Clinical trials: Respiratory Allergy
Asthma
Modulation Of Airway Reactivity With Chronic Mechanical Strain
The purpose of this study is to see if the use of a machine called CPAP will help children with asthma breathe better. CPAP is a machine that produces airflow to help people with breathing problems.
- Trial name
- NCT02396849
- Testing
- Continuous Positive Airway Pressure (CPAP)
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Indiana University
Pulmonary TB, Pulmonary Tuberculosis
Phase 2 Trial Assessing TBAJ876 or Bedaquiline, With Pretomanid and Linezolid in Adults With Drug-sensitive Pulmonary Tuberculosis
The goal of this clinical trial is to evaluate 3 dose levels of TBAJ876 for 8 weeks in combination with pretomanid and linezolid, compared to 8 weeks of Isoniazid, rifampicin, pyrazinamide and ethambutol (2HRZE), in adult…
- Conditions
- Pulmonary TB, Pulmonary Tuberculosis, Drug Sensitive Tuberculosis
- Trial name
- NCT06058299
- Testing
- sorfequiline, Pretomanid, Linezolid
- Where
- 22 sites in Georgia, Philippines and 3 more
- Volunteers
- 309 people
- Sponsor
- Global Alliance for TB Drug Development
Asthma
Efficacy of Mobile Phone Short Message Service (SMS) Reminder and Consultation on Asthma Control
Asthma is the disease being studied. The main objective of this study is to assess the clinical efficacy of mobile phone short message service (SMS) reminder and consultation on the self-management and outcomes of poorly…
- Trial name
- NCT02189616
- Testing
- SMS reminder, SMS consultation, regular care
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Xijing Hospital
Asthma, Rhinitis
Kansas City Community Environmental Remediation And Training (KC CERT)
Objective: Our overall objective is to test the hypothesis that the health of children with chronic respiratory symptoms or chronic exposures to environmental hazards can be improved through a combination of standard home…
- Conditions
- Asthma, Rhinitis, Allergy
- Trial name
- NCT00144443
- Testing
- Basic home repair, Asthma Trigger Education
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Children's Mercy Hospital Kansas City
Asthma
Asthma Diagnosis Through Peak Flows
The guidelines indicate the possibility of diagnosing asthma through peak flow. This recommendation being the result of expert consensus, but the evidence is limited and contradictory.
- Trial name
- DAPF-CSL (NCT05439915)
- Volunteers
- 100 people
- Sponsor
- Consorci Sanitari de Terrassa
Preschool Severe Asthma
Preschool Bronchial Remodeling and Risk of Exacerbation
Bronchial remodeling is an abnormal tissue repair process of the bronchial wall components that characterizes severe asthma which can include epithelial abrasion, thickening of the reticular basement membrane (RBM), an increase…
- Trial name
- RESPIRE (NCT04558671)
- Testing
- asthma exacerbations
- Where
- 2 sites in France
- Volunteers
- 56 people
- Sponsor
- University Hospital, Bordeaux
Allergic Bronchopulmonary Aspergillosis
Voriconazole Versus Oral Steroids in Allergic Bronchopulmonary Aspergillosis
This is a research project to evaluate the efficacy and safety of two different treatment protocols in Allergic bronchopulmonary Aspergillosis.
- Trial name
- NCT01621321
- Testing
- Prednisolone, Voriconazole
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Perennial Allergic Rhinitis
Hypothalamic-Pituitary-Adrenal (HPA) Axis Study in Adult and Adolescent Subjects With Perennial Allergic Rhinitis (PAR)
The purpose of the study is to evaluate the effects of BDP HFA Nasal Aerosol on HPA-axis function.
- Trial name
- NCT01133626
- Testing
- Prednisone capsules, Beclomethasone dipropionate
- Where
- 3 sites in United States
- Volunteers
- 107 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Rhinitis, Urticaria
The Effect of Levocetirizine on Inflammatory Mediators in Dermatographism
Levocetirizine (Xyzal®), the active levorotatory enantiomer of cetirizine (Zyrtec®), is a FDA-approved drug used in the treatment of symptoms associated with seasonal and perennial allergic rhinitis and chronic idiopathic…
- Trial name
- NCT01008592
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Wake Forest University
Asthma
A Study to Evaluate the Effect of Repeat Doses of GW870086X in Mild to Moderate Asthmatics
This study will measure the effect of repeat inhaled doses of GW870086X on lung function.
- Trial name
- NCT00945932
- Testing
- GW870086X
- Where
- 8 sites in Germany
- Volunteers
- 37 people
- Sponsor
- GlaxoSmithKline
COVID-19, Chronic Heart Failure
Analysis of Health Status of Сomorbid Adult Patients With COVID-19 Hospitalised in Fourth Wave of SARS-CoV-2 Infection
Depersonalized multi-centered registry initiated to analyze dynamics of non-infectious diseases after SARS-CoV-2 infection in population of Eurasian adult patients.
