Clinical trials: Resorption
Impacted Mandibular Third Molar, Alveolar Bone Loss
Healing of Mandibular Third Molar Extraction Sockets Using Platelet Concentrates and Photobiomodulation
Surgical removal of impacted mandibular third molars is a common procedure that may be associated with postoperative pain, swelling, limited mouth opening, and delayed bone healing.
- Conditions
- Impacted Mandibular Third Molar, Alveolar Bone Loss, Impacted Mandibular Third Molar Extraction
- Trial name
- NCT07324213
- Testing
- Mandibular Third Molar Extraction With Primary Wound Closure, Autologous Platelet Concentrates, Photobiomodulation
- Where
- Poland
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Medical Innovation Center Wroclaw
Osseointegrated Dental Implantation
Effect of Platelet-rich Factor on Implant Stability and Bone Resorption in the Lower Posterior Mandible
The main objective of this clinical trial study is to consider the effect of Platelet-Rich-Factor (PRF) on implant stability and marginal bone resorption around dental implants.
- Trial name
- NCT02349620
- Testing
- PRF
- Where
- Iran
- Volunteers
- 30 people
- Sponsor
- Reza Tabrizi
Alveolar Bone Loss
Effectiveness of Alveolar Bone Preservation in Alveoli With Infectious Process
Alveolar ridge preservation (ARP) is a surgical technique that aims to minimize the degree of dimensional changes following extraction.
- Trial name
- NCT06661863
- Testing
- alveolar ridge preservation with bioactive glass, alveolar ridge preservation with autologous bone
- Where
- Ecuador
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Universidad de Especialidades Espiritu Santo
Refractory Multiple Myeloma
Tivantinib in Treating Patients With Relapsed, or Relapsed and Refractory Multiple Myeloma
This phase II trial studies the side effects and how well tivantinib works in treating patients with relapsed, or relapsed and refractory multiple myeloma.
- Trial name
- NCT01447914
- Testing
- Tivantinib, Diagnostic laboratory biomarker analysis, Questionnaire administration
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Cancer Institute (NCI)
Alveolar Bone Atrophy
Comparative (Short vs. Standard) Length Implants in Early Stability Patterns.
Early Stability of Short vs. Standard Dental Implants in the Posterior Mandible This study compares how well short dental implants (7mm) work compared to standard-length implants (11mm) when placed in the back part of the lower…
- Trial name
- NCT07162389
- Testing
- Shallow-Threaded Short Implant (SHI), Shallow-Threaded Standard Implant (SDI)
- Where
- Yemen
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Science and Technology, Yemen
Intrabony Defect, Periodontal Diseases
RGD With Minimally Invasive Non-Surgical Technique in Treatment of Periodontal Intrabony Defect
Periodontal regeneration is a complex process that involves coordinated activities and interactions of many cell types, extracellular matrix, cytokines, and specific growth factors to restore tissue integrity.
- Conditions
- Intrabony Defect, Periodontal Diseases, Alveolar Bone Loss
- Trial name
- MINST + RGD (NCT06936605)
- Testing
- RGD Peptide
- Volunteers
- 45 people
- Sponsor
- Minia University
Horizontal Alveolar Ridge Deficiency
Comparison of Split Box and Split Bone Block Techniques in Horizontal Ridge Augmentation
Horizontal alveolar ridge deficiencies may prevent the placement of dental implants and often require bone augmentation procedures before implant treatment.
- Trial name
- SBBTvsSBT (NCT07656662)
- Testing
- Split Bone Block Technique, Split Box Technique
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people
- Sponsor
- Marmara University
Alveolar Bone Loss
Comparison of Coronally Advanced Lingual Flap to Modified MPI for Flap Advancement in Partially Edentulous Patients
Comparison of cronally advanced lingual flap to modified periosteal releasing incision (MPRI)
- Trial name
- NCT03466840
- Testing
- The coronally advanced lingual flap, Modified periosteal releasing Incision
- Where
- Egypt
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Cairo University
Root Resorption, Pain Perception
AI-Designed Clear Aligners: A Randomized Clinical Trial
The goal of this clinical trial is to evaluate the clinical performance and validity of applying AI-based TruRoot-designed clear aligners in adult orthodontic patients.
- Conditions
- Root Resorption, Pain Perception, Treatment Duration
- Trial name
- NCT06968325
- Testing
- AI-based TruRoot group:, Conventional clear aligner group
- Where
- Iraq
- Volunteers
- 40 people
- Sponsor
- University of Baghdad
Crestal Bone Resorption, Implant Primary Stability
Clinical Evaluation Of Dental Implants Stability Placed In Healed Bony Sites Following Over-drilling Compared To Conventional-Drilling Protocol
Clinical Evaluation Of Dental Implants Stability Placed In Healed Bony Sites Following Over-drilling Compared To Conventional-Drilling Protocol
- Conditions
- Crestal Bone Resorption, Implant Primary Stability, Implant Osseointegration
- Trial name
- RCT (NCT03250949)
- Testing
- implant site over drilling protocol
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Azhar ALI ELSAYED SELEEM
Bone Resorption, Dental Diseases
Allogeneic Bone Paste Versus Allogeneic Bone Powder
Autogenous bone graft has been considered the gold standard in Guided Bone Regeneration (GBR) technique used for bone augmentation.
