Clinical trials: Respiration Failure
Respiratory Insufficiency
Efficacy of Early Tracheostomy to Reduce Incidence of Ventilator Acquired Pneumonia (VAP)
The study aims to assess early (one to three days after intubation) tracheostomy effectiveness in terms of reduction in ventilator associated pneumonia (VAP) incidence.
- Trial name
- NCT00262431
- Testing
- Tracheostomy on day 3-5 in early group and 10-12 in late group
- Where
- Italy
- Volunteers
- 320 people
- Sponsor
- University of Turin, Italy
Esophageal Foreign Body, Esophageal Obstruction
Point of Care Ultrasound for the Detection of Esophageal Food Bolus
This will be a prospective, observational, case-control study of adult patients presenting to the WellSpan York Hospital Emergency Department (YHED) with signs and symptoms of esophageal food or foreign body impaction.
- Trial name
- NCT06507670
- Testing
- Point of care ultrasound
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- WellSpan Health
Respiratory Depression
Single Dose Crossover Study to Compare the Respiratory Drive After Administration of Belbuca, Oxycodone and Placebo.
The purpose of this study is to explore and compare VRH after administration of Belbuca, Oxycodone HCl and Placebo in recreational opioid users.
- Trial name
- NCT03996694
- Testing
- Belbuca 300 µg, Belbuca 600 µg, Belbuca 900 µg
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- BioDelivery Sciences International
Infant, Newborn, Respiratory Insufficiency
Inhaled PGE1 in Neonatal Hypoxemic Respiratory Failure
This pilot study was a randomized, placebo-controlled, clinical trial to test the safety of using the intravenous form of Prostaglandin E1 (PGE1) in an inhaled form for treatment of hypoxemic respiratory failure in term newborns.
- Conditions
- Infant, Newborn, Respiratory Insufficiency, Pulmonary Hypertension, Respiratory Distress Syndrome, Newborn
- Trial name
- IPGE1 (NCT00598429)
- Testing
- Inhaled Prostaglandin E1
- Where
- 11 sites in United States
- Sponsor
- NICHD Neonatal Research Network
Weaning Failure, Complication of Respirator [Ventilator]
Evaluation of a Systematic Approach to Weaning From Mechanical Ventilation
Prolongation of mechanical ventilation poses serious personal and financial threats to healthcare consumers. The investigators objectives are create and implement an multidisciplinary evidenced-based ventilator-weaning protocol…
- Trial name
- NCT01482429
- Testing
- Multidisciplinary weaning-ventilator protocol
- Where
- Brazil
- Volunteers
- 235 people
- Sponsor
- Federal University of Uberlandia
Respiratory Insufficiency
Description of Fluid Balance in Patients With Acute Respiratory Failure
The specific aim of this study is to gather data on fluid balance, intravenous medication administration, electrolyte balance, and diuretic and dialysis use in patients with acute respiratory failure who might benefit from a…
- Trial name
- NCT02523872
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Smiths Medical, ASD, Inc.
Respiratory Failure With Hypoxia, Respiratory Failure Without Hypercapnia
Prone Positioning During High Flow Oxygen Therapy in Acute Hypoxemic Respiratory Failure
Background High-flow nasal cannula (NHF) are a promising tool for administering oxygen to critically ill patients with high respiratory demand.
- Trial name
- Optiprone (NCT03095300)
- Testing
- Prone position
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Catholic University of the Sacred Heart
COVID, Acute Hypoxemic Respiratory Failure
Helmet CPAP Versus HFNC in COVID-19
We aim to investigate whether the use of Continuous Positive Airway Pressure using a Helmet device (Helmet CPAP) will increase the number of days alive and free of ventilator within 28 days compared to the use of a High Flow…
- Trial name
- COVID HELMET (NCT04395807)
- Testing
- Helmet CPAP, HFNC
- Where
- Sweden
- Volunteers
- 2 people
- Sponsor
- Lund University
Heart Failure, Sleep Disorder
Substudy on the Mechanistic Plausibility of the Clinical Benefits of Adaptive Servo-ventilation
The purpose of this study is to assess changes in left ventricular performance using echocardiography as well as ventricular remodelling, changes in sleep and changes in mood, anxiety and cognitive functions occurring as a result…
- Conditions
- Heart Failure, Sleep Disorder, Cheyne Stokes Respiration
- Trial name
- MS (NCT01164592)
- Testing
- adaptive servoventilation (ASV)
- Where
- 94 sites in Australia, Czechia and 6 more
- Volunteers
- 312 people
- Sponsor
- ResMed
Patients With Moderate to Severe Pain Requiring Analgesic Medications
Observation and Study on the Application of Different Analgesic Regimens in Critically Ill Patients Without Mechanical Ventilation
Pain management is a common treatment measure in the Intensive Care Unit (ICU). Due to their underlying diseases and invasive treatments, patients often experience discomfort and pain, leading to agitation, unplanned extubation…
- Trial name
- NCT07031453
- Volunteers
- 80 people
- Sponsor
- Peking University People's Hospital
Respiratory Failure, Obesity
Transpulmonary Pressure Guided Mechanical Ventilation Weaning in Obesity
This study will look at whether accounting for the amount of pressure generated by the chest wall and abdomen in a obese patient, using a measurement called transpulmonary pressure, can help shorten the amount of time patients…
- Trial name
- NCT05530434
- Testing
- transpulmonary pressure guided positive end expiratory pressure, standard positive end expiratory pressure
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Mississippi Medical Center
Feeding Tube
Self-Propelled Versus Standard Percutaneous Endoscopic Gastrojejunostomy(PEG-J); RCT
Our main hypothesis is that self-propelled Percutaneous Endoscopic Gastrojejunostomy tube (PEG-J) that has a balloon on it's tip is associated with lower J-tube retrograde migration rate, and lower rates of short- and long-term…
- Trial name
- NCT01892267
- Testing
- PEG-J placement
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Johns Hopkins University
Congestive Heart Failure, Mechanical Ventilation
Nesiritide for Ventilated Congestive Heart Failure
The congestive heart failure is a common disease among patients who receive cardiac surgery and may lead to prolonged ventilation support. Nesiritide was a potential therapy for congestive heart failure.
