Clinical trials: Respiration Failure
Acute Hypoxemic Respiratory Failure
Respiratory Mechanics Assessment During Assisted Mechanical Ventilation
To verify the association between respiratory system mechanical properties (ΔP, ΔPL,dyn, Pmus, Pplat and CRS and CL,dyn) assessed during assisted modes of ventilation (as average over the first three days since enrollment) and…
- Trial name
- ICEBERG (NCT05203536)
- Where
- 8 sites in Canada, Germany and 3 more
- Volunteers
- 298 people
- Sponsor
- University of Milano Bicocca
Obesity, Obesity Hypoventilation Syndrome
Factors Associated With Chronic Respiratory Failure in Obesity
Some overweight individuals develop problems with their breathing such that they gradually breathe less and less. This leads to a lack of oxygen and a buildup of carbon dioxide in the blood, called ventilatory failure.
- Trial name
- NCT01380418
- Where
- United Kingdom
- Volunteers
- 78 people
- Sponsor
- Oxford University Hospitals NHS Trust
Acute Hypoxemic Respiratory Failure, High-Flow Nasal Cannula Therapy
Protocolized Weaning of High-Flow Nasal Cannula in Adult Patients
High-flow nasal cannula (HFNC) is a type of oxygen therapy commonly used in adults with breathing problems. While HFNC can help patients avoid breathing tubes and improve oxygen levels, there is no standard method for deciding…
- Trial name
- PRO-WEAN HFNC (NCT07452406)
- Testing
- Protocolized HFNC Weaning Strategy, Usual Care HFNC Weaning
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Rush University Medical Center
Chronic Obstructive Pulmonary Disease, Respiratory Failure
NHF vs NIV in Patients With Acute Exacerbation of COPD
Although non-invasive ventilation (NIV) usage has increased significantly over time in COPD exacerbation, a great percentage of patients (~30%) present contraindications to NIV or cannot tolerate it.
- Conditions
- Chronic Obstructive Pulmonary Disease, Respiratory Failure, Acute Exacerbation Copd
- Trial name
- NCT03466385
- Testing
- Nasal High Flow, Non-Invasive Ventilation
- Where
- 3 sites in Greece
- Volunteers
- 498 people
- Sponsor
- Evangelismos Hospital
Airway Extubation
Maximum Expiratory Pressure in Induced Cough as a Predictor of Extubation Failure
Clinical trial for the evaluation of diagnostic tests. The sample was composed of adults under mechanical ventilation who passed the spontaneous breathing trial and was ready to be extubated.
- Trial name
- NCT04356625
- Testing
- MEPic
- Where
- Argentina
- Volunteers
- 80 people
- Sponsor
- Hospital Nacional Profesor Alejandro Posadas
COPD, Severe Early-Onset, Ventilatory Failure
Customized Masks in Non-Invasive Mechanical Ventilation
In non-invasive mechanical ventilation (NIMV), the interface is the primary determinant of success, as adherence and quality of therapy mainly depend on it.
- Conditions
- COPD, Severe Early-Onset, Ventilatory Failure, Als, Non Invasive Ventilation
- Trial name
- NCT06215391
- Testing
- 3d printed mask
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Hospital Universitario 12 de Octubre
Mechanical Ventilation Complication, Weaning Failure
A Modified Cuff Leak Test and Reintubation in Mechanically Ventilated Patients
We hypothesized that the accuracy of the modified cuff leak test in predicting re-intubation in tracheal intubated patients is better than that of the conventional balloon leak test, thereby further reducing the re-intubation…
- Conditions
- Mechanical Ventilation Complication, Weaning Failure, Airway Obstruction
- Trial name
- NCT05550220
- Testing
- Cuff Leak Test
- Where
- China
- Volunteers
- 586 people
- Sponsor
- Beijing Chao Yang Hospital
Ventilator Weaning, Weaning Failure
Voices of Patients' Relatives to Support Weaning From Mechanical Ventilation
Patients with severe brain injuries, such as ischemic stroke and intracranial hemorrhage, frequently require mechanical ventilation. Weaning of stroke patients is complicated by impaired consciousness and respiratory drive.
- Conditions
- Ventilator Weaning, Weaning Failure, Brain Injuries
- Trial name
- VOICE-WEANING (NCT03795623)
- Testing
- Voice-Weaning
- Where
- Germany
- Volunteers
- 45 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Nasal Congestion
The Safety and Efficacy of a SinuSonic Intervention
This study aims to test the safety and effectiveness of the SinuSonic device on adults with moderate to severe nasal congestion.
- Trial name
- NCT03906968
- Testing
- SinuSonic Device
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Medical University of South Carolina
Lung Disease Airways, Lung Diseases, Obstructive
TruFreeze™ Airway Obstruction: TAO STUDY
The purpose of this study is to prospectively assess the efficacy and safety of spray cryotherapy ablation with the truFreeze System in conjunction with mechanical dilation or debridement for the treatment of clinically…
- Conditions
- Lung Disease Airways, Lung Diseases, Obstructive, Airway; Obstruction, With Emphysema, Airway Obstruction
- Trial name
- TAO (NCT01903850)
- Testing
- spray cryotherapy
- Sponsor
- CSA Medical, Inc.
Acute Respiratory Distress Syndrome, Acute Lung Injury
Effects of PEEP and FIO2 in ALI and ARDS
Current American-European Consensus Conference (AECC) definitions for ALI and ARDS are inadequate for inclusion into clinical trials due to the lack of standardization for measuring the oxygenation defect.
