Clinical trials: Respiration Disorder
Covid19, Respiratory Failure
Proning Early in Awake COVID-19 Hypoxic Respiratory Failure (PREACHR) Study
The aim of this proposal is to study whether proning, a technique that has previously been shown to improve lung function in patients with acute respiratory distress syndrome (ARDS), can prevent those with mild to moderate…
- Trial name
- PREACHR (NCT05130541)
- Testing
- Proning, Supportive Care
- Where
- United States
- Volunteers
- 219 people
- Sponsor
- New York Hospital Queens
Obstructive Sleep Apnea Syndrome
Cow's Milk Allergy in Infants With Obstructive Sleep Apnea (OSA)
Cow's milk allergy may be involved in the evolution of sleep apnea in infants. The study will assess the effects of specifies diet changes (i.e. non-milk based formula) on the infant.
- Trial name
- NCT00659854
- Testing
- Non milk or soy based formula, milk based formula
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Soroka University Medical Center
Respiratory Distress Syndrome, Adult
Reproductibility of TM-mode Ultrasound Diaphragm Measures in Patients With Acute Respiratory Distress in the ER
The main objective of this study is to evaluate the inter-rater reproducibility of diaphragmatic excursion measures via time-motion-mode ultrasound (evaluation performed on the first measure) in patients experiencing acute…
- Trial name
- EDDRA-Repro (NCT01743105)
- Testing
- Diaphragm excursion measures 1, Diaphragm excursion measures 2
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Respiratory Disorders, Asthma and Rhinitis
Bioequivalence of GW483100 10 Milligram (mg) Tablets in Healthy Subjects Under Fasting Conditions
This study is conducted to determine whether the test product (GW483100 10 mg containing montelukast sodium equivalent to 10 mg of montelukast) is bioequivalent to the reference montelukast sodium 10 mg tablets (innovator…
- Trial name
- NCT02658422
- Testing
- Test Montelukast, Reference Montelukast
- Where
- India
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
COPD, Dyspnea
Ventilation Imbalances in Mild to Moderate Chronic Obstructive Pulmonary Disease
The Investigators plan a single center study to get preliminary data to answer a number of fundamental questions directly related to management of COPD.
- Conditions
- COPD, Dyspnea, Respiratory Disease, Lung Diseases
- Trial name
- VAPOR (NCT04880551)
- Testing
- Fluoroscopy
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Oregon Health and Science University
Cough
Promoting Safe Use of Children's Cough/Cold Medicines
This study seeks to identify ways to help parents safely use cough/cold medications with their children. The study focuses on 3 key tasks that have been found to be difficult for parents: 1) decision-making about whether…
- Trial name
- NCT03126851
- Testing
- Label
- Where
- United States
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Apnea
Sleep Apnea and Visual Perceptual Skill Learning
The purpose of this study is to determine whether obstructive sleep apnea affects sleep dependent memory and learning. Subjects with apnea will be given a test of perceptual skill learning (the Visual Discrimination Task (VDT))…
- Trial name
- NCT01852929
- Testing
- Subject using usual positive airway pressure therapy while sleeping for one night
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Heidi Roth, MD
Critical Illness
Effects of Positional Therapy on Pulmonary Physiology in Patients Undergoing Mechanical Ventilation.
The aim of this project is to evaluate the effects of positional changes in mechanically ventilated patients.
- Trial name
- NCT04471090
- Where
- Spain
- Volunteers
- 32 people
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
Head and Neck Cancer, Obstructive Sleep Apnea
Intraoperative Ansa Cervicalis Nerve (ACN) Stimulation
Recently published data suggest that stimulation of the infrahyoid strap muscles increases pharyngeal patency in patients with obstructive sleep apnea, but the innervation of these muscles by the ansa cervicalis is variable.
- Trial name
- ACS (NCT05650710)
- Testing
- Nerve stimulation using nerve stimulation device and sterile wire electrode.
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Vanderbilt University Medical Center
Respiratory Failure, Weaning Failure
HVNI for Successful Weaning in Respiratory Failure
The goal of this randomized active-controlled study is to investigate the role of high velocity nasal insufflation (HVNI) in the immediate post-extubation period and compare it with non-invasive positive pressure ventilation…
- Trial name
- REVIVER (NCT05855213)
- Testing
- High Velocity Nasal Insufflation, Non-invasive positive pressure ventilation
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Alexandria University
Pulmonary Aspiration of Gastric Contents
Prophylaxis for Aspiration of Gastric Contents.
