Clinical trials: Resolution of Pathologic Process
Pancreatic Cyst, EUS-FNA
CHARM II: Chemotherapy for Ablation and Resolution of Mucinous Pancreatic Cysts
The purpose of this study is to evaluate the efficacy and safety of chemotherapeutic pancreatic cyst ablation using ethanol lavage followed by the infusion of a dual-agent chemotherapeutic cocktail (paclitaxel + gemcitabine)…
- Trial name
- CHARM (NCT03085004)
- Testing
- Ethanol, Normal saline, Paclitaxel + Gemcitabine admixture
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- Milton S. Hershey Medical Center
Sensorineural Hearing Loss (Disorder)
Clinical Applications of Round Window Imaging Anatomy in Cochlear Implant Surgery
The purpose of this study is to measure the size of the round window niche and its relation to the mastoid segment of the facial nerve and the mastoid cortex, using high resolution computerized tomography of the temporal bone, in…
- Trial name
- NCT02093806
- Testing
- measurment
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Bnai Zion Medical Center
Hydronephrosis, Gestational Diabetes
Mild Fetal Hydronephrosis, Gestational Diabetes and Spontaneous Resolution vs Moderate-severe Fetal Hydronephrosis, Obstructive Causes and Worse Postnatal Outcome
Renal pelvis dilatation can be a relatively common finding on obstetric antenatal ultrasounds occurring in 1% to 5% of all pregnancies, with a known predilection for the male sex.
- Trial name
- FHYDO (NCT06896149)
- Testing
- Obstetric ultrasound
- Where
- Italy
- Volunteers
- 800 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Hypovolemia
Comparison of Two Gelatine Solutions
The aim of volume replacement is to compensate a reduction in the intravascular volume e.g. during surgery and to counteract hypovolemia in order to maintain hemodynamics and vital functions.
- Trial name
- NCT01515397
- Testing
- Gelofusine balanced, Gelofusine 4%
- Where
- 2 sites in Germany
- Volunteers
- 40 people
- Sponsor
- B. Braun Melsungen AG
Chronic Cerebral Ischemia
Safety and Efficacy of Sequential Therapy With Mexidol® in Patients With Chronic Cerebral Ischemia
The purpose of this study is to evaluate safety and efficacy of sequential treatment with Mexidol® in patients with chronic cerebral ischemia (CCI).
- Trial name
- MEMO (NCT06834490)
- Testing
- Mexidol
- Where
- 14 sites in Russia, Uzbekistan
- Volunteers
- 318 people
- Sponsor
- Pharmasoft
Tobacco Use Disorder
Low Intensity Focused Ultrasound for Tobacco Use Disorder: High Resolution Targeting of the Human Insula
The goal of this clinical trial is to to inhibit the dorsal anterior insula (dAI) with low intensity focused ultrasound (LIFU) to determine the causal role for the dAI in smoking cue induced craving in individuals with tobacco…
- Trial name
- LIFU_TUD (NCT06405074)
- Testing
- low intensity focused ultrasound (LIFU)
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Washington D.C. Veterans Affairs Medical Center
Gastroesophageal Reflux
Coordination Versus Pressure in Oesophageal Peristalsis
High Resolution Manometry (HRM) is a new advance in oesophageal measurement that permits the acquisition of pressure data through the entire length of the oesophagus over time via closely spaced sensors that continuously record…
- Trial name
- NCT00482885
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Moderate to Severe Acute Postoperative Pain
Use of Tapentadol Oral Solution for Pain After Surgery in Children From Newborn to Less Than 2 Years Old
This is a multicenter, open-label (all people involved know the identity of the intervention), single dose trial to evaluate the pharmacokinetic (PK) profile (how drugs are absorbed in the body, how are they distributed within…
- Trial name
- NCT02221674
- Testing
- Tapentadol
- Where
- 7 sites in United States, Poland and 1 more
- Volunteers
- 40 people
- Sponsor
- Grünenthal GmbH
Dysphagia, Swallowing Disorders
Novel Pharyngeal Metrics to Predict Dysphagia Outcomes
This multi-site trial will follow a cohort of Veterans with dysphagia for 8 weeks as they undergo clinically guided oropharyngeal exercises with oropharyngeal strengthening as the primary goal.
- Trial name
- NCT04569097
- Testing
- standard of care lingual strengthening
- Where
- 3 sites in United States
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Gastroesophageal Reflux Disease (GERD), Gastroesophageal Reflux (GER)
Development of Machine Learning Models to Predict Postoperative GERD Symptom Resolution After Laparoscopic Nissen Fundoplication
This study aims to develop machine learning models to predict postoperative gastroesophageal reflux symptom resolution after laparoscopic Nissen fundoplication using Elastic Net regression and synthetic minority oversampling…
- Trial name
- NCT06862037
- Testing
- Laparoscopic Nissen fundoplication
- Where
- South Korea
- Volunteers
- 112 people
- Sponsor
- Korea University Anam Hospital
Interstitial Lung Disease
HR Chest CT Visual Scoring, Spirometry and Health Related Quality of Life in Evaluating Severity of ILD Patients
To establish a simplified approach for assessment of severity of interstitial lung disease by evaluating the relationship between HRCT findings, the clinical severity score,spirometry and quality of life.