- Conditions
- Congestive Heart Failure, Mechanical Ventilation, Using Nesiritide, Venous Return
- Trial name
- HENCHF (NCT04455477)
- Testing
- Nesiritide
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Zhongshan Hospital
Acute Respiratory Failure, Exacerbation of COPD
Multicenter National Randomized Controlled Open Label Study Assessing Interest of Non Invasive Ventilation in out-of Hospital Setting During Acute Respiratory Failure in Chronic Obstructive Pulmonary Disease Patients. VeNIS BPCO
Goal of the study: To show that prehospital NPPV use for COPD decompensation, as compared to only standard medical treatment, might enable a decrease in intubation rate.
- Conditions
- Acute Respiratory Failure, Exacerbation of COPD, Non Invasive Positive Pressure Ventilation, Out of Hospital Setting
- Trial name
- VeNIS BPCO (NCT01626937)
- Testing
- Non invasive ventilation, conventional medical treatment
- Volunteers
- 398 people
- Sponsor
- Centre Hospitalier d'Agen
Heart Failure, Sleep Respiratory Disorders
Effectiveness of the Treatment With Continuous Positive Airway Pressure(CPAP)in Stable Heart Failure With Ejection Fraction More Than 45% and Sleep Disordered Breathing
The respiratory sleep disorders are a major cardiovascular risk factor. In fact there is enough scientific evidence that supports the association between apnea-hypopnea syndrome (SASH) and cardiovascular disease (hypertension…
- Trial name
- NCT01347411
- Testing
- CPAP
- Volunteers
- 420 people
- Sponsor
- Basque Health Service
Pulmonary Disease, Chronic Obstructive
Severe Chronic Respiratory Failure and Citrulline
Because of its very high bioavailability and its specific and direct action on protein synthesis, the investigators hypothesize that citrulline supplementation would be an innovative nutritional strategy to improve the peripheral…
- Trial name
- NCT03694964
- Testing
- ProteoCIT®
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Grenoble
Nutrition
Individualized Metabolic Assessment and Nutritional Optimization in Children With Chronic Respiratory Insufficiency
The investigators aim to examine the feasibility of individualized diet intervention in children dependent on long-term mechanical ventilator support at home.
- Trial name
- NutriCAPE (NCT02354495)
- Testing
- Changes in energy and protein intake
- Volunteers
- 16 people
- Sponsor
- Boston Children's Hospital
Abdominal Sepsis, Acute Respiratory Failure
Evaluation of Regional Ventilation Distribution in Patients Affected by Abdominal Sepsis After Emergent Laparotomy
The goal of this clinical trial is to evaluate regional ventilation distribution in patients admitted to the intensive care unit after emergent laparotomy due to abdominal sepsis.
- Conditions
- Abdominal Sepsis, Acute Respiratory Failure, Ventilation Therapy; Complications, Emergencies
- Trial name
- CHESTOMY (NCT05726500)
- Testing
- Arterial blood gas analysis, Venous blood gas analysis, Esophageal pressure monitoring
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Università degli Studi di Ferrara
Acute Hypoxemic Respiratory Failure
Respiratory Mechanics Assessment During Assisted Mechanical Ventilation
To verify the association between respiratory system mechanical properties (ΔP, ΔPL,dyn, Pmus, Pplat and CRS and CL,dyn) assessed during assisted modes of ventilation (as average over the first three days since enrollment) and…
- Trial name
- ICEBERG (NCT05203536)
- Where
- 8 sites in Canada, Germany and 3 more
- Volunteers
- 298 people
- Sponsor
- University of Milano Bicocca
Diabetes Mellitus, Type 2, Congestive Heart Failure
Improving Patient Prioritization During Hospital-homecare Transition
This research work is focused on building and evaluating one of the first evidence-based clinical decision support tools for homecare in the United States.
- Conditions
- Diabetes Mellitus, Type 2, Congestive Heart Failure, Obstructive Pulmonary Disease, Dyspnea
- Trial name
- PREVENT (NCT04136951)
- Testing
- PREVENT clinical decision support
- Where
- 2 sites in United States
- Volunteers
- 1,915 people
- Sponsor
- Columbia University