Effect of orally administered two equal and consecutive doses of proton pump inhibitors, omeprazole, lansoprazole, esomeprazole , rabeprazole and pantoprazole and Histamine 2 receptor antagonists cimetidine…
- Trial name
- NCT02703896
- Testing
- Drug either PPIS or H2RA and prokinetics, orogastric intubation
- Volunteers
- 1,920 people, healthy volunteers welcome
- Sponsor
- King Saud University
Pneumonia
Doripenem in the Treatment of Hospital-Acquired Pneumonia
The purpose of this study is to compare the safety and effectiveness of doripenem in patients with hospital-acquired pneumonia (HAP).
- Trial name
- NCT00211003
- Testing
- doripenem
- Volunteers
- 240 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Acute Respiratory Distress Syndrome
Prediction of Outcomes With a Miniaturized Transesophageal Echocardiography Probe in Patients With Acute Respiratory Distress Syndrome
The Superior Vena cava Respiratory Collapse Index (cVCS) is a haemodynamic parameter measured exclusively by transoesophageal ultrasound (TEE), which is used to assess cardiac precharge-dependence status.
- Trial name
- PreMiTE-ARDS (NCT03763773)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Lille
Atrial Fibrillation Paroxysmal
Atrial Fibrillation Lifestyle Project
The objectives of the investigators are to demonstrate a reduction in frequency and symptoms of AF and improvements in cardiovascular risk factors following a lifestyle intervention in patients with paroxysmal AF.
- Trial name
- ALP (NCT03724383)
- Testing
- Risk Factor Management Consult, Diet Classes, Stress Management Classes
- Where
- 7 sites in Canada
- Volunteers
- 80 people
- Sponsor
- Teddi Orenstein Lyall
Nasal Obstruction, Septal Defect
Does Batten Grafting Improve Nasal Outcomes in Septoplasty and Turbinate Reduction?
The objective of this study is to compare the effectiveness of batten grafts plus septoplasty and turbinate reduction (intervention arm) compared to septoplasty and turbinate reduction alone (control arm), both in terms of…
- Conditions
- Nasal Obstruction, Septal Defect, Allergic Rhinitis, Nasal Polyps
- Trial name
- NCT05287841
- Testing
- Batten batten graft, Septoplasty, Inferior Turbinate Reduction
- Where
- 3 sites in United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Myopathy
Efficacy and Tolerance of AVAPS Mode in Myotonic Dystrophy
Myotonic dystrophy type 1 is a myopathy with complex respiratory pattern and at risk to develop respiratory failure. Classical mode of ventilation are sometimes not tolerated or ineffective in this population.
- Trial name
- NCT01530841
- Testing
- Nocturnal ventilation
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
Respiratory Failure
A Pilot Study of Synchronized and Non-invasive Ventilation ("NeuroPAP") in Preterm Newborns
There is currently a consensus that non-invasive ventilation (NIV) in preterm infants is preferred over intubation. There are two ways of delivering NIV in preterm infants, nasal continuous positive airway pressure (CPAP) or…
- Trial name
- NeuroPAP (NCT02480205)
- Testing
- NeuroBox to deliver the NeuroPAP
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- St. Justine's Hospital
Transurethral Resection of Bladder Tumor, Transurethral Resection of the Prostate (TURP)
Effect of Cyclic Sighing Breathing Exercise on CRBD, Pain, and Sleep Quality in Patients Undergoing TUR
Transurethral resection (TUR) is a common minimally invasive surgical procedure for lower urinary tract diseases. However, postoperative urinary catheterization often causes catheter-related bladder discomfort (CRBD) and pain due…
- Conditions
- Transurethral Resection of Bladder Tumor, Transurethral Resection of the Prostate (TURP), Transurethral Resection of the Bladder
- Trial name
- NCT07843602
- Testing
- Cyclic Sighing Breathing Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Mersin University
Rhinoplasty
Effect of Use of Endotracheal Tube With Subglottic Suction in Rhinoplasty
Suction Above Cuff Endotracheal Tube (SACETT) has a dorsal port above the cuff designed to allow continuous or intermittent suctioning of secretions from the subglottic space.
- Trial name
- NCT03584503
- Testing
- Suction Above Cuff Endotracheal Tube
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 132 people
- Sponsor
- Yuzuncu Yil University
Respiratory Insufficiency, Obesity Hypoventilation Syndrome
Juno Perth Clinical Trial
This study is to evaluate the efficacy of a new therapy (Automatic Expiratory Positive Airway Pressure with intelligent Volume Assured Pressure Support (AutoEPAP iVAPS)) designed to treat respiratory insufficiency, respiratory…
- Conditions
- Respiratory Insufficiency, Obesity Hypoventilation Syndrome, Chronic Obstructive Pulmonary Disease (COPD), Neuromuscular Disease
- Trial name
- NCT02317042
- Testing
- Juno
- Where
- 2 sites in Australia
- Volunteers
- 25 people
- Sponsor
- ResMed