Clinical trials: Respiratory Allergy
Cough
Functional Magnetic Resonance Imaging of ATP Cough in Chronic Cough Patients
Persistent cough is a distressing symptom for people with respiratory disorders. Patients also often experience an ongoing urge-to-cough that prompts coughing, and which fails to resolve the sensation.
- Trial name
- NCT03722849
- Testing
- Adenosine Triphosphate, Capsaicin, Functional Brain Imaging
- Where
- Australia
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Stuart Mazzone
Asthma
A Study Comparing the Safety and Efficacy of Fluticasone and Formoterol Combination (FlutiForm™) With Fluticasone or Flovent to Treat Moderate to Severe Asthma in Adolescents and Adults
The medications being used in this study are individually approved by the Food and Drug Administration (FDA). The medication under investigation is a combination of two medications in one inhaler.
- Trial name
- NCT00649025
- Testing
- FlutiForm 250/10, SKP-Fluticasone, Flovent Fluticasone HFA
- Where
- 103 sites in United States, Argentina and 8 more
- Volunteers
- 438 people
- Sponsor
- SkyePharma AG
Asthma
Glucagon-Like Peptide-1 Receptor Agonist in the Treatment of Adult, Obesity-related, Symptomatic Asthma (GATA-3)
This is a randomized placebo-controlled trial of semaglutide, an FDA-approved therapy for the treatment of type 2 diabetes mellitus and obesity, in adults with symptomatic asthma despite the use of inhaled steroids and with…
- Trial name
- GATA-3 (NCT05254314)
- Testing
- Semaglutide Pen Injector 2.4mg weekly
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Vanderbilt University Medical Center
Asthma, Health Personnel
Changes in Physician Performance Through Continuous Professional Development
The purpose of this study is to determine whether having physicians evaluate their management of certain diseases as part of board recertification results in improved patient care.
- Trial name
- NCT00115284
- Testing
- ABIM asthma practice improvement module
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Rhinitis, Allergic, Perennial
The Effect of Apple Fruit Extract (Malus Sylvestris Mill) as an Antioxidant and Anti-Inflammatory on Allergic Rhinitis
This study was conducted to see before and after treatment whether it provided improvement in the patient's clinical symptoms.
- Trial name
- NCT07380178
- Testing
- Quercetin, Apple Extract, Loratadine 10 Mg
- Where
- Indonesia
- Volunteers
- 40 people
- Sponsor
- Universitas Sebelas Maret
Asthma, Allergic Rhinitis
Molekule for Allergic Rhinitis/Asthma
Exposure to airborne allergens and pollutants is linked to symptom severity of allergies, asthma and other respiratory problems.
- Conditions
- Asthma, Allergic Rhinitis, Allergic Conjunctivitis
- Trial name
- NCT03627689
- Testing
- Active air purifier in respiratory allergies/asthma
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Molekule
Asthma
A Practical Model to Transform Childhood Asthma Care - Spirometry Training in the Primary Care Setting
Spirometry is a recommended component of asthma diagnosis and treatment in the primary care setting, however, few primary care providers report routine use of spirometry in the provision of care for their asthma patients.
- Trial name
- NCT01161433
- Testing
- Virtually delivered spirometry quality improvement program
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Washington
Asthma
A Study of GSK3511294 (Depemokimab) Compared With Mepolizumab or Benralizumab in Participants With Severe Asthma With an Eosinophilic Phenotype
This study will assess whether switching participants who have benefitted from mepolizumab or benralizumab to GSK3511294 (Depemokimab) is non-inferior to maintaining current treatment on the annualized rate of clinically…
- Trial name
- NIMBLE (NCT04718389)
- Testing
- GSK3511294 (Depemokimab), Mepolizumab, Benralizumab
- Where
- 397 sites in United States, Australia and 19 more
- Volunteers
- 1,717 people
- Sponsor
- GlaxoSmithKline
CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ASTHMA
Inhaler Lung Deposition in Chronic Obstructive Pulmonary Disease (COPD)
Patients with chronic obstructive pulmonary disease (COPD) experience breathing difficulties because the airways deep in their lungs become narrowed. COPD patients use inhaler drugs to provide relief from breathlessness.
