- Experimental Arm
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Giant Cell Arteritis, Visual Impairment
Visual Involvement in Giant Cell Arteritis
This observational study aims to enhance the description of the different ways Giant Cell Arteritis (GCA) affects vision. The latest technology and knowledge are used to improve how we diagnose and predict patient outcomes.
- Conditions
- Giant Cell Arteritis, Visual Impairment, Central Retinal Artery Occlusion, Anterior Ischemic Optic Neuropathy
- Trial name
- Visu-GCA (NCT06500728)
- Testing
- Fluorescein and Indocyanine green Angiography, High-resolution Optical Coherence Tomography, Angio-Optical Coherence Tomography
- Where
- Italy
- Volunteers
- 762 people
- Sponsor
- ASST Fatebenefratelli Sacco
Arterial Aneurysm Wall Enhancement on HRMRI
Risk Assessment and Mechanism Analysis of Intracranial Multiple Aneurysm Instability Based on High-resolution Magnetic Resonance, Imaging Histology and Hemodynamics
This project proposes to establish a prospective cohort of MIA based on a preexisting multicenter MIA database and to combine multidimensional methods such as high-resolution magnetic resonance, hemodynamics, ambulatory blood…
- Trial name
- NCT06539767
- Where
- 2 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Zhujiang Hospital
Gastrointestinal Dysfunction
Use of High Resolution Colonic Manometry in Studying Motility
An injury to the spinal cord (SCI) results in numerous medical complications, including gastrointestinal (GI) function. Individuals with SCI may experience severe constipation (prolonged stool retention), incontinence…
- Trial name
- NCT02574611
- Testing
- Neostigmine, Glycopyrrolate, High Resolution Colonic Manometry
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Chalazion
Local 5-Fluorouracil Injection for the Treatment of Chalazia: A Prospective, Comparative Study
Local injection of 5-fluorouracil into a chalazion (stye) is as effective as local injection of triamcinolone (steroid) and incision and curettage for treatment of chalazia.
- Trial name
- CTS (NCT02025023)
- Testing
- 5-fluorouracil Injection, Triamcinolone Acetonide, Incision and Curettage
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Washington
Sepsis, Acute Kidney Injury
Comparison of Balanced Crystalloids and Normal Saline in Septic Patients
In this prospective randomized controlled trial, investigators attempt to study the effects of acetated Ringer's solution on the prognosis and renal function of patients with sepsis in intensive care unit compared with normal…
- Conditions
- Sepsis, Acute Kidney Injury, Septic Shock, Sepsis, Severe
- Trial name
- NCT03685214
- Testing
- 0.9% saline, lactated Ringer's solution
- Where
- China
- Volunteers
- 500 people
- Sponsor
- ZhiYong Peng
Prostate Cancer, Prostate Disease
High Resolution Diffusion Weighted Imaging in Prostate
hrDWI might be an alternative to cDWI for the prostate imaging. 1. increase the signal-to-noise ratio and contrast-to-noise ratio, yielding high-fidelity images with less noise in general 2.
- Trial name
- NCT06636747
- Where
- 2 sites in China
- Volunteers
- 500 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Bariatric Surgeries, Metabolic Surgery
Five-year Outcome of Laparoscopic Gastric Sleeve
The aim of this study is to evaluate the long-term (5-year follow-up) results of laparoscopic gastric sleeve (LGS) in terms of weight loss and obesity related comorbidities, as well as the risk factors associated with…
- Trial name
- NCT03467581
- Where
- Estonia
- Volunteers
- 500 people
- Sponsor
- Tartu University Hospital
Partial Epilepsy
Localizing the Epileptogenic Zone With High Resolution Electroencephalography
Multicenter prospective study comparing the diagnosis value of high-resolution EEG and depth-EEG to localize the epileptogenic zone in drug resistant partial epilepsies.
- Trial name
- EEG-HR (NCT01090934)
- Testing
- High Resolution EEG, Stereo-electroencephalography
- Where
- 2 sites in France
- Volunteers
- 115 people
- Sponsor
- Central Hospital, Nancy, France
Fasting
The Effects of Carbohydrate-electrolyte Solution on Metabolic Responses in Paediatric Patients
The aim of this study is to evaluate the effects of oral administration of carbohydrate-electrolyte-containing fluid, compared to standard clear fluid during preoperative fasting on metabolic responses, preoperative anxiety and…
- Trial name
- NCT05729100
- Testing
- Oral carbohydrate-electrolyte solution, Control
- Where
- Indonesia
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Pancreatitis, Chronic, Pancreatic Duct Stone
Aggressive Intravenous Hydration With Lactated Ringer's Solution for Prevention of Post-ESWL Pancreatitis
The goal of this clinical trial is to clarify whether aggressive intravenous hydration with lactated Ringer's solution could reduce the incidence of post-ESWL pancreatitis in patients with chronic pancreatitis.
- Trial name
- HYPER (NCT05772234)
- Testing
- Lactated ringers solution, normal saline
- Where
- China
- Volunteers
- 1,066 people
- Sponsor
- Changhai Hospital
Hypopharyngeal Peak Pressure
Normative Swallowing Physiological Metrics of Pharyngeal High-Resolution Impedance Manometry in Chinese Adults
As Taiwan enters a super-aged society in 2025, the number of elderly patients and patients with multiple comorbidities continues to increase, and the risk of dysphagia rises with advancing age.
- Trial name
- NCT07594561
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Barrett Esophagus
High Resolution Virtual Chromoendoscopy Versus Seattle Protocol for the Surveillance of Barrett's Esophagus
The investigators hypothesize that careful examination of Barrett's esophagus by high-resolution endoscopy combined with virtual chromoendoscopy could replace the Seattle protocol for Barrett's esophagus monitoring and detection…
- Trial name
- CONVERSE (NCT05229783)
- Testing
- Electronic chromoendoscopy, White light endoscopy with Seattle protocol
- Where
- 15 sites in France
- Volunteers
- 110 people
- Sponsor
- Nantes University Hospital
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