- Trial name
- NCT04141215
- Testing
- BIOBank bone paste, BIOBank cortico-cancellous bone powder
- Where
- France
- Volunteers
- 86 people
- Sponsor
- Biobank
Malocclusion of Anterior Teeth
Effects of Laser Therapy and Vitamin D Pills on Braces Tooth Movement: A Random Controlled Study
This clinical trial aims to evaluate the efficacy of low-level laser therapy (LLLT) in conjunction with oral vitamin D3 supplementation in accelerating orthodontic tooth movement in adults with crowded mandibular anterior teeth…
- Trial name
- LLLT (NCT07286474)
- Testing
- Cholecalciferol (Vit D3), Low-Level Laser Therapy, Fixed Orthodontic Appliance
- Where
- Saudi Arabia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Peri-Implantitis, Bone Resorption
Surgical Treatment of Peri-implantitis With Adjunctive Application of Platelet Rich Fibrin (PRF)
Platelet-rich fibrin (PRF) is a second-generation platelet concentrate used for tissue and bone regeneration. PRF releases growth factors such as TGF-β, PDGF, VEGF, IGF, and FGF, which are known to promote wound healing and bone…
- Conditions
- Peri-Implantitis, Bone Resorption, Platelet-Rich Fibrin
- Trial name
- PRF (NCT06679283)
- Testing
- Open flap debridement with a chemo-electric device + PRF, Open flap debridement with a chemo-electric device alone (control)
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Bern
Mandibular Bone Resorption
Comparison of Short Implant Assisted Mandibular Overdenture Designs
The aim of the study was to clinically and radiographically evaluate and compare the use of unsplinted and splinted short implants with ball abutments to support mandibular overdentures in cases with severe mandibular ridge…
- Trial name
- NCT04582162
- Testing
- Unsplinted implants, Splinted implants
- Where
- Egypt
- Volunteers
- 12 people
- Sponsor
- Nourhan M.Aly
Spinal Cord Injuries
Gut Peptides and Bone Remodeling in Individuals With Spinal Cord Injury
Both GLP-2 and GIP reduce bone resorption (measured as CTX) in healthy persons. In this study, we will investigate whether GLP-2 and GIP is reducing CTX in individuals with spinal cord injury.
- Trial name
- NCT05181150
- Testing
- Meal test, GIP, GLP-2
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Bone Atrophy, Alveolar
Conventional and Ultrasonic Implant Site Preparation
multi center study with randomized controlled trial design, split mouth
- Trial name
- PI-DRI (NCT03357406)
- Testing
- ultrasound implant site preparation, conventional implant site preparation
- Where
- Italy
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- International Piezosurgery Academy
Maxillofacial Bone Defect, Alveolar Bone Loss
Bone Marrow Mononuclear Cells for the Repair of Severe Maxillofacial Bone Defects
This is a single-center, single-arm, open-label clinical study conducted at the Department of Stomatology, Nanjing Drum Tower Hospital.
- Trial name
- NCT07852806
- Testing
- Autologous bone marrow-derived mononuclear cells (BMMNCs), Bio-Oss bone graft material with collagen membrane
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Alveolar Bone Loss, Tooth Loss / Rehabilitation
Bone and Soft Tissue Healing After Socket Preservation With NOVAMag or Permamem Membranes
After tooth extraction, the surrounding bone and soft tissue may undergo dimensional reduction. Socket preservation involves placement of a bone graft into the extraction socket and coverage with a membrane to support healing…
- Conditions
- Alveolar Bone Loss, Tooth Loss / Rehabilitation, Alveolar Bone Grafting, Socket Preservation
- Trial name
- NCT07856693
- Testing
- NOVAMag Membrane, permamem Membrane, Alveolar Socket Preservation With an Allogeneic Bone Graft
- Where
- Croatia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Zagreb
Vertical Ridge Deficiency, Atrophic Maxilla
Fixation Free Sandwich Osteotomy With an Interpositional Inlay Graft in Compere to Conventional Sandwich Osteotomy
The atrophatic anterior maxilla present a considerable challenge for both surgical and prosthetic rehabilitation, as it may require bone augmentation to enable implant placement.
- Trial name
- sandwich (NCT06089928)
- Testing
- vertical augmentation
- Where
- Egypt
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Cairo University
Edentulism, Bone Atrophy, Alveolar
Short Implants in Atrophic Posterior Maxilla
This study aims to evaluate the clinical and radiological outcomes of short implants in the rehabilitation of single-tooth edentulism in the posterior maxilla.
- Conditions
- Edentulism, Bone Atrophy, Alveolar, Sinus Pneumatization
- Trial name
- NCT06759246
- Testing
- implant placement
- Where
- Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Bari Aldo Moro