Clinical trials: Respiration
Respiratory Disease, Pulmonary Disease
Engineering Evaluation of the Helix Ventilator
This study will be used to evaluate and observe the overall performance and controls of the Helix ventilator. Pressure and flow data between participants' current devices and the Helix ventilator will be assessed in either…
- Conditions
- Respiratory Disease, Pulmonary Disease, Pediatric ALL
- Trial name
- NCT03613363
- Testing
- Helix Ventilator
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Philips Respironics
Mechanical Ventilation, Critical Illness
Dexmedetomidine Versus Propofol in the Medical Intensive Care Unit (MICU)
This is a randomized controlled trial to compare propofol to dexmedetomidine for prolonged sedation (> 24 hours) in critically ill patients who require mechanical ventilation.
- Trial name
- NCT01059929
- Testing
- Dexmedetomidine, Propofol, Fentanyl
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Chicago
Asthma
Bronchodilator Effects and Safety of Glycopyrronium Bromide (25 ug and 50 ug o.d.) in Asthma
The purpose of this trial is to characterize the bronchodilator effects and safety of 25 ug and 50 ug o.d. NVA237 (glycopyrronium bromide) doses compared to placebo in asthma patients
- Trial name
- NCT03137784
- Testing
- NVA237 (glycopyrronium bromide)
- Where
- 21 sites in United States, Belgium and 4 more
- Volunteers
- 148 people
- Sponsor
- Novartis Pharmaceuticals
Ambulatory Surgery, Coughing
Effect of Fentanyl on Coughing and Recovery After Anesthesia With an LMA Laryngeal Mask Airway)for Airway Management
The purpose of this research is to evaluate the effectiveness of fentanyl for reducing coughing during the perioperative period (i.e., insertion of an LMA [Laryngeal Mask Airway] device, maintenance period during surgery, and…
- Trial name
- LMA (NCT01368809)
- Testing
- Saline, Fentanyl
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Cedars-Sinai Medical Center
Complex Sleep Apnea Syndrome
Complex Sleep Apnea Syndrome (CompSAS) Resolution Study
The purpose of this study is to determine whether adaptive servo-ventilation (ASV) or continuous positive airway pressure (CPAP) is better at treating complex sleep apnea over time.
- Trial name
- CompSAS (NCT00915499)
- Testing
- VPAP Adapt SV
- Where
- 6 sites in United States
- Volunteers
- 66 people
- Sponsor
- ResMed
Nasal Airway Obstruction
Novapak Prospective Observational Clinical Trial
The Novapak study is a prospective, observational, multi-site, non-controlled, non-randomized, case-series, with a 2 week and 1-month follow-up in adults undergoing nasal/sinus surgery with Novapak Nasal Sinus Packing and Stent…
- Trial name
- Novapak (NCT05747014)
- Testing
- Novapak Nasal Sinus Packing and Stent
- Where
- 4 sites in United States, Canada
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Medtronic Surgical Technologies
Chronic Obstructive Pulmonary Disease (COPD)
Efficacy and Safety of Twice Daily 60mg AZD9668 in COPD for 12 Weeks in Patients on Background Budesonide/Formoterol
The primary objective is to evaluate the efficacy of AZD9668 compared with placebo in symptomatic COPD patients by assessing the effects on lung function and symptoms of COPD
- Trial name
- NCT01023516
- Testing
- AZD9668
- Where
- 66 sites in Bulgaria, Czechia and 4 more
- Volunteers
- 615 people
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Disease
The Study Will Evaluate the Effect of AZD9164 in Patients With Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease (COPD) is a chronic respiratory condition with deteriorating lung function over the years. Patients with COPD experience symptoms of shortness of breath, cough and sputum production.
- Trial name
- LaCrossE (NCT00939211)
- Testing
- AZD9164, Tiotropium
- Where
- 3 sites in Sweden
- Volunteers
- 25 people
- Sponsor
- AstraZeneca
Mechanical Ventilation, Ventilator-associated Conditions
ED Lung Protective Ventilation to Reduce Complications
Early mechanical ventilation, if delivered with injurious settings, can lead to pulmonary complications, such as acute respiratory distress syndrome (ARDS).
- Conditions
- Mechanical Ventilation, Ventilator-associated Conditions, ARDS
- Trial name
- NCT02543554
- Testing
- lung protective ventilation
- Where
- United States
- Volunteers
- 1,705 people
- Sponsor
- Washington University School of Medicine
Stress Disorders, Post-Traumatic
Efficacy Study of Mindfulness-Based Exercise for Posttraumatic Stress Disorder (PTSD)
This study will explore the relationship between changes in plasma cortisol and symptom reduction resulting from individuals with posttraumatic stress disorder (PTSD) participating in an 8-week program of mindfulness-based…
- Trial name
- NCT01462045
- Testing
- Mindfulness-based exercise
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Hypothermia, Rewarming
Heated Humidified Breathing Circuit Rewarming in Hypothermic Post Cardiopulmonary Bypass Patients.