- Conditions
- COVID-19, Chronic Heart Failure, Diabetes Mellitus, Chronic Kidney Diseases
- Trial name
- ACTIV4 (NCT05226416)
- Where
- Russia
- Volunteers
- 3,554 people
- Sponsor
- Eurasian Association of Therapists
Pulmonary Disease, Tuberculosis, Pulmonary
Evaluate Safety, Tolerability, PK of TBAJ-876 in Healthy Adults
A Phase 1, Partially Blind, Placebo Controlled, Randomized, Combined Single Ascending Dose (SAD) with a Food Effect Cohort (Part 1), Multiple Ascending Dose (MAD) (Part 2), and Relative Bioavailability (rBA) (Part 3) Study to…
- Conditions
- Pulmonary Disease, Tuberculosis, Pulmonary, Tuberculosis, Multi Drug Resistant Tuberculosis
- Trial name
- NCT04493671
- Testing
- TBAJ-876 suspension, TBAJ-876 100 mg tablet, TBAJ-876 25 mg tablet
- Where
- United States
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Global Alliance for TB Drug Development
Asthma
A Repeat Dose Study to Investigate the Interaction of GSK2190915 on the Pharmacokinetics of Rosuvastatin
Leukotrienes are potent inflammatory molecules produced mainly by mast cells, eosinophils, monocytes/macrophage and neutrophils in response to allergic or inflammatory stimuli.
- Trial name
- NCT01411111
- Testing
- Rosuvastatin 10 mg, GSK2190915 30mg, GSK2190915 100mg
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Pulmonary Disease, Chronic Obstructive, Lung Diseases, Obstructive
Diagnosing Obstructive Lung Disease With Point of Care Ultrasound
The objective of this study is to evaluate the diagnostic accuracy of Point of Care Ultrasound (POCUS) in identifying obstructive lung diseases (OLDs), using pulmonary function tests (PFTs) as the gold standard for comparison.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Lung Diseases, Obstructive, Asthma, COPD
- Trial name
- NCT06251271
- Testing
- Point-of-Care Ultrasound
- Where
- Israel
- Volunteers
- 301 people
- Sponsor
- Soroka University Medical Center
Asthma
Effects of Su-Huang Antitussive Capsule on Cough Variant Asthma
This study aims to observe the therapeutic effect of Su-Huang antitussive capsule on cough variant asthma. The investigators hypothesize: Cough score and cough reflex sensitivity will be improved after treatment with Su-Huang…
- Trial name
- NCT01584804
- Testing
- Su-Huang antitussive capsule, Sugar pill
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Status Asthmaticus
Comparison of Albuterol for Status Asthmaticus
This study is designed to compare the length of continuous albuterol administration between two different albuterol formulations, BAC containing albuterol versus preservative free albuterol.
- Trial name
- NCT02966184
- Testing
- preservative free albuterol
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Norton Healthcare
Seasonal Allergic Rhinitis
A Study to Assess the Efficacy and Safety of PG-011 Nasal Spray in Adults With Moderate to Severe Seasonal Allergic Rhinitis
The study is a multicenter, randomized, double-blind, placebo-controlled seamless and adaptive-designed phase IIb/III study encompassing a phase IIb and a phase III component.
- Trial name
- Pumecitinib (NCT06837233)
- Testing
- Pumecitinib Nasal Spray 0.3%, Pumecitinib Nasal Spray 0.6%, Pumecitinib nasal spray 0.6%(twice daily)
- Where
- 20 sites in China
- Volunteers
- 179 people
- Sponsor
- Prime Gene Therapeutics Co., Ltd.
Asthma
Asthma Comparative Effectiveness Study
The objective of this study is to compare the real-world effectiveness of BFC and FSC in asthma patients new to ICS/LABA combination therapy in a population of U.S. health plan enrollees.
- Trial name
- Asthma CER (NCT01623544)
- Volunteers
- 6,086 people
- Sponsor
- AstraZeneca
Hypertension, Diabetes Mellitus, Type 2
ENCOMPASS: Expansion Study A, RCT
Some patients living with multiple long-term health conditions have difficulty accessing the services they need, despite available primary care and community resources.
- Conditions
- Hypertension, Diabetes Mellitus, Type 2, Chronic Kidney Diseases, Ischemic Heart Disease
- Trial name
- ENCOMPASS (NCT04790604)
- Testing
- Community Health Navigator Program
- Where
- Canada
- Volunteers
- 96 people
- Sponsor
- University of Calgary
Asthma
SOLO-Symbicort® in the Treatment of Persistent Asthma in Adolescents & Adults
The purpose of this study is to compare Symbicort Single Inhaler treatment with the Best Conventional Practice in patients with persistent asthma
- Trial name
- NCT00238784
- Testing
- Budesonide/formoterol Turbuhaler
- Where
- 3 sites in Canada
- Volunteers
- 1,300 people
- Sponsor
- AstraZeneca
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