Clinical trials: Resource-Limited Setting
Adolescent Pregnancy
Family Intervention to Improve Maternal and Child Mental Health
This pilot study will assess the acceptability, feasibility and efficacy of a family-based intervention to improve maternal and child mental health by increasing maternal sensitivity and decreasing offspring abuse among…
- Trial name
- MCMH (NCT04700059)
- Testing
- Virtual perinatal home visiting
- Where
- Peru
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Birth Outcomes, Labor and Delivery
Limiting Adverse Birth Outcomes in Resource-Limited Settings
The primary objective of this research is to exhaustively document the course and outcomes of hospitalization, labor, delivery, and early postpartum course of up to 15,000 mother-newborn pairs in settings where the occurrence of…
- Conditions
- Birth Outcomes, Labor and Delivery, Respiratory Infection
- Trial name
- LABOR (NCT04102644)
- Testing
- Observation
- Where
- 4 sites in Ghana, India and 1 more
- Volunteers
- 12,020 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Hepatitis B
Treatment of Hepatitis B in Resource-limited Settings - a Pilot Program in East Africa
Viral hepatitis kills nearly one million people each year, even though effective treatment exists. The aim of this study is to establish a treatment protocol for hepatitis B, which is simple and cheap enough to be implemented in…
- Trial name
- NCT02344498
- Testing
- Tenofovir disoproxil
- Where
- Ethiopia
- Volunteers
- 7,350 people
- Sponsor
- Oslo University Hospital
HIV
Pediatric HIV Disclosure Benefits Study (PhD-BS) - Sankofa 2
The purpose of this study is to conduct a pragmatic, stepped wedge cluster randomized trial in 12 HIV pediatric clinics in Ghana to determine effectiveness, health benefits, cost and implementation to inform scale-up and…
- Trial name
- NCT04791865
- Testing
- Disclosure intervention, Usual Care
- Where
- Ghana
- Volunteers
- 748 people
- Sponsor
- Boston University
Penicillin Allergy
Evaluating the Feasibility of High-volume, Low-risk Penicillin Allergy De-labelling to Maximise Efficiency in a Resource-limited Setting
Plenty of studies have now established the safety of low-risk penicillin allergy de-labelling, but few have addressed how to organise de-labelling at the clinic level.
- Trial name
- De-Label Me (NCT06532448)
- Testing
- Single dose low-risk penicillin challenge
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Cesarean Section Complications, Anesthesia Complication
Prophylactic Phenylephrine Co-administration During Caesarean Section
This single centre prospective alternating intervention study will aim to compare prophylactic phenylephrine given in the first litre of Ringers lactate as co-load in healthy patients having an elective caesarean section under…
- Trial name
- NCT04005664
- Testing
- Phenylephrine
- Where
- South Africa
- Volunteers
- 300 people
- Sponsor
- University of KwaZulu
Sepsis
Prediction of Disease Severity in Young Children Presenting With Acute Febrile Illness in Resource-limited Settings
Note that this is a study that is co-sponsored by Medecins Sans Frontieres, Spain, and the University of Oxford. The primary objective is to develop a risk prediction algorithm, combining measurements of host biomarkers and…
- Trial name
- SPOT-SEPSIS (NCT04285021)
- Where
- 6 sites in Bangladesh, Cambodia and 3 more
- Volunteers
- 3,433 people
- Sponsor
- Medecins Sans Frontieres, Spain
Cancer Palliative Care
R21 India Pal-Care Evaluation
The goal of this pragmatic clinical trial is to test and evaluate a home-based palliative care intervention for utilizing community health workers to facilitate the delivery of palliative care to cancer patients in rural India.
- Trial name
- NCT04972630
- Testing
- Pal-Care, Control-Usual Care
- Where
- India
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Iron-deficiency, Iron Deficiency Anemia
Iron Fish for Dominican Republic (DR) Infants
This study evaluates the feasibility of cooking with an iron ingot, Lucky Iron Fish™ (LIF), and evaluate the natural history of hemoglobins and iron status among infants of families using this iron ingot in a population with a…
- Trial name
- NCT03606993
- Testing
- Lucky Iron Fish (TM) - An iron ingot that is a Cooking supplement
- Where
- Dominican Republic
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Global Health, Education
Can VAST Improve ACLS in Rwanda
Aim The purpose of this study is to determine if the addition of the VAST Course to technical resuscitation skills training enhances healthcare providers' resuscitation performance in a resource-limited setting.