- Trial name
- NCT05999838
- Testing
- HRCT chest visual scoring
- Volunteers
- 50 people
- Sponsor
- Assiut University
Catheter Related Infection, Bacteremia
Efficacy and Safety of an Ethanol/Sodium Citrate Locking Solution: A Pilot Study
Currently in Canada, either 4% sodium citrate or heparin 1,000-10,000 U/ml solutions are "locked" into hemodialysis catheters between dialysis sessions to prevent thrombosis.
- Trial name
- NCT01394458
- Testing
- 30 % ethanol / 4% sodium citrate catheter locking solution, Heparin 1000 u / ml
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Manitoba
Age 18 to 80 Years, Malignant Mechanical Bowel Obstruction Diagnosed Clinically/Radiologically, With Prior Abdominal Surgery for Relief
Postbiotics for GI Recovery After Malignant Bowel Obstruction Surgery
Objective: To evaluate the effects of the postbiotic preparation JK-5G on gastrointestinal function recovery (GI-2 time), gastrointestinal dysfunction, nutritional status, and safety in patients after surgery for malignant bowel…
- Conditions
- Age 18 to 80 Years, Malignant Mechanical Bowel Obstruction Diagnosed Clinically/Radiologically, With Prior Abdominal Surgery for Relief, Hemodynamically Stable Within 24h Post-op, Per Investigator, Informed Consent Obtained Before Surgery or Randomization
- Trial name
- NCT07850089
- Testing
- High-Concentration Compound Lactic Acid Bacteria Metabolite JK-5G
- Volunteers
- 80 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Depressive Symptoms, Stress Disorder, Acute
Neurophysiological Mechanisms of Accelerated Resolution Therapy (ART)
In brief, ART is an innovative "mind-body" (body-centric) psychotherapy that makes use of established core components of trauma-focused therapy including imaginal exposure and imagery rescripting to promote memory…
- Conditions
- Depressive Symptoms, Stress Disorder, Acute, Prolonged Grief Disorder, Alcohol Abuse
- Trial name
- M-ART (NCT04121884)
- Testing
- Accelerated Resolution Therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of South Florida
Hemorrhagic Shock
Efficacy, Safety of Solution Containing Hyperosmolar Sodium Lactate Infusion for Resuscitation of Patients With Hemorrhagic Shock
Indication: Resuscitation in pts with hemorrhagic shock due to multiple injuries Prospective, open label RCT in pts. with traumatic hemorrhagic shock in RS Hasan Sadikin Hospital, Indonesia. PI: Dr.
- Trial name
- NCT01433276
- Testing
- Hyperosmolar sodium lactate, Ringer's lactate
- Where
- Indonesia
- Volunteers
- 71 people
- Sponsor
- Innogene Kalbiotech Pte. Ltd
Peri-implant Mucositis, Peri-Implantitis
Experimental Peri-implant Mucositis on Implant Sites That Were Previously Treated With or Without Implantoplasty
This controlled clinical trial will assess clinically, immunologically, and microbiologically the healing of experimental peri-implant mucositis (PIM) lesions in implants treated previously with implantoplasty (IP) compared to…
- Trial name
- NCT06063876
- Testing
- Induction of experimental peri-implant mucositis, Resolution of experimental peri-implant mucositis
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Unspecified Complication of Lung Transplant
High-resolution Computed Tomography (HRCT) Evaluation of Airway Distensibility in Lung Transplant Recipients
Lung and heart-lung recipients at the University of Texas Medical Branch who have participated in the "Assessment of Cough Reflex in Lung Transplant Recipients" study who meet the specific study inclusion/exclusion criteria will…
- Trial name
- NCT00584181
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Hiatus Hernia
Effects of Position and a Test Meal on Esophago-gastric Junction Morphology and Function Assessed by High-resolution Impedance Manometry (HRM)
Retrospective analysis for HRM measurements using liquid swallows and a test meal for the presence of hiatal hernia. The investigators will correlate hernia descriptions with presence of acidic reflux and clinical complaints.
- Trial name
- NCT02397616
- Testing
- high resolution esophageal manometry
- Where
- Switzerland
- Volunteers
- 380 people
- Sponsor
- University of Zurich
Hematopoietic and Lymphoid System Neoplasm, Malignant Solid Neoplasm
Psychotherapy (Accelerated Resolution Therapy) for Cancer Related Trauma and Distress
This trial studies whether a form of psychotherapy called accelerated resolution therapy can help with cancer distress and psychological trauma.
- Trial name
- NCT04436835
- Testing
- Psychotherapy, Questionnaire Administration
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Mayo Clinic
Chronic Hepatitis B
Study of Efficacy and Safety, Tolerability and Pharmacokinetics of Telbivudine in Children and Adolescents With Compensated Chronic Hepatitis B Virus Infection
The purpose of the study was to assess the efficacy and safety of telbivudine at a dose of 20 mg/kg up to a maximum of 600 mg q.d.
- Trial name
- NCT02058108
- Testing
- Telbivudine
- Where
- 29 sites in Bulgaria, Greece and 5 more
- Volunteers
- 53 people
- Sponsor
- Novartis Pharmaceuticals
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