- Conditions
- CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ASTHMA, HEALTHY SUBJECTS
- Trial name
- NCT01721291
- Testing
- SALBUTAMOL
- Where
- United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Non Small Cell Lung Cancer
Study to Assess the Effect of AZD9291 on the Blood Levels of Rosuvastatin, in Patients With EGFRm+ Non-small Cell Lung Cancer
This is a Phase I, open-label, 2-part study in patients with a confirmed diagnosis of epidermal growth factor receptor (EGFR) mutation positive (EGFRm+) non-small cell lung cancer (NSCLC), who have progressed following prior…
- Trial name
- NCT02317016
- Testing
- Pharmacokinetic sampling - AZD9291, AZD9291 tablet dosing, Rosuvastatin
- Where
- 13 sites in United States, France and 2 more
- Volunteers
- 44 people
- Sponsor
- AstraZeneca
Lung Disease, Chronic Obstructive Pulmonary Disease (COPD)
Lung Disease Collection (Qatar): Evaluation of the Lungs of Individuals With Lung Disease
The purpose of this protocol is to obtain biologic samples from the blood and lungs from patients with lung diseases in order to study the causes and indications of these disorders, learn how these lung disease manifest and…
- Conditions
- Lung Disease, Chronic Obstructive Pulmonary Disease (COPD), Asthma
- Trial name
- Q-LD (NCT00504738)
- Where
- Qatar
- Volunteers
- 75 people
- Sponsor
- Weill Medical College of Cornell University
Pleural Effusion, Malignant
The Added Value of CT Scanning in Patients With an Unilateral Pleural Effusion
To investigate the diagnostic power of computed tomography for discriminating malignant from nonmalignant causes to pleural effusions in consecutive patients with no malignant cells found at a cytological examination and a chest…
- Trial name
- NCT03270215
- Testing
- Computed tomography
- Where
- Denmark
- Volunteers
- 232 people
- Sponsor
- Naestved Hospital
Invasive Fungal Disease, Lung Transplant Recipients
Assessing Diagnostic Methods for Invasive Fungal Disease in Lung Transplant Recipients
This study aims to assess the diagnostic performance of different tests, including metagenomic next-generation sequencing (mNGS), real-time PCR, galactomannan assay, and lateral-flow device tests, in detecting invasive fungal…
- Conditions
- Invasive Fungal Disease, Lung Transplant Recipients, Invasive Pulmonary Aspergillosis, Pneumocystis Jirovecii Pneumonia
- Trial name
- NCT06654076
- Volunteers
- 109 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Allergy to House Dust Mite, Allergic Asthma
Effects of Tregalizumab on Allergen-induced Airway Responses and Airway Inflammation in Asthmatic Patients
The study will be conducted as a randomized, double-blind, placebo-controlled, single-center study in adult patients with mild controlled allergic asthma and house dust mite allergy.
- Trial name
- Tregulaire (NCT04673591)
- Testing
- Tregalizumab
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- T-Balance Therapeutics GmbH
Perennial Allergic Rhinitis, Rhinitis, Allergic
Efficacy and Safety of AM-301 on Allergic Symptoms of Perennial Allergic Rhinitis Sufferers
Alleviation of allergic symptoms induced by house dust mites when using the medical device AM-301. This clinical investigation explored the efficacy and safety of AM-301 when used to reduce symptoms of house dust mite sufferers.
- Trial name
- NCT05122143
- Testing
- Treatment A, Treatment B, Treatment C
- Where
- Canada
- Volunteers
- 37 people
- Sponsor
- Altamira Medica Ltd.
Asthma, Inflammation
Innovative Steroid Treatment to Reduce Asthma Development in Children After First-time Rhinovirus Induced Wheezing
The overall objective of the study is to determine the efficacy of corticosteroids in preventing recurrent wheezing and asthma in high-risk, first-time severe wheezing children with rhinovirus infection, stratified by rhinovirus…
- Trial name
- INSTAR (NCT03889743)
- Testing
- Dexamethasone treatment during 3 days
- Where
- 8 sites in Finland, Norway and 1 more
- Volunteers
- 280 people
- Sponsor
- St. Olavs Hospital
Asthma
QUARTZ: Comparative Effectiveness of Switching From Albuterol to Albuterol/Budesonide Versus Adding Low-dose ICS or LTRA to Albuterol
The QUARTZ study is a retrospective observational cohort study using a prevalent new-user design and U.S. healthcare claims data to evaluate treatment effectiveness among patients with asthma.
- Trial name
- QUARTZ (NCT07787117)
- Testing
- None (observational study)
- Where
- United States
- Volunteers
- 8,681 people
- Sponsor
- AstraZeneca
Asthma
A Randomized, Double-Blind, Placebo-Controlled Study of Gastroesophageal Reflux Disease Therapy.
Asthma and gastroesophageal reflux disease (GERD) are common disorders, which although are not usually lethal, both have high morbidity, and high healthcare costs.
- Trial name
- NCT00237068
- Testing
- Lansoprazole; Solutab
- Where
- 3 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Emory University
URTI, Bronchiolitis
Assessement of Effectiveness of Seawater Nasal Sprays on Sinonasal Symptoms
The purpose of this post-market clinical investigation is to assess in a real-life setting, the effectiveness, usage, tolerance, safety and satisfaction of 4 isotonic and hypertonic seawater-based CE-marked nasal sprays.
- Conditions
- URTI, Bronchiolitis, COVID - 19, Allergic Rhinitis
- Trial name
- SeaBridge (NCT07262450)
- Testing
- Respimer® Hygiene-Prevention -Baby, kids, adults, Respimer® Hygiene-Prevention Kids, adults, Respimer® Decongestion Baby, kids, adults
- Where
- 32 sites in France
- Volunteers
- 1,065 people
- Sponsor
- Laboratoire de la Mer
Large Airway Collapse, Asthma
A Randomised Feasibility Study of CPAP in Large Airway Collapse
Large airway collapse (LAC) is an increasingly recognised condition characterised by either bowing of the posterior membrane/trachealis muscle into the trachea or main bronchi (also known as excessive dynamic airway collapse…
- Trial name
- RE-LACS (NCT07504926)
- Testing
- CPAP
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Liverpool School of Tropical Medicine
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