- Conditions
- Acute Respiratory Distress Syndrome, Acute Lung Injury, Acute Respiratory Failure
- Trial name
- HELP (NCT00435110)
- Testing
- standard ventilatory settings, PEEP and FiO2
- Where
- Spain
- Volunteers
- 178 people
- Sponsor
- Instituto Canario de Investigacion Biomedica
ESRD, Sleep Apnea
Identification of Desaturation Episodes by Means of Continuous Measurement of Oxygen Saturation During Hemodialysis
The clinical diagnosis of sleep apnea is difficult among ESRD patients since the characteristic clinical features of sleep apnea may be absent and since sleep-related symptoms, such as fatigue and sleepiness, may be attributed to…
- Conditions
- ESRD, Sleep Apnea, Oxygen Deficiency
- Trial name
- NCT02987179
- Testing
- Observational
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Renal Research Institute
Obstructive Sleep Apnea, Acute Kidney Failure
Effect of Obstructive Sleep Apnea on Central Blood Pressure and Kidney and Endothelial Function
Obstructive sleep apnea (OSA) is a frequently underdiagnosed condition that has emerged as an increasing medical problem with important social and financial implications worldwide.
- Conditions
- Obstructive Sleep Apnea, Acute Kidney Failure, Chronic Kidney Disease
- Trial name
- OSA-AKI (NCT00947479)
- Testing
- continuous positive airway pressure (CPAP)
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Medical University of Lodz
Critical Illness, Mechanical Ventilation
Cost-Effectiveness of Inhaled Sedation Versus Intravenous Propofol in Mechanically Ventilated Critically Ill Adults
The goal of this observational study is to learn whether inhaled sedation is a cost-effective alternative to intravenous propofol in mechanically ventilated critically ill adults admitted to the intensive care unit.
- Conditions
- Critical Illness, Mechanical Ventilation, Respiratory Insufficiency
- Trial name
- NCT07734350
- Testing
- Isoflurane, Propofol (Astra-Zeneca)
- Volunteers
- 400 people
- Sponsor
- Hospital H+ Queretaro
Ventilatory Failure
Postextubation Management in Patients at Risk for Extubation Failure
At the time of weaning from mechanical ventilation, patients with heart and/or lung conditions will be given oxygen support with alternating bilevel positive airway pressure (BiPAP; oxygen via face mask) and heated high flow…
- Trial name
- NCT04258020
- Testing
- BiPAP, HFNC
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- OhioHealth
Weaning Failure, Pulmonary Edema - Acute
Quantification of Systemic Congestion by Ultrasound As a Predictor of Weaning Failure From Mechanical Ventilation
Mechanical ventilation is an essential, life-saving therapy in the ICU, allowing critically ill patients to rest and recover. Transitioning patients back to spontaneous breathing-known as weaning-is clinically challenging.
- Conditions
- Weaning Failure, Pulmonary Edema - Acute, Mechanical Ventilation, POCUS
- Trial name
- SCOUT (NCT07343882)
- Testing
- point of care ultrasound
- Volunteers
- 350 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Cardiac Failure, Respiratory Failure
A Post Market Surveillance Study of the Hemovent Extracorporeal Cardiopulmonary Support System:The MOBYBOX Trial
The purpose of this study is to evaluate prospectively the safety and performance of the MOBYBOX System in the veno-arterial configuration in patients with cardiorespiratory failure or in the veno-venous configuration in patients…
- Conditions
- Cardiac Failure, Respiratory Failure, Cardio-Respiratory Failure, Imminent Cardiorespiratory or Respiratory Failure
- Trial name
- NCT04183660
- Testing
- MOBYBOX System
- Where
- 4 sites in Germany
- Volunteers
- 60 people
- Sponsor
- Hemovent GmbH
Respiratory Distress Syndrome, Adult
The Role of Morphological Phenotype in ARDS
Although most of the information focuses on understanding how the ventilator produces lung damage, the pulmonary factors that predispose to ventilator-induced lung injury (VILI) have been less studied.
- Trial name
- MPARDS (NCT04157946)
- Testing
- CT
- Where
- Argentina
- Volunteers
- 12 people
- Sponsor
- Hospital El Cruce
Ventilatory Failure, Cardiac Failure
Non-invasive Monitoring of Mixed Venous Oxygen Saturation Using the Capnodynamic Method in Adults
The objective of this study is to compare the accuracy and correlation of the capnodynamic method for measuring mixed venous oxygen saturation (SvO2) with the standard reference method (pulmonary artery catheter), with the…
- Conditions
- Ventilatory Failure, Cardiac Failure, Mechanical Ventilation Pressure High
- Trial name
- CAPNO-SVO2 (NCT06632197)
- Volunteers
- 25 people
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
Hypercapnic Respiratory Failure
High-flow Air Via Nasal Cannula vs Non-invasive Continuous Positive Airway Pressure for Hypercapnic Respiratory Failure
The study will be performed as a randomized controlled non-inferiority trial. HFA has been increasingly used in the last years to treat hypoxic respiratory failure (i.e.
- Trial name
- HIGHforHyper (NCT03944525)
- Testing
- High flow nasal cannula, Continuous positive airway pressure
- Where
- Austria
- Volunteers
- 62 people
- Sponsor
- Medical University of Vienna