- Conditions
- Global Health, Education, Resuscitation
- Trial name
- NCT05278884
- Testing
- Advanced Cardiac Life Support Training, Vital Anesthesia Simulation Training
- Where
- Rwanda
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Acute Illness
Evaluation of the Basic Assessment of Severity of Illness in Children (BASIC) Scale
The purpose of this study is to assess whether the BASIC Scale--a simple, non-invasive clinical triage protocol--predicts severe illness, hospitalization or death among children under age five presenting for acute care in a rural…
- Trial name
- NCT01068574
- Testing
- BASIC Score (Observational)
- Where
- Rwanda
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
HIV-1 Infection
Nevirapine vs Ritonavir-boosted Lopinavir in ART Naive HIV-infected Adults in a Resource Limited Setting
In resource-limited setting, concerns remain regarding the emergence of virologic failure and high-level drug resistance mutations (DRM) during WHO recommended first-line antiretroviral therapy (ART) with non-nucleoside reverse…
- Trial name
- NCT01772940
- Testing
- nevirapine, ritonavir-boosted Lopinavir, Tenofovir/emtricitabine
- Where
- Republic of the Congo
- Volunteers
- 425 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Hepatitis C, Chronic
Directly Observed Therapy for HCV in Chennai, India
The primary objective of this pilot trial is to evaluate the feasibility of 12 weeks vs. 24 weeks of field-based directly observed therapy (DOT) for HCV therapy in a resource-limited setting.
- Trial name
- C-DOT (NCT02541409)
- Testing
- Sofosbuvir, Pegylated Interferon alfa-2a, Ribavirin
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
HIV Infections
Prospective Evaluation of Anti-retroviral Combinations for Treatment Naive, HIV Infected Persons in Resource-limited Settings
This study compared 3 different three-drug combinations in HIV infected individuals starting their first HIV treatment regimens.
- Trial name
- PEARLS (NCT00084136)
- Testing
- Atazanavir, Didanosine (enteric-coated), Efavirenz
- Where
- 42 sites in United States, Brazil and 7 more
- Volunteers
- 1,571 people
- Sponsor
- Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Malnutrition, Pneumonia
Childhood Acute Illness and Nutrition Network
The CHAIN Network aims to identify modifiable biomedical and social factors driving the greatly increased risk of mortality among young undernourished children admitted to hospital with acute illness, as inpatients and after…
- Conditions
- Malnutrition, Pneumonia, Diarrhea, Sepsis
- Trial name
- CHAIN (NCT03208725)
- Where
- 8 sites in Bangladesh, Kenya and 3 more
- Volunteers
- 4,335 people
- Sponsor
- University of Oxford
Jaundice, Serum Bilirubin
A Study to Evaluate a New Jaundice Stick Test
This is an observational prospective study. The main purpose is to evaluate the stability of the Bilistick system in a humid and hot climate compared to the quantitative test for serum bilirubin (SBR) measurement currently used…
- Trial name
- Bilistick (NCT02926131)
- Testing
- Blood sampling
- Where
- Thailand
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Oxford
HIV
Early HIV Therapy in Patients With High CD4 Cell Counts
A study of antiretroviral therapy (ART) initiation under a "streamlined model of care" in HIV-positive patients with CD4+ cell counts greater ≥ 250 cells/uL
- Trial name
- EARLI (NCT01479634)
- Testing
- Standard ART, Study-Provided ART
- Where
- Uganda
- Volunteers
- 279 people
- Sponsor
- University of California, San Francisco
Locally Advanced Cervical Cancer, Brachytherapy
This is a Multicentre International Study Evaluating CT-based IGABT With / Without Either TRUS During BT/Pre BT MR as Per IBS-GECESTRO-ABS Recommendations for Target contouring-as an Alternative to MRIGABT for Cervical Cancer From Implementation Perspectives Under EMBRACE-III:TRIPLET IMPACT Study.
Title: Integration of Multi-modality Imaging Protocols with Emphasis on CT in Image-Guided Adaptive Brachytherapy (IGABT) for Cervical Cancer - EMBRACE III-TRIPLET : IMPACT Study Locally advanced cervical cancer (LACC) remains a…
- Conditions
- Locally Advanced Cervical Cancer, Brachytherapy, CT, Transrectal Ultrasound
- Trial name
- IMPACT (NCT07249021)
- Testing
- CT IGABT
- Where
- India
- Volunteers
- 1,200 people
- Sponsor
- Homi Bhabha Cancer Hospital & Research Centre
Resistance Bacterial
Impact of Antimicrobial Stewardship Programs in the Global Setting
Antimicrobial resistance is one of the greatest threats to human health, and is driven by inappropriate antimicrobial use. Antimicrobial stewardship programs (ASPs) improve the use of antimicrobials in hospitals.
- Trial name
- PEARL (NCT03382470)
- Testing
- Antimicrobial stewardship advice
- Where
- Sri Lanka
- Volunteers
- 3,115 people
- Sponsor
- Duke University
Maternal Death, Maternal Morbidity
BetterBirth: A Trial of the WHO Safe Childbirth Checklist Program
The purpose of this study is to measure the impact of a checklist-based childbirth safety program (the WHO Safe Childbirth Checklist Program) on reduction of severe maternal, fetal, and newborn harm in institutional deliveries in…
- Conditions
- Maternal Death, Maternal Morbidity, Stillbirth, Neonatal Death
- Trial name
- BetterBirth (NCT02148952)
- Testing
- WHO Safe Childbirth Checklist Program
- Where
- India
- Volunteers
- 157,689 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)