Hypothermia on admission to the intensive care unit (ICU) following cardiopulmonary bypass (CPB) is common. The investigators propose that rewarming hypothermic (≤ 35 C) patients admitted to the intensive care unit following…
- Trial name
- NCT03697122
- Testing
- Heated Humidified Breathing Circuit and Forced Air Blanket
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Duke University
Obstructive Sleep Apnea
Study for Efficacy and Dose Escalation of AD313 + Atomoxetine (SEED)
The SEED study is designed to assess the safety and efficacy for Obstructive Sleep Apnea (OSA) of 3 escalating dose combinations of atomoxetine with AD313 compared to baseline and to atomoxetine alone.
- Trial name
- SEED (NCT05101122)
- Testing
- Dosing 1: Atomoxetine, AD313
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Apnimed
Intubated Infants Were Intend to Extubation Using Noninvasive Ventilation Strategies
A Trial Comparing Noninvasive Ventilation Strategies in Preterm Infants Following Extubation
Respiratory distress syndrome (RDS) is the main cause of respiratory failure in preterm neonates, its incidence varying from 80% to 25% depending on gestational age.When optimal prenatal care is provided, the best approach to…
- Trial name
- NCT03181958
- Testing
- NHFOV, NCPAP, NIPPV
- Where
- China
- Volunteers
- 1,493 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
COPD
Capnography-Assisted Learned Monitored (CALM) Breathing Therapy for COPD
This pilot study is part of a phased approach to refine, optimize, and test the feasibility of CALM Breathing. Preliminary participant feedback from the Capnography-Assisted Respiratory Therapy (CART) study was applied to adapt…
- Trial name
- CALM (NCT04786184)
- Testing
- CALM Breathing, Traditional outpatient PR
- Where
- 2 sites in United States
- Volunteers
- 42 people
- Sponsor
- Columbia University
Obstructive Sleep Apnea
Belun Ring Validation Study for Assessment of Obstructive Sleep Apnea
This study aims to determine the overall accuracy, sensitivity, and specificity of the Belun Ring device in evaluating obstructive sleep apnea by comparing the device to the attended overnight in-lab polysomnography which is the…
- Trial name
- NCT03997916
- Testing
- Belun Ring, PSG
- Where
- 2 sites in United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
COPD, Interstitial Lung Disease
An Observational Outcomes Study for Autologous Cell Therapy Among Patients With COPD and Interstitial Lung Disease
The purpose of the Lung Institute is to collect and isolate a patient's own cells and platelet rich plasma (PRP) and deliver the product back to the patient same-day.
- Trial name
- NCT03040674
- Testing
- Cell therapy
- Where
- United States
- Volunteers
- 489 people
- Sponsor
- Lung Institute
Chronic Obstructive Pulmonary Disease
The Effect of QVA149 on Patient Reported Dyspnea in Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
This study assessed the effect of QVA149 on patient-reported dyspnea in moderate to severe Chronic Obstructive Pulmonary Disease (COPD) patients.
- Trial name
- BLAZE (NCT01490125)
- Testing
- QVA149, Tiotropium, Salbutamol/albuterol
- Where
- 43 sites in Belgium, Canada and 3 more
- Volunteers
- 247 people
- Sponsor
- Novartis Pharmaceuticals
Cough
Bronchial Hyper-responsiveness in Reflux Cough
The study aim is to determine the effect of 8 weeks of anti-reflux treatment (full acid suppression) on bronchial hyper-responsiveness and whether there is a symptomatic improvement.
- Trial name
- NCT00668317
- Testing
- Omeprazole, Ranitidine
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Chronic Cough
A Study of Gefapixant (MK-7264) in Adult Participants With Chronic Cough (MK-7264-030)
The primary objectives of this study are to evaluate the efficacy of gefapixant (MK-7264) in reducing cough frequency as measured over a 24-hour period, and to determine the safety and tolerability of gefapixant.
- Trial name
- NCT03449147
- Testing
- Gefapixant 15 mg BID, Gefapixant 45 mg BID
- Where
- 171 sites in United States, Australia and 18 more
- Volunteers
- 1,317 people
- Sponsor
- Merck Sharp & Dohme LLC
One-lung Ventilation
Clamping the Double Lumen Tube
Nowadays, lung isolation techniques are an essential part of thoracic anesthesia. The two principal devices used in order to achieve one-lung ventilation (OLV) are the double lumen tube (DLT) and the bronchial blocker (BB).
- Trial name
- C-TDL (NCT03508050)
- Testing
- Clamping the Double Lumen Tube
- Where
- Canada
- Volunteers
- 37 people
- Sponsor
- Jean